PREMARIN Reviews (ESTROGENS, CONJUGATED)

Average Rating: 3.4 (505 Ratings)

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PREMARIN  (ESTROGENS, CONJUGATED):  This medication is a female hormone. It is used by women to help reduce symptoms of menopause (such as hot flashes, vaginal dryness). These symptoms are caused by the body making less estrogen. If you are using this medication to treat symptoms only in and around the vagina, products applied directly inside the vagina should be considered before medications that are taken by mouth, absorbed through the skin, or injected. Certain estrogen products may also be used by women after menopause to prevent bone loss (osteoporosis). However, there are other medications (such as raloxifene, bisphosphonates including alendronate) that are also effective in preventing bone loss and may be safer. These medications should be considered for use before estrogen treatment. Certain estrogen products may also be used by men and women to treat cancers (certain types of prostate cancer, breast cancer that has spread to other parts of the body) and by women who are not able to produce enough estrogen (for example, due to hypogonadism, primary ovarian failure).    (Sources: U.S. Centers for Medicare Services, FDA)

  

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More on PREMARIN: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR PREMARINCOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 1  Total Hysterectomy Weight gain (esp in abdominal area which was never a problem before) EXTREME joint stiffness in lower body (lumbar spine, hips, ankles) edema, breast size went from a 34C to a 34DDD in 1 year I just decided this week to discontinue this medication after taking it for a year. After just 4 days, I have noticed that my joint pain/stiffness is getting better, my breasts are not as engorged and I actually feel happier. I haven't experienced any hot flashes yet but will buy a fan rather than deal with the side effects. F 45 1 years
3/29/2007
 1  total hysterectomy 4/06 Started taking 0.3mg Feb 15th after having night sweats and insomnia. I preffered not to take any hrt. I started having severe pain in my left lower hip. It extended down my left inner thigh to my knee. I had severe muscle spasms in my inner thigh. I was unable to stand for more than 2 min w/o experiencing excruciating pain. I took muscle relaxant to ease the pain. Also I observed that I am constantly hungry which is not normal for me. It helped the hotflashes and nightsweats somewhat. Also hepled severe itching on different parts of my body which resulted in severe welts. But the severe leg cramps was unbearable. I stopped taking this pill today after visiting this website and other sites and learning that others experienced the same problems. I'm still having pain extending to the knee. A friend suggested climara patch. dont know what to do. Any suggestions? Does anyone know how long the leg pain will last? F 47 35 days
3/25/2007
 2  Severe Menopause Symptoms Hysterectomy 16 years ago w/1 ovary balanced ok for 10 yrs. Subsequently, a stress event caused raging hormone imbalance; horrific night sweats both day & night, horrible insomnia, daily weeping spells; placed on Premarin for 6 years; stopped due to fears & risks (Women Health Initiative study results. Plus I erroneously thought I was Estrogen Dominant. I abruptly stopped the Premarin (.925); substituted natural progesterone cream(published recommendations Dr. Christianne Northrup & Dr. John Lee). Managed ok but was struggling; progressively worsened. Around 3 month mark I was in really bad shape; unable to get out of bed or perform daily functions; raging insomnia & daily weeping. Completed hormone saliva test through ZRT Labs(again as recommended by Drs. Northrup & Lee). I was astounded to learn I was not Estrogen Dominant; I was estrogen deficient. The high dosing of natural progesterone cream had raised my progesterone level to a very high imbalance. I h Next, I plan to try to at least switch from Premarin to an RX bio-identical product (Estradiol)and see if that works for me. Along with many others,I hate the side negative effects and increased risks of Premarin. But, when estrogen deficiency makes you bedridden and unable to take care of yourself or perform basic daily functions, it seems there may be no other choice:( Now, I did later read in Dr. Lee's book that when Premarin is ABRUPTLY stopped it can result in a return of raging symptoms. Dr. Lee states that our estrogen receptors go through rage withdrawals when the Premarin is suddenly stopped. Therefore, he recommends a 6 month progressive step down withdrawal. At some point after I get my system stablized again, I want to retry stopping the Premarin through the 6-month taper down process. But, after the horrid symptoms I have had the past 3 months I am not going to stress my body further by starting that any time soon....maybe in 6 months or so. F 56 6 days
3/21/2007
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 1  Post hysterectomy at 39 yrs old Profound panic attacts F 62 180 days
2/8/2007
 2  complete hysterectomy foggy head, blurry vision, double/triple vision, huge belly bloating, hair loss, blood pressure above normal Hate this drug but have no choice. The cancer board insists I continue taking 1.25 until I hit menopausal age due to my family history with ovarian cancer. I hatenot having a clear head and forgetting things all the time. Never mind the huge tummy! I play a lot of sports and my weight does not change...gained 30 pounds since starting this drug. In the last 2 years, my eye sight is starting to blur and when I play sports, I find that I have double/triple vision. Hard to kick that soccer ball or catch the lacrosse ball when 2 or 3 are coming towards you. My doctor has no idea what to do and is sending me to a neurologist. Hoping he can help me but I think it is just premarin. F 41 7 days
