LUPRON DEPOT Reviews (LEUPROLIDE ACETATE)

Average Rating: 3.0 (783 Ratings)

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 ANTERIOR PITUITARY HYPOTHALMIC FUNCTION ANTINEOPLASTICS

 Type: Rx Drug

  

LUPRON DEPOT  (LEUPROLIDE ACETATE):  Leuprolide is used to treat advanced prostate cancer in men. It is not a cure. Most types of prostate cancer need the male hormone testosterone to grow and spread. Leuprolide works by reducing the amount of testosterone that the body makes. This helps slow or stop the growth of cancer cells and helps relieve symptoms such as painful/difficult urination. Talk to your doctor about the risks and benefits of treatment.   FDA Approval Date: 1989-01-26 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on LUPRON DEPOT: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR LUPRON DEPOTCOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 3  for endo and fibroids nausea,dizziness, pain everywhere,lack of focus felt like I had no control over my body whatsoever. The worst was the first two weeks after the shot. Had continuous pain where I got the shot in my hip. very emotional, lost about 12 pounds. took 1 3 month shot. will not take another one. Can anyone tell me how long after, you received your period asfter you stopped the shot. I will be having a hysterectomy on 3/11/09. Had a myomectomy back in July 08. Pain is back to where it was before the shot. Had about three good weeks all together. F 45 60 days
2/1/2009
Email
 2  Fibroids Night sweats, Loss of libido,headaches, chills, Period still the same heavy bleeding after 3months injection,periods lasting over two weeks, very painful, passing clots, Will get the next shot march 2, 2007 hope this one works better. This medicine takes you on a roller coaster hope you can stand the ride. F 45 2 months
2/6/2007
Email
 1  Endometriosis I am currently 45. I had endometriosis, family history of ovarian cancer, personal history of multiple cysts and took Lupron when I was about 30. I had approximately 3 injections and consequently had a 5cm ovarian cyst that grew and ruptured. Along with the short-term side effects of Lupron were overall body aches/pain, rash/bumps and sickness. Unfortunately as I discovered later that was not reported to me was the chance of bone loss of over 20% which is exactly what I ended up with within a few years. The only other health problems that I have been diagnosed with over the years are Type 2 Diabetes and Osteoporosis/Osteopenia with bone loss of approximately 30%. I have been doing weight bearing exercises and taking estrace which has improved my bone loss. Overall I would not recommend Lupron for anyone with the side effects that I have described. I had a lot more effects initially that lasted for a long time then I have reported. If the Lupron had worked for the endometriosis F 45 3 months
12/27/2006
 1  endometriosis/fibroids/painful per, SEVERE, CONSTANT nausea, extreme weight gain. This drug made me sick as a dog. DO NOT TAKE THIS DRUG!!!! Remember, once you're injected, there's no taking it back. I had to seek alternative medicine to counteract the debilitating side effects of Depot Lupron. My periods/endo/monthly pain are as bad as they ever were. I received NO relief from this POISON drug. After complaining a couple of times to my "personal case nurse", who was supposed to check in every few days, she stopped calling me! I've been unable to lose the "menopause weight/shift of weight around the middle", and I'll just have to go through natural menopause again! DO NOT TAKE IT!! F 45 4 months
7/15/2007
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 1  fibroid I WENT FROM HAVING A MENSTRUAL OF 7 DAYS TO 2 MONTHS. LYPRON WOULD STOP MY MENTSTRUAL FOR 3 MONTHS BUT WHEN THE LUPRON LEFT MY SYSTEM MY MENSTRUAL WOULD STAY FOR 2 MONTHS. I FEEL THAT THE DRUG IS NOT SAFE. I HAD TO END UP HAVING A HYSTERECTOMY BECAUSE I WAS LOOSING TO MUCH BLOOD ONCE THE LYPRON LEFT MY SYSTEM. IT CAUSE ME TO HAVE A PROLONG PERIOD F 45 1 days
1/5/2006
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 1  Endometriosis First month only had chills and diarrhea. Second shot humm not so bad until....... ok let me back up a little bit. As anyone know with endo one of the signs, one may have is diarrhea well I did. Had my surgery to clean up endo then I was to start Lupron with the 5th day of may cycle. So I had to go thru all that. Well the diarrhea never stopped and instead of hot flashes I got cold flashes. Time for second shot...... Into second week "Oh My" Major flu like aches and pains the diarrhea increased lost about 7 lbs. Went to the ER for help because I didn't put two and two together. No one told me about all this nor is it on the information page. Thank God for this page because I thought I was going crazy. I also have dryness and pain with intercourse. Please let this be tempory or someone will pay for that part of my life being over with. Needless to say that was my last shot. Instead of the 11.7 Million dollars going to further the study for this Drug can we maybe fi Read up on Lupron before doing it or conitune it. It could mean your life or how you live the rest of your life. FDA needs to do something about this. TAKE IT OFF THE MARKET. F 45 6 months
