Heartburn is an uncomfortable digestive condition that most of us have experienced at one time or another. The feeling of burning below the breastbone or in the throat is symptomatic of stomach acid moving its way up through the esophagus. This can happen after a meal containing food like onions, caffeine, peppermint, chocolate, fried foods, sodas, and alcohol. Certain drugs, including aspirin, ibuprofen, and osteoporosis treatments can also irritate the esophagus and cause heartburn.
How can you avoid this condition? Most doctors would first tell you to avoid the
foods and medicines that trigger your heartburn. There are also some items in
your kitchen (like
apple cider vinegar) that might bring relief for an upset
stomach. But when it is late at night (and the offending meal has already been
eaten), you might be seeking relief by looking at treatments inside your
medicine cabinet, kitchen, or at the drug store. Since three distinct categories of
heartburn medicines are now available over-the-counter, make sure you choose the
right one. The following categories of treatments are listed from mildest
(safest) to strongest (powerful med but more risk of side effects):
Antacids
The safest of the OTC medications for heartburn. They have always been available without a prescription. These treatments neutralize excess acid in the stomach.
Examples:
Baking Soda mixed with water, Tums, Maalox, Milk of Magnesia, Gaviscon
Histamine2 Blockers (H2 blocker)
Available OTC since 1995. These drugs partially block production of stomach acid.
Generic names:
famotidine, cimetidine, nizatidine, ranitidine
(newly available under a new formulation; see information on previous
recalls below)
Brand name examples:
Zantac
(ranitidine),
Pepcid
(famotidine),
Pepcid AC (famotidine)
Tagamet
(cimetidine),
Axid
(nizatidine),
Duexis (famotidine)
Zantac 360 is a replacement product for
Zantac and contains famotidine instead of ranitidine. In
November 2025, after a pause of more than five years, the
FDA approved a reformulated version of H2 blocker ranitidine
that addresses the shelf-life deficiencies and impurities
present in the previous versions. It is not known if the
previous "Zantac" will be relaunched with ranitidine.
Proton Pump Inhibitor (PPI)
These drugs
have been available since 1989 and act by blocking the secretion of stomach acid
and are used to treat severe cases of
heartburn (or Gastroesophageal Reflux Disease - GERD) and as a
treatment for stomach ulcer. They are meant to be used
short-term unless prescribed for longer term use by a health
care provider. GERD has been defined as heartburn episodes that occur frequently or at least two times a week.
Generic names:
omeprazole,
esomeprazole,
lansoprazole.
Brand name examples:
Prilosec
(became over-the-counter (OTC) in 2003 with active ingredient
Omeprazole),
Nexium (became OTC in 2014
with active ingredient esomeprazole),
Prevacid (with
active ingredient lansoprazole as a 24 hour OTC version was
approved in 2009; Rx version still available),
Zegerid OTC
While PPI drugs are very effective at reducing symptoms,
severe side effects can occur, especially with long-term use.
For example, long-term use has been linked to nutrient
malabsorption, kidney disease, and osteoporosis-related
fractures. Recently, research has
countered previous findings suggesting a link
between PPIs and gastric cancer or Alzheimer's disease.
Ironically, certain conditions being treated, such as H.Pylori infection, can actually be caused by PPIs with long-term use. Also, sometimes after stopping the drug, heartburn symptoms increase, leading the patient to start taking it again. However, the exacerbated heartburn symptoms may be "rebound symptoms" and not indicative that the patient really has GERD. The rebound symptoms often resolve with time, and those patients may successfully use occasional H2 blockers, antacids, and/or dietary changes to combat heartburn.
If no relief is gained from OTC treatments, a visit to the doctor is in order. The doctor may recommend prescription-only version of a PPI drug. Many of the prescription-only PPIs are for treating more serious cases of GERD or stomach ulcers and may be used in conjunction with other medicines to eliminate H. Pylori bacteria. Examples include Aciphex (rabeprazole) and Dexilant (dexlansoprazole), Protonix and Pantoprazole Sodium.
Non-PPI drugs for treating active stomach ulcers that are to be taken short term (eight weeks or less) include Carafate (sucralfate).
Sources and More Reading:
Links above on drug names go to patient reviews.
