ACCUTANE Reviews (ISOTRETINOIN)

Average Rating: 3.3 (746 Ratings)

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 DERMATOLOGICS

 Type: Brand name discontinued; available as generic

  

ACCUTANE  (ISOTRETINOIN):  This medication is used to treat severe cystic acne (also known as nodular acne) that has not responded to other treatment (e.g., benzoyl peroxide or clindamycin applied to the skin or tetracycline or minocycline taken by mouth). It belongs to a class of drugs known as retinoids. It works by decreasing facial oil (sebum) production. High amounts of sebum can lead to severe acne. If left untreated, severe acne may cause permanent scarring.   FDA Approval Date: 1982-05-07 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on ACCUTANE: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR ACCUTANECOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 3   Chapped lips, dry nose, ridiculous muscle pain I've gone through a pattern of side effects....first it was dry lips, than random nose bleeds, back to dry lips now its dry skin (face), little red bumbs on the back of my hands, really uncomfortable muscle pains in both my thighs and I still have dry lips. I'm really hoping this is all worth it!!!!!!! M 25 1 months
80MG 2X day
2/12/2010
 1  Acne (mod-severe) depression,anxiety,paranoia,knee pain,peeling skin on face,chapped lips,back ache,hair thinning,loss of appetite,anger,mood swings,blurred vision/ Do not take this medication it ruins your life! i would rather have slightly marked skin than a life of the side effects i am experiencing now beilieve me, my advice is never to pick or pop spots leave them alone they will heal themselves. Wash your face with aqueous cream and tepid water and pat dry and use the topial sloution zineryt this will not cure your acne but will help significantly! M 26 4 months
2X day
2/12/2010
 5  acne Some mild lower back pain, usual dryness of lips and skin I took it 14 yrs ago when I was 15 and it cleared up my horrible acne. I had some scarring but it would have been much much worse without this drug. It was a god send. F 29 4 months
40-80mg 1X day
2/10/2010
 1  Acne treatment I had a baby 1 week ago born with Sirenomelia an extremely rare congenital disease occurring only 1 in 100 000 births. After researching the condition in some detail the only possible cause and common factor that recurs in my research is Roaccutane usage. I used Roaccutane 20 years ago. My pharmaceutical knowledge tells me that It is physically impossible for drug traces to remain inside the body for such a lengthy And extended period of time as all traces are considered expelled within 6 months. The area too coincidental is Roaccutane. This is implicated with birth defects in Sirenomelia as well as the anotia which does not present in any of the other sirenomelia cases I have read. I had an approximate 6 month treatment of roaccutane approximately 20 years ago. This might seem a total improbability I know and I might be clutching at straws. I am a pharmacist who has studied further in the area of natural health during the last few years. During my natural health stud F 38 6 months
3X day
2/8/2010
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 4  Acne I cleared up after an initial breakout at about 3 months into taking it. I am 4 months off and started breaking out but nothing as bad as before. I may go on a second round. I feel like these posts I have read are all from the same person. Give me a break...I had NO real terrible side effects. I think some may have them but I really think this board is full of whiners. F 35 6 days
60 1X day
2/6/2010
 5  severe acne dry lips, hair loss, and joint pain I realize that I did not start experiencing adverse side effects until I started taking the drug irregularly. I would take it in the mornings and then skip a day and take it the following night. One day, I started noticing, joint pain and hair loss. I decided to do something I should have been doing all along... take vitamins. I am happy with the results as I had gotten to the point where I did not wish to step outside my door to pick up the paper let along go into my office and work. I was just too embarrassed. I am employed full time as a financial analyst and attend college full time; and have not noticed a decrease in attention to detail or depression. I came to this site because of the joint pain I have been experiencing but once you understand the ideation, you can make better decisions for your life. The choice is truly yours. Accutane has truly been good for me. F 43 5.5 months
2/3/2010
