ENBREL Reviews (ETANERCEPT)

Average Rating: 3.7 (533 Ratings)

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 TUMOR NECROSIS FACTOR-ALPHA INHIBITORS

 Type: Rx Drug

  

ENBREL  (ETANERCEPT):  This medication is used alone or in combination with an immunosuppressant (such as methotrexate) to treat certain types of arthritis (such as rheumatoid, psoriatic, juvenile idiopathic, and ankylosing spondylitis). Some brands of this medication are also used to treat a skin condition called psoriasis. These conditions are caused by an overactive immune system (autoimmune disease). The immune system attacks the body's own healthy cells, causing inflammation in the joints and skin. Etanercept controls your body's defensive response by blocking the action of a certain natural substance (TNF) that is used by the immune system. Treatment decreases redness, itching and scaly patches in psoriasis as well as the pain, swelling and stiffness of joints in arthritis. This medication can stop the progression of disease and joint damage, resulting in improved daily functioning and quality of life. This medication treats but does not cure autoimmune diseases. Symptoms usually return within 1 month of stopping the medication.    (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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RATING  REASONSIDE EFFECTS FOR ENBRELCOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 2  Seronegative RA Its my 3rd shot today, for the last 2 weeks I experienced almost constant headaches and flu-like symptoms for 2-3 days after taking the shot. Didn't want to take it today, but need to see if I improve. My blood results ESR and CRP are much improved, but I dont feel any better. My rheumatologist is seeing me in 2 weeks, but I think I felt better on a conbination of methotrexate and leflunamide - however had mad raised BP with the leflunamide. I'm still on methotrexate, and that was a total life saver for me. Still waiting for my miracle. Can't imagine continuing to effectively lose 2-3 days per week. Worried that I'm getting pain down my neck & spine also - I've never had pain there before. F 45 21 days
1/13/2009
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 1  Psoriasis/ankolising spondilitis My brother-in-law was on Enbril injections for a year without check ups. He developed lung cancer. After partial lung removal, he thought he was clear, but three months later it was found to have spread to his spine. The cancer is now terminal and he is now receiving palliative care. It's so shocking as we don'y know how long he's got left to live. So, even though Enbrel helped his original condition, we never thought it could kill him in the end. Please, everyone, be aware of side effects of taking any drug. F 55 365 days
1/11/2009
 4  Sero-neg. RA and arthrosis Not sure if from Enbrel, but: increased fatigue, blurred vision, digestive problems, bloated abdomen, weight gain despite no change in diet. 50 once week, find it hard to administer and feel dizzy afterwards (cancel any Thursday appointments on principle now)but no rash at inj site. Scared as have had TB in the past; now almost constantly suffering from cold infections but doc said keep shooting as long as no high temperature Took a while to notice any difference (but final diagnosis had also taken around 3 years, so fairly advanced by then) but it seems to have solved the RA almost completely; arthrosis remains, hands semi-crippled. Taken with MTX and NSAIDs. Has changed my life, but aware that the price for that may be high in terms of serious infections F 58 3 years
1/6/2009
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 4  RA & OsteoA I take one 50mg dose of Enbrel weekly for RA. I started out with the pre-filled syringe and then was changed to the auto-injector due to a prescription snafu. While the syringe requires a little more care when using, it is a wonder compared to the extremely painful Sure-Click. If you let the syringe warm up for about 1/2 hour and inject it slowly, there is no pain. If you are squeamish about using the syringe, you may want to have your doctor help you the first time. It's actually quite easy. While I think the potential side effects of this drug are very scary, it's vastly improved the quality of my life. I've been off of the Enbrel for about two weeks now as I was to go for knee replacement surgery today. Unfortunately, I've picked up some type of "flu" and I have to wait another week for surgery. F 56 10 months
1/5/2009
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 3  Psoriasis, Sapho Syndrome Possibly edema and increased psoriatic breakouts Took 50 mg Enbrel for 6 weeks every seven days. After extremely high SED rate came within normal range, was advised to take every ten days which I've been doing for two months. I seem to be getting more psoriasis flare-ups and little red bumps all over my body more frequently. Does anyone else feel that the Enbrel makes their psoriasis worse? F 68 4 months
1/3/2009
 5  psoriasis, psoriatic arthritis Slight headache for the first couple weeks, but no side effects since. I do experience a slight flu like weakness pain all over which is controlled with pain meds. I dont know if this is from the drug or the arthritis itself. A miracle drug for me. Virually took away 95% of psoriasis. Could hardly walk on sore ankles at times before taking drug. I can lead a somewhat normal lifestyle now. M 54 2 years
1/1/2009
 4  Plaque psorasis Have been taking enbrel for nearly 3 years, find it has kept posoriasis at bay. Have just started getting large sores on one leg very weepy and sore hope it is not the start of ulcerated leg. Anyone else experienced this? F 51 3 years
12/28/2008
 3  Psoriatic arthritis/psoriasis Tired constantly, lethargic, weight gain (a lot) no energy, constant yeast infections. I never realized that I was having any side effects from Enbrel other than being tired. I had to have foot surgery and my surgeon made me stop the drug, I began to diet and exercise to help with the PA symptons as there was no way to stay on pain killers to help with the pain from the PA. I have never felt better, being off this drug has allowed me to control my PA in a more healthy way. I also feel that it was causing fungal infections within my body, this causes so many other problems. And I do believe this caused my weight gain, 40lbs over the 2 1/2 years I was on the drug. I was finally able to loose weight when I quit taking Enbrel, that never happened before. Yes, in the beginning is was great...but to what sacrifice!! Trust in your body, I suggest looking up and staying with anti-inflammatory foods, the right foods can help you control arthritis!!! And you would be surprised what foods can help or hurt your body.....get off the drugs, be healthy from the inside. F 44 2 years