3.75 1X M
4/24/2011
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 1  Fibroids, before hysteroscopic myo Abdominal swelling or bloating. Not weight gain - I am only 92 pounds! - but rather seems to be PERMANENT water retention. The bloat occurred immediately after ONE Lupron shot during the estrogen flare phase, then diminished during the brief menopausal phase, then returned suddenly five weeks after I took the shot, as my estrogen levels returned to "normal". Seven months later I fear that my pituitary gland is permanently damaged. I am seeing an endocrinologist who is mystified by such localized bloat. My lower abdomen has an uncomfortable swelling about the size of a baseball and this has led to depression, anxiety, and high blood pressure. Also insomnia and kidney stones which I attribute to the calcium I took while on Lupron. This nightmare was totally unnecessary and I was the picture of health and fitness before I took this shot. If anyone has seen their abdominal bloating eventually subside, PLEASE PLEASE email me here and tell me how long it took and what, if a DO NOT TRY THIS DRUG EVEN ONCE !!!!! YOU WILL NEVER FORGIVE YOURSELF. It is NOT a cure for fibroids or endo. If your doctor suggests this drug, run like hell and find a better doctor!!! The whole medical community will deny Lupron caused your problems but we know the truth. We MUST all work to get this drug off the market. F 45
3.75mg 1X day
2/27/2010
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Patient History
 1  Endometriosis !5 years after I suffer bone pain , Ostiopinia , degenerative disc disease, arthritis, Memory loss, cfs, and so many other symptoms. At 45 I feel 90. I believe this drug damageges your adreanal and petuituary glads causeing a host of side effects.Please educate yourself before taking this poision. We are not alone and we are not crazy there are many support groups for us on the internet. We are many! F 45 3 months
5/3/2008
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 1  Endometriosis Hot flashes/sweats, Vaginal dryness, mood swings, breast enlargement, weight gain, , Joint pain, Depression/emotional lability, Various skin ailments, like Rosacea, Keratosis Pilaris, Allergic Contact Dermatitis, Oral Alergies This drug ruined my life and my marriage. My body has never been the same and the beautiful skin that runs in my family has gone crazy on me. I realize that everybody reacts in a different way to the same drug, I can only speak from my own experience. My personality changed in such a dramatic way that people thought I was going crazy. And yes, my husband and I ended up divorced. It took 6 months for me to go to my normal self again. My Endometriosis has come back and I have had 2 doctors tell me I need to take Lupron again. As painful and bad the endo is, a second round with Lupron will drive to me to suicide. I will try to control the pain with alternative treatment. Please be careful with this drug, do your research and consider other options. In spite of this drug working wonders for other people, it wrecked my life. I took Lupron at 31 after a laparoscopy, after 5 years of pain free periods my pain came back every year getting progresively worse. Now I am 45 and will not agree to L F 45 6 months
12/7/2008
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 1  endo naseau, fatigue,anxiety attacks, SWEATS, chest pain,MIGRAINES, and many many more! i only took one 3 month injection of lupron and that was enough for me. i have had every side effect going and more. I started lupron in sept of 2007 the first injection, and was to have the second injection in january of 2008, i cannot continue with the lupron ewwwwwwww!!!!! I also am still having the side effects after 4 months, it still is in full in my system....When will i return to normal????? Not recommended by me even to my worst enemy. F 45 3 months
1/31/2008
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 1  To prep for hysterectomy Sick to my stomach the whole time, nausea, panic attacks, anxiety,depression, hot flush, cold sweat, blurry vision, lost appetite, back pain, I DO NOT RECOMMEND IT TO ANYONE This has been the worst 3 months of my life, my gynecologist recommended this poison 3 months ago due to my anemia and fibroids, well let me tell you that didn't work 2 weeks after I have lupron, I had an emergency hysterectomy because I was losing to much blood. First I was happy that finally I had the surgery then I realized that I still have lupron on my system for anothe 2 months and a half.. it has been so difficult, this side effects are not joke... when they tells you the you might get this side effects IT MEANS "you will get it for sure" I'm over the 3 months now and I still have this side effects .. can't wait to be normal again. I haven't worked all this 3 months due to all this side effects Please please please don't do lupron ask your doctor for more opcion, this medicine is a killer F 45 3 months