 2  acne I had very dry lips and skin. I'm sure I had more side effects, I just didn't realize at the time. I took Accutane about 8 yrs. ago. I am now having so many side effects. I have joint, knee, and back pain. My hair is thinning out. My vision is blurry and getting worst. I have very dry itchy skin now. And last of all,I even have THYROID CANCER. I didn't realize that Accutane can caused all these problems. I have seen so many doctors for my pain and problems and never got any answers from them as to why I'm having all these problems. From reading all other people comments on Accutane side effects, I finally realize this could be the caused of my pains and health issues. Oh and by the way, Accutane only some what helped clear up my acne while taking it but now I'm breaking out as always. F 34 6 months
2/1/2010
 4  I have little girl skin (sensitive May cause lips to be dry, strange sleep pattern, very exhausted for no reason, lack of concentration, varying in mood, lack of motivation. I find all external things very manageable by doing the following. Although lips can very quickly become dry. I use “Blistex Complete Moisture” and have no issues. I apply like 10 plus times a day, but as a result I have perfect lips with no issues and don’t go anywhere without it. Skin becomes dry easily, so I use “Aveeno Moisturizing Lotion” after the shower. The doc told me the 3min role. Meaning put all lotions, lip chap, etc on your body within 3mins of washing that area to prevent dry skin and it works for me. I find the mental thing a whole different game that requires constant attention that is difficult to give. I am an average kind of guy, get good marks. But it all changed with the drug. Dropped my Avg. 10% due to a few things. Lack of concentration would be the main thing and I am exhausted very quickly, rendering me almost useless to concentrate for long periods of time, even if I am interested. As a result I have went from an avg. 5-7 hours sleep a night to a minimum of 8-9 hours. If I get less than 8 hours, I am junk. Can’t do much, days are hard, very low motivation, question my existence, oddly emotional?. Basically makes me think I am going crazy. There were some warning signs of this prior when I was only on 20mg, but now at 60mg it is full out. So if I were to suggest anything it would be. 1. Don’t do things that are important to you in life when you take this drug i.e. College, making first M 28 5 months
1/26/2010
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 2  oily skin, acne mild to extreme headaches, darkening of urine, eye pain, mild to extreme fatigue (usually extreme fatigue) after taking accutane for about 2 weeks now, i am starting to questing whether or not if taking accutane was a good idea. the thought of having acne free skin and non oily skin would be a great improvement in confidence. i am experiencing more difficulty concentrating than usual and i am alot more depressed than usual. headaces i am experiencing feel like my head is icnreasing in pressure and same is happening to my eyes. my scalp, forehead, upper cheek and nose are still very oily but in contrast my chin and mouth are incredibly dry and skin is flaking. initially before taking accutane my sleeping habbits could withstand being awake for extended periods (staying up for 2 days would be no problem, and sleeping for 4 hours would be no problem), now i can barely stay awake(or sleep) after sleeping for at least 12 hours. sofar the medication seems to have more side effects than beneficial/intended effects. i am hoping that improvements will show soon. i am currently on a 1-2 month trial period to see whether or not accutane is right for me, sofar its screwing me up more than i expected. i really hope it doesnt affect me negatively after i stop :s M 18 2 months
1/24/2010
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 1  Acne Severe osteopenia,sjorgen's like disorder,chronic blepheritis,joint,muscle and tendon problems,hormonal problems (such as thyroid)low iron,fragile/thin skin and wrinkles. Do Not take this Chemotherapy drug. It will ruin your life. I had 3 cysts the color of my skin. I have never been the same since. The doctor told me I would only have dry skin and body. I had only dry lips while on it till the last 2wks of tx which I stoped the med due to not feeling right. This poison continues to work even after you stop the med. It causes cell death, hormonal problems. I continue to still live with theese issues after 1-1/2. I am now on a drug to combat my chronic inflmation state with a drug that lupus pts take. My Osteopenia may or may not improve. My autoimmune thyroid disorder will always be a constant battle. To top it all off I still have thoose 3 cysts, they never went away. to the women who wrote about hormonal problems you can contact me and anyone elese who has questions or needs help F 32 8 months
1/23/2010
Email
