ZOLADEX Reviews (GOSERELIN ACETATE)

Average Rating: 2.9 (291 Ratings)

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 ANTERIOR PITUITARY HYPOTHALMIC FUNCTION

 Type: Rx Drug

  

ZOLADEX  (GOSERELIN ACETATE):  Goserelin is used in men to treat prostate cancer. It is used in women to treat certain breast cancers or a certain uterus disorder (endometriosis). It is also used in women to thin the lining of the uterus (endometrium) in preparation for a procedure to treat abnormal uterine bleeding. Talk to your doctor about the risks and benefits of treatment. Goserelin is similar to a natural hormone made by the body (luteinizing hormone releasing hormone-LHRH). It works by decreasing testosterone hormones in men and estrogen hormones in women. This effect helps to slow or stop the growth of certain cancer cells and uterine tissue that need these hormones to grow and spread.   FDA Approval Date: 1989-12-29 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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RATING  REASONSIDE EFFECTS FOR ZOLADEXCOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 4  Prostate Cancer Phimosis. Penis contracted to less than half normal. Consultation on 15Jan2010 with regard to full Circumcision. On Zoladex 10.8 for six years. Total Impotence since 2004. PSA 1.7 down from 86 but now increasing. Awaiting latest PSA test result M 77 6 years
1/10/2010
 3  Endo and enlarged ovaries Moodiness, hot flushes, insomnia, weigh gain, migraines, tiredness Even though Zoladex has really helped with my symptoms, I am really struggling with the side effects, especially the weight gain. I usually weigh 49 kilos, but since starting Zoladex 2 mths ago I have put on 6 kilos!!! The headaches are also really draining and I have lost my sex drive completely. Saying that, I used to never be able to have sex due to severe pain and since starting Zoladex, sex has been pain free, something which hasn't happened in 12 years!!! F 29 2 months
1/9/2010
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 1  Stage 4 - Breast Cancer Mets Hot flashes first few months; headaches; dizziness up to 1 week after injection; nausea; extreme breast pain and lower back pain for up to 3 months; fatigue that gets worse with every injection; jaundice and kidney damage; rage; mood swings and severe depression; loss of sex drive/life; very, very dry vagina The idea of this drug seemed wonderful, the side effects have been horrible! I am now suffering from kidney damage and jaundice caused by long-term use. It is ridiculous that the literature on this drug says that this type of thing occurs in only 2% or less of the population taking this drug. Do not take it!!! F 34 13 months
1/3/2010
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 5  Endometriosis (severe -post lap) Hot flushes, Sweats, sleepless nights,bleeding in 1st month, slightly emotional, lowered sex drive (was given hrt add-back treatment after 3rd month when these side effects disappeared!). Absolutely amazing...to have suffered for 18/19years with such intense pain to have it disappear was/is amazing! the side effects I have listed are more than welcome compared to the pain (as many endo sufferers can agree with). I take the hrt to counteracts the menopausal side effects so now I am perfectly balanced - unfortunate we can only take this medicated for a short limited amount of time! F 33 4 months
12/10/2009
 5  Endometriosis Stage 3 The occasional hot flash I am on my second month of zoladex and have no pain other than during intercourse which I am hoping will decrease over time. I have had one laparoscopy + treatment to remove some of the endometriosis however I still have a deposit on the recto-vaginal septum and appendix which will (fingers crossed) shrink with the zoladex treatment. All in all, I am happy with this treatment. F 33 35 days
11/30/2009
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 3  Stage 4 Endometriosis Breast tenderness, hot flushes and night sweats, difficulty sleeping. The Zoladex stopped my periods therefore stopping my terrible period pains. However did not help at all with the pelvic pain I have on a daily basis from endo, and did not help to reduce pain during sex and pain passing stools. F 22 6 months
11/28/2009
 2  Breast Cancer stage 3, HER2/Es + Continues eye infection,headaches, nausea, extreme abdominal pain, diaree, fever & chills, hot flushes, bone pain, back pain, no sleep, no sexual desire - fear of sex because of the pain of vaginal dryness!!, mood swings, depression and I can still go on!!! I have been taking Zoladex now for almost 2 years - just had my 7th injection and it was like hitting a brick wall. Side Effects became so bad that I felt like I was dying. My oncologist decided now to stop Zoladex and to start Tamoxifen, luckily then when I do get very sick again I can stop treatment not like now I have to wait for the Zoladex to work out of my system (another 3-5 months). I sometimes feel that I would rather take my chances with the cancer than with these drugs... Feel worse now that I did when I was on 8 months of chemo.... F 33 20 months
11/26/2009
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 5  Post-breast cancer treatment Hot flashes I began monthly Zoladex injections following chemo, bi-lateral mastectomy and radiation. I also take Tamoxifen daily. My main complaint was hot flashes, in particular at night, that were causing sleep loss. My doctor put me on a very small dose of Effexor, which I take every morning and it's worked wonderfully. I do still occasionally have a hot flash at night, but they're rare and not as bad as they were. F 45 8 months
11/14/2009
 4  fibroids Hot flushes headaches and can't sleep zoladex has stopped my pain thank god F 33 3 months
10/29/2009
 3  Prostate Cancer Hot Flushes, but taking 40mg of Megestrol Acetate in morning. Helps in daytime!Low energy, memeory hassles, concentration hassles, I have the prostate cancer that has spread to rib area, psa now at 2.6 from initial 68, seems the Zoladex helps, I am in the STAMPEDE clinical trials. Seems to work but the side effects not fully explained. Will continue and be monitored every 3 months for now. M 53 22 months
10/26/2009
