ENBREL Reviews (ETANERCEPT)

Average Rating: 3.7 (533 Ratings)

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 TUMOR NECROSIS FACTOR-ALPHA INHIBITORS

 Type: Rx Drug

  

ENBREL  (ETANERCEPT):  This medication is used alone or in combination with an immunosuppressant (such as methotrexate) to treat certain types of arthritis (such as rheumatoid, psoriatic, juvenile idiopathic, and ankylosing spondylitis). Some brands of this medication are also used to treat a skin condition called psoriasis. These conditions are caused by an overactive immune system (autoimmune disease). The immune system attacks the body's own healthy cells, causing inflammation in the joints and skin. Etanercept controls your body's defensive response by blocking the action of a certain natural substance (TNF) that is used by the immune system. Treatment decreases redness, itching and scaly patches in psoriasis as well as the pain, swelling and stiffness of joints in arthritis. This medication can stop the progression of disease and joint damage, resulting in improved daily functioning and quality of life. This medication treats but does not cure autoimmune diseases. Symptoms usually return within 1 month of stopping the medication.    (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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RATING  REASONSIDE EFFECTS FOR ENBRELCOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 4  Sero Neg. Poly Arthritis Severe pain on the left side of my head and left eye. My doctor says its Occipital Neuralgia, probably caused by the arthritis in my neck. I don't agree. These headaches started appearing after I started Enbrel. They usually last 1-3 days plus one recovery day and have no pattern of occurrence. The strongest meds. I've tried are Tylenol 3 with no relief. A hot pack feels nice, but also does little for the pain. I started Enbrel in June/06 on a 6 month study by Amgen(the makers).The study ended in Dec./06 and so did my relief from arthriris. I went 3 months without it while waiting for my provincial government to decide if they would cover the costs of my treatment. During that 3 months all my symptoms returned, times 10. Coverage was approved, and I started Enbrel again on Mar.11,2007. Although not a "wonder" drug, it has relieved many of my symptoms. I have concerns about the side effects, but I am enjoying feeling somewhat better. F 41 11 months
8/29/2007
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 4  RA None yet. Today will be my fourth injection, and so far so good. Prior to Enbrel the quality of life for me was hell, the winter months were the worst, and people who are not sick don’t want to hear you complaining. People think that you are lazy. I am normally a busy person. My ankles and hands were unrecognizable they were that swollen, but now they look and feel great. I am back to polishing my nails and wearing my rings. And, I am once again walking like normal people. I am afraid of the day that it stops working as well. Additionally, I have found that if you leave it out to warm for about 45 mins it will not burn going in. I think the reason it burns so much going is that it might be too cold. F 50 3 weeks
8/23/2007
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 3  RA None At first it seemed to work well, it helped with the fatigue, and the stiffness. I have been on it for 6 months, now my blood work is showing it isn't doing the job my DR wants it too. My inflammation rates are sky hig again, so we try another drug. The drug HURTS going in, you can leave it out for the 20 min and it makes no difference, it still burns going in. F 38 6 months
8/10/2007
 5  rheumatoid arthritis none I began taking Enbrel about 10 years ago on 3rd phase testing, double blind study. I knew the first two weeks that I had the drug and not a placibo. I went into a complete remission for about 2 1/2 years. I haven't had even one flare since I started injecting Enbrel. However, I feel that it isn't working as well as the first 2 1/2 years, but I am still very happy with this drug. I feel that it has changed the course of my RA, I have only one MCP joint that has some damage. Great Drug!! F 63 10 years
7/29/2007
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 3  Psoriosis 2 weeks after starting twice per week injections, had injection site reactions that made it seem I was doing more harm than good. Completely went away. Has taken 4 months to notice any improvement on my body but is slowly coming along and looks good. My scalp, behind my ears, face and elbows have worsened to the point that I am going to ask my doctor for another treatment. Depending on what the reason is for taking the Embrel, it works well but I am skeptical about how damaging it really is to my system. F 40 5 months
7/17/2007
 4  PA and Psoriasis Fatigue, shooting pain on the arm of injection site at the time of injection (even when at room temp), buzzing in ears, increased infections and severity of infections. This as well as for others has been a life safer. It worked fantastic for the first couple of months and then a switch in my insurance company had me off my medicine for 3 months. When I was back on, the injections did not work the same. I was increased from 25 mg a week to 50 mg, since I begin to feel the need for more medicine within about 5 days. 50 mg made me lethargic and I developed serious infections. I now take 25 mg within 7-10 days. My psoriasis is controlled, but has not cleared on my scalp, behind the ears, & my elbows. I was diagnosed with PA early and but on Enbrel early on. F 28 1.5 years
7/7/2007
 5  Psoriatic Arthritis General "unwell" feeling The swelling in my wrists went down the first week of injecting 50mg of Enbrel...I had been on Methotrexate alone for about a year with minimal results. M 53 2 weeks
6/26/2007
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 4  Inflammatory Arthritis Pain and occassion swelling at the injection site Works well on the joint pain - still have some swelling in my ankles and wrist. But a LOT less painful. F 40 1 years
6/26/2007
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 3  Psoriatic Arthritis I am about to begin Enbrel in conjunction with 15 mg. of Methotrexate (which has not relieved my joint pain). Any thoughts on this....I am told to expect some side effects from the Enbrel....has anyone else taken these two drugs together. Thanks M 53 0 days
6/13/2007
