TRINTELLIX Reviews (VORTIOXETINE HYDROBROMIDE)

Average Rating: 2.8 (307 Ratings)

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 ANTIDEPRESSANTS

 Type: Rx Drug

  

BRINTELLIX  (VORTIOXETINE HYDROBROMIDE):  This medication is used to treat depression. It works by helping to restore the balance of a certain natural substance (serotonin) in the brain. Vortioxetine is an SSRI (selective serotonin reuptake inhibitor) and serotonin receptor modulator. This medication may improve your mood, sleep, appetite, and energy level and may help restore your interest in daily living.   FDA Approval Date: 2013-09-30 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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  Charts & graphs: Drug Safety Information

RATING  REASONSIDE EFFECTS FOR TRINTELLIXCOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 2  Depression Worsening of depression, nightmares, vivid dreams, flashbacks, blurred vision, eye pain. F 34 7 days
10 mg 1X day
7/17/2015
 4  Depression In the beginning nausea, constipation (short term) I had to restart Brintellix twice due to waiting on insurance to approve it since it's new. The second time I only got the nausea maybe two days. Start at half a pill the first few days to build up. It's the only thing that has worked for me in years. The only thing I'm getting used to is the added energy I have...I'm not used to having any so believe it or not it does taking getting used to. But this is a good thing! I'm on 5 mg and will probably stay there. Took about a week but I'm feeling better than I have in a while. F 46 21 days
5 mg 1X day
7/12/2015
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 2  depression/anxiety Loss of energy appetite decrease and always will feel sick to my stomach. F 48 5 days
10mg
7/10/2015
 5  Depression minor nausea at the beginning but taking it with food helped Brintellix saved my life. My improvement was dramatic, and when I weened off it after 10 months to become pregnant I had no difficulty with withdrawal. A friend of mine also agrees this is a miracle drug for major depression. F 40 10 months
20 mg 1X day
7/8/2015
Email
 3  major depression itching, headaches every day, slightly foggy but it does help with depression a bit, and Ive tried every other med there is, even seizure drugs and lots of combos F 63 1 years
5 1X day
7/8/2015
 2  major depression Weight gain. Night eating. Abdominal bloating. F 45 2 months
20
7/7/2015
 1  Borderline Personality Disorder This is the worst experience I have ever had with an antidepressant. I already have insomnia and now my medicine for sleep is useless. I have severe appetite and am extremely violent. I feel like I may need to go to the hospital. I have been on many things and I am switching immediately! This drug is not worth it! NO just NO. 3 days
5mg
7/7/2015
 2  Bipolar depression Severe untenable itching...everywhere! Also very easily angered and tired. Even Benadryl combined with prescription reactine didn't help itch! Headaches and sore esophagus. F 50 3 weeks
20 mg
7/3/2015
 2  MDD Weight gain. Night eating. Angry. Crying.Anxiety. no discernible help with atypical depression. Considering hospitalization, but no support system...Medical professonal.Changing to wellbutrin. F 58 5 months
20 mg
7/1/2015
 1  Depression Headache, itching, muscle aches, nausea, more depression, anger, constipation, feet swelling, general feeling of uneasiness Made me feel terrible F 54 2 weeks
10
7/1/2015
 2  Severe depression Pressure headaches, dizziness or disoriented, mood swinds, bursts of anger and unable to focus to complete tasks. Fell out of bed a few nights ago, also had fallen previous that day. Very badly bruised foot and hip. F 43 1 months
6/27/2015
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 2  Depression 4 days now so not long enough to get an idea how it will help my depression. Side effects: nausea (ugh!), dizziness, hot flushing, fatigue, headache and lack of appetite. Going to try to go a couple more weeks but the side effects are so unpleasant! F 52 4 days
10
6/26/2015
 5  Depression and anxiety The first 4 days taking 5 mg of brintellix I experienced headaches, sweating and pain in my esophagus After 8 days I started on 10 mg and experienced a 5 lb weight gain and occasional pain in my esophagus . Brintellix snapped me out of my depression immediately. I feel hopeful again. It's been 3 weeks now and life seems worth living again. I'm getting chores done that I have put off for months and I'm enjoying things in general. I plan on going up to 20mg as I am tolerating this drug well. I was on cymbalta for 7 years but it lost its efficacy. Brintellix helps my cognition whereas cymbalta made me feel numb. I'm interested in reading how other people are doing on it. Not particularly pleased with the 5 lb weight gain so I'm going to get super strict with carbohydrates. Good luck to all and looking forward to reading your experience with Brintellix . F 53 3 weeks
10mg
6/13/2015
