ZOLADEX Reviews (GOSERELIN ACETATE)

Average Rating: 2.9 (291 Ratings)

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 ANTERIOR PITUITARY HYPOTHALMIC FUNCTION

 Type: Rx Drug

  

ZOLADEX  (GOSERELIN ACETATE):  Goserelin is used in men to treat prostate cancer. It is used in women to treat certain breast cancers or a certain uterus disorder (endometriosis). It is also used in women to thin the lining of the uterus (endometrium) in preparation for a procedure to treat abnormal uterine bleeding. Talk to your doctor about the risks and benefits of treatment. Goserelin is similar to a natural hormone made by the body (luteinizing hormone releasing hormone-LHRH). It works by decreasing testosterone hormones in men and estrogen hormones in women. This effect helps to slow or stop the growth of certain cancer cells and uterine tissue that need these hormones to grow and spread.   FDA Approval Date: 1989-12-29 (Sources: U.S. Centers for Medicare Services, FDA)

  

Results are sorted by Date added.

Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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RATING  REASONSIDE EFFECTS FOR ZOLADEXCOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 5  Breast Cancer Weight Gain and Hot Flushes Was on Tamoxifen and Zoladex - but hopeless with a pill a day, so only on Zoladex monthly injections now. Doing my injection myself each month is a nice reminder that I AM a survivor and that I'm grateful for this medicine to put me in a better position further on down the track. Zoladex for me is easy - no fuss. And I'm so grateful I don't have periods anymore!! Just gotta remember to get out there and exercise more to combat the weight gain. F 41 18 months
3.6mg 1X M
2/15/2012
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 3  elevated PSA Following radiation and protstatectomy put on Zoladex. Hot flashes (20 per day),total loss of libido and personality changes (not for the better) and joint pain ensued. Vowed I would rather die than do it again, but when presented with that alternative last week when PSA rose to 5.8 have reluctantly decided to resume Zoladex injections. Like so many others have commented, while the PSA will go down and the metastased cancer areas will no doubt stop growing, perhaps even shrink, the side effects for some are very disturbing. Having been off Zoladex for 5 years and vowing never to go on it again, there are no other options if you wish to keep living. Perhaps the antidepressents I have been prescribed will help the dreaded side effects. As a male I certainly sympathize will all the ladies suffering from menopause and the hot flash syndrome. 20 of those attacks a day and living in perspiration at night along with the mood swings are no treat. An alternative to this drug without so many side effects would be most welcome. For any man reading this post, if you need the drug and suffer afterward you are not alone, hang in and hopefully after a few injections (I had 3) you can go off for a few years before facing the ordeal again. I must mention that I have an older (80 yr) male friend who has taken Zoladex with relatively few side effects so there is hope your personal experience will be better. M 69 9 months
10.8 1X O
2/12/2012
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 5  Endo & Chocolate Cysts Migraines, Hot Flushes, Night Sweats & Joint Ache in the latter months of taking it. F 37 10 months
1xM
1/21/2012
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 3  endometriosis feel,weak, nauseated, vomiting, and tired constanly. hot flashes and joint pain.It has only been one month 5 more to go. hope to see improvement. F 30 6 months
??? 1X M
11/22/2011
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 3  pre TCRE emotional and irritable after 1st dose, with one day of whole body pain.....after 2nd...unbearable bone pain,vomiting, vaginal dryness/soreness,permanent headache, wheezing and generally feeling like im going to die. Thankfully i dont have to have another of these nasty implants, but if the surgery following this drug is successful i would say that however horrendous it has been, it will be a small price to pay to get my life back. :) F 40 2 months
3.6mg 1X M
10/30/2011
 4  Recovering from Endometriosis Night sweats / hot flushes, constipation, headaches, fatigue, moodiness Had a cyst removed from my ovary & severe endo removed. Post-surgery - Im well into month 2 of Zoladex. Initially I had nausea but this could have been the onset of my first period which arrived a week after my first shot! Pain was still there but far less than pre-surgery. Night sweats started 2 weeks after 1st shot & now into 2nd shot Im having hot flushes during the day too. Headaches regularly & constipation plague me too. Looking forward to my last shot in 4 months!! F 33 6 months
3.6mg 1X M
10/22/2011
