LUPRON Reviews (LEUPROLIDE ACETATE)

Average Rating: 2.7 (853 Ratings)

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 DRUGS USED IN DISORDERS OF GROWTH HORMO HORMONAL BIOLOGICAL RESPONSE MODIFIERS

 Type: Rx Drug

  

LUPRON  (LEUPROLIDE ACETATE):  Leuprolide is used to stop early puberty (precocious puberty) in children. It helps to delay sexual development (such as growth of the breasts/testicles) and the start of menstrual periods. It also helps slow down early bone growth to increase the likelihood of reaching normal adult height. Leuprolide works by decreasing the amount of sex hormones that a child's body makes (estrogen in girls, testosterone in boys).   FDA Approval Date: 1985-04-09 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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RATING  REASONSIDE EFFECTS FOR LUPRONCOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 4  uterine fibroid of 22cm Lupron wasnt as bad as i read other people's comment on it.was on lupron for 6months to shrink my fibroid prior to surgery and it worked for me. it wasn an easy 6months either but i was positive about it by eating lots of fruits and veggie with soy milk. F 30 6 months
3.75mg 1X M
11/15/2010
 4  long EXTREMELY painful periods Hot flashes, night sweats, trouble sleeping, itchiness, headeaches I started on the monthly dose and only had the hot flashes and night sweats. Then my insurance began to cover the 3 month injection and the side effect worsened. I am in month 2 of the 3 month shot and the hot flashes are more frequent and now I am itchy EVERYWHERE. The minute I am slightly warm, I start itching. It's the summer and I can't enjoy outdoor activities because of the itchiness. My husband and kids are freezing because I leave the air on constantly. However, the horrible pain I had with my period is gone because after month 2 on Lupron, my periods went away. I haven't had too many mood swings, but I have very bad headaches. I don't have much of a sex life as I am not interested at all. I am hoping that will go away once the medicine is stopped. All in all, I can deal with this for another few months rather than that pain. F 30 4 months
1X M
8/14/2011
Email
 4  Endometriosis Hot flushes, mood swings, loss of bone density, weight gain. With the HRT and calcium treatments side effects have been controlled. But worth it as greatly reduced the Endo pains. F 30 4 years
Monthly
2/10/2012
 4  Endo I have been on Lupron for almost a year. I did 3 month shots for the first 9 months and have been on one month shots the last 3. At first, I had dryness and almost complete loss of sex drive - sex began to hurt and has not felt right since I started the shot. Now, I have gained almost 15 pounds and can't seem to lose it. My mood swings are worse on the one month shot. My short term memory is very bad. I have even wondered if I am experiencing early signs of Alzheimers. Lupron has helped tremendously for the pain and bleeding. I have zero pain and have not had any spotting or bleeding. Basically, horrible memory loss, low sex drive, dryness and pretty bad mood swings. I would recommended this drug as a last resort before having a hysterectomy; however, it does work for the pain and suffering of endo. I feel like it can be handled as long as you know what you are getting into and possibly take an anxiety drug like Prozac to help with the mood swings. A healthy diet and daily exercise helps a lot, too with the weight gain. F 30 12 months
1/20/2010
Email
 4  Endometriosis/Fertility Muscle aches in my legs after injection(goes away after a day or so) hot flashes, night sweats and minor headaches. I just had my second shot (getting them monthly) and side effects are mild. After the 1st shot the pain was much worse but it lasted only about three weeks. Now everything is great, no pain no weight gain. I do recommed drinking a lot of water and also exercise on regualr baises. If you take care of yourself and eat healthy I firmly believe that will help reduce the side effects of deppression and wieght gain. I'm actually loosing weight!! F 30 2 months
5/4/2009
 3  Endo, fibroids and cysts Headaches, hot flashes, night sweats, nausea Doc put me on this and to be honest, I'm not sure it's worth it. At first I was happy because I had super high estrogen levels, so I felt good once those went down, then it started to get unpleasant. Every afternoon I get a foggy headache which sometimes develops into a migraine and I find it difficult to eat past noon. My doctor just prescribed me zofran to combat the nausea but I'm starting to wonder if I'd rather deal with the horrible cramps and constant bleeding rather than nausea and headaches. I'm debating whether or not to go back for the next shot. I did not have all the other horrible side effects I heard about like vaginal dryness, decreased libido or acne though. Small victories. Every body is different though so it's difficult to compare experiences. Just need to weigh the pros and cons. F 30 2 months
