ZOLADEX Reviews (GOSERELIN ACETATE)

Average Rating: 2.9 (291 Ratings)

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 ANTERIOR PITUITARY HYPOTHALMIC FUNCTION

 Type: Rx Drug

  

ZOLADEX  (GOSERELIN ACETATE):  Goserelin is used in men to treat prostate cancer. It is used in women to treat certain breast cancers or a certain uterus disorder (endometriosis). It is also used in women to thin the lining of the uterus (endometrium) in preparation for a procedure to treat abnormal uterine bleeding. Talk to your doctor about the risks and benefits of treatment. Goserelin is similar to a natural hormone made by the body (luteinizing hormone releasing hormone-LHRH). It works by decreasing testosterone hormones in men and estrogen hormones in women. This effect helps to slow or stop the growth of certain cancer cells and uterine tissue that need these hormones to grow and spread.   FDA Approval Date: 1989-12-29 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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RATING  REASONSIDE EFFECTS FOR ZOLADEXCOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 1  breast cancer severe hot flushes day and night - sometimes up to 2 an hour during the night and about 10 during the day, depression, terrible headaches, insomnia, totally physically exhausted, aching all over, weight gain but loss of appetite, My quality of life since starting on Zoladex has deterioriated significantly - I feel physically drained and haven't slept a night since I started it. I put on nearly a stone in weight in the first couple of weeks even though I didn't feel like eating and was living on one meal a day. The hot flushes are awful - sometimes more than 24 in a day and seem to be worse at night. My husband had to move to the spare room as I wasn't sleeping at all and so our physical relationship is under pressure too although my sex drive is not so bad as when I was on Tamoxifen for a year. Overall I'd much rather take my chances without this drug than the side effects when I'm on it. I have had other drugs prescribed to counteract the side effects but they have their own side effects which left me in a trance most of the time even though they helped the hot flushes. F 42 3 months
7/4/2009
 4  Endometriosis stage II Hot flushes, memory loss, headaches, nausea, loss of appetite, moodiness, insomnia, no periods Don't know yet if this drug has helped with my condition, but extremely happy with no menstruation. That on its own has been a relief, I have had a lot of problems with side effects, all of which I can deal with as the benefits outweigh the discomfort. The injection itself looks scary, but not very painful, am happy to have it without a local. I will be relieved when the six months is up, and I'm curious to find out the results of treatment. My doctor also prescribed Livial to counteract the side effects, so I'm guessing that has helped as my problems don't sound as bad as some others on this site. My doctor has been brilliant, so I'd recommend finding one you can really trust. F 28 5 months
5/31/2009
 4  Failed ablation, endometriosis Short-term memory loss, mild hot flashes, unexplained tears (onset was 1 week after 3rd injection) At this point in time, it's better than a hysterectomy. The slight bruising at the injection sites is my only physical reminder. NO JOINT PAIN. Will update my satification, side effects and comments after my 6th injection (4th injection was this morning). F 45 3 months
5/26/2009
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 4   hot flushes,total loss of libido.joint pain,and unpleasant mood swings. there is insufficient advance information regarding the effect on your emotional swings and the dangers of depression arising M 68 5 years
5/16/2009
 1  prostate cancer impotent hot flushes weight gain do not take it M 61 3 days
4/30/2009
 3  Prostate cancer Mild breast tenderness, hot flushes and joint pain started after about 2 months. Hot flushes occur every 2 hours or so and last about 5 mins - not a mjor problem, just annoying. Joint pain is getting more severe all the time. Started in toes and fingers, spread to ankles, knees, shoulders, hips, back of neck. It hurts a lot now, and I'm getting fed up with it. Pins and needles just starting in hands and arms. PSA <0.1 after radical prostatectomy, radiotherapy, and 3 months of Zoladex, so it is probably doing its job. M 45 5 months
4/14/2009
 5  IVF - Down regulation I suffered very few side effects, other than a very mild headache in the evenings and a slight feeling of tiredness. As someone who sneezes a lot I couldn't take the nasal spray down regulation drugs so was given a single injection of Zoladex. The drug worked as it was supposed to and my down regulation was a success. F 31 28 days
3/18/2009
 1  prostate cancer Severe hot flashes - day & night, lasting 2 years after my last injection, weight gain on stomach, loss of mental acuity (none to spare), change in emotional reaction to stress and other situations, complete loss of libido, possible cause of loss of bone mass (I have some, don't know if it was preexisting). This drug had the desired effect of reducing my PSA by about 90% prior to radiation, but at a significant cost to my my physical and emotional health. These side effects, for the most part, were not disclosed to me prior to treatment; I only learned they are directly attributable three years after treatment as a result of reading an article in the Globe and Mail. I do not think the people prescribing this drug understand the life altering effects it can have on your health, relationships and career. Waking up several times, every night, soaked in sweat affects every aspect of your life (on the other hand, having zero libido frees up some extra time for work, too bad you won't give a shit). I understand there are alternatives, and I would suggest men investigate them before accepting this treatment. I would also suggest, if you do decide to take this drug, that you have a blood test done so you know what your normal testosterone level is, so you will know afterwards when (if) you ha M 55 12 months
3/4/2009