 4  Depression Nausea the first 2 weeks, zero sex drive, no weight gain, but trouble losing weight despite intense exercise regimen and clean eating/calorie restriction I was experiencing intense depression due to coming off of an addiction to prescription pain medicine. I had no energy, was binge eating, couldn't get off the couch, extreme apathy for life and just couldn't experience any joy no matter what the occasion. Within 2 weeks of starting the Brintellix I was a completely different person. I could live again. I started with 5 mg for 2 weeks and then went up to 10 mg. After 3 months I started feeling apathetic again and wanted to live on the couch. Upped it to 20 mg and also started an exercising daily and started a big weight loss program to lose the weight I gained in the winter. Despite everything I've done to lose weight, I'm not losing any. My blood work came back normal and I've never had trouble losing weight so I'm assuming the Brintellix is to blame. I also have absolutely NO sex drive and I feel sorry for my husband. I don't even want him to touch me. I've always had a high libido so this is definitely a negative. I never planned to stay on Brintellix long term and I feel like it was what I needed to get me out of my original depression. Now that I've started exercising daily, eating healthy and taking supplements, I feel like it's time to start weening off so that I can have my sex drive back and lose weight. I would definitely recommend this drug because it brought me out of a terrible depression. I've also noticed that irritability and PMS symptoms have greatly decreased as well as anxiety. F 37 5 months
20 mg
6/10/2015
 3  Major Depression Grogginess, difficulty getting out of bed, a bit foggy throughout the day, desire to take naps, very slight nausea (however not much since I take it right before bed). I'm not sure if I will be able to stand these side effects for the long term. The sleepiness is too much! I started taking Brintellix on May 4th when my doctor was helping me get off Venlafaxine (Generic form of Effexor). I was tired of the venlafaxine. I alternated doses of each for the first week, and now I've been on Brintellix only full time since May 11th. Very groggy still, however my mood is stable for the most part. It has helped me tremendously since the passing of my father on May 14th. I've been able to cry and there is no emotional numbness. No deep despair. F 46 18 days
10 mg 1X day
5/28/2015
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 5  MDD dehydrated and constipation. That will pass by adjusting my diet a bit. I feel normal now not manic not emotional. Little things that used to make me frustrated don't even bother me. Best thing is I am starting to lose some weight. I've been struggling with rapid weight gain last 8 months from lack of sleep and depression. All my blood work came back perfect no thyroid problems nothing that would cause weight gain. I can actually get out of bed now. I'm one mood all day where before I was manic to the point of exhaustion. I didn't know what was coming next from hour to hour it was really uncomfortable I felt out of control. It's only been a week at this point I'm just happy to feel relaxed and can concentrate. F 44 7 days
10 mg
5/26/2015
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 1  depression NAUSEA! Itching the skin off my feet & constipation. I used to have panic attacks & haven't had one for nearly 15yrs since taking this med I've become so anxious & panicky I've had to start back on xanax. Feel extremely nervous, feeling guilty & a bit paranoid at times. Can't cry but want to. Increased depression & feeling hopeless. Won't leave my house, don't want to talk to anyone & unmotivated to do ANYTHING!BUT FEEL ANXIOUS AT THE SAME TIME! HORRIBLE uneasy feeling, can not get happy! Was taking Cymbalta 60mg prior to this with Ability but weight gain made me switch to Brintellix, REGRET! Calling my doc first thing in a.m. to change this! I'm miserable! No help at all & now don't know what to do. Feeling scared but don't know why, this med is not a good fit for me...Need something fast acting to switch to as I can't live like this, its horrible. F 46 1 months
5-20 mg
5/24/2015
 1  MDD Severe nausea, vomiting, aggressive anger, headaches, muscle stiffness I have recently been diagnosed with Hashimoto's a thyroid auto immune disease and also have MDD. I have taken so many different antidepressants that's I'm terrified to switch to another but I also can't keep living like this on Brintellix. I don't know what to do anymore to make this better. F 22 3 months
20 MG
5/21/2015
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 2  depression Nausea, headaches, anger I wish this drug worked. I've tried so many my Dr. Doesn't know what to give me anymore. I feel numb which is somewhat good that I'm not crying but I'm also not happy. I feel angry and irritated over stupid stuff. Just feel hopeless. F 41 1 months
20mg
5/19/2015
 1  Anxiety / Depression Crippling nausea, abdominal pain most of the day and night. Dizziness. Unable to sleep due to painful nausea. Switched from Lexapro 10 mg hoping to help lose weight. No weight lost even with diet. Medical effectiveness no different than the Lexapro. Not worth the all day all night intense nausea. F 49 3 weeks
10mg
5/19/2015

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