TRINTELLIX Reviews (VORTIOXETINE HYDROBROMIDE)

Average Rating: 2.8 (307 Ratings)

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 ANTIDEPRESSANTS

 Type: Rx Drug

  

BRINTELLIX  (VORTIOXETINE HYDROBROMIDE):  This medication is used to treat depression. It works by helping to restore the balance of a certain natural substance (serotonin) in the brain. Vortioxetine is an SSRI (selective serotonin reuptake inhibitor) and serotonin receptor modulator. This medication may improve your mood, sleep, appetite, and energy level and may help restore your interest in daily living.   FDA Approval Date: 2013-09-30 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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  Charts & graphs: Drug Safety Information

RATING  REASONSIDE EFFECTS FOR TRINTELLIXCOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 1  Depression, anxiety Started at 5mg and had mild nausea and sleeplessness but did experience some improvement in depressive symptoms and anxiety. Even noticed improved cognitive functioning and concentration. But that all changed after 2 weeks when massive even worse anxiety and depression ensued. Became completely obsessive about every little thing and brain was racing with random negative thoughts. Would awake every night after 4 hours sleep with mind racing so badly sleep was impossible. Developed a severe pressure headache and fogged out disassociated feeling as well as noticeable problems with memory recall and even slurred speech. Went straight to Dr after finishing 1 month supply of pills and was told to stop immediately and was placed on Prozac which produced immediate improvements. Obviously this drug works for some but not for others -- everyone has different body chemistry and genetic make-up -- but for me this drug, after early promise, proved to be a 2 week psychotic roller coaster ride that made me far worse mentally. Hope and perseverance are not reliable methods to address severe symptoms. If it's not working for you talk to your doctor fast. There are other options. M 53 1 months
5mg
12/31/2015
 4  Sadness. Many meds failed. First week scratchy eyes and irresistible sleepiness at odd times. In addition: Second week constipation, almost non-stop belching, and abdominal bloating. Throat irritation from belching. I am sensitive to meds and at the end of 1st week was elated by how I was feeling even on low dose. Worried now that side effects in 2nd week may not resolve and I may have to stop Brintellix. F 63 2 weeks
5mg 1X day
12/28/2015
 5  PTSD and MDD Nausea,tummy problems for a while.I also have M.S.so my biggest issue is VERY bad constipation that all usual remedies fail.Some Insomnia,occassional nightmares. I am dosing off 150 mg Wellbutin,but have dropped odd 2 other meds since starting this Med! Tried to do it too soon and had a setback.I have had to do some navigating, like switching from day to night to offset tummy stuff,in the beginning. Now,I take early morn .If insomnia is bad I can augment with a low dose Xanax.I was determined to hang with this and am thrilled that I have. Feeling peaceful and grateful. F 63 4 months
20
12/26/2015
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 5  Major Depressive Disorder Itchiness I was having days I couldn't even get out of bed, eat, or do anything for myself that's how bad my depression was. I've been on over 40 different psych drugs in hopes of reducing my depression. This is the ONLY drug I've taken that didn't give me sexual side effects, or any other bad reaction. Within two week I started noticing a slights change for the better and now after a month in feeling amazing even at the lowest dose. Give it some time and realize the therapeutic dose is ideally 15-20mg a day. So, if you don't notice much in the beginning its because you're probably not on the right dose for you. I HIGHLY recommend this med. It even helps me focus. M 24 1 months
5mg
12/26/2015
 3  Depression/anxiety Not sure if this related to med but I never got a real cycle this month. No, I'm not pregnant. I'm also very snappy and weepy. I have more energy tho. So need to contact to find out do I increase it or just start weaning off of it! F 44 2 months
10
12/26/2015
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 3  Depression Anxiety itching, extreme dizziness, weird feeling over all, hyper active, trouble concentrating I was on Zoloft for 10+ years, it worked very well for me, but like any SSRI it began to lose it's potency. Dr. suggested this med and I felt it helped a little with anxiety, but gave me more weird feelings of dizziness, depression, feelings of doom etc. Then the hyperactive spells came and I hated that, still on it right now, thinking of switching else. M 39 60 days
10 1X day
12/12/2015
 3  Depression resistance to other trea It seems to help with my depression but also seems to be aggravating anxiety and trouble sleeping. Nausea is terrible but lessening with time. It is better if taken with food. Although it seems to make me extremely tired feeling, when I lay down to sleep, my mind is racing and I can't sleep. Only sleep short amounts even with xanax. I have been on xanax/kloni for years. Have never had trouble sleeping with the xanax before. I am going to try changing up the time that I take it and see if that helps. I am also going to try to continue it and see if the sleep/anxiety thing is maybe another side effect that may reside with time. F 35 1 months
5-10
12/9/2015
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 3  depression My head gets very itchy. keep scratching my head. sometimes have to take Benadryl for it. was keeping me awake but switched to morning which is better. If i eat with food dont get nauseaus. my memory is fabulous on Brintellix. so smart. remember things from childhood. Trying to figure out if there is weight gain just upped it I dont feel it helps me depression as much as Prozac did. I would like to combine them but my dr wont let me. Just upped to 20 to see if that helps with obsessive thoughts. dont know yet F 55 9 months
12/6/2015
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 4  Bipolar Disorder, GAD, MDD Fatigue So far, Brintellix has worked for me. I still have to take Xanax for GAD, but overall I'm feeling a lot better than I've felt in a while. Prozac, made me feel crazier for reason. Lamitcal worked only for a short period of time, and ended up in the hospital taking Viibryd. Good luck to everyone. F 37 10 days
