ZOLADEX Reviews (GOSERELIN ACETATE)

Average Rating: 2.9 (291 Ratings)

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 ANTERIOR PITUITARY HYPOTHALMIC FUNCTION

 Type: Rx Drug

  

ZOLADEX  (GOSERELIN ACETATE):  Goserelin is used in men to treat prostate cancer. It is used in women to treat certain breast cancers or a certain uterus disorder (endometriosis). It is also used in women to thin the lining of the uterus (endometrium) in preparation for a procedure to treat abnormal uterine bleeding. Talk to your doctor about the risks and benefits of treatment. Goserelin is similar to a natural hormone made by the body (luteinizing hormone releasing hormone-LHRH). It works by decreasing testosterone hormones in men and estrogen hormones in women. This effect helps to slow or stop the growth of certain cancer cells and uterine tissue that need these hormones to grow and spread.   FDA Approval Date: 1989-12-29 (Sources: U.S. Centers for Medicare Services, FDA)

  

Results are sorted by Date added.

Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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RATING  REASONSIDE EFFECTS FOR ZOLADEXCOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 4  adhesions, cysts hot flushes,night sweats,nausea vaginal dryness and tiredness My pain has certainly eased off, hoping it will last after I have completed the course, otherwise it is a operation which I would rather avoid. I was two minded at first after reading reviews,but my doctor really thought we should give it a go, but must say everyone reacts differently to all medication and I do not regret it at this point in time. I am also on HRT which seems to help with the side affects. F 49 5 months
3.6 1X M
6/29/2010
 3  endometriosis weight gain just under 3 stone in 6 months night sweats pain free for 6 months once stopped Zoladex pain returned after 6 weeks awaiting surgery now. M 39 6 months
1X day
6/18/2010
 1  endo,cystic ovaries,adenymosis urinary problems, night sweats, depression/anxiety, insomnia, moodiness, joint pains, loss of libido, brain fog, fatique. After more than 25 years of chronic pelvic pain and multiple surgeries for polycystic ovaries, endo and adhesions, I agreed to take Zoladex in preparation for surgery for Thermachoice and laparoscopy. Surgery was successful as there was no evidence of endo either in the pelvic cavity or uterine wall. The side effects of the drug impacted severely on my quality of life and if I had been in a better space and not consumed with desperately trying to find relief from chronic pelvic pain, I would have thought long and hard before agreeing to take this drug. My husband of 28 years said that if I had contd. taking this drug our marriage would have been in serious trouble. Think carefully before resorting to this drug! F 47 5 months
3.6mg 1X M
6/4/2010
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 4  Endometriosis Fatigue, hot flushes, emotional, spots I was terrified after reading reviews but it's the best thing I've ever done. I've had 3x monthly injections followed by 1 implant lasting 3 months and the pain of endometriosis has all but vanished. I had a horrendous period 3 weeks after the 1st injection but no problems since. I take Premarin to counteract any side effects and wish I could stay on it forever! The needle isn't as bad as expected - it's nothing compared to the pain of endometriosis but you can have a local anaesthetic. I've had it with and without local and prefer without as it's over and done with in seconds. My last injection should have worn off a couple of weeks ago but no period yet - apparently it can last a month or two longer than expected. I'd recommend trying it! F 27 6 months
1X O
6/2/2010
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 2  Breast CA severe hot flashes( about 1 an hr) trouble sleeping from hot flashes,nausea if hot flashes are after I eat, crying alot,kinda feel spacey (not sure if this is from hot flashes and lack of a good nights sleep)joint and muscle pain which is getting worse and making me feel like an old lady, trouble walking, pain in knees and hips,really bad shoulder and back pain (worse at the end of the day)fatique and sad alot of the time from all these side effects which are making me feel crappy and cranky. My doctor gave me a mild antidepressant to get rid of the hot flashes but I have not taken them as I don't like taking all these drugs and am afraid that another drug will just have more side effects to deal with. He recommended accupunture which I am going to try in a few weeks (already talked to the doctor who does the accupuncture and she said she has had success with it for hot flashes..so wish me luck or its going to be a long hot summer). As far as the muscle and joint pain, this better go away soon. The accupunture doctor said she could probably help with that as well if it persists. Wish there was a better way to reduce the risk of breast ca returning,not sure if I will be able to take this for the entire time recommended if I continue to feel like this. F 49 4 months
1X M
5/30/2010