11.25
5/28/2017
 5  endometriosis hot flashes around the time the medication is due again. I have also had memory loss and irritableness which I didn't connect to the med until reading this site and learning it could be a side effect. I just thought I was aging quickly. LOL! I have had endometriosis since before my first period at 11. I have had so much pain with my periods (bed ridden for 3 days), prior to my periods and with ovulating. At the time there was nothing to help. Years later tried Depo Lupron and have now been on it for probably 15+ years. With depo lupron I was finally pain free and it has been amazing for me. Tried to go off of it 1X and the cramps came back unbearably so I am on it again. Note: I have been taking it continuously for 15+ years. I have had a bone density test 1X and it was fine. My memory has been bad and getting worse for about 10 years but never connected it but my family has a history of poor memory too! Any one know of statistics for breast ca or ovarian ca, etc for those taking depo lupron for extended periods? F 44 15 years
9/14/2009
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 5  fibroids, cysts, enlarged uterus hot flashes at night, not too bad, about a week of migraines besides the few side effects, this was a miracle for me! I got my life back, felt as if a bowling ball had been taken out of my body! I can bend now, put clothes on easily now, sleep comfortably too! I am thrilled with the results it has had on me. F 44 28 days
4/14/2009
 4  fibroid tumor(s) Slight spotting immediately after injection (received 2 days before my period. Otherwise, no hot flashes, or anything else that I had been warned about. I guess my only concern? is that my period has still not returned yet. Is it possible to continue on into menopause after taking this drug? F 44 4 months
4/16/2006
 3  Prostate cancer metastasized bone Only been a week. Tired and painful in butt where shot was given. Pain in my hip and lower back I was diagnosed last week with prostate cancer that has spread to lymph nodes and bone.My first 4 month shot was last Monday. I have blockage in bladder and have tube to external bag which will remove next week. PSA 210 AND GLEASON 9. I am very hopeful and know it is very early. I am only 44 and have wife and two young kids. Thanks everybody for input - I have a million questions. M 44 7 days
7.5 1X M
10/13/2010
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 3  Fibroids Hot flashes, cold flashes, headaches in the first mo. Still bleeding, my bleeding has not stopped yet and it's almost been 2 mos. F 44 90 days
11.5 1X O
9/8/2021
 1  Adenomyosis Ataxia and falling, loss of consciousness, depression, insomnia, extreme hypertension, brain seizure, fibromyalgia symptoms, rheumatoid arthritis symptoms, 30 lbs weight gain, complete inability to function. Even after stopping Lupron I am now dealing with the same side effects. This drug needs to be taken off the market. Much important information regarding the drug is not made known the patient in particular that it is a chemo drug with steroids. F 44 4 months
Injection 1X M
4/26/2015
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 1  Fibroids HOT FLASHES, NIGHT SWEATS AND ANXIETY ATTACKS! I took my shot in Jan. (3 months dosage) and I'm still experiencing these symptoms. My doctor said they should start tapering off in April- THEY'VE GOTTEN WORSE! F 44 1 days
6/28/2009
 1  endometrosis Within the first month of treatment, I became gray in palor, listless, had daily migraines, developed a terrible full body folliculitis, and was barely able to walk across a room after the first week! The doctor insisted that this was a great drug, for me, IT RUINED MY LIFE!!! I would never take this for any reason again! I would rather die than live like that! CAVEAT EMPTOR F 44 90 days
11/29/2007
 1  to treat endometriosis chronic insomnia one year after last injection, Also restless arms and legs, nervous twitching, seizures, depression, facial aging, bone and joint pain, and poor memory. This is a disaster drug that causes permanent neurological damage. The FDA must be reaching in the pockets of Lupron's manufacturer, TAP pharmaceuticals. Nothing else explains such blatant lack of concern for the victims of this horrid drug. Get it off the market! This drug is pure evil. F 44 6 months
3/7/2007

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