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 5  Endometriosis Headaches (only the first week or so), hot flushes, night sweats, slight forgetfulness So far so good! Having hot flushes and night sweats is much better than being in pain - though I had the Zoladex LA 10.8mg injection right after my laparoscopy to remove chocolate cysts on my ovaries, so maybe the surgery helped with the pain too. F 32 3 months
10.8mg 1X O
8/12/2011
 2  Possible endometriosis Insomnia, nausea, memory loss, hot flushes I was asked to try Zoladx injections by the gynaecologist as he suspects I have endo. I have all the symptoms however only have small adhesions on the ligaments at the bottom of the uterus. There is no other sign of the endo. I tried tri-cycling the contraceptive pill which worked for a few months as I didn't experience pain mid-cycle but then the usual pains and swelling returned and the last period was that bad that I was about to ask for a hysterectomy! I had 1 x Zoladex injection and although there was no endo pain the side effects were horrendous. I am seeing the gynaecologist privately and he had written to my GP to ask that they perform the remaining injections. GP told me that they would use Prostap instead of Zoladex and the 2nd injection was therefore Prostap. Since then I have experienced no pain whatsoever, the insomnia and nausea have disappeared and I only occasionally have a hot flush. I saw the gynaecologist a couple of weeks after the 3rd injection (so 2nd Prostap) and he is really pleased that I am not experiencing pain and has suggested I continue for up to 18 months. I will now start to take some form of add back therapy to stop me fully going into the menopause. I am also going to take calcium vitamins. All in all I am happy on the Prostap but suffered on the Zoladex. F 33 1 months
3.6mg 1X M
7/22/2011
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 3  Adenomyosis Terrible Headaches, Whizzing fuzzy head. Hot flushes. Extreme fatigue. Weight gain. dizzyness. Very emotional and tired during week 4 of each injection. Dry skin too. Have possible Adenomyosis which is difficult to diagnose. Prescribed 3 months zoladex to confirm diagnosis before hysterectomy. Adenomyosis symptoms disappeared by week 2 so Zoladex did work well. However side effects so bad Doctor didn't do 3rd injection as Zoladex had already shown what he needed & I couldn't bear it anymore. F 40 2 months
1X M
7/17/2011
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 3  endometrosis Memory loss confusion horrendous hot flushes and night sweats swollen feet and ankles joint pain numb toes and feet.Weight gain changes in hair I had a hysterectomy 14 years and my endometrosis has returned and i have cysts on my ovary i would not take zoladex again due to hot flushes and night sweats i have not had more than 30 minutes sleep at one time for 4 months. I have hot flushes every 30 minutes this is affecting my work and family life .I have aching joints swollen ankles and feet nunb toes i can hardly get down the stair in the morning due to joint pain in my feet and ankles. What have i done to myself i have now to go for a bone scan due to bone thinning caused by zoladex i wish i had pushed to have my ovaries removed. Cant wait to stop Zoladex and get my life back F 47 5 months
3mg 1X M
6/19/2011
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 3  Stage 2/3 Endometriosis Hot flashes, more emotional/irritable Ever since I was 12, I have been having horrible periods. After being on Depo Provera for a year, I started bleeding for two months straight and I became severely anemic. I was put on birth control pills along with Depo then taken off Depo and put on a pill with a higher dosage. Long story short, I finally saw an OB-GYN and the next day I got surgery to diagnose Endometriosis. I am 4 shots into the 6 shot Zoladex treatment. The only time I bled was when I first started on Zoladex due to estrogen withdrawal. I haven't noticed a change in my endo symptoms because I'm not bleeding (I didn't bleed on high dose BC pills either). After the 6 months are over, I am going to go back on Depo. If severe cramps and heavy bleeding return, I will have another surgery to burn off the lesions. I have hot flashes all day long and very bad ones at night as well. I am from the heat and have sweat more in the last 3 months than I have my whole life. I am a lot more emotional and at times when I get frustrated I just want to cry and punch something. F 19 3 months
3.6mg 1X M
5/19/2011
