ZOLADEX Reviews (GOSERELIN ACETATE)

Average Rating: 2.9 (291 Ratings)

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 ANTERIOR PITUITARY HYPOTHALMIC FUNCTION

 Type: Rx Drug

  

ZOLADEX  (GOSERELIN ACETATE):  Goserelin is used in men to treat prostate cancer. It is used in women to treat certain breast cancers or a certain uterus disorder (endometriosis). It is also used in women to thin the lining of the uterus (endometrium) in preparation for a procedure to treat abnormal uterine bleeding. Talk to your doctor about the risks and benefits of treatment. Goserelin is similar to a natural hormone made by the body (luteinizing hormone releasing hormone-LHRH). It works by decreasing testosterone hormones in men and estrogen hormones in women. This effect helps to slow or stop the growth of certain cancer cells and uterine tissue that need these hormones to grow and spread.   FDA Approval Date: 1989-12-29 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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RATING  REASONSIDE EFFECTS FOR ZOLADEXCOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 3  Shrink Fibroids before operaton 3 to 4 years ago i was put on Prostap had 3 injections to help shrink fibroids..due to very high blood pressure op had to be cancel twice. Moved years later..fibroids bigger and causing problems..i have now to start 2 doses of Zoladex one taken this month and the last to be given next month prior to op in March..so far i have been emotional for no reason, spots, aching and very tired..can't switch off from everything..irritable. Fingers crossed will have my operation 3rd time lucky i hope! F 40 1 months
1X M
1/30/2011
 4  Prostate Cancer - Stage 4 Hot Flushes, zero libido, some muscle loss My PSA went from 100 to 6 after first injection. My last PSA was .19. I get the 10.8 every 3 months. During the day I drink cool drinks (O.J., Cider, etc.) or splash my face with cold water for the hot flushes. I talk it over with the ladies. During the sleep hours I kick the covers off until the flush dissipates. As far as muscle loss goes I intend to get off my butt and start some exercise. I'm 75 and so my libido wasn't all that great to start with. Apart from the side effects I mentioned I feel great. Hopefully this will continue. My cancer has metastasized so it would seem that Zoladex is my only treatment. No point in operation, radiation, etc. As I mentioned I'm 75 so compared to many I am a lucky guy. M 75 9 months
10.8 10X O
1/3/2011
 3  Stage IV Breast Cancer Severe headaches; weight gain (10 lbs.+); blurred vision/eye twitching; Hot flashes. Taking Zoladex with Tamoxifen to curb estrogen production(premenopausal); Also on Herceptin; I tried Zoladex injections for 11 months and finally threw in the towel;there were days I could not function after the injection because of the headaches and eye twitching/vision issues. Did not experience weight gain right away - just over the last few months. I have been in remission for over a year and am generally in good health. I did not feel bad after every injection and the worst side effects may have occurred when the injection coincided with my Herceptin infusion. Zoladex did work - it kept me in menopause -hot flashes and all. Opted for surgical removal of the ovaries. F 49 11 months
1 1X M
11/30/2010
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 2  endo my experience with zoladex have been good and bad. after my first implan i hardly had any bleeding and pain which was fantastic. ive bled sooo heavy and lost lots of large clots and am always aneamic so having the bleeding and pain stopped was just fantastic. then it all went downhill from my 2nd implant. the headaches are unbearable, hot sweats, extreme anxiety, mood swing, crying, nervousness, lack of concentration, memory loss, chronic joint pain and then yesterday i collapsed at home and my husband rang an ambulance. my blood pressure was 230/130, which the paramedic said was life threatening. i also had a temperature. the a and e doctor said it was down to the zoladex. im supposed to have my 3rd implant this friday and my family dont want me to have it done. its a catch 22 situation, if i dont have it then the pain and bleeding will start but if i do have it then im so scared of the side effects as its got worse with each one. my only hope for getting my life back is for my specia F 38 2 months
1X M
11/16/2010
 3  to shrink fibroids Hot flushes, irritability, anger, lack of concentration, pain, no period I am on my 2nd of 3 injections to help shrink fibroids pre-op. I am now experiencing severe hot flashes. It feels like I'm in a waffle maker, hot on all sides. This wakes me up at night. As quickly as I'm hot, I'm cold. I am nervous that I'm becoming forgetful and lack the required concentration to do my job. I'm keeping more reminder notices and to do lists on my computer. I also notice that I am having more anger issues. Even though I rationalize that there are real reasons for my anger at the moment, this is different, I am becoming destructive. THe other day, I threw a bunch of things across the room. This scared me later. I use to be anxious about things but now I'm more carefree and numb.I am trying to maintain a healthy diet to keep some of these side effects at bay. I exercise regularly. Since I need to keep my job, I am doing all I can to check my attitude at the door. I am also experiencing pain all over especially in my abdominal area and in my lower back. Pain was severe today so much so that need to take motrin. Pain also noticeable at last injection site. My last shot will be at the end of this month. I see my gynecolgist next week. I do see the end in sight and hope to hang in there. I will post update on whether the Zoladex was worth it. F 46 6 weeks