 5  Prostate cancer Loss of libido, hot flushes, impotence, gaining weight, tiredness and lack of concentration. I get injected every 12 weeks. After taking zoladex PSA down to 0.1 from 7.0 Side effects a bit of a nuisance but it seems to keep PSA down. M 54 18 months
1X O
5/21/2010
 1  prostate Cancer I take the injection once every 3 months. I have been feeling muscula joint pain, weekness, loss of appetite, swollen feet, bone pain, energy loss, hard to lift myself, can't walk, and get tired fast. M 86 12 months
10.8 mg 4X O
5/16/2010
 3  Shrink fibroids prior to conception Immediately over emotional about everything and anything. Crying for no given reason. Very tired, possibly due to waking up 3-4 times through the night, which is now more like 2-3, due to major uncontrolable hot flushes like I cant describe. Absolutely exhusted all of the time. Severe headaches from the start, went after third injection but have now returned albeit not quite so frequent. Feel like my body is aching, particularly around my joints.. wrists, knees, shoulders and feet and sometimes even my knuckles! I am usually rather laid back but now not very rational in pressing situations. Very forgetful. Possible decrease of sex-drive. Generally feel like a space cadett. Been put on this as an attempt at shrinking my fibroids. Main one being the size of a four month term pregnancy, in the hope that conceiving/being pregnant will be easier once Im off the drugs.. Quick examination after third injection showed signs that largest fibroid (5x6x9cm) has halved in size. In the mean time, I cry over the smallest things, and sometimes I dont even know why Im crying. So tired I could fall asleep during my journey both too and from work (40mile round trip.) Hot flushes that feel like my head is about to blow off. Headaches like a band is around my head. My knees and wrists ache the most to the point were I end up holding/rubbing them to feel better. I am shocked at such a short fuse I have before I become an emotional wreck. I forget the simplest of things (so my Fiance tells me) causing understandable frustrations from all concerned. Dont feel very sexy, partly due to nearly a full stone of weight I have gained since starting 4 and a half months ago..therefore have noticed decrease in the want for sex. Many a time I have been somewhere like the local supermarket, only to not really remember what I was there for, or where the beans are - even through Iv shopped there for quite some time! Oh, and felt a bit 'unfocused' at times whilst driving.. not good! F 33 4 months
1X M
5/6/2010
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 1  stage one breast cancer A walking zombie, , just a slow one!!! I felt spaced out/flat affect/severe hip pains/nausea daily/ slept 12-14 hrs day and still fatigued- yes, a zombie aged 100!! sums it up well. Oncologist sugg. not doing this any more. Had good chemo regime and some on/off attempts wih Tamox. ( also, had severe bone pain, so , ceased that) ( P.S every one's response is very very different and the advice above suited my diagnosis only) Most likely i would have same symtoms with oopherectomy, so, advised against that also. QUALITY of life is what counts for me and on Zoladex I had zero. I now look forward to getting on with life without pain/fatigue, and thats better than winning a lottery::) F 47 1 months
3.6 mg inj 1X M
5/6/2010
 1  prostate cancer muscular and joint paine M 87 1 years
10.8 1X AN
4/30/2010
 3  Endometriosis Hot flushes, continuous bleeding after day 3. Emotionally I felt so much calmer and relaxed. Trouble sleeping- insomnia, not due to flushes. Shaky hands and slightly nauseous. Immediate loss of libido and climaxe not as strong. Have just started first course of six to prepare for full hysterectomy at age 34. Had laproscopy 4 weeks ago and found out I had stage 4 endo. Needle for z was ok and affordable. Skin is already clearer and appetite scarily growing. Only had 1st injection 4 days ago. Fingers crossed F 34 1 months
3.6 1X M
4/19/2010
 5  Severe endometriosis Initially hot flushes, vaginal dryness etc. However once I started taking Kliovance (HRT) it counteracted all side effects. Bone density scan was also ok. Fantastic. Would stay on it forever. Gave me back a normal life without any pain. F 33 2 years
3.6 1X M
4/15/2010
 5  endometriosis Night sweats I can honestly say that having this implant is the best thing thats happened to me, apart from night sweats, all my pain goes while using it, weight decreases and general wellbeing is excellent. Ive had two implants in, last one in november, and the decision has been made to have two more as symptoms are returning. These will probably be my last as it can decrease bone density so I have to take oestregen while using it. I had no other problems at all while using it and am eternally grateful for doctors introducing me to it!! Anyone wanting to email me is more than welcome, I havent actually spoken to anyone properly with endometriosis, would be interesting to find out other peoples symptoms etc. F 29 6 months
10.8 1X O
4/12/2010