 4  cystic acne dryness of lips and face. looking back probably depression I took Accutane in 1981-82. I had to have 2 rounds of the medicine but I do not remember the dosage. The first round cleared up my back and shoulders but it took another round to clear the cystic acne on my face. The only thing I do remember was the dryness and sensitivity to the sun. But since then I have dealt with depression through out my adult life. I don't remember the joint/muscle pain but getting older or what I have had creeky knees and such for a long time. My daughter,who took it at the age of 16-17 still has break outs and I am concerned about her taking it again. I would like to hear feedback on how the medicine has affected females and their hormones. I think that rather than losing hair it has messed mine and my daughter's hormones up and has caused an increase in thicker/darker body hair especially arms and chin. I went into early menopause at the age of 36 and have a thyroid condition. I don't know if these things are related to taking Accutane but I would like to find out if others have experienced anything similar. F 45 4 months
1/21/2010
 5  moderate-severe acne chapped lips, dry skin I took 60mg of accutane for 10 months, 8 years ago. It was the only thing that worked with my skin after years of other medications. I was highly involved in sports at the time and noticed no aches or pains except those natural to the workouts and conditioning I was doing. Even my chapped lips and skin were't that bad. (I remember my doctor starting me at the lowest dose and upping it each visit until the 60mg dosage finally worked. And trust me, it was really obvious which dosage 'worked'. She said that a number of other doctors begin with high dosages and adjust from there, but the building up from a lower doseage was supposed to help combat some of the dryness and ensure I was using the lowest dosage possible for my skin). Anyway, I've been acne-free ever since. I still have dry skin (nothing a good moisturizer doesn't help), but have not had acne since (I can literally count on one hand the pimples I've had in the last 8 years). Accutane for me was a life-saver. My flawless skin (that I receive a number of compliments on being that I'm SNOW white, so any blemish would show) is the only indication of my time on this drug. I would recommend to anyone dealing with severe acne that he/she take with a (large) grain of salt many of the scares that are out there regarding this drug. F 23 10 months
1/12/2010
 1  acne Dry lips eyes nose Took 80mg for 4 months in mid 80s when I was 19 had the basic side effects had to stop after 4 months could not take it any longer it was rough. But I have to stop here and say the drug changed my life the first for the good acne oily hair and skin where gone for good. I went for seven or eight years with no problems some chapped lips and dry skin in winter but then started having Bowel problems and muscle & joint pain lower back, elbows, hands, I get out of bed like a 70 year old man my back and kidneys ache every morning, Doctor thinks I have Fibromyagia but symtoms are not the same. I always blamed it on the Accutane but was told not possible. Then I started checking on the long term side effect of Accutane for my 14 year old daughter and started seeing the same problems over and over in people that had taken Accutane over twenty years ago. Don't do it M 44 4 days
1/10/2010
Email
 5  cystic acne dry lips, dry cracking skin on arms and hands, nose bleeds inside of nose, mood swings, irritability, low libido, vaginal dryness. My skin got a little bit worse the first and second month, but cleared up after that. It has been amazing most of the time. I have been moody about things that would not normally bother me. I also do not want to do many things I once did. I cannot wash with body wash because my skin gets too dry, my lips are only bearable because of medicated chapstick and prescription medicine. I would recommend accutane but be ready for the side effects. I am counting down the days until I am done. I'm only on it because absolutely nothing else worked. I want my normal life back. F 22 4 months
1/6/2010
 4  Adult acne Extremely dry skin on my face, dry scalp, chapped lips, joint/muscle pain. Neosporin Lip Health is the best thing I have found for my lips. I took Accutane about 10 years ago with only the dry skin and chapped lips to contend with. I am into my 2nd week and my lips are very dry and this time I have horrible back pain and stiffness in my hips and ankles. The stiffness does go away after I have gotten up and walked around. I have found a fantastic OTC chapstick that helps better than Vaseline. The Neosporin Lip Health is fantastic!!! I have also been using the Walgreens Shea Butter Vaseline on my face/inside my nose at night. It has been helping. Since I knew what to expect I was prepared for the side effects. It does get better!!! I am thankful that my sister is a massage therapist and that is helping with the sore muscles. F 28 14 days
