PROLIA Reviews

Average Rating: 1.4 (262 Ratings)

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 Type: Biological Drug
  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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  Charts & graphs: Drug Safety Information

RATING  REASONSIDE EFFECTS FOR PROLIACOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 1  Osteoporosis Felt weak. Sense of balance off. Poor results on next bone density test Terrified F 88 0 days
2X D
9/13/2021
 4  Osteoporosis Teeth sensitive and needing root canals and crowns. Hair became very thin. Bone pain in neck area. Worried about taking Bisphosphonates for relay drug. F 68 4 years
1X O
8/24/2021
Email
 1  Aromatose inhibitor and osteoporosi I developed leg and hip pain, and difficulty walking, combined with poor balance. Attributed them to other medications a d post Quimo. However, after three years and symptoms getting worse with the addition of headaches, nausea, and constipation, I began to suspect Prolia. Side effects or the fact that it cannot be discontinued we're not stated by doctor.would have never taken it if informed. Do not take it. It's badf you take it and bad if you discontinue it. F 80 3 years
Donâ€T 7X AN
8/22/2021
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 1  Osteoporosis Three weeks after injection my colon shut down. Multiple laxatives, abdominal bloating, severe fatigue.8th day I did digital stim..inflammation so severe liquid could not pass without assistance. Then 4 UTIs with trip to urogynecoligist AND emergency cardiologist referral with upcoming stress and echo. Dentist said NEVER have tooth extraction. This drug needs to be removed NOW! And I paid $200.00 to suffer for 3 months with no end in sight. 70 3 months
60 mg 1X O
6/22/2021
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 5  Bone density Steady got to feeling sicker after the shot thought I would die. EXTREME weakness, muscle pain, skin problems little red dots, skin got very dry itching, chills night sweats severe blatter infections, headaches, heat feeling in both hips started out problem only in one hip now they both hurt!!!!! Severe jaw pain now problem with dentist worried about treating me. That's in the process maybe. All I can say is this drug is truly poison and just as bad as chemo. Never again will I trust pharmaceutical drugs. I'd rather die than continue this drug. Went to the hospital thinking I had a kidney stone and they found a lower spine problem that is also am having looked at this week. Life is not even good anymore! 68 0 years
60 mg 1X O
5/29/2021
 1  Osteoporosis In a lot of pain. Muscle weekness. Being sick. Depressed. Giddy. No energy. Itching eyes. Teeth and jaw pain. I have just about every side effect listed. I felt well before taking this. DO NOT TAKE THIS IS POISON. I feel like life is not worth living anymore! F 64 2 months
1 shot 1X M
5/23/2021
 1  Osteoporosis; nonfragility fracture Problems began after 2nd shot and got worse with each shot: dry sore throat and severe shoulder pain radiating down back for 2 months each; bladder pain/frequency for 3 weeks but no infection found; dizziness and general malaise; to ED with severe chest pains, again no cause found; finally red blotchy marks and swelling on eyelids, cheeks. New GP diagnosed bad reaction to Prolia. No other doctors had made the connection and nor had I. Just felt worse and worse for 18 months. My DEXA showed 15% increase in spine and 8% in hip while on Prolia but I was so ill after 2 years that I couldn't carry on taking it. Of course, I then had the problem of how to get off it safely without sustaining multiple vertebral fractures of which there is a 10-15% chance, apparently. I'm now on Actonel as a relay drug, having regular CTx blood tests to check bone turnover, and under the management of an endocrinologist to wean off the Actonel. No-one should be put onto Prolia as a first line drug for osteoporosis as you're on it for life and if you can't take it and can't take bisphosphonates either as a relay drug, then what do you do? The risks of osteonecrosis of the jaw and atypical femoral fractures are very real when on these osteoporosis drugs. Dentists will be very wary of doing any invasive dental work, so a significant problem if you need essential work done. You can't postpone your Prolia shot by even a few weeks without risking vertebral fractures. Once off the Actonel, I will not be taking any of these drugs ever again. In my opinion, they do more harm than good. I feel as if I've lost years of my life being ill while on Prolia and now Actonel which comes with its own set of side effects. I was put onto Prolia after a shear fracture of my tibial plateau (knee) so not a fragility fracture. This was wrong and irresponsible of the medical professionals concerned. F 66 2 years
60mg 4X O
5/19/2021
 1  Oestoporosis Couple of days after the injection I became unwell with swollen glads. Other symptoms- Headaches, terrible back pain in areas I didn't it have before, joint pains, increased reflux, increased fatigue, increased muscle weakness. I was diagnosed with chronic fatigue syndrome about 3 years ago & have managed it well till going on Prolia. I had a discussion with my doctor about my concerns about taking it & we agreed on a half dose of 30mg & I'm already regretting having it. Be careful if you're CFS. F 63 1 months
30mg 1X O
5/13/2021
 1  Osteoporosis With each injection the symptons became more severe. On 5th injection lost all body strength and energy. Muscle spasm twitches and weakness. Doctor thinks I might have neuro muscle disorder. Uti infection. Two antibiotics later can't get rid of it Must now see urologist and neurologist for muscle problems. Will not ever take this drug again. This drug is not fit for human consumption and should be taken off the market. Seriously dangerous drug. Patients need more information before ever taking this drug. Also read the testmonials and no one would ever take prolia. F 61 5 times
60mg 5X O
4/24/2021
