ZOLADEX Reviews (GOSERELIN ACETATE)

Average Rating: 2.9 (291 Ratings)

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 ANTERIOR PITUITARY HYPOTHALMIC FUNCTION

 Type: Rx Drug

  

ZOLADEX  (GOSERELIN ACETATE):  Goserelin is used in men to treat prostate cancer. It is used in women to treat certain breast cancers or a certain uterus disorder (endometriosis). It is also used in women to thin the lining of the uterus (endometrium) in preparation for a procedure to treat abnormal uterine bleeding. Talk to your doctor about the risks and benefits of treatment. Goserelin is similar to a natural hormone made by the body (luteinizing hormone releasing hormone-LHRH). It works by decreasing testosterone hormones in men and estrogen hormones in women. This effect helps to slow or stop the growth of certain cancer cells and uterine tissue that need these hormones to grow and spread.   FDA Approval Date: 1989-12-29 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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RATING  REASONSIDE EFFECTS FOR ZOLADEXCOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 5  Endometriosis & Adenomyosis headaches and migraine, severe fatigue/tiredness, dizziness, sweating, hot flushes, joint aches, hair thinning, greasy skin and hair, acne, poor temperature control, anxiety,occasional pains (poss linked to endometriosis rather than drug!) Zoladex has worked well in relieving my severe pain which was debilitating. For me the side effects are better than having pain and a change in add-back therapy is improving some of these symptoms. F 26 7 months
4/21/2008
 3  Endometriosis Panic attack's. feeling faint.severe hot flushes. the fear of passing out while driving. This is my 2nd course of Zoladex and definately my last. The 1st was fine but the side effects have been horrendous this time. I cant wait for the drug 2be out of my system and try and feel normal again..... F 35 5 months
3/16/2008
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 3  endometriosis Hot flushes, panic/anxiety, tiredness/sleeplessness, crying, rage, horny, depressed, acne, very dry skin, some weight gain, hair loss, short term memory affected, vaginal dryness, aching bones, loss of appetite, "unsettled" feeling. Z helped greatly with the endo symptoms. I could deal with all of the side effects, except for the panic/anxiety attacks, sleeplessness and emotional changes. The panic was the worst. I hate it. I always felt I was going mad and that I couldn't do anything to make it better. It felt like I was in a living nightmare 24/7. My heart felt fluttery for most of the day. The lack of sleep exacerbated the condition. I also felt rage for several hours at a time (about 4-6 hours). Something minor would make me angry, and for the next few hours, I'd be so angry and taking it out on my partner =( I'd be fixated on the issue and try to provoke further rage in myself and my partner. After the rage subsided, I'd crash back into reality and feel really depressed and ashamed of what I've done. The interesting thing is that I didn't feel the panic/rage until the second month of injections. Z is a great drug for the endo symptoms, but it's quite disruptive to your life. Given the choice F 25 2 months
3/16/2008
 5  endometriosis I found Zoladex to be brilliant. My endo pain went within days of the first injection. I had no mood swings and felt really well on it. I would definately recommend it. I did get hot flushes, slight weight gain and my skin was occasionally spotty. F 40 9 months
2/15/2008
 4  endometriosis Menapouseal symptoms: headaches, extremely emotional, night sweats, hot flashes, vaginal dryness. the worst side effect was painful abdominal cramps that lasted 7-10 days each month. 1)The first injection I had without any aneasthetic and it was extremele painful. The second time I insisted upon a local aneasthetic and couldn't feel it at all. I recommend getting a local. 2) The Dr. didn't want me to get the period so he gave me progesteron with zoladex for 3 weeks, only I was already in the stage of pre-period, so it didn't help and I got the worst period in my life ever. If you can avoid having the period on zoladex by having it beforehands - do so! F 29 6 weeks
1/30/2008
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 4  Breast Cancer Bone Metastasis hot flushes, soreness at injection site, vaginal dryness,weight gain I was given Zoladex initially in 3 monthly form, now being given it monthly. It enables me to be truly post-menapausal and there can take Arimidex F 48 4 months
12/27/2007
 3  continuous and heavy bleeding Stiffness; muscle & joint pain was the worst; hot flushes; weight gain; also fatigue. It did stop my bleeding. F 40 6 months
12/12/2007
 3  Endometriosis Severe headaches, for about 2 weeks between injections, hot flushers, severely emotional, could cry at anything. Mood Swings exactly one week before injection. I could go on and on... I was diagnosed with Endometriosis in 1996 and have had 2 Laparotomy's, 5 Laparoscopies, as well as several radical exicions of endo. I was first prescribed Zoladex in 1998 and was on it until 2000, I came off this after a Laparoscopy but within 4 months I needed to go back on it. With regards to my Endometriosis it is brilliant, I am about 80% free of pain, but to be honest the side effects do take over my life. Life is an emotional rollercoaster, to which most people think I just cope with and probably think that everything is fine, but in reality it isn't. I cry most days and sometimes don't want to go on, but I will, as I am going for IVF and the main reason I do carry on with the zoladex is it is the only thing that gives me hope of conceiving!!!!!! F 29 9 years
12/11/2007
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 5  endometriosis Hot flushes, vaginal dryness, lots of tears, panic, jitters - but soooo much better than the pain of the endometriosis - its saved my life (literally!!) I had to have a kidney removed and a ureteric reimplantation as a result of the most severe endometriosis my surgeion had ever seen - oh joy! took 10 months of zoladex and its been such a relief - just petrified of coming off now!!! F 30 10 months
12/3/2007