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 5  psoriatic arthritis + psoriasis I quell injection site stings by icing site before and after injecting. Enbrel is a life-saver for me. At 100mg/wk, it retards disease process & inflammation, & restores my pre-illness energy level, concentration, alertness. Unfortunately, HMO will not cover 100mg/wk past 1st 3 mos. for plaque psoriasis. So I must do with 50mg/wk which retards disease/inflammation, but stops short of fully restoring pre-illness function. Few Drs know enough about biologics or about prescribing them to include them in treatment choices for patient relief of certain debilitating conditions. Of Drs who know of & prescribe biologics, few apprise themselves of insurance protocols for expensive drugs, so fail their patients by leaving them, already handicapped by illness, to deal alone with coverage intricacies. Benign neglect is not patient care. While the longterm effects, if any, of using Enbrel beyond 7 or 8 years are unknown, many patients need many more doctors to know about biologics and how to prescribe them. F 56 3 years
5/14/2007
 3  RA Having extreme fatigue. Fatigue is robbing my life. F 48 8 months
4/23/2007
 3  PP I am currently having this horrible rash that is covering 70% of my body and my face...My eyes are also very swollen. I went to the emrgency room last night, but it seems like they are unsure of what to do. I am going to see my dermatologist tomorrow, but I am afraid that he also would not know what to do. I am in desperate need! Hope someone out there has had this sort of reaction, and can tell me what they did to resolve it. M 21 12 months
4/22/2007
 5  Plaque, guttate psoriasis painful injection at times... it burns! Had no real side effects for awhile, but four months into it I am now experiencing backaches and seem to be a little more listless and forgetful at times than I used to be. The benefits of this drug have FAR OUTWEIGHED the side effects thus far! I was covered from head to toe with plaque psoriasis and couldn't shower or even lie down at night without being in excruciating pain. I will gladly suffer the side effects described in exchange for considerable clearing. I'm on 50 mg 2x weekly and have only had a few 'breakthrough' plaques. I went through the winter without so much as a cold while on this med, so I've not seen any of the increased infections some folks describe. F 42 4 months
4/17/2007
 5  psoriatic arthritis None so far, but I'm only on my second weekly injection. Was diagnosed with psoriatic arthritis just a few weeks ago. Had excruciating pain and inflammation all over--elbows, wrists, fingers, neck, both knees, left ankles and right toes, plus severe scalp psoriasis. Three days after my first injection, the pain had decreased by about 90% and I was able to walk without a cane/crutches for the first time in two months. I'm cautiously optimistic, only time will tell how long this will continue to work for me, but my mobility, pain and overall energy are night and day from the severe condition I was in just a little over a week ago to today. F 42 2 weeks
4/14/2007
 2  R A Haven't began to take it yet , but am scheduled for next month. I am afraid of the side affects. I read that it can cause T B and just recently I saw on Date Line, that there were people with active TB being locked away in quarrentine I am so tired of the pain and stiffness... not being able to do simple chores with ease; but I am afraid of the shots...I do not know what I am going to do..I put a 1 in length of time because I had to put something. F 46 1 days
4/13/2007
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 2  R A Haven't began to take it yet , but am scheduled for next month. I am afraid of the side affects. I read that it can cause T B and just recently I saw on Date Line, that there were people with active TB being locked away in quarrentine I am so tired of the pain and stiffness... not being able to do simple chores with ease; but I am afraid of the shots...I do not know what I am going to do..I put a 1 in length of time because I had to put something. F 46 1 days
4/13/2007
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 3  psoriatic arthritis sinus infections, if this is what is causing them read that it can cause multiple sclerosis...anyone else hear of this? costs about $30 k a year...if wasn't for medicare/aid couldn't afford is helping the joint pain and skin lesions...don't itch constantly, at least M 51 6 months
4/11/2007
 4  rheumatoid arthritis Enbrel was wonderful for the first 2 years but it has now started to wear off so will be trying it with Methotrexate..Injection site rash but that was the only side effect. Felt like a real person again. F 46 2 years
4/3/2007
 3  psoriatic arthritis It has helped with the artritis as far pain. But not so much in the range of motion. I also have experienced leg and hand swelling. After about six months of injections the psoriasis has come back. Has anyone experienced a high eosinophil count with this drug? Mine is five time normal. I have a four page list of what I don't have. No one can find a cause for the high eosinophils. The high eosinophils began when the psoriatic artritis did. The Dr. says they are not related. I have reseached this also and have found no relationship as far as studies go. Prednisone kicks ass on the eosinophils. But as everyone knows it is the devil drug. Can't take it for very long. no site of injection reactions. Pricey M 54 7 months
3/19/2007
 1  RA Non-Hodgkin's Lymphoma Enbrel was a miracle drug enabling me to function free of joint pain and fatigue, changing my life. However, little did I know just how much it would change my life for the worse. I recently had surgery to remove a typical fibroid that had taken over the majority of my ovary, which resulted in my entire ovary removed. The fibroid was benign; HOWEVER, the small portion not effected by the fibroid tested positive for Non-Hodgkin's Lymphoma, Diffuse Large B-Cell. Although those of us with RA are twice as likely to develop Lymphoma than the average person, my oncologist, associated with renowned UCLA, strongly feels Enbrel has played a large role in the deveopment of this cancer in my body. The only way Lymphoma is detected by blood tests typically taken by Rheumatologists is if it is in your liver, unlike my case. I am thankful now for the fibroid as the cancer would have gone undetected until it had progressed much further. My lymphoma today is in my neck and chest area, only det F 38 15 months
3/16/2007

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