TRINTELLIX Reviews (VORTIOXETINE HYDROBROMIDE)

Average Rating: 2.8 (307 Ratings)

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 ANTIDEPRESSANTS

 Type: Rx Drug

  

BRINTELLIX  (VORTIOXETINE HYDROBROMIDE):  This medication is used to treat depression. It works by helping to restore the balance of a certain natural substance (serotonin) in the brain. Vortioxetine is an SSRI (selective serotonin reuptake inhibitor) and serotonin receptor modulator. This medication may improve your mood, sleep, appetite, and energy level and may help restore your interest in daily living.   FDA Approval Date: 2013-09-30 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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  Charts & graphs: Drug Safety Information

RATING  REASONSIDE EFFECTS FOR TRINTELLIXCOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 5  bipolar, anxiety some nausea, now resolved. no other side effects Bipolar x 30 years, resistant depression for over 2+ years, was about to give up on everything, had lost all faith in medications, doc and I were considering ECT. I haven't felt this good in over 2 years, I was even able to stop the adderall I was taking for energy because I have plenty now. No more naps needed. Life changer. No weight gain either! F 47 14 days
5 mg 1X day
11/26/2014
 2  depression headache, no motivation at all. hard to get out of bed and if i do i go straight to the couch and go back to sleep. not having as many crying spells, but i cant see myself living like this any further. F 52 1 months
20mg 1X day
11/24/2014
 3   Nausea! I hate nausea..i would rather throw up F 2 days
10 1X day
11/16/2014
 5  major chronic depression; anhedonia This is the ONLY anti-depressant that has NOT given me any intolerable side effects. All the others (yes, ALL) either cause severe headache, constipation, wild nightmares, trouble peeing, etc. This one has no side effects for me, other than maybe a little gas. I titrated up to 20 mg from 10 (day 3), and I am doing fine!! Hallelujah!!! Miralcle. Maybe now I can start to live. Oh, and Brintellix has totally regulated my sleep, so I wake up at 7:29 each morning!! F 51 2 weeks
20 mg
11/9/2014
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 2  Anxiety Intense itching, irritability, confusion, memory changes F 36 8 days
10 mg 1X day
11/8/2014
 5  bipolar depression Makes me sleepy when I take Ativan. Otherwise no nausea, no GI upsets, no sexual side effects. First antidepressant I have tried that seems to actually work. M 58 30 days
10 1X day
11/5/2014
 1  depression anxiety My legs itched so bad I literally ripped the skin off itching so bad. My legs bled and now scabbed over with severe bruising. I would ONLY send this to Guantanamo Bay or anywhere else they torture prisoners. I threw it in the garbage. Another failed prescription. I give up on the whole thing. I'm pretty sure drug companies make these types of drugs to make themselves billions. Not because they care about the itchiness of our legs. F 42 2 weeks
10 mg
11/4/2014
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 1  Depression severe headaches, nausea, vomiting, muscle aches, low energy, no sex drive, weight gain, depression is worse, loss of memory, blurred vision, severe dry skin, itching, fever like symptoms, just want to sleep I would not recommend this to anyone. I am having more issues than I had before taking this. My depression / anxiety is worse and I am going to see another doctor to come off of it. F 48 7 months
10 mg 1X day
10/23/2014
 1  Severe Depression Severe itching. Raised little watery type blisters, extremely itchy..Manic / hyper with higher dose I literally have ripped my skin off of my legs the itching was so intense. They are clusters of little bumps that do not stop itching even with prescription medicine. They got worse as I was increased to 10 mg which in turn also made me manic/hyper. M 51 4 weeks
5 mg 1X day
10/20/2014
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 1  Depression increased heart rate, sleep problems, tension, irritability I was taking this drug for 8 weeks. 10 mg for 6 weeks and 20 mg for the last two weeks. The drug was ineffective and exacerbated some of the symptoms of my illness (exacerbated anxiety, isolation from the people, lack of motivation, anhedonia). In addition, I had nasty side effects - increased heart rate, sleep problems, tension, irritability. As for me, a waste of time and money. M 30 2 months
10-20 MG 1X day
10/14/2014
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 1  bipolar depression practically non-stop flatulence; bloating, nausea, diarrhea to the point of rectal bleeding; swollen hands and feet; somnolence lasting until 3 pm each and every day in spite of sleeping 10-11 hours each night. 45 days
10 mg 1X day
10/5/2014