11/17/2019
 3  Endometriosis Hair loss. Not to the extreme of bald spots but my once thick long healthy hair, is now long birittle and thin. Even 6 months after treatment. During treatment, extreme hot flashes! To the point where I froze my poor family out by opening the doors and windows in the middle of winter 24/7 and wore summer clothes to battle them. This was on top of hormone replacement therapy too! But lupron did help shrink my endometriosis significantly so my hysterectomy was a success. F 30 6 months
10/16/2015
Email
 3  Fibroids Forgetfullness, loss of appetite, tired, daily spotting, sleeplessness, weight gain (10 lbs), emotional fits, a quick period every 3 weeks, mood swings I felt the need to comment on this drug. I took this for 3 months, and unfortunately did not have any shrinkage of my fibroids. I will be getting a myomectomy in a little bit. The most profound side effect was a very intense period about 2 weeks after I had my initial injection. I thought I was going to die... Otherwise, most of my physical symptoms weren't bad. My emotional state was not good, mood swings certainly present, and marked emotional times happened every few weeks. Also, I noticed my general heart rate/pulse went down. Just a strange drug. F 30 3 months
3 month 1X M
7/12/2010
 3  11 cm fibroid Was initially scared to take Lupron after reading the side effects. In 3rd week of first shot and it hasnt been too bad. I've lost some weight (about 6-7 pounds) from nasuea/vomiting and get night sweats and have some trouble sleeping through the night. But I can tell that the fibroid has shrank some because there isnt as much pressure on my bladder and kidneys. I got my period about 10 days ago and only bled for 2-3 days but have had constant fluid leakage since then. Possibly from the fibroid shrinking. It definatley hasnt been the nightmare I expected it to be but it hasnt been a joyride either. F 30 3 weeks
3.75 1X M
8/4/2010
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 3  Edenomyosis with polysitic ovaries Hi i am diagnosed with edenomyosis and polysistic ovaries. My dr. had given me 2 options as my bleeding was heavy with hugh clots and it last for months and months .. now its been two years that i am having this edenomyosis and polisystic ovaries.. i wanted to have children as the 2 option that dr gave is to take a lupron injection or to have a hystronomy.After the 1st injection for 1 week i couldnt get out of bed due to heavy bleeding and cramps on my lower abdomen. Now my 6 months is over with 2 dose of lupron injection for 3 months each and i am subscribe with calcium and folic acid tablets. My dr said i will get my period and can try for a baby but the thing is that the bleeding sometimes is very mild and sometime a but like spotting. And today i had spotting and then a gain with hugh clots .. whats going on?? I cant even try for a baby and I dont want to get worse like before.. can anyone help?? F 30 3 months
1 1X M
4/1/2010
Email
 3  To treat endometriosis post surgery I'm coming up on my 4th month/shot of Lupron. I've been spotting with heavier episodes of bleeding since about the 3rd week. Hot flashes, extreme night sweats, mood swings, congestion, headaches, overall feelings of achiness/generally just feeling bad. Slight blurred vision moments, extremely dry eyes. Starting to have weight gain. I had 5 ovarian cysts removed on 12/1/09, one being the size of a grapefruit. I also have a few fibroids remaining. My dr. recommended Lupron right after to ensure that no cysts grow back. At first, I lost weight. Now I'm gaining weight and never seem to be full or control my appetite. I'm up about 5-7 pounds from month 1. I work out, but find it hard to muster up the energy. I've also been bleeding with terrible cramps since about the 3rd week of treatment. Most of the time it is spotting, then it flares up. It especially flares up after working out including bad cramps. My dr. gave me Ponstel for cramps. I have to keep working out to manage this weight gain and bloating, but it's frustrating because of the bleeding/cramps. I'm nervous about my upcoming shot in about 2 weeks; it's a 3 month dose instead of the monthly shots. If my hair starts falling out, I might quit this treatment. This drug is also costing me a fortune. I hope it works and controls future periods/fibroids/cysts. I'm 30 and haven't had children yet....I would love to have children some day! Has anybody else been bleeding constantly for 3 months? (I'm also taking the ad-back therapy daily pill which helps limit the extremity of side-effects, although doesn't take them away). F 30
1xmonth 1X day
2/27/2010
Email

