ZOLADEX Reviews (GOSERELIN ACETATE)

Average Rating: 2.9 (291 Ratings)

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 ANTERIOR PITUITARY HYPOTHALMIC FUNCTION

 Type: Rx Drug

  

ZOLADEX  (GOSERELIN ACETATE):  Goserelin is used in men to treat prostate cancer. It is used in women to treat certain breast cancers or a certain uterus disorder (endometriosis). It is also used in women to thin the lining of the uterus (endometrium) in preparation for a procedure to treat abnormal uterine bleeding. Talk to your doctor about the risks and benefits of treatment. Goserelin is similar to a natural hormone made by the body (luteinizing hormone releasing hormone-LHRH). It works by decreasing testosterone hormones in men and estrogen hormones in women. This effect helps to slow or stop the growth of certain cancer cells and uterine tissue that need these hormones to grow and spread.   FDA Approval Date: 1989-12-29 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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RATING  REASONSIDE EFFECTS FOR ZOLADEXCOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 1  Fibroids Have a large fibroid recommend hysterectomy, have been put of zoladex for 6 months within 5 days I feel horrendous, extreme bloating of stomach , my co ordination is off brain fog ?anxiety , extreme lower back pain I can't sleep for more than a few hours . I will NOT be having further implants No no NO do your research first I was totally sprung with this option and wish I had read up first what I was getting myself In to F 42 5 days
1X day
3/20/2021
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 5  Endometriosis Hot flashes- controlled with noriesterone. Sweaty palms & feet, sweaty nights, increased pulse rate, increased appetite & some weight gain. At times, increased heart rate with tingles in chest. Forgetfulness / brain fog Although there seems to be a lot of side effects, this is still way better than managing the pain of endo. I was regularly taking a multitude of pain killers just to get through the day & it led to me being so stressed I suffered dramatic weight loss. On Zoladex, I feel like myself again. No more pain but I'm still spotting. After the second injection, I felt feverish and ill but I think this is due to the implant going too deep. I haven't needed to take any strong pain killers since I've been on it. Occasionally, I'll need paracetamol but that's it. The side effect which annoys me most is the forgetfulness, I'm far less efficient at my job now but my coworkers are patient! My advice is to write important things down. I've got another 4 months of this before endo surgery then IVF - I'm hoping to go through the process without ever having a real period! F 34 2 months
3.6mg 1X M
2/16/2021
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 1  Endometriosis with cycle symptoms Absolutely awful The injection was nothing compared to the utterly debilitating side effects Within 7 days skin lesions painful headaches Joint pain and CFS increased Pulsitile Tinitus Fibromyalgia pain worsened and mental health Very fragile Warned about onset menopause hardly any hot flushes took Addback therapy but felt so ill probably wouldn't have noticed Terrible medication completely useless for me only made me worse and had to stop working due to side effects that were worse then my original diagnosis F 44 6 months
Monthly 1X M
2/3/2021
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 3  Shrink fibroid prior to removal I had one zoladex implant to shrink a small fibroid prior to an endometrial ablation. It has now been 8 weeks since my implant and I am still suffering with hot flushes day and night! I was told the symtoms would wear off after 4 weeks! F 46 1 days
1 1X day
1/28/2021
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 1  Fibroid, bleeding/hysterectomy Within 24hrs I started with excruciating headache, and have had it continuously since, only pain relief that seems to take edge off is codine but never completely pain free. I also started on day 10 with tinnitus! Its totally debilitating. This was a month trial, I was supposed to have it before Xmas but I changed mind as it was the 3 month jab, consultant changed it to 1 month to try as I also have hemiplegic migraine and didn't know if it would effect those. I will not be having any more! I'm waiting for hysterectomy on nhs due to fibroid and excessive bleeding. I can honestly say I can't wait for it to be out of my system. I would rather deal with the excessive bleeding than have another injection .Never again! F 48 15 days
I month 1X M
1/27/2021
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 1  Metastatic breast cancer Hot flushes, mood swings, weight gain, abdominal lesions attributed to a metastases of my cancer. My cancer was perfectly under control under zoladex, which I was given to combat bleeding caused by tamoxifen. Within four months there were 'tumours' in my liver (when I was diagnosed there were 'lesions' which I was assured weren't cancerous). Zoladex was stopped and my next scan was fine. The bleeding started again and zoladex was started again for another three months. The 'tumours' are now worse and after complaining about pain in the injection site (which bled a lot!), I now have 'tumours' there also apparently. I am five years post-menopausal, so shouldn't have been given zoladex anyway (according to AstraZenecas own indications). Coming off it suddenly left me suicidal, depressed and made my insomnia worse. Absolutely horrendous experience F 41 9 months
120mg? 1X M
1/20/2021
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 1  Endo & Pmdd Increase in heart rate had to go to A&E I have IST and was told this was fine and not related the heart issues on the pamphlet. I'm still struggling 6 weeks later. Intense headaches, feeling sick, very weak, dizziness, heavy bleeding. Awful drug, if you have a gut feeling about this, then don't take it. I'm struggling with day to day activities and my specialist won't give me any add back. F 44 30 days