1/26/2007
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 5  Complete Hysterectomy None I have no side effects from premarin. I see most complained about weight gain. Tried climara patch and retained fluid so decided to switch to premarin. The patch is what really put weight on me and since I switched to premarin lost 25 pounds. Back to being thin again but I also exercise, try to eat right, and drink alot of water. Only advice I can give you. Reading what others had said about estrogen levels I have not been tested yet since my surgery. I'm on .625 and take it every other day. I wonder if that's enough although I feel okay. Actually feel better now, more leveled out and calm compared to when I was still getting my menstrual cycle. As of right now I feel too good to consider going off even though I'm aware of the side effects you can get for long term use. Chance I'll take I guess. F 38 1 days
1/21/2007
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 4  HOT FLASHES, NIGHT SWEATS I do not know if this was the cause but gained 70 lb in 15 years. Now with bio-identical creams I've lost 15 lb in 2 mos. Five of those lb came off during a bout with extreme carsickness on an 18 hr trip. I think I felt better on Premarin .625 mg. Had severe side effects when switching to the cream--horrible itching, swelling to the point I could not sleep. And a 7 day heavy period. F 62 20 years
1/16/2007
 5  total hysterectomy @ 24 None other than I look younger than my 50 years have greater energy and a better disposition. I have taken 1.25 for 26 years and even though I still take it, I am now experiencing the sweats. No weight gain except the usual difference of youth & maturity. I don't sleep but I never did as a child. My eyesight has been bad for sometime and my prescription for them changes each year. My legs do not feel abnormally heavy, I've just gotten out of shape and lazier. I no longer go to drs because they won't listen to me when I tell them how I feel and simply want me to go off it. At last check my blood pressure was perfect and cholesterol was low on the bad side, high on the good. I would like to go off but don't see that happening anytime soon. Its about the quality of my life and every minute I want to enjoy it. F 50 26 years
1/11/2007
 1  Total Hysterectomy I took premarin .5 dose for over a year. I gained weight but started to suffer from depression. I actually wanted to run away or kill myself. My sister took premarin but changed I asked her why and she said 'it gave me bad thoughts'. Changed straight away to Elleste Solo, 2mg. May be I needed a higher dose. Whatever it was I feel great now and have done for a year. Lost a stone and no mood swings. Oh, and it made my nails break and my hair started to fall out - my cleaning lady suffered the same symptoms but wouldnt' believe it was the premarin. I would like to hear if anyone else suffered these type of side effects. F 48 1.5 years
12/25/2006
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 1  hysterectomy, removal of ovaries Short term memory loss, weight gain, Difficulty with multi-tasking, vision problems such as blurred vision and floaters. I was taking 1.25 mg daily for 8 months. I have been off the medication for one week and have noticed an improvement in my memory and the multi-tasking. I do not know if the "floaters" are from the Premarin but I have begun taking Omega 3 for my eyesight. I've lost 3 pounds without trying and most importantly, I nearly put my grandson in danger while baby sitting him because of the short term memory loss and after investigating the benefits of premarin, night sweats, and hot flashes I can handle and I'd much rather break a hip due to osteoporosis than put my grandson in danger. Would not recommend this medication to anyone, ever. F 49 8 months
12/17/2006
 1  Menopause at 50, hot flashes After about 6 months, I realized my legs were bothering me. Dr. said it must be arthritis, NOT the premarin. Legs got worse. My leg and hip joints gradually worsened over the 8 years I took premarin. I exercised alot, but still I felt like I was walking through water. Legs felt full, heavy, achy. I continued to think it must be arthritis. Dr. urged me not to quit premarin. I couldn't stand the way I felt, so I decided to experiment. I went off premarin for three weeks, and the hot flashes started immediately, but the leg pain immediately stopped. I went back on premarin, and the hot flashes stopped, leg pain came back. I finally decided that the leg pain could be a warning sign. My grandfather died of a heart attack when he was 78. I am 58. Though I don't like the hot flashes, they are normal. Leg pain may not be so normal. My grandmother did have verweight. I do hope I benefitted from 8 years on premarin. My bone density is still excellent. Now, I rely upon the exercise and good diet to promote bone density. Mom had osteopenia.y bad arthritis, and that's why I thought I was coming down with arthritis. But once off premarin, the "arthritis" pain is gone. So I assume it was the premarin, and not arthritis. I was hoping to lose weight once off premarin, but I haven't lost any. Dang. F 58 8 days
12/14/2006