BMJ:
Study reveals no link between long-term use of PPIs and stomach
cancer
Medline Plus Drug Information, such as omeprazole (used in Prilosec and Zegerid)
Overview of GERD:
https://medlineplus.gov/gerd.html
List
of Medications in the Ask a Patient database in the category of
GERD (and other stomach acid reducers)
Hiatal hernia and treatment for acid-related disorders (with
PPIs): A question and answer with a gastroenterologist.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3099358/
Overview and symptoms of hiatal
Hiatal Hernia presented by Cleveland Clinic.
Ask a
Patient article:
Strange Symptoms: Caused by Long Term Omeprazole Use
Update on H2 blocker Ranitidine (Zantac) Recalls
In November 2025, after a pause of more than five years, the FDA approved a reformulated version of H2 blocker ranitidine that addresses the shelf-life deficiencies and impurities present in the previous versions. It is not known if the previous "Zantac" will be marketed under that name.
History of the Ranitidine Recalls
In April 2020, the FDA recalled ALL versions of ranitidine because
the FDA found that the impurity in some ranitidine products
increases over time and when stored at higher
than room temperatures may result in consumer exposure to
unacceptable levels of this impurity. As a result of
this immediate market withdrawal request, ranitidine products
were not available for new or existing prescriptions or OTC
use in the U.S.
https://www.fda.gov/safety/medical-product-safety-information/all-ranitidine-products-zantac-press-release-fda-requests-removal
The following ranitidine (generic for heartburn drug Zantac) products were recalled in the U.S.: Brand name Zantac (Sanofi); Over-the-counter (OTC) generic tablets with CVS, Walgreens, Walmart, and Rite-Aid labels; some prescription and OTC capsules, tablets, and syrups labeled by Glenmark Pharmaceuticals, Precision Dose Inc., Golden State Medical Supply, Amneal, Aurobindo, DG Health, Sandoz, Teva, Perrigo, Novitium Pharma, Apotex, and Lannett. The products have been recalled due to possible contamination with NDMA, the same carcinogen involved in the recent losartan/valsartan recalls. Read more and get specific lot numbers at the FDA here: https://www.fda.gov/drugs/drug-safety-and-availability/fda-updates-and-press-announcements-ndma-zantac-ranitidine.
January 8, 2020 a recall happened for ranitidine products by Appco Pharma LLC and Northwind Pharmaceuticals. In addition, Mylan initiated a recall for its nizatidine H2 blocker antacid product on January 8, 2020. The FDA does not have one comprehensive list of ranitidine recalls (as it does for valsartan products), but provides links to separate announcements for each company initiating a recall.
On Friday, November 1 2019, the FDA released lab results for ranitidine (brand name Zantac) and nizatidine (brand name Axid) they have completed so far. Results indicate nizatidine had much lower levels of NDMA than ranitidine, which is also what independent pharmacy Valisure had found during their product testing. Valisure brought the problem to the FDA's attention through a "Citizen Petition," as they also did last year because of concerns about lab test results for ARB valsartan/losartan/irbesartan blood pressure medications.
FDA equates the amount of NDMA found in ranitidine to the amount of carcinogen one might receive when eating grilled or smoked meat. Nevertheless, some versions of the over-the-counter medicine had as much as nine times the "acceptable limit" for NDMA. FDA has set the acceptable daily intake limit for NDMA at 0.096 micrograms or 0.32 ppm for ranitidine. Here are the laboratory testing results by product and manufacturer name: https://www.fda.gov/drugs/drug-safety-and-availability/laboratory-tests-ranitidine
In Canada, at least four
companies announced recalls of ranitidine: Apotex, Pro Doc
Limitee, Sanis Health and Sivem Pharma, along with previously
announced recalls by Sandoz (Novartis).
https://uk.reuters.com/article/us-health-canada-heartrburn/health-canada-says-four-more-companies-recalling-versions-of-zantac-id
Many countries worldwide have different recalls, so consumers
outside the U.S. should check with the appropriate regulatory
agency for more information.
Ask a Patient article: "Overseas manufacturing of key pharmaceutical ingredient leads to massive generics recalls"
Questions and Answers about NDMA carcinogen in Ranitidine: FDA Q&A