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 4  to reduce fibroids prior to surgery slight hot flushes, small amount of spotting, tiredness, slightly emotional, slight acne I had my first of 3 injections 3 weeks ago and apart from the slight side effects listed I have felt fine. I thought it would useful to describe an experience that is not as horrible as others listed here! F 36 21 days
10/20/2009
 4  severe endometrosis severe hot flushes, memory loss, fatigue, imsomnia, weight loss, headaches, period like pains, moody etc i feel so helpless i just want to scream out for help. i feel like someome who suffers from post-natal depression i assume thats how they felt.the injection is horrible i go into a panic attack. Today i got my final of six injection, i will see the doc in the second week of december. i pray everything is well and i can then have my three beautiful children. i will have a panic attack as i enter the room. that needle is so huge and it is painful, my period stops immediately which is the best thing of all with that horrible pain not there anymore except the day before my next injection i will feel some discomfort. thank God this is over for now am just dreading what my period will be like when it does return. F 30 5 months
10/20/2009
 4  prostate cancer Hot flushes,some joint pain,loss of libido. 2-year course of injections every 3 months,with radiotherapy reduced psa from 28 to less than 2. am just about to start further injections to try to reduce psa which has risen to 9 after 2 further years. M 72
10/13/2009
 2  Endometriosis Weight gain, sever hot flushes, tender breasts. I am on my 4th and last injection as I am having surgery in a few days. My ovary and tube are stuck to the back of my pelvis due to the endo and I was given this to stop my periods while waiting for my surgery. Although my periods have stopped, my pain has not changed at all (constant pulling pain, not endo flare ups). The hot flushes in the 1st 3 months were so severe that I had to constantly have a fan on during the night and they made me feel sick. Also I have put on around a stone and a half since starting it even though i'm not eating as much. F 28 4 months
10/12/2009
 5  Protate cancer Pains in the joints which seem to be getting worse,some nights I wake up after two hours sleep and can feel myself getting hotter and hotter aand have to go and lie down in a cool room.I seem to be muscularly weaker in the legs, perhaps this is just my age. My weight around the middle particularly has increased and I get swollen feet and ankles. The joint pains are the worst feature along with swollen feet I have very understanding doctor, she has said I may see the urologist any time I wish to. My only fear was incontinence, this did not happen. I felt quite rough initially, but it has had a dramatic effect on my pSA, going from something like 32 to 1.8. I would rather live and am glad I opted for it. M 76 270 days
10/11/2009
 2  endometrial ablation hot flushes, nausia, dry mouth, tiredness, severe bleeding. nausia, dry mouth, severe bleeding, sore booobs,hot flushes, back and pelvic pain, tiredness,insomnia. had the implant with local anesthetic so painless, expected and was told no bleeding, flooding and extremely painful. F 40 1 weeks
10/9/2009
 3  prior to ablation HORRIBLE hot flushes esp at night, complete loss of libido, have had period for 1 1/2 weeks (I thought that was the whole point of taking it!??) and v achy finger joints. Have scared myself reading all these people's side effects, esp re bone density, but realistically I have only had 1 shot, 1 to go next week, so I should be fine. Am looking forward to period ending!!! Thankfully no weight gain, spots, etc. F 35 3 weeks
10/6/2009
 1  prostate cancer I am writing this on behalf of my husband. this medication turned my once loving gental husband into Mr. Hyde the monster created by a Dr. thats only part of the nightmare we are ready for divorce court.the sweats, no libido,no erections, incontenence is increasing daily.our 2 growe up daughters want nothing to do with their father. our grankids heard him say he's going to kill our sons 2 baby kittens he is a monster and he demonstrates the behavior of someone suffering a phycosis hopefully he'll return to himself before it's too late my husband was first injected with a 30 day dose. then a 90 day . last time a 6 month dose andit's been 9 months of sheer hell ......... F 51 300 days
10/5/2009
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 1  prior to ablation for endometriosis severe moodiness - became so nasty. anxiety, tearfulness, so forgetful, lack of concentration, unable to cope with stress. Panic attacks, dizziness, headaches, leg pains, back pain, spotting, very sore breasts, exhausted, shakes, night sweats, gained weight, palpitations, insomnia, hair loss, tearful, cramps I have never felt so unbalanced, out of control and incapable of coping with life as I have the past 2 weeks after having the first injection. I can't drive as i am so light headed and the slightest thing I panic. My husband thinks I have become possessed as I have been so moody and angry and irrational! I can't sleep properly and it has made my lower back and sciatica ( I have degenerative disc disease) so much worse I am popping so many pain killers to try to sleep. Everyone who knows me has commented on how I have turned from such a coper and bubbly person to such a wreck. Is it worth it I wonder but its too late now...........surgery in 2 weeks lets hope that work as I have never felt this unwell. F 41 15 days
8/27/2009
 4  Breast Cancer Hot flashes and night sweats resulting in tiredness the next day but overall worth it. Much better than the side effects of tamoxifen, and no painful periods for first time in my life! Strange as it may seem, I actually found that exercise helped the tiredness - seemed to counteract it somehow, and thus kept weight under control, as well as helping with the flushes as heat was escaping naturally. Am thinking of opting for another course as a possible oestrogen reducer as Tamoxifen is a definite no no for me - terrible abdominal side effects that are quite worrying. F 47 2 years
7/15/2009

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