TRINTELLIX Reviews (VORTIOXETINE HYDROBROMIDE)

Average Rating: 2.8 (307 Ratings)

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 ANTIDEPRESSANTS

 Type: Rx Drug

  

BRINTELLIX  (VORTIOXETINE HYDROBROMIDE):  This medication is used to treat depression. It works by helping to restore the balance of a certain natural substance (serotonin) in the brain. Vortioxetine is an SSRI (selective serotonin reuptake inhibitor) and serotonin receptor modulator. This medication may improve your mood, sleep, appetite, and energy level and may help restore your interest in daily living.   FDA Approval Date: 2013-09-30 (Sources: U.S. Centers for Medicare Services, FDA)

  

Results are sorted by Date added.

Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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  Charts & graphs: Drug Safety Information

RATING  REASONSIDE EFFECTS FOR TRINTELLIXCOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 5  Major Depressive Disorder Decreased sex drive (as with all antidepressants I've taken) Brintellix cured me of MDD. I have been on antidepressants for 7 years and this is the only medication that helped me. I was on Celexa, Zoloft, and Effexor before I took this and the previous medications all failed. I took Brintellix for 2 years and I'm now in my final days of weaning off the medication. F 25 2 years
10mg 1X day
5/4/2016
 1  Anxiety Nausea at night whilst sleeping and anxiety F 41 1 months
5mg
4/27/2016
 1  Anxiety and Depression Depression / feeling flat / Stomach cramp / diarrhea / loss of motivation / burning skin Tried most of the SSRI's but only got limited results. My main problem is anxiety. This drug did nothing for me. It made me feel flat. Did not improve my mood at all in fact it made me emotionless and depressed. **IMPORTANT** - Just because it did not help me does not mean it won't be your "wonder drug". Remember everyone is different and you may find this drug works great for you. Unfortunately it did nothing for me. M 53 5 weeks
20 1X day
4/22/2016
 1  Depression and anxiety I dealt with itchiness and bruising. The former didn't worry my pdoc too much but when I told her about the bruising she insisted I stop taking it. Disappointed because I wanted to give it a chance. F 36 10 days
10
4/15/2016
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 1  depression Horrible dizziness and nausea Heard such good things, had hoped this would help me. I've been pn paxil 2 years, hate it and need to get off it, but weaning without side effects was hard, and this drug just made those worse. F 31 2 weeks
10mg
4/4/2016
 3  Major Depressive Disorder Dizziness, headache, gas I am switching to Brintellix from Paxil as the Paxil has seemed to run its course in helping my depression. Doctor said she's seen good things with this med and thinks it will be good for me. The first couple of days were fine. Yesterday and today I have alot of dizziness and headaches. When I move my head, it feels like my brain has to physically catch up. Have to work hard to absorb information or listen right now. We stopped the Paxil cold turkey and started with the 10 mg of this hoping that would ease some of the withdrawal symptoms. Not sure if this weird thing I'm having is withdrawal from the old med or side effect of this new one. I knew Paxil is hard to withdrawal from, but I'm going to hang in there with this one and hopefully this feeling gets better. Super gassy-I know that's the Brintellix. No itching yet. Lots of racing thoughts, but that's my norm anyways. Slept fine last night, but took 1/2 an Ambien before bed. F 46 4 days
10 MG 1X day
3/28/2016
Email
 1  Major depression Too many to list After being hopeful too hopeful in fact I find this medicine to be the worst I've ever taken ! After 15 years trying everything under the sun this is so disappointing. I can't get out of bed , can't concentrate , major itching , major stomach problems , just more anxious about life , scared of life . My worst experience ever , considering going to hospital F 48 4 weeks
Started 5
3/13/2016
 5  Major Depression and GAD No Side effects experienced Have experienced major depressive episodes on and off for 20 years. Had limited success on Lexapro but transitioned to brintellix due to unpleasant side effect on the Lexapro. ( weight gain, sexual dysfunction) Best thing I have ever done, feel re-engaged with my wife an children. Vastly improved concentration at work. More energy around the house, and have re-started projects I had lost the motivation to continue with. Still effected by anxiety but with less severe attacks and much shorter in duration, M 41 4 months
10mg 1X day
3/11/2016
 5  Major Depressive Disorder Anxiety Horrible itching Dr. added Atarax 3 x daily as needed itching tappered off over the next two weeks itching totally gone by week three Was already on 300 Wellbution XL and Xanax 1mg three times daily Dr added 20mg Brintellix Worked wonders for me no other side effects other than the itching. Results noticed within the first week Worked well enough that Xanax is now only PRN Really expensive med about $385 for 30 pills without insurance F 45 10 months
20 1X day
3/6/2016
 3  Depression/anxiety At first I wasn't have any side effects to my knowledge, Then a few days later the itching began, On my legs and chest and back, it comes and goes and its worse at night! This seems to be the only side effect but it's terrible! I'm going to talk to my doctor about getting off of it. F 36 2 weeks
10mh
3/2/2016
 4  Major Depression Slight nausea I started with a 5mg taper up dose and moved to 10mg/day after 1 week. As soon as I started the 10mg dose I was able to feel an improvement in my thought processes. Prior to Brintellix, I had been constantly obsessing with anxiety and depressed, feeling hopeless and that I was just hear to wait until death took me. A week after the 10 mg/day dose, I was able to think about my day and things that I needed to do. No more obsessing. And, I am able to make life meaningful with just my day to day activities again. Before it was work and come home. Now, it's work, come home and find meaningful things to do! F 58 21 days