 3  Endometriosis Since being on the Zoladex Implant i have suffered from only a couple of the side effects but they have been really bad. I have lots of spots all over my face and they aer under the skin and very sore... i also get hot flushes and sweat alot at night which stops me from being able to sleep... my skin so sooo bad on my face with the spots its very depressing F 21 2 months
3/3/2009
 4  Endometrosis Headaches, some severe, SEVERE joint pain, especially in knees, night sweats, hot flashes, nausea, short term memory loss, spaced out feeling at times, no weight gain, actually swelling went down in abdominal area so I felt thinner, no period after 2nd injection which was great! VERY painful intercourse after second month which probably lead to my lost of interest in sex and muscle aches, I increased my potassium intake and that helped some. I felt better emotionally and somewhat physically. I would recommend this for short term say to prep for surgery. F 41 3 months
2/11/2009
 1  Endometrial ablation Terrifying headaches, fainting, joint pain so bad it was hard to text on on iPhone!! Sickness, shaking, unable to form a sentence, memory loss, had to think carefully before speaking, didn't stop the bleeding, liked the free boob job though when they weren't very tender. Make sure you read the side effects, sickness is caused by the removal of calcium from bones hence joint pain. Bone density damage is irreversible. F
1/28/2009
 3  Endometrosis Insomnia, anxiety, moodiness, soreness around injection site, aching muscles in legs Just received my second shot today. I have noticed quite a bit of pain relief from it though do have insomnia; which my doctor prescribed a sleeping pill for me that I take a couple of nights a week. Amazing what a good night sleep does! I havent had a period and I do notice a difference in the pain. Hoping it will continue to get better. Night sweats are coming a little more often and the anxiety is there but it is something that I just keep reminding myself that nobody should have to live in pain so we will see what this month brings for the side effects and keep going on! F 35 2 months
12/8/2008
 5  Endometriosis UPDATE: Hot Flashes, Bones Cracking, VERY slight joint pain UPDATE:Had my 3rd injection the day before Turkey Day. Started a different OTC joint supplement and that has 'cured' the severe joint pain I was experiencing. Hot flashes have calmed down and are more managable because the cold weather has arrive!. My bones crack quite frequently but it doesnt hurt. NO mood swings. NO weight gain. This medicine is pretty darn close to PERFECT! F 26 58 days
11/28/2008
 3  Endometriosis hair loss, hot flashes, joint pain, slight moodiness, decreased sex drive I have only had one injection and I am not sure if I want to continue for another 5 months. My BIGGEST complaint is the joint pain. Before I started, I did heavy weightlifting 4 days a week and now I can barely do it at all! my joints ache doing nothing. I will get my 2nd injection in a couple days but paln to request some kind of medication. Maybe they will give me Celebrex because OTC products have not worked. Will update in a few weeks. The sweating is so bad I am thinking about getting Botox injections under my arm. I find it hilarious that I am HOT in the Fall/Winter and everyone else is cold. F 26 26 days
10/26/2008
 2  Secondary Breast Cancer Severe hot and cold flushes, shivering, sweating, Vomiting, nausea, anxious & panicky, loss of appetite. Im due to have my 5th Z in a couple of days but after the last month or so I have now decided that Im just not gonna take this poison any more. I have felt way more dreadful than evan the chemo (taxotere) made me feel over the last week or so. The hot & cold sweats have been relentless and Ive vomited on & off since i started it - the last week in particular has been awful - i cant keep food down due to the constant vomiting - im sweating so much im having to change my clothes about a dozen times a day !! F 36 5 months
10/19/2008
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 2  endometriosis hot flushes , blured vision, emotional, worse pain in tummy , loss os sex drive, shaking,headaches, sever bleeding, dizzy and faintness.rattyness. im 21 i was told i had endo at 20yrs old. am on my 5th dose of zoladex and i have found it has not helped me at all, i have more pain than normal and feel worse than when i went to the docs . having the inkections are really painfull. i have only got 1 dose left but i know i will have to go through other treatments as im still the same. i would advise anyone who is going to have this ttreatment to think it through as its not 100% correct for everyone F 21 6 months
10/13/2008
 4  Endometriosis Severe hot flushes mostly at night followed by extreme tiredness next day, light headedness/nausea,'spaced out' sensations throughout the day, short bursts of memory loss, feeling of vagueness (more than usual!) a concern whilst driving... migraine,emotional/teary, depression sneaking in following 4th injection. Lethargic, sleeping for extended periods, severe acne around jawline, oily hair, no sex drive (was expected),moods low though not agressive. The lesser of the two evils I guess. Short term sacrifice for a long term gain. Surgery was not an option.The initial three treatments were relatively without side effects, I only have two more to go, these side effects are a small price to pay. It certainly is doing the job it was prescribed to do. Obviously everyone is different. F 37 4 months
10/6/2008
 3  prostate cancer hot flushes!! major weight gain, bone aches, sever depression, breast formation, no libido, just hate it! I am not going to continue therapy, my only regret now is taking 10.8 dose, now gotta wait it out. if you use, get the 3.6 just in case you want to stop soon M 46 9 months
6/9/2008
 1  postrate cancer hot flashes chills fevor low blood presure weight loss loss of appetite M 74 6 months
5/24/2008
 1  Endometriosis Servere hot flushes, migrains, no sex drive, moody, loss of period. I stopped taking Zoladex 2 1/2 years ago and if i knew back then what i know now i would have never trusted the doctor and gone the Zoladex i would have opted for the Surgery. 2 1/2 years on i still have no sex drive, No period, No fertility and im still moody.... DONT TRUST DOCTORS F 27 6 months
4/28/2008

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