Patient History
 3  Endometriosos and fibroid cysts Hot flashes, mood swings, mild depression, irritability, weight gain, blurry vision, bone/joint pain, bleeding, severe cramping, migraine headaches, total loss of sex drive - you name it, I probably experienced it! I have been unable to get pregnant in over 5 years because of my medical issues. I had surgery 3.5 years ago, and although it helped for a while, my symptoms have gotten severely worse in the past year. I finally decided to try Lupron to see if it would help the pain, if nothing else. I was desparate and looking at a hysterectomy in the next 5 years if this didn't help. I experienced all the side effects at the beginning, but figured that I could live with them if it would help. Then shortly after my third shot, I began bleeding, which lasted for over 5 weeks. During that time I received my fourth and final shot. My doctor and I decided not to continue the 6 month cycle, as the bleeding wasn't stopping. I had severe cramping, and I was unbearable to live with, so I decided it wasn't worth it. It has only been 3 weeks since that final shot, so I don't know what the long term effects are going to be and I am nervous. The bleeding has finally stopped though. I hope this drug ha F 30 4 months
10/23/2007
Email
 3  Endometriosis Headaches at first, severe mood swings, depression, NO sex drive at all, rare night sweats and few hot flashes I had a 3 month injection, with the option of taking another 3 months. It has only been about 3 1/2 weeks since the injection. I started with severe headaches and some night sweats for about 1 week after the injection. Called the doctor and she prescribed me Norethindrone 5 mg to take daily. It helped to almost completely stop the headaches and the night sweats are only about 1 or 2 a week now. I have had a few hot flashes, but not too severe. I have been in medically induced menopause 3 times previously for endo and the hot flashes and night sweats were miserable!!! So this is not too bad. I ahve not had any bleeding at all. But now I have started with major mood swings. Biting my husbands head off one second and crying my eyes out the next. I have never had mood problems before so this is very foreign to me. I cannot manage my moods at all. I hope this is not a sign of how bad everything will be for the next 2 months, but I won't be opting for the 2nd injection. Make sure you stay in F 30 3.5 weeks
5/21/2007
 3  Endometriosos and fibroid cysta Mood swings, hot flashes, night sweats, weight gain, mild depression, irritability, loss of energy, bone/joint pain, complete loss of sex drive, blurry vision, you name it, I experienced it. I have endometriosis as well as fibroid cysts, which have prevented me from getting pregnant in over 5 years. I had surgery 3 years ago, which helped a little, but both problems have severely increased since then. I began having very severe periods with much more pain than usual, and I finally decided to try Lupron. I hoped that even if it didn't increase my chances of conceiving, that at least I would have some relief from the pain. The alternative was to keep trying on our own and be facing a hysterectomy within the next five years, at 35 years old. The first couple of months weren't too bad. I felt like a different person, meaning I didn't recognize myself in my behaviors. I was moody, irritable, unhappy, but I had expected some of this, so I adjusted. However, shortly after receiving my third shot, I began bleeding. I had a light to moderate but continuous flow, as well as severe cramping, for over 5 weeks straight. I did receive the fourth shot, but my doctor and I decid F 30 4 months
10/18/2007
Email
 3  Endometriosis/Hysterectomy Night sweats, hot flashes, mood swings, headaches, either nausea or the munchies, depression, acne, fatigue, insomnia I have stage 4 endometriosis and have major scar tissue all over. My doctor feels there are no other options other than giving me a full hysterectomy (at age 30). I was given the shot of Lupron September 9th. I have really started feeling the side effects the last three weeks. My doctor wanted me to take Lupron before my hysterectomy in December as she feels it will help my surgery not to be so evasive. If she would not have wanted me to take it, I wouldn't have. I haven't felt relief other than not having my period. I still have the pain and now have all these other symptoms to have to deal with. F 30 3 months