12/27/2008
 5  Sero-negative RA (w/ Sjogrens) Sometimes a "bubble" of Enbrel is visible raising the skin on my thigh - an area the size of a quarter. Sometimes a few days later an area about double in size turns pink and itchy. Lately I have had more itchy and dry patches on my skin and have begun to wonder if Enbrel is influencing this. I felt improvements in my energy only hours after taking my first Enbrel injection! It has given me my life back. Remicade worked in the past and put the RA in remission for 5 years. The RA came back a year after the birth of my first child (who is almost 2 now). I have the RA under control now and I am able to space out injections to at least 4 weeks with no return of symptoms. I hope some day to go off Enbrel altogether. Meditate your healing from within. Thank heaven for medicine. My best to you. F 32 6 months
12/22/2008
 1  my husband My husband had no side effects for about 10 months and was in a perfectly healthy condition prior to taking this dreadful drug Enbrel. He was taking it for psoriasis, which cleared up beautifully. After 10 months he started to develop back pain and went from doctor to doctor and was subsequently diagnosed with Diffuse B-Cell Lymphoma.It has been an absolute nightmare ever since. I really feel that for some people this is a highly dangerous drug....so, please, please be careful!! F 60 10 months
12/21/2008
 5  RA-Myositis extreme burning at injection site. I use the 50mg prefilled syringes. As others have said, let it warm to room tempreture. I liked when they had the powder-mix before. No burning with that, and I am not bothered by needles. Injecting in your stomach can help also, as others have said. This drug has been a lifesaver for me! I have been on it over 8 years for RA and Myositis (an autoimmune muscle disease) I take this and methotrexate and it has put be in remission with very few flares. Before I was in a wheelchair, a month after starting enbrel I was walking again on my own. I do notice if I miss and injection, I get a flare! I have never had an infection in all the years I have been on it. F 44 8 years
12/20/2008
 2  Rheumatoid arthritis, spondylitis Extremely heavy legs,unable to walk. And it is supposed to give you energy? It did the opposite to me! It made me feel totally helpless. I was able to do nothing while on it. And it did not help at all. F 36 2 months
12/20/2008
 5  RA It's like my immune system becomes a screen door with every little bug or virus flying right in. I have not been able to stay on Enbrel for a sustained amount of time because you have to go off it when you get an infection and I am ALWAYS getting infections. And if you end up with the flu, it's like a truck ran over you. F 43 3 years
12/15/2008
 4  Pa/Psoriasis This is the 3rd time I have been on Enbrel. B/c of worries of long-term effects, I only take it when I cannot function. The first time (3 years) - no side effects. 2nd time(1 year)- no side effects. 3rd time (2 weeks)- migraine-like headaches uncontrolled by tylenol and possible tightness in chest. First time Enbrel was a life-saver. I could not dress myself or care for my child - I was extremely depressed. I did go to work(to cover med expenses) - within weeks, I was fully functional. 2nd time was for psoriasis 75% covered. Cleared in a year. This time is for pa again. immediate relief from joint pain - full functionality, psoriasis is diminishing. F 40 2 weeks
12/7/2008
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 4  RA I am frequently bothered with sinus pain, followed by nausea & throwing up..I can expect to loose a couple days when this happens.I see others have problems also.. any solutions?? Enbrel has been life changing for me. I see in other comments that you didn't inject Enbrel until the sinus issue passed.Was this by order of your Dr.or did you find that it helped on your own? Over all it has been great,just wish I could get past the sinus thing! F 63 4 years
12/6/2008
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 4  Psoriasis Quite a bit of fatigue, slight pain at injection site but not nearly as bad as pre-filled syringes, swelling and itching around injection site, stomach issues, headaches Overall the side effects are not too severe. I take 50mg auto-injector twice a week for 4 months and definitely feel is worth all the effects. My psoriasis is about 80-85% cured! :) F 18 4 months
11/27/2008
 4  psoriatic arthritis + psoriasis I have trouble waking up. Seem to be tired all the time. I also seem to be depressed and irritable since injections started. The 50mg once a week do hurt but worth the pain. no infection at the injection site(leg). I have had 2 needles not retract after injection. M 22 2 years
11/24/2008
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 4  RA I have been taking 50mg once a week. Painful injection (pen) and medicine burns. Enbrl hurts worse than Humira that I had been on prior to. I have noticed that my arms itch really bad every few days now....weird. I will scratch them so bad that I cause them to bruise. I can't really tell if Enbrel is working yet since it's new and I had been on Humira for 7 months prior to. I also take 6 Methotrexate weekly as well. F 26 2 weeks
11/24/2008
 5  RA No side effects so far. I was diagnosed at age 11; my RA was consistent and severe, but I dealt with it. It became much worse and was progressing so I finally sought out something new. I couldn't walk in the morning or at night, I couldn't move my hands, and I was so tired I could barely function. My first shot of Enbrel changed my life within days! I'll be taking my seventh weekly shot soon. Yes the injection hurts, but it's not THAT bad as long as you don't psych yourself out about it. I will say, let it warm up first, big difference! F 32 45 days
11/23/2008
 4  RA Severe pain with injection (50mg autoinjector). Things that seem to help: let the medicine sit out for 30 min b4 taking it, prop the leg u are taking it in up on something so it is straight (hurts much less). Icing the site doesn't help me at all. I have been taking it since July and the pain seems to decrease with every shot but it still hurts. Doctor offered me other forms and doses but its only 10-15 sec of pain (ok..severe pain) The benefits are soooooooo worth it for me! I cried before, during, and after for the first few months too. Now its not quite that bad. Other side effects: weight loss (yeah), decreased appetite, decreased pain and swelling in joints. Dramatic reduction in fatigue and pain! F 33 5 months
11/15/2008
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