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 4  Possible Endometriosis Side effects: Hot flushes (daily and nightly) Occasional headache (never used to have them before) Brain "fog" Interrupted sleep (sometimes due to night sweats) Feeling over emotional Doctor is trialling me on Zoladex to try get a diagnosis as to whether it is Endo or not. It's been the best 3 months of my life for years. No periods at all - it's been the best break ever! I used to get severe painful periods that lasted 3-4 weeks in full swing which meant I was off work most of the time. I've had a full 3 months in work and it's been fantastic to be back properly. Yes the hot flushes are awful and some of the other side effects but compared to what I was experiencing before it is absolutely worth it - hands down. I can't rate it as a 5 as I'm not "cured" yet, going back in a couple of weeks to see if I'm going to stay on Zoladex for a few more months (fingers crossed) and what they'll do next. Am a bit worried about the whole "bone density" thing but I've got freakishly strong bones anyway so I think I'll be alright but I don't want to be on this forever. I've had an "increased appetite" and probably have put on a little bit of weight but nothing noticeable, just be stern with yourself if you get any cravings!! I've upped my excercise to try counter this effect. I'm hoping if I', allowed to take this for a few more months then they'll give me something for the hot flushes - that would be ideal BUT if not it doesn't matter, I've got most of my life back again and I'm enjoying it whilst it lasts. For anyone with Endo/Possible Endo then I recommend giving this a shot, don't rule it out. F 23 60 days
3.6 1X M
5/12/2011
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 3  Gyno problems hot flushes, headaches, migraines, full body sweats, back aches, UTI, blocked batholin glands, mid to sever depression I had it for gyno pains, got 1 period after injection that lasted for 18 days very heavy, flushes and sweats very extreme, mild depression, turn into sever depression, constant headaches turning in migraines by the end of day, 2nd and 3rd month no period yay!!. Didnt stop infections associated with my 1st period. But on the up pain improvement was remarkable, I was in sever pain for over 6 months and within 2.5 weeks pain improved by 80% and now by 95% I would recommend for the pain but as for other side effects will never take zoladex again, i went from being bed ridden with pain, to being bed ridden with sever depression, really not worth it when you work full time and have 4 children to raise on your own. F 35 90 days
10.8mg 1X O
5/2/2011
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 3  Pre-fibroid removal operation Insomnia, acne, some forgetfulness, mild night sweats i wouldn't have taken this drug if it wasn't a necessary pre-requisite for the operation. I was hoping that at least the benefit would be mild or no period to counter balance the side effects but no... I had a full on heavy period as usual 2 days later than normally expected and it dragged on for two and a half weeks but the last week or so was spotting which I seem to have intermittently now since my second injection. The sweats aren't so bad but contribute to the insomnia. I suspect that as a result of a lack of sleep I have caught a cold. F 43 7 weeks
lowest dos 6X W
5/1/2011
 2  Fibroids Hot flashes, migraines, short term memory loss, moodiness, irritability I took Zoladex for 4 months in an attempt to shrink very large fibroids. Largest of 4 fibroids was 10 cm; my entire uterus was involved, some of the fibroids were calcified. My gynecologist was optimistic about shrinking them enough to do a vaginal hysterectomy. Initially, the fibroids seem to shrink a little, however, by the 3rd shot, they started to grow at a rapid rate. A little after the 4th shot, I had a total abdominal hysterectomy; the fibroids had grown significantly larger. Even though the result was disappointing for me, I'm glad that we tried this course of treatment. F 46 4 months
3.6mg 1X M
4/18/2011
 3  Fibroids Breast tenderness and increase in size, no concentration, tingling in hands and legs, muzzy thinking, weird rush like feelings in my head, itchy scalp. I have to do one thing at a time, not my usual self and a bit crabby. But if it can stop the bleeding and reduce the fibroids it will take pressure of other areas - Increasing exercise does help release the tension, swimming is good. F 47 14 days
1X M
4/1/2011
 4  Prostate Cancer after maximum x-ray Very depressed, slight weight gain, total impotence and zero libido. Rarely hot flushes. Considerable muscle loss which is not possible to regain thru exercise. Want to be left in hibernation. Too bad there isn't something to counteract these damned side effects of an otherwise good drug. M 78 12 months
10.8 mg 1X O
3/21/2011
 4  prostate cancer most difficult are depression, very poor sleeping weight gain around waist sweating +++ total loss of sex drive psa 13 prior to starting 7.5 weeks of radiotherapy back in September 2010. which went very well. last psa in Jan was 0.4 last and final injection on the 4th Jan 2011 just hope that the awful side effects will start to lessen M 67 9 months
10.8mgs 1X O
3/16/2011
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 3  fibroids to shrink mood swings,headache,sickness,hot flushes,forgetful,tired Nurse told me only side effects was hot flushes! Didn't believe her. F 43 3 months
3.5 1X M
2/14/2011
 4  gynae probs now on 4th implant and experiencing problems. started having hot flushes, headaches, diarreahoe,not sleeping. regardless of side effects the pain i experienced is no where as bad as it was. F 37 4 months
30mg 1X M
2/10/2011

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