10/28/2008
Email
 3  Endo and ovarian cysts Severe headaches, mood swings, fatigue, bone pain, and major hot flashes and night sweating! I'm going for my fourth shot next week and I'm really rethinking it. It definitely works for the endo pain, but the side effects are just not worth it. It's hard with three kids! F 30 90 days
7/25/2007
 2  endometriosis ughhhh. nausea, hot flashes, migraines, weight gain, EMOTIONAL WRECK, lost my job due to complications leading to missing work, cramps...still. i cry and can not control my ANXIETY to save my life. had a dr. tell me i'm the only one with side-effects this bad. well, lucky them...i know i am not the only woman to suffer greatly from the side-effects of this drug, and i don't appreciate being treated like i have no reason to be unhappy and unhealthy. i have noticed in the postings here that the satisfaction of lupron seems to have something to do with the AGE OF THE PATIENT. the younger the woman, the better they seem to do on this drug...and the opposite holds true...the older the woman, the worse the negative symptoms. unfortunately...i am on the "older side"...comparatively anyway. i am miserable and the WORST of it all is my pain does not seem to be improving...and i'm on the extended treatment schedule. if i would have had an intelligent, human dr. that would have listened to me long ago my level of disease would not be as far along...stage III with no endometriomas, just the "hemo-deposits"...("just"...like it's not a horrific and painful experience). F 30 8.5 months
7/12/2006
 2  Endo & cysts I started experiencing side effects 4 days ago. I'm extremely bloated, and have gained four pounds in a week! Decreased appetite, have barely been able to eat, but I'm gaining. I have the feeling something's loose, or going to fall out. Severe joint pain, especially in my arms. Extreme fatigue, I could sleep all days if you you let me. Nausea, in spirts the last couple of days. If this continues, this will be my first & last shot. F 30 11 days
4/23/2007
Email
 2  Endometriosis night sweats, hot flashes, fatigue, severe abdominal pain, insomnia I read comments on this site before getting my 1st shot about 3 weeks ago; not only was I having doubts due to the cost (even WITH insurance, it's still expensive)but the uncertainty of it even working with horrible side effects made me all the more skeptical. Well, I wasted 1 month's worth of $$ and that will be all! The pain I've been experiencing in my abdomen after the 1st week is I think worse than the endo! I have to be in the fetal position most of the time to get any "relief". I can't sleep and I'm SO tired so I can't concentrate at work either! I wouldn't tell anyone not to take it, there are some people with positive experiences; try it at least once and see how you do. F 30 20 days
11/30/2007
 2  Post-Laparoscopy Therapy (Endo) Hot Flashes-Night Sweats- Insomnia- Always Felt Hot- Irritability- Anxious-Depressed-Abdominal Tenderness and Cramping- Fatigued- Loss of Appetite First 2 weeks after shot felt great- week 3 and 4 started to feel irritable and have hot flashes and night sweats- felt exhausted due to insomnia and lack of sleep- week 5 and 6 were the worst-abdominal pain/cramping for 2 weeks, very intense hot flashes/night sweats and very emotional/ irritable- week 7 almost like clockwork/over night felt back to normal, abdominal cramping gone, sex drive back to normal, emotionally stable, hot flashes substantially diminished. My advice if you have endometriosis like me- have surgery- which I did. That is the only real way to get rid of the problem. Lupron used post surgery for therapy to allow body to heal and to not get a period/inflame any endometrial cells that may have not been removed with surgery. If you don't have to go on this medication do not. It is a very very uncomfortable drug to be one. Makes you want to crawl out of your skin. Alternative therapies/drugs should be considered. There is nothing more unnatural for your body than to go F 30 1 months
12/3/2007

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