12/27/2009
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 5  Acne Dry lips, joint pain I took Accutane when I was 23, when it was first approved. It cleared up 13 years worth of acne in a few weeks, with few side effects. No lasting side effects.I took it again at age 40 but noticed severe joint pain, and discontinued after two months. I am taking it again at age 52 for the occasionall hormonal flair up and again have severe joint pain. I am slim, very active, work out, eat pretty well, don't smoke. The joint pain will go away once I stop the dug. For the other reviewers, please know they may not be revealing anything else about their lives: do they smoke? Drink? Take other drugs? Symptoms are different with each person and it's hard to say Accutane caused this or that. It might be, but other things may also be affecting ther symptoms. I know it is giving me joint pain, but every time I stopped it, I went back to working out, running, being in good shape. So you need to take care of yourself very well and not just blame Accutane right away. Every patient should dsicuss their treatment and side effects with their physician, as every patinet is unique and may experience things differently. F 52 3 months
12/20/2009
 2  For severe acne Im currently taking accutane and I have the normal dryness but a couple months ago, I felt a horrible hip and back problem and haven't been able to run without or walk a while without the pain returning. I thought it happened from too much physical activity but now idkk.... I also just had eye twitching and bLurryness today which made me come too this site. My cholesterol shot up 50 points in the first month as well but I'm getting it under control now. Anyways, should eye be worried about the eye problems and back/hip problems??? F 16 4 months
12/19/2009
 4  cystic acne Dry skin, chopped lips, constipation,increase of appetite, Mood swings, dry eyes, fatigue, back pain and recently left hip pain going all the way down to my heel. I m on the first week on my 4 month of accutane, my back cleared up completly with just one zit or two left but everything else is gone. My face is 90% clear now. however i am scaredthat i have developped a hip pain on my left side...-i don`t want it to be sth permanent! F 28 4 months
12/12/2009
Email
 1  Pimples Dry skin, severely cracked lips.....PANCREAITIS!!!!! BEWARE!!! Before taking this tablet you have you seriously be aware of the life threatening side effects which actually don't occur untill years after taking it! I'm a 25 yr old man, I took Roaccutane when I was 16 for bad acne that I had...I wish I never did. When I was 22 I developed Pancreaitis (Inflammation of the Pancreas) Just like normal people would I had a drink or two at the weekend, I would never say I had a drink problem which seems to be a reason for getting Pancreaitis. Ended up in hospital with 10% chance of life, was in high dependency and was told I can never drink again for the rest of my life...being a young fella I still had the odd drink when I was out and again I have taken Pancreaitis twice more, the doctors have told me there is only a certain number of times I can take this again before there will be nothing more they can do for me, my life is more important to me so I stay away from having a sociable drink now which is hard because I'm only a young man but I'm getting married soon so life is more important. My Fiancee has been perscribed Roaccutane and I have talked her out of taking it, it's a serious drug, if I could turn back time I wouldn't take it again, my life has been ruined by this drug, Pancreaitis is a side effect of this drug! M 25 4 months
11/27/2009
 3  Acne I took accutane three years ago, it could be the biggest regret of my life. While on it, it was not bad at all. I used blistex DCT for my lips it worked very well. Anyway treatment ended and I still had some acne, but 75% of it cleared up. The doc tried to put me on another 4 months but I turned it down, thank god. Exactly 1 YEAR LATER I developed eczema. It started on my thighs and behind my legs. A few months later it was on my face right around my eye lids. I got steroid creams to combat it but they only helped a little bit. The following winter the same thing happened. Now it is November and my exczema will be back for the winter of 09/10. I regret accutane, it ruind by body but I'm lucky it hurt some other people out there worse then me. If you value your body please do not take this. I took it three years ago and I am still hurting from the side effects. It cleared 75% of my acne up but it wasn't worth it to go through what I'm going through now. I have not taken a hot shower in 2 years. M 21 6 months
11/23/2009
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