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 2  endometriosis sweats, shakes, back pain, abdominal pain, pain down my legs, mood swings, bleeding, temp i have been put on zoladex 3.6mg and put on lival 2.5mg for my flushes and sweats and the rest im new to this drug and since having the implant i am now bleeding heavy serious pain in my back and legs even pain killers anit taking it away F 24 5 days
3.6mg 1X M
4/5/2010
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 4  residual ovarian tissue I get the night flushes, Ive had 2 unexplained frozen shoulders, i have swelling of legs due to water retention. My hair has thinned, but I have thick hair anyway, lack of sex drive, nipple discharge I had numerous operations for ovarian cysts, probably due to endometriosis. The operations caused more harm as i developed adhesions. After an early hysterectomy aged 27 with no children, i thought i could begin my life. How wrong I was. Deep down in the adhesions is ovarian tissue, leftover form the endometriosis. Its unattainable, without major mojor surgery which may damage my bladder, circulation to legs and result in a colostomy bag. So, every month for 11 years I have my injection, with HRT top up. I ve had 4 further cysts in that time, because i was a few days late getting my injection.BUT, and a big but, when you read about our fellow human beings suffering from all theside effects and dealing with cancer, it makes me humble. I am thankful for small mercies F 39 11 years
3.6 1X M
4/4/2010
 3  endometriosis really tender breasts, constipation, weight gain of 9 lb in 1 month, occasional mood swings Although I m suffering from the side effects I mentioned, I do think that the injection has eased the stomache ache I was getting before and my sex drive has actually improved. I have still had a period this month too. I still have another 5 months of injections so I will update this as I go. F 35 1 months
1X M
4/3/2010
 2  endometriosis and adhesions Extreme tiredness, forgetfulness, mood swings, aching body, legs feel filled with concrete when i walk, head filled with cotton wool fuzzy moments,period began heavy,bowel disturbance,craving sweet things Have been taking this exactly one month with Tibolone Addback HRT to i presume balance my hormones as Zoladex shuts down my ovaries. First noticable side effect was extreme tiredness, everyday tasks seem even harder and more exhausting, fuzzy head and heavy achey feeling in my body generally. Feel like i want to become a hermit, aware of sudden flare ups of anger or emotion followed by exhaustion. Had to give this a go, hysterectomy next option but endometriosis has spread into my pelvis around belly button as well as right ovary which was recently burnt away from bowel fallopian tube stump (previously removed in surgery) had adhered to surrounding organs. Pinching is constant. Previous surgery worked for very short time relief immense but it returned with a vengence. Convinced it has readhered to ovary. Despite zoladex pinching very evident one month into injections and feel a bit sick at times as well as other symptoms but determined to give it a go along with tibolone. Whole thing is really scarey and information is sparse even GPs have to look it up, nurse administring it claims she only ever gives it to men with prostate cancer! Im in the hands of the gods,nhs and in the meantime i just sit back try to live with the side effects and wonder where this is all going to end up, i have to have hope! (ps confession not been able to give up some smoking and the odd drink im so stressed i need a prop but taking supplements vit c, eating cheese (although a veggie that eats F 51 30 days
1X M
3/31/2010
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 3  breast cancer I have been taking Zoladex for a little over a year now along with Tamoxafin my main side effects of the drug is Severe mood swings, Weight gain( 28 pounds so far), swelling( water retention) of the hands, loss of energy, and hot flashes F 32 1 years
1X M
3/1/2010
 3  Prostate cancer T3 Weight gain, zero libido, general aches, short term memory loss, tiredness. Apparently not connected but acute pain in my left testicle a couple of days after first injection - not had it before or since. Hot flushes etc. Used before, during and after radiotherapy radiotherapy. PSA is down to undetectable, hopefully due to the radiotherapy. Would love to get off Zoladex. Hope PSA doesnt rise. Its a worry that psa may begin to rise indicating rt hasnt worked and Zoladex no longer working. What a dilema. Rate 5 for keeping psa down but 1 for side effects. Not much choice though. M 50 1 years
10.8 1X O
2/10/2010
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 3  Endometriosis Hot flushes,mood swings and weight gain-about 4kg in 6 months. cannot wait for end of medication although not having a period is ahuge relief as no pain.Very concerned about my weight gain and I am hoping that I can shed this weight after medication.Would like to know from those who are no longer on meds. F 30 6 months
1/17/2010
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