30mg 1X day
1/15/2021
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 1  Endometriosis Sweaty palms sweaty feet. Racing heart! Shakiness high anxiety! Foggy brain. Been about 5 weeks and still having side effects every now and again! Never again!! Feel like my head is above the clouds and not my normal self! This feels horrible!! F 29 0 months
50mg 1X day
11/11/2020
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 5  Endometriosis Headache which has not stopped for 3days/nights, hot flushes, anxiety, lack of concentration, brain fog , disturbed sleep Side effects significantly less after taking daily tibelone. After 3 surgeries, 10 years of leaving in pain which was getting unbearable I finally got my life back. Had 1 period while on it , pain stopped, sometimes can feel slightly worse around when my period was due but it's just few days. I was dreading it so much I postponed it for 5 years. Now worrying what alternative to have as need to stop , I'm on waiting list for hysterectomy being 40 . Please give it a go if you are desperate. F 40 5 months
3.6mg 1X M
11/5/2020
 4  PMDD Constant headache, extreme body fatigue, bad joint pain, muscle soreness, nausea. Initially felt like my body was shutting down, horrible. With add back of estrogen it lessened symptoms. Helps psychological symptoms of PMDD well. F 36 7 weeks
2X day
10/18/2020
 1  Uterine fibroids Hot flashes, severe headaches almost everyday, joints and bone pain, hair loss, tiredness, anemia. My obstetrician said I will only experience hot flashes and advised me to keep taking pain killers/ iron supplements for everyday bone pain and headache symptoms. Heavy bleeding stopped after a month which shrunk my fibroid. Was able to resect most of it through the hysteroscopy procedure but the side effects of these injections are quite adverse. It helped in treating my fibroid but the side effects are too intense and difficult to cope with. F 35 6 months
3.6mg 1X M
10/7/2020
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 5  Pmdd Hot flushes! And.... -no acne (for the first time In my life my skin is beautiful) -lovely hair ( soft and lustrous, never greasy) -weight loss (but my boobs are still big!) I suffered from severe pmdd for almost 20 years, Now with Zoladex it's all gone! I have a new life! I'm so thankful F 43 1 years
3,6 1X M
9/11/2020
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 1  Gynae investigation Hot flushes, very foggy brain, bone and muscle ache headache, lethargic. Thyroid complications that started after this drug and now 6 months later have nearly no oestrogen I was not warned about side effects and with a osteoporosis history prob shouldn't have been given this, and with the added thyroid and potential menopause.. would never have taken it! F 39 3 months
10.8 1X O
9/1/2020
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 2  Complication of Ablation Headache, Nausea, Dizziness, Mood swings, Joint Pain - Day 8 - worse pain Ever! On Zoladex to supress ovarian function. Ablation 2018 resulted in full blockage due to scar tissue; monthly messes unable to escape, resulting in semi solid mass and fluid in uterus. Frightening to say the least. The complication of the ablation ( body rejected Mirena) has taken away the ability to diagnose any Cancer in future. F 50 9 days
3.6mg impl 1X M
8/27/2020
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 1  To prevent breast cancer recurrence Slight headaches that are continuous, palpitations and chest pains? Hot flashes and my skin is so dry. I feel like the oncologists down play the side effects, they only mention the hot flashes and dry skin but they don't mention depression and cardiac arrhythmia which is very dangerous F 34 17 days
3.6 1X M
8/21/2020
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 4  Prostate cancer Insomnia and slight weight gain Periodic pains on the shoulders M 60 1 years
10.8 4X O
8/16/2020
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 1  Endometrioma of womb Sick headache weak hot cold not eating it come back up Definitely mood changed i can be bothered anymore cant go out poorly Going to 8 hours day to save job but sleep its affecting my life wont operation I have cysts on ovary and this in ovary keep thinking something else wrong Horrible F 44 6 months
3.6 1X day
8/9/2020
 2  PMDD Increased anxiety. High Blood pressure. Fatigue. Hot flushes Depression and insomnia elevated. I didn't use ad bac therapy so I can't comment if it side effects would have been lessened As with all drugs they affect everyone differently. I will try another hormone injection before my total hysterectomy. F 39 2 months
3.6 1X M
7/31/2020
 3  Breast cancer Where do I start...hot flashes,severe morning headaches,sore breast,pain in the back,total insomnia,vivid dreams/night terrors ,sweating all the time especially night time,body temperature going up and down in a matter of seconds,pain in the fingers(very difficulty to hold on to your beverage)dry skin,zero sex drive,crazy mood swings,extra cry and extra screaming,depression,out of body/space feeling...I could go on and on and on....almost forgot to mention the only positive thing I can say about zoladex is that my appetite is gone and nothing taste delicious any more(so I'm finally losing a bit of my overweight and battered body) Diagnosed with breast cancer at 34...since then developed osteoporosis,arthritis and million side effects thanks to combination of tamoxifen &zoladex! F 37 2 months
1X day
7/25/2020
Email
 3  Fibroid shrinkage/hysterectomy No major side affects, flushes and feeling tearful. Have since developed high blood pressure and palpitations with rapid heart beat. All started after coming off the drug. I feel there are long term side affects not documented. F 43 18 months
3.6mg 1X M
7/15/2020
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