3.6mg 1X M
11/14/2010
 4  Endometriosis I didn't find the side effects to be too bad. I did not have hot flashes at all and only had some mild leg tingling for the first two months or so. I was prescribed estrogen add-back therapy which made me nauseous so I only used it twice. Felt much better when I didn't have the estrogen. I was on a six month course of Zoladex for endometriosis. My last injection was 5 weeks ago. While I was on Zoladex I was still feeling a lot of pain and didn't think it was working. I did have some pain free days but not many. Now that I am off the medication, I wish I was still on it. This last week has been terrible. I am supposed to go in for surgery soon and have adhesions removed again. I am going to ask my doctor if I can go back on Zoladex after my surgery. Not being on it is much harder than I thought it would be. F 35 6 months
3.6 mg 1X M
11/13/2010
 4  Endometriosis Very bad headaches nearly all the time, aching all over (similar to the flu)dizziness, forget-fullness I have been prescribed Zoladex because I have really bad endometriosis plus frozen pelvis (where my left ovary my bowel and my tubes are all adhered to each other by the endo) My Surgeon will not operate on me until the endo had shrunk by the Zoladex. I had the implant in my tummy (which lasts for 3 months) on the 2nd Sept 2010 and I'm booked in for surgery on the 7th Dec 2010. The pain has completely gone since I have taken the Zoladex, I started to bleed a week after the implant which they told me would happen this lasted 2 weeks and nothing since except really really bad headaches and also this really weird aching sensation which is all over but really bad in my legs, my legs feel really heavy and bruised. F 33 3 months
10.8mg 1X AN
10/28/2010
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 4  prostate cancer Hot flashes. loss of libido, change of charactor(very moody,an absolute asshole).Ive been off of zoladex one year now. seem to be coming out of the mental changes but still no libdo and have hot flashes yet. My midsection and breast are large despite working out 3 times a week and I eat healthy. Went from psa 27 to 0. Don't know if I would do it again. M 67 2 years
10.8 1X O
10/27/2010
 4  Endometriosis Hot flushes, mood swings. Following surgery to remove an endometrioma I was advised to have these injections for 6 months. I have had minimal side effects but best of all no periods. Sexual activity had been restored too! Not sure what is going to happen now. It has been nearly 7 weeks since I had the last one and I'm wanting to get pregnant...If you are having this injection, you can ask for Emla cream to put on beforehand so that it doesn't hurt....ask your doctor. After reading a few websites, I asked my doctor who happily prescribed it. F 31 6 months
3.6mg 1X M
10/12/2010
 4  Breast cancer Horrible hot flushes, weight gain As the side effects are not too bad so far I am happy to continue. Taking it to increase my chances of stopping recurrence of cancer. Have gained 7lbs in the last two months and am worried about how much more I might put on. Hot flushes more bearable in cooler temps so looking forward to Winter. F 41 7 months
3.6mg 1X M
10/2/2010
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 1  endo extreme hot flushes, fatigue, exhaustion, moody, close to tears often,weight loss, dry mouth, constipation This drug did not help one bit other then the no periods. The pain during intercorse didn't stop at all and the hot flushes were chronic and interupted my day to day activities. Even though I didn't have my period it felt like I did for the whole six months just no bleeding. my last injection was 3 months ago and my period has returned and I have had it for 20 days even though I am on the pill. My gyne is not the greatest in the world and believes that Zoladex is the cure and that it should have worked on me and she is refusing to do surgery. F 23 6 months
1X M
9/20/2010
Email
 1  Endrometriosis Hot flushes, night sweats, moody, loss in libido, headaches, acne, sore breasts, Taken zoladex for 2 months now and unfortunately I am still in pain but I also have the side effects of the zoladex. I had a partial hysterectomy last year and had the zoladex for 5 months which helped a lot I was like a new woman but unfortunately the endrometriosis has come back and this lot of injections are not helping. I am very lucky as I have got 3 children. F 30 2 months
1X M
9/10/2010