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 4  Depression Sleepiness was the main side effect when I was taking only this drug and Wellbutrin. In combination with 5mg Prozac I am experiencing significant nausea and constipation. Never had these effects on even 40mg of Prozac long-term in the past. I'm a fan of this drug. I've taken just about every SSRI, and this gives me fewer side effects than any of them. I was avoiding SSRIs (like Prozac) due to them only working partially, and basically feeling chemically castrated on them. I had a mind-blowing orgasm after 4 weeks on Brintellix, which is encouraging. I'm feeling less depressed after 6 weeks. I'm able to keep my Wellbutrin dose lower on this--more Wellbutrin leaves me feeling angry and agitated. F 35 6 weeks
10mg 1X day
9/19/2014
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 2  Manic Depression & anxiety I'm on day 5 & have developed severe itching & skin prickling. No significant improvement in depression. Having fatigue & also constipation. F 44 1 days
10 mg
9/15/2014
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 4  Depression Nausea for the first 2 weeks which has now subsided. Itching but not so bad that I've had to take benedryl. Extreme fatigue which has been the most annoying side effect. BUT i noticed a significant difference in my depression the first week I was on this since I'm pretty sensitive to meds. I will definitely keep taking this. F 30 1 months
10mg 1X day
9/12/2014
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 2  Anxiety/Depression. I am experiencing relief from depression but my skin is red from being itched! I have no rash (raised, red bumps); however, the discomfort has disrupted my life. My skin is so itchy, I have had to take Benedryl for 2 days in hopes that the inflammation will stop. F 46 5 days
15
8/30/2014
 2  Major Depession, Anxiety Anxiety and instability at times (and very possible it made my depression worse), irritability at times, minor somnolence (moderate at doses of 5mg and up), spaciness (at higher doses), sweating/flushing, increase in hunger at higher doses (but restricts appetite at lower doses), red/dry eyes, mild headache for first couple hours after ingestion (at higher doses). I'm med sensitive so I can only take lower dosages of most medications. I had high hopes for this being better than the SSRI/SNRI category, but it's definitely a lot less effective for depression and I'm pretty certain it made my anxiety worse. M 37 3 months
5-10 1X day
8/14/2014
 3  Depression Constant itching of the skin. Mostly on my breasts, arms, and right at the bottom of my stomach. Some gas. I have only been on it for a few days, but the itching is constant F 27 7 days
10MG 1X day
8/12/2014
 2  GAD, Depression Minimal side effects, really. Some decreased sexual desire, and decreased sexual pleasure. I wasn't gaining weight at first, but now it appears I've put on about 10 lbs since starting. Not sure if this is due to the drug itself. And, also recently, some itching in my arms that wasn't there before. On the positive side, Brintellix was more effective for my GAD and depression than Viibryd (similar mechanism of action). I'd give Brintellix a 3.5/10 and Viibryd a 0.5/10. Brintellix gives me a mild anti-anxiety, antidepressant effect. But it is not robust. I still feel anxious, paranoid, and codependent. I lack the ability to interact fully with others, and to feel good about myself. I still feel very disabled. I am considering giving an MAOI a try (such as Nardil or Emsam) as I have pretty much lost faith in SSRI-type meds. M 48 4 months
30mg 1X day
8/7/2014
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 5  MDD Itching (Went away), Nausea (Still present, but easily countered with taking the medication on a full stomach), Weight Loss (Started when I took 20MG) I originally started on 10MG and titrated my way up to 20MG. This is by far the best AD I've taken in my 5+ years of trying to find a medication. I've tried almost every AD on the market (SSRI's/SNRI's/TCA's/MAOI's/Antipsychotics). The pros definitely outweigh the cons for me. Also, when I started taking 20MG of this medication I started loosing weight (20+ lbs so far). The only downside to this medication is that it's brand new and the co-pay is pretty high, but I usually get samples at my psychiatrist's office and there is always the option of payment assistance from the pharmaceutical company. M 22 3 months
20MG 1X day
8/2/2014
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 2  Anxiety/OCD Nausea for about 1 hour after taking it and heartburn/indigestion all day. Nausea stopped after about 1 week. The heartburn/indigestion continued. I really wanted this to work well for me. I have been through so many different medications that gave me terrible side effects. After the first week, the only side effect I had was heartburn/indigestion. It was very tolerable. Unfortunately, it didn't help my anxiety and OCD at all. I was actually worse after 6 weeks. I did not try to increase the dose because I didn't want the heartburn to get worse. Brintellix is not actually indicated for Anxiety and OCD but considering it is an SSRI I figured it would still work. F 37 6 weeks
10 MG 1X day
6/9/2014
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