10mg
12/5/2015
 2  Depression Some cramping, neck, shoulder, back pain and fatigue. Mood swings and slurred speech. Dr. having me take with 150 mg of Wellbutrin with Brintellex. I have consulted pharmacist and both are in the same class and doesn't recommend being on both. Will be speaking to another Dr about combo. F 43 5 months
10mg
12/4/2015
 2  Depression/anxiety Brintellix made me gain 15 pounds even though it was not supposed cause weight change. It made me sleepy and drowsy for the first hour after taking it. It helped with anxiety but not mood. I could not increase the dosage because of the side effects. F 1 years
5mg
11/28/2015
 3  and SNRI that I'm struggling to thi Day 2 was extreme mania day 3 was extreme headaches and brain zaps with extreme dizziness I couldn't move my head without having trouble walking because of the dizziness I'm hoping that goes away therefore I just took the pills so I don't know what'll happen but last night I did sleep I know that was because I was so exhausted from zero sleep the night before so I'm hoping that today is a better day rent alex is working wonders for my daughter she has bipolar disorder and is 25 I have a host of symptoms and problems and I have found nothing that works that's far hoping brintellix might be the answer but the side effects are pretty extreme I have cramping in my leg and I don't know if that has anything to do with it but its all the way from my hip to my foot and at night I just roll around in my and make myself comfortable this began the night I started taking Ben to Alex Hoping it works and curious if anyone else is experiencing the brain zaps also called brain shivers or you may think of it as dizziness it is overwhelming and I cannot drive my car 55 3 days
10
11/27/2015
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 3  Anxiety and depression Mild to moderate stomach cramps, nausea and mood swings. I started off on 5mg and was having mild relief from anxiety and depression and was getting out more. Seemed promising so after 2 weeks my doctor bumped me up to the 10 mg. Yikes!! Cramps were almost unbearable. I was in bed for the next 2 weeks. When I was able to get out I was moody and nauseated. Stopped cold on week 4. It's been 4 days and I've been experiencing itching and still the cramps intermittently lasting for days at a time. No other side effects. Very unhappy but gave it a 3 because it was helping me in the beginning. F 31 1 months
10mg
11/25/2015
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 3  Major depression, bipolar Weight gain, sleeplessness, emotionless, tired, worse feeling the longer I take it F 50 9 months
10mg
11/23/2015
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 1  depression Very nauseating and vomiting headache made me feel worse than I was Dr gave me samples for a month but after a week I called her and told her I need something else this medicine made me very nauseated and headaches not taking anymore its bad Worst experience with medication I have had F 37 1 days
10
11/12/2015
 4  depression nausea at first but has since disappeared. At times I feel like I dont give a crap about anything and then there are times when I am smiling and I feel like I am getting better. But mostly good thus far. Started at 5mg for one week and now have been on the 10 mg for 1 week. I am hoping after a month I will feel better from this. I stopped Celexa for the weight gain and the decreassed libido . I was also on the wellbutrin before and I could not tolerate the vivid dreams and insomnia. Dr. recommended this. My insurance does not cover this medication and I am hoping they will change and approve if it works. Right now I have samples. F 53 2 weeks
10mg 1X day
11/10/2015
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 3  Took Cymbalta not working Slightly nauseated My Dr had me taper off Cymbalta by going from 60 mg to 40 mg for 1 week while also taking 5mg of Brentillex & the next week 20 mg of Cymbalta & upping Brintellix to 10 mg. it seems to be going okay so far. I am feeling flushed & a little anxious. Not sure if it has to do with the decrease of Cymbalta. Saturday will be my first day with no Cymbalta & just the 10mg of Brentillex. I am praying that this transition goes good & the Brentillex helps. F 43 2 weeks
20
11/5/2015
Email
 2  MDD Horrendous nausea and vomiting, which began 1 week after starting Brintellix. Increase of Migraine headaches. Have lost 12 pounds due to constant nausea and have been in the hospital twice for extreme vomiting and dehydration. Brintellix really helped my depression at 20mg per day, which then was tapered down to 10mg per day. The CONSTANT NAUSEA and frequent vomiting has become intolerable and am meeting with my Dr. to discuss changing meds. This was the first drug - IN 20 YEARS - that made a positive improvement in my depression, so am upset that I cannot use it. F 54 7.5 months
10 1X day
10/31/2015
 5  Depression/Medication resistant Sometimes nauseated out of the blue, weight loss-YAY!! I'm on many others meds so I cannot blame any other side effects on this med. I LOVE this med! My depression has decreased as has my weight & hunger. I'm feeling much better! F 42 6 months
10MG
10/30/2015
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 2  MDD, anxiety and sleep diorder/ fib In the beginning I had nausea and vomiting, weight gain and difficulty concentrating. The nausea has passed, but I am in such a fog state that I am unable to function. I feel more depressed and less active than prior to taking this medication. I am going to see my psychiatrist tomorrow. I will be suggesting to stop the medication because I feel worse after taking this medication. But my psychiatrist has been less than helpful, she keeps threatening to drop me as a patient. She says none of her other patients complain about these symptoms. I also have had numbness in one hand since taking this med. She says it is not medication related, but I'm concerned about permanent nerve damage. This psychiatrist has no compassion and is in the wrong business. I feel like I have no life, being in constant pain and unable to sleep. Drug also causes nightmares that wake me up. F 51 1 months
5mg
10/23/2015
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