 1  endometriosis sore boobs, sharp pains in boobs, stomach pains, origional pains not subsided back and leg pains no better, severe anxiety(im actually worried by how bad it has become so quickly), flushes, sweats, insomnia, dizzyness, fuzzyness, forgetfulness, lack of concentration, headaches ( also noise seems alot louder than usual and irritates), shakes only my first injection the injection its self didnt bother me but the side affects i dont think i can handle, the pain im suffering from seems to of gotten worse not better, i have had no releif as yet and the side effects i feel may not be worth it, i am suffering from severe anxiety, crying all the time, panicing, i feel lost or something im not sure, if im left on ly own im scared and cant stop myself from cring, this has only come on since the injection (implant) i am going to docs tomorow to see what my options are, i cant have another 5 months of not being left alone and panic, i keep running through everything all the time, its like constant butterflies in my tummy! aswell as all the other side effects im seriously doubting zoladex worth for myself! i have had not much help from my gynae specialist im hoping my doc can do something F 33 3 weeks
implant 1X M
9/6/2010
 5  Endometriosis Mild headaches, Hot Flushes Zoladex has been amazing. Was is severe pain before and on many painkillers, am now pain free and have started on HRT and now have no side effects. F 16 6 months
3.6 1X M
9/1/2010
 3  Prostate cancer Gleason 9 score Hot flushes, concentration loss, loss of libido, penis and testicle shrinkage, insomnia,hip pain,harder to push myself to physical training. Pre Zoladex diet change seems to have cut psa in half and then Zoladex reduced it to zero(so far). Worried about bone loss as I have light bones and can feel the strain/pain in my hips when I walk up stairs or in the hills.Temperament seems unaffected. Might voluntarily not have next 3 month injection, watch my PSA and hope for some sex to return. Will review results and might try Flutomide after that but still learning about my condition? Oncologist agrees to bone density test after 12 months on Zoladex but doesn't know I might not take the 4th injection.Scared to be on Zoladex continuously but may have no choice. M 62 9 months
10.8 /3mth 1X O
8/16/2010
 5  Fibroids Hot flushes, nausea, cold sweats, insomnia, lack of libido, dry vagina Treated for 6 months to shrink and firm up extremely large fibroids. Worst effect was nausea and hot flushes, especially during the night. Also, I seemed to be always tired and fuzzy due to lack of sleep. Result excellent as fibroids shrunk enough to be safely removed. It was worth 6 months of feeling unwell to retain my uterus. I also made an effort to go to the gym to keep up my fitness and help bone strength. Difficult at times but again, worth the effort. F 35 6 months
1X M
7/25/2010
 4  Endometriosis ocasionally sweats, more emotional than usual, pain in joints, vaginal dryiness I was very scared about taking this, but the symptoms are insignificant. I started to take it after a laparotomy surgery where the doctors find a big endometrioma, and so far no other endometrioma has been found. F 27 4 months
10.8 X 3M 1X M
7/24/2010
 5  endometriosis night sweats,headaches,lack of concentration,weight gain,puffy face,aches in joints.On the plus side,sex drive back to normal. my consultant decided to try me on zoladex to see if a hysterectomy would be suitable and so far so good.The benefits far outweigh the side effects and i feel almost back to normal.I have another 2 months of injections to get.I have been taking livial tibolone hrt to combat menopausal symptoms.I am very happy with zoladex. F 32 1 months
3.6mg 1X M
7/22/2010
 4  Endometrioma/ Fibroids Hot flushes, Loss of libido (never had a high sex drive for starters), Pain in shoulders, I am eating so much and always hungry, tingling sensation This has been a life saver compared with daily pain from endometrioma, severe period cramps and living my life in pain. After my first injection i had my normal period but thankfully on my second injection last month i had no period. I will take my third injection at the end of this week. This is in preparation for IVF as i've had 2 unsuccessful one's. I am hopeful it will end well. F 36 6 months
36mg 1X M
7/7/2010
 3  Endometriosis - Stage 3 nausea, insomnia, fluid retention found endometriosis after starting investigations into a pain near my kidneys. Liver & kidney scans showed nothings, so we started going down the list and next was ovary scan which showed a large cyst. Gyno did an internal scan which showed a suspected chocolate cyst and then I had a laproscopy to investigate. Had had no trouble with periods except the occasional cramping, but doctor said that the Implanon had probably been helping with that even though it didn't stop my periods all together, so the endo was growing "silently" as such. Have had my first injection of Zoladex, haven't had too many side effects so happy with that, but have had a period which I thought was meant to stop during treatment so the endo didn't grow anymore. Having the injections for 3 months, then deciding if more surgery to laser lesions or go straight on to Depo-provera injections. F 30 1 months
3.6mg 1X M
7/1/2010

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