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 1  Menopause at 50, hot flashes After about 6 months, I realized my legs were bothering me. Dr. said it must be arthritis, NOT the premarin. Legs got worse. My leg and hip joints gradually worsened over the 8 years I took premarin. I exercised alot, but still I felt like I was walking through water. Legs felt full, heavy, achy. I continued to think it must be arthritis. Dr. urged me not to quit premarin. I couldn't stand the way I felt, so I decided to experiment. I went off premarin for three weeks, and the hot flashes returned immediately, but the leg pain immediately stopped. I went back on premarin, and the hot flashes stopped, but the leg pain came back. I finally decided that the leg pain could be a warning sign. My grandfather died of a heart attack when he was 78. I am 58. Though I don't like the hot flashes, they are normal. Leg pain may not be so normal. My grandmother did have bad arthritis, and that's why I thought I was coming down with arthritis. But once off premarin, the "arthritis" pain is gone. So I assume it was the premarin causing leg pain, and not arthritis.. I do hope I benefitted from 8 years on premarin. My bone density is still excellent. Now, I rely upon the exercise and good diet to promote bone density. Mom had osteopenia. I was hoping to lose weight once off premarin, but I haven't lost any. Dang. F 58 8 years
12/14/2006
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 2  perimenopause/left oopherectomy Hair loss, weight gain , chest pains, body aches,headaches I started perimenopause at 31, since then I have had a left oopherectomy(removal of ovary and fallopian tube), and multiple cycst removed on right ovary now again I have 2 more growing cycst for 4 months,my insomnia hot flashes, night sweats are intense. My Dr. just put me on the highest dose of premarin 1.25 to see if the cycst will bleed i guess,he doesnt want to do a hysterectomy, I still have a uterus and am woorried about fibroids this is the third time he put me on this and I feel worse than ever & still dealing with all menopausal symptoms, I am confused on why I am still taking this and he won't do the hysterectomy since I have not had a period in over a year now? does anyone have a suggestion, please? F 36 5 years
12/7/2006
 1  Total Hysterecomy SEVERE joint pains after only 1 month. Crippling pain in knee, both ankles and wrists. Also having blurry vision. I never associated my joint pain with this medicine. I only knew it started shortly after my hysterectomy in 9/06. The surprising thing is how RAPIDLY my joints have deteriorated. After going from my family doctor to a rheumatologist, and FINALLY figuring out that the pain onset shortly after I started taking PREMARIN, I began to do research about the drug on my own. I found a site that was FULL of women on PREMARIN experiencing symptoms IDENTICAL to me, and it was like finding my way home after being lost. Today, I can barely walk anymore, but I will no longer take the drug after today. Add to that, I also learned that they harvest the hormone from PREgnant MARes urINe (PREMARINE). There is info on the web about it. WTF are they thinking??? Educate yourselves, ladies. I'm calling a homeopathic M.D. to work out a NATURAL alternative. F 37 2 months
11/20/2006
 4  TAH just one complaint ... fullness and weight gain.. cant lose the 10 pounds and I have been the same weight for 20 years before beginning the HRT. Oh well its not that I look horrible I just feel that I have a big belly but it is better than suffering those flashes anyone agree here? F 55 1 days
10/4/2006
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 4  TOTAL BADOMINAL HYSTERECTOMY MY CHIEF AND ONLY COMPLAINT IS WEIGHT GAIN.. 9 MONTHS SINCE SURGERY AND I HAVE BEEN THE SAME WEIGHT GIVE OR TAKE 5 POUNDS NOW I AM BLOATED FULL BELLY AND 10 POUNDS HEAVIER,, BUT NO HOT FLASHES SO ITS WORTH IT IF I CAN DROP THE WEIGHT I WOULD BE HAPPY.. TRIED TO WEAN OFF BUT GOT THR FLASHES AND THEY ARE HORRIBLE F 55 9 days
7/25/2006
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 5  Hysterectomy and mood swings None..but, my Doctor thinks it has caused a high gamma GT reading in my liver.On his advice I am taking a reduced level ie 0.625 evert third day.I want to stay on it forever, I feel and look great Can it cause "liver sludge" ? F 61 15 years
7/17/2006
 5  Hysterectomy and mood swings None..but, my Doctor thinks it has caused a high gamma GT reading in my liver.On his advice I am taking a reduced level ie 0.625 evert third day.I want to stay on it forever, I feel and look great Can it cause "liver sludge" ? I came ff it when the panic about HRT started,the result was I felt terrible,I had awful night sweats,tiredness,moody and miserable.i am doing as the doctor suggested for 1 month to see if the liver count goes down. i feel OK o the reduced level so i will probably stick to that doseage. F 61 15 years
7/17/2006
 5  Hysterectomy and mood swings None..but, my Doctor thinks it has caused a high gamma GT reading in my liver.On his advice I am taking a reduced level ie 0.625 evert third day.I want to stay on it forever, I feel and look great Can it cause "liver sludge" ? I came ff it when the panic about HRT started,the result was I felt terrible,I had awful night sweats,tiredness,moody and miserable.I am doing as the doctor suggested for 1 month to see if the liver count goes down. At the moment I feel OK on the reduced level so I will probably stick to that doseage. F 61 15 years
7/17/2006
 5  Hysterectomy and mood swings None..but, my Doctor thinks it has caused a high gamma GT reading in my liver.On his advice I am taking a reduced level ie 0.625 evert third day.I want to stay on it forever, I feel and look great Can it cause "liver sludge" ? I came off it when the panic about HRT started,the result was I felt terrible,I had awful night sweats,tiredness,moody and miserable.I am doing as the doctor suggested for 1 month to see if the liver count goes down. At the moment I feel OK on the reduced level so I will probably stick to that doseage. F 61 15 years
7/17/2006

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