 1  Endometriosis Hot Flashes, Irritability, Mood Swings, headaches on right side of head POSSIBLE WARNING to THOSE WITH SEVERE MYOPIA....I had 4 eye surgeries as a child, as I have a very rare eye condition...while on this medication, I suffered a likely irreversible loss of central vision to my right eye. My Moscow opthalmologist commented that I was not the first woman on Zoladex or other type of hormone therapy to suffer this problem. This is a VERY POWERFUL drug...You have to make sure the benefits outweigh the potential side effects. F 40 3 months
11/15/2007
 2  metastatic breast cancer hot flushes, sweating, insomnia, vomiting not helping malignant effusion F 44 3 months
11/5/2007
 3  Endometriosis Short term memory loss, loss of concentration, weight gain, excess hair growth, complete lack of sex drive, bad skin, severe mood swings, anxiety/panic attacks, hot flushes, spaced out feeling I was diagnosed with endometriosis when I was 17, since then I have had 5 normal laparoscopies (which did nothing) and one lazer laparascopy to remove the endometrial tissue which basically stuck my internal organs together like glue. This is the second time I have been on Zoladex, prior use was for only 3 months. I have not experienced any pain since being on zoladex but the side effects are severe. The memory loss was significant and devastating especially since I am in the process of studying for my Masters degree. Have not had a period since coming off zoladex as I was told by my doctor to take the contraceptive pill continuously until such time I want to fall pregnant. F 24 15 months
9/17/2007
 4  endometriosis The only side effect iv'e had is a bit of cramping. Like period pains, but they only last a day or two at a time mainly to the right side of my stomach. Apart from that its been fine I had to get one shot of this injection to thin the lining of my uterus before endometrial ablation. F 40 1 months
9/16/2007
 3  endometriosis Just got 4th shot. Have had constant r.side hip pain, knee pain, heel pain for past two months. Insomnia as well, and had to be put on Wellbutrin for mood issues. Hair thinning some. No period. NO sex drive. Frequent UTIs and yeast infections (never had before) memory problems, forgetfulness, major fatigue, hot flashes After 4 months I can't say how much this has helped me. I started Z. shortly after lap to remove left ovary, tube and huge cyst, at which time dr. saw extensive severe endo in "inoperable" places. Next month I go to Femara to try and relieve the constant grinding pain. No periods, though, so at least it is doing something. Side effects are debilitating some days, manageable others. Last week before next implant is the worst for mood. First week after implant is worst for pain. (BTW- I use Emla + local anesthetic before getting implant shot. Can't feel a thing!) Memory loss, bone pain and fatigue have been the worst and most persistant symptoms, although the hot flashes are intense and annoying. Also recently married, and have had sex three times (in horrible pain) in past four months- no desire, and horrible vaginal dryness/ pain. I'm prone to migranes, but no headaches on this med. I probably wouldn't have taken it if additional surgery was an option (I took 1 dos F 28 4 months
8/22/2007
 1  endrometreosis hot flashes, severe joint and muscle pains - I lasted 2 months then my doctor said we'd try something else. It's been 6 weeks since my last shot and still I can hardly walk, or even go to school because of the pain in my shoulder, hips, knees and ankles! F 23 60 days
8/7/2007
 4  prostate cancer hot flashes, breast development, caused loss in bone density M 73 36 months
5/16/2007
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 3  Endometriosis (Stage III) Hot flushes, joint pains, short-term memory loss, persistent headaches, dizziness. This is my first month (of 6, with more likely) taking Zoladex. I do still have quite a fair bit of endo pain occurring. The hot flushes are frequent but can be tolerated much more than the pain. Severe headaches, joint pains and memory loss has been the most troublesome side effects for me. F 27 1 months
5/13/2007
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 4  Prep for endometrial ablation Hot flushes (worse with the second injection of the two I was prescribed); permanent bleeding for 5 weeks, then stopped completely; spaced-out feeling at times; difficulty recalling simple words at times; the injection isn't so bad: one nurse advised me to cough as she stuck the needle in and I didn't really feel it at all; hypertension (to which I am susceptible) F 44 2 months
4/23/2007
 4  BREAST CANCER FIBROIDS HOT FLUSHES VERY NICE IN WINTER SAVED ON HEATING COST, NOT SO NICE IN THE SUMMER! NO INTEREST IN SEX VERY DRY VAGINA. THIS IS NOTHING TO WHAT I HAD PUT UP WITH FOR 10 YEARS NO MORE PAIN OR BLEEDING. After loosing so much blood and having to have an emergency blood tranfusion, I think Zoladex a miracle, had tried all other drugs to help stop the bleeding none worked did not want to have a hysterectomy as only 38. then at 40 breast cancer so kept on Zoladex on and off for 4 years now. 3 month course stops my periods for about 6 months which gives me a rest from the pain and bleeding then I have my periods for about 3 months, sex drive returns,until they are to bad and cannot cope without a few days in bed. The another 3 month course have been looking at uterus removal only leaving ovaries and cervix in place but looks like you can only have it in america. F 44 4 years
4/20/2007
 5  endometriosis Mainly hot flushes. They don't last very long and I don't sweat or turn noticeably red. Sometimes I wake up at night and have to push blankets off. Vaginal dryness. I also seem to be thirstier than usual and going to the loo more often. I don't know if this is related to the zoladex or the fact I am exercising a bit more to try to build up my bone density. It has helped immensely with my endometriosis pain. The hot flushes are sometimes a bit annoying, but they're nothing compared to the endo! The hot flushes can sometimes be great in cold weather! I wish I could stay on it forever but I'm worried about osteoperosis F 34 5 months
4/14/2007

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