10mg 1X day
2/29/2016
 4  Major Depression,PTSD, anxiety So far I have only experienced little red spots appearing all over my skin. I have had a bit of insomnia but then again I always do. My anxiety is a bit higher but not unbearable. I am concerned about the red spots because this is what happened to me when I took Paxil. It turned into extreme itching after the spots appeared. I haven't had any of the nausea that people complain about so far. I have taken it on an empty stomach and with food. The amazing thing about it so far is that it has already stopped my constant thoughts of suicide. I haven't been crying all the time or had mood swings. I am concerned about the people who said that they gained weight with this drug. I know it is supposed to be weight neutral. I am already over-weight from taking in the past Depakote, Zyprexa, Remeron and other drugs that make you gain weight. Right now I am only taking Brintellix, Xanax and Trazadone. I just read that someone said it wasn't good to take Trazadone and Brintellix together. I am supposed to stay on the dose I'm on for 2 weeks and then bump it up to 10mg. If the spots turn into itching I will have to discontinue this drug I guess. I also read about the short term memory loss. That worries me as I already have that from taking various different Benzos for years. I know what they do to my memory. F 54 4 days
5 mg. 1X day
2/18/2016
 2  Depression Terrible nausea and dull headache. After several weeks of nausea and headaches, I tried taking the Brintellix with food: no side effects when taken with food. Decreased sex drive. (Never had side effects with any other SSRI) I've never had side effects with other antidepressants. This one has also caused decreased sex drive. It was 6 weeks before I had relief from my depression. While not as tearful as before the therapeutic dose, I feel blah and lacking emotion such as laughter. Not interested in things I used to enjoy. F 4 days
20 mg 1X day
2/17/2016
 4  major depressive disorder Nausea extreme sometimes vomiting. First relief I had felt in over 20 years. I had suicide thoughts daily. I haven't felt that after this medicine. F 5 months
20
2/14/2016
 2  Anxiety Gave me nausea. I took it at night.. It's constantly giving me restless legs, I'm exhausted and have gained 8 lbs in 2 weeks. I actually feel worse now that I'm on this medicine. F 27 2 weeks
10mg
2/14/2016
Email
 3  depression First 2 weeks very horrible nausea. Helps to take right b4 bed with some crackers. Side effects muscle tension, especially neck...some weight gain. At 2 month mark began to have serious memory lapses which continued so unfortunately I am now tapering off. Started at 10 mg...too much nausea and just felt "weird" .. so backed down to 5 mg after 3 weeks. At 5mg felt great -- able to exercise, lifting of suicidal thoughts, energy returned, able to sleep, in a good mood. Unfortunately the memory lapses became intolerable around 2 month mark,i gave it another month but still problematic so now tapering off. Sad this didn't work out - tbe mood improvement was a relief but the memory effects were a little scary and caused me stress. F 45 3 months
5
2/9/2016
 2  Depression nausea, flatulence, lethargy I have treatment resistant depression. Have tried many meds and always have a horrible reaction and no benefits. I started Brintellix on 5mg, in case of bad reaction. Took that for 2 weeks, then upped to 10mg for 2 weeks, then 15mg for 3 weeks. My depression did not lessen. In fact, I possibly felt worse. However, I did stop crying daily, but was probably just too numbed out. I didn't actually feel any better, had no energy, and just sat on the couch all the time. I did have nausea daily but I have a pretty iron stomach so no vomiting. After nearly two months, I gave up on the med. Within 2 weeks of stopping, I gained 7 lbs. I had been the same weight for over a year and suddenly was rapidly gaining weight. Aside from lethargy and moderate nausea, I really had no noticeable side effects. It was hard to tell that I was taking anything at all. F 35 2 months
15 mg 1X day
1/29/2016
 5  MDD Immediate satisfaction on 5 mg. increased after one week to 10mg. I have not been this happy for years. Nothing upsets me. My children and I are having fun together. I no longer obsess on small things and have quit tearing up for absolutely no reason. Flatulance is an issue. Yep. Pretty bad. I think the world would be a better place if they all felt the way I do on BrinT M 46 2 months
10 mg
1/7/2016
 3  Depression I was fine the first day, I swore I even felt more like myeself the next day, had some nausea... But it was tolerable. The next evening I took it..... Whoa nelly! It was like I took ipecac syrup! Violent vomiting. Is there anything you can do to slow the absorbtion to minimize this side effect until my body adjusts? F 37 2 days
10
1/1/2016
Email
 1  Depression/anxiety I've been taking 60mg of Cymbalta with success for 9 years. Until the last 3 months I've experienced severe depression which may be due to becoming perimenopausal but regardless my doctor switched me from 60mg Cymbalta to 10mg of Brintellix without tapering. Felt manic, had great energy but agitation, anxiety and intense irritability within 2 days. In short, I felt terrible. Doctor changed me back to cymbalta at 120mg which I've been on for exactly a month now but I'm in severe depression still. Started birth control to see if hormones will help and looking into a Novasure procedure to see if that makes a difference. I've was diagnosed with depression 30 years ago and have taken Effexor, Zoloft, Wellbutrin, Serzone, abilify, at multiple long-term periods in my life. Has anyone experienced depression during perimenopausal time? Suggestions? Wouldn't transition from one med to Brintellix without tapering off and overlapping. F 45 1 months
10
1/1/2016
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