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 1  Osteoporesis Extreme burning in the vagina area, headache, nausea and leg cramps. First shot on Wednesday, February 3, 2021 and the burning in vagina area started Thursday morning. Burning in the vagina area every time I go to the restroom. Two negative UTI tests. Several visits to my primary care doctor to figure how I can get some relief, still working on it. Since the shot, I have had a headache every day. Called Amgen about medicine to find out whether or not it could be reversed - NO. Making a daily diary for the doctor and cancelled second shot. Will not be taking this medication again. I pray this medication is out of my system in six months. F 62 1 times
?? 1X O
2/23/2021
Email
 1  Osteoporosis Nausea, insomnia, jaw pain, general flu like symptoms, but the very worst is the dental problems. I did not make the connection until my most recent dentist visit. I had 4 upper implants with a removable denture. After shot #3, one implant had to be removed due to infection and bone loss. Couple weeks ago, after shot #4, same thing. My dentist does not seem to know or care - he wants to replace them and have me spend thousands more to remove one more, add bone, and redo them. Makes no sense to me. At this point, I just do not know what to do and I am just ignoring it until I can get COVID vaccine. I just hope that once I stop this drug, the damage and pain stops too. F 70 2 years
4X D
2/22/2021
Email
 1  Osteoporosis Vertigo, frozen shoulder, back neck pain, could only walk short distance. Nurse told me no side effects said she had patients that reversed osteoporosis with 2 or 3 shots then stopped. Later after research discovered that after 2nd shot you cannot stop due to rebound spinal fractures. That has been two years ago. Will never do any of the drugs again and sadly do not trust doctors F 64 0 days
1 shot 1X O
12/5/2020
 1  Bone loss Will never take again. High blood pressure, extreme fatigue, hair loss, leg pain, weight loss after taking this. Can't wait until it wears off. F 64 0 days
1X O
11/27/2020
 1  Osteoporosis Infection in my mouth that gets worse with every shot and I have to take antibiotics. The infection is always in the same area around an implant. F 59 4 years
60 2X O
11/21/2020
Email
 1  To strength my bones First within a couple of days developed shortness of breath, heaviness in my chest. Had stress test, was negative. Two weeks later developed severe lower legs cramps. I continue to have leg cramps and generalized aching . Spent night in hospital and they pushed fluids to help flush the prolia from my body to help the effects/discomfort I was experiencing. I still deal with symptoms. F 81 1 times
1X D
11/10/2020
Email
 1  Osteoporosis Headache, itching arms and back, jaw pain, blood blister type sores on my forearms, extreme back and leg pain. I took Forteo for two years with no problem but this is hideous. I will never take this again. I had the 1st dose 4 weeks ago and now I can't walk without a cane due to the pain and weakness. F 71 30 days
1X O
10/12/2020
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 5  Osoprolus Not any yet. Feel better for some reason so far. More energy F 76 7 days
60 1X D
10/1/2020
Email
 1  Osteoporosis Severe pain .. muscle and bone pain ... I would never recommend this drug!! I was already in pain ... awful!! I have taken it for 41/2 yrs. sometimes had only some pain ... lasted 2 weeks .. this last shot has been 7 weeks of terrible pain ... F 69 4 years
7X D
9/28/2020
 1  Osteoporosis I've been taking this for 4 years and recently discovered that even though it's supposed to make your bones stronger one of the side effects is it makes them weaker . Aww the irony! Two dentists this week told me how dangerous and risky Prolia is for the jaw bone and teeth.. I was told that I can not get implants or extractions. My rheumatologist told me dentists don't like Prolia but it's perfectly safe . No more Prolia for me ! Ugh! F 61 4 years
Not sure 2X O
9/25/2020
Email
 2  Because I am on an estrogen blocker I had my first prolia shot 7 weeks ago. I had bad headaches the first week and by 21/2 weeks terrible leg pains. There were days I could barely walk because of the pain. Diarrhea, weird sore throat pain and discomfort in my ear. Dr gave me tramadol for the pain but it just knocked me out and made me light headed when I was awake so I stopped taking it. Waited a month to see dr and when I went in today I saw the nurse practitioner instead. She dismissed all my symptoms and said it wasn't from the prolia shot! I even pulled up the prolia website and showed her the side effects that they list. I even showed her where they said side effects can last one week ( like she kept telling me) or they can last for months. I was so glad I found this site when I got home today because it confirms that my side effects are from prolia! I'm disappointed in the nurse practitioner dismissing my pain!! F 65 7 weeks
1X O
9/22/2020
Email
  

PROLIA  (DENOSUMAB):  Denosumab is used to treat bone loss (osteoporosis) in women who are at high risk for bone fracture after menopause. It is also used to treat bone loss in men who are at high risk for bone fracture. Osteoporosis causes bones to become thinner and break more easily. Your chance of developing osteoporosis increases after menopause (in women), as you age, if someone in your family has osteoporosis, or if you take corticosteroid medications (such as prednisone) for long periods. Denosumab is also used to treat bone loss in women who are at high risk for bone fracture while receiving certain treatments for breast cancer. Denosumab is also used to treat bone loss in men who are at high risk of bone fracture while receiving certain treatments for prostate cancer that has not spread to other parts of the body. This medication works by slowing bone loss to help maintain strong bones and reduce the risk of broken bones (fractures). Denosumab belongs to a class of drugs called monoclonal antibodies. It prevents certain cells in the body (osteoclasts) from breaking down bone.   (Sources: U.S. Centers for Medicare Services, FDA)

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