PRILOSEC Reviews (OMEPRAZOLE)

Average Rating: 1.9 (1667 Ratings)

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 DISORDERS, ACID PEPTIC

 Type: Rx Drug

  

PRILOSEC  (OMEPRAZOLE):  Omeprazole is used to treat certain stomach and esophagus problems (such as acid reflux, ulcers). It works by decreasing the amount of acid your stomach makes. It relieves symptoms such as heartburn, difficulty swallowing, and persistent cough. This medication helps heal acid damage to the stomach and esophagus, helps prevent ulcers, and may help prevent cancer of the esophagus. Omeprazole belongs to a class of drugs known as proton pump inhibitors (PPIs).   FDA Approval Date: 1998-01-15 (Sources: U.S. Centers for Medicare Services, FDA)

  

Results are sorted by length of time drug was taken from shortest to longest duration (reviews with no time reported listed first).

Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on PRILOSEC: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR PRILOSECCOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 2  Gastric erosion Numbness and tingling in feet, hands, face, neck. Some joint pain and muscle spasms. Woke up on two different occaisions with a feeling that a lightning bolt was shooting down my left arm into my hand. Extreme anxiety (possibly a cause and/or effect of the above symptoms) and despair; felt certain that I was dying of a terrible disease or at the very least had MS or something. Complete fatigue and loss of interest in everything, had trouble working and focusing. Prior to this period, had been very healthy and active (runner, etc). I didn't notice any of these issues until around 4 months on the drug, and I am still not sure if the drug had anything to do with them. I started having mild numbness and tingling which was weird. Then one morning I woke up and my entire left side was numb. I went to the ER thinking I had a stroke or something. They admitted me and ran CTs, MRIs, tons of bloodwork. Nothing found (thankfully). The hospital neurologist said my symptoms were consistent with neuropathy so he referred me to a specialist (still waiting for an appointment). Two hospital doctors said very rarely this medicaton could cause issues, so they told me to stop taking it (and an RN there told me she had arm numbness with PPIs). My GI doctor said he hadn't heard of it, but was open to me trying something else, so he switched me to Protonix (another PPI which has similar complaints on this site) but is having me taper off of it. The numbness and tingling are still there, but have improved a lot in the past three weeks. No more lightning jolts. The anxiety has improved quite a bit, but that might just be because I don't feel like I'm about to die. I don't believe in the conspiracies about evil doctors mentioned here, but I do find it interesting that so many of us have the same experience. Millions of people take this drug, so perhaps we are in the unlucky 0.1% that has these side effects. Or maybe are just prone to anxiety and this drug exacerbates it. But see a doctor to make sure. M 35 6 months
40 1X day
7/9/2020
 2   Major, intense, debilitating joint pain. I never put 2 & 2 together until now, but from the moment I started taking Emeprazole, I experienced gradual pain in my hands & wrists. Eventually, it got to the point where I started having blood tests, X-Rays & MRI's done to check for arthritis. All tests came back negative. Eventually, the pain worsened to the point where I would wake up with such intense pain, that I couldn't even pull up my socks, wash my hair or pick up my small dog without being in agonizing pain. Even shaking hands with someone became absolute torture. My knuckles appeared swollen, as did my elbows. On a hunch, I stopped taking Emeprazole 5 days ago, & low & behold, the pain is starting to subside! I have never felt worse in my entire life, & now a drug that was helping with my acid reflux might be to blame! The other side effects I've read on here (chest pain, increased heart rate, etc., I have NOT experienced). Please, if anyone has had agonizing hand/wrist pain, please let me know. Thanks. M 40 6 months
11/18/2009
 2  gerd leg pain and muscle pain to the point I had difficulty walking, fatigue, weight gain. Before I saw a doctor about the symptoms, I checked online for prilosec side effects since this was the only medication I was on to see if this might be causing the problems. I found all my side effects had been experienced by other people so I stopped taking it. I noticed a difference within 2-3 days. The muscle pain has greatly decreased and my energy level is starting to return to normal. I am looking for other ways to deal with the acid reflux but prilosec is definitely not the answer for me. F 59 6 months
7/5/2009
 2  Gastritis Tingling & numbness in feet, knee & ankle pain, swelling in ankles, anxiety, depression, tremors in hands, night sweats, chills, extremely dry mouth, blurred vision, heart palpitations, head always feels foggy, always tired. I was put on Prilosec in January due to a severe gastritis attack in December. My doctor insisted that it was "safe" to use daily for extended periods of time. He said his father has been on it for years and never had a problem. Well since I started taking it I haven't had 1 day that I felt good. Never associated all my symptoms with Prilosec until recently. I couldn't figure out why I was feeling so bad and then I realized that I've felt sick & have had these symptoms for the past 6 months - the same amount of time I've been on Prilosec. So I started researching the side effects and alot of my symptoms were the same. Then I found this web site and I'm about 95% sure it's the Prilosec. All the comments I've read pretty much sums up what I've been going through. I've been to several doctors, had blood work done, an MRI and everything is normal. I've been put on steroids twice, and they help some, but the symptoms always come back. Hopefully my symptoms will disappear after I go off the Prilosec. F 51 6 months
20 mg 1X day
7/5/2010
 2  GERD/Barrett's Esophagus Frequent diarrhea, stomach pain, racing heart, knee and ankle pain, panic attacks, mild depression, occasional blurred vision, night sweats and chills. 35 year old male taking for 6 months. Haven't really felt "good" for the past 6 months. Didn't put 2 and 2 together until the knee pain started and began doing some internet research finding the side effects related to long term use of omeprazole (prilosec). Just went to family doctor last week to get knee pain checked out. X-rays were taken and they revealed early bone degeneration. I told my Dr. I believed drug was causing the side effects I read about. She did a blood test and found that I have extremely low Vitamin D and low Vitamin B. Advised to take supplements and continue using Prilosec. Now rethinking those orders but don't want to go back to having stabbing pains in my stomach and frequent dizzy spells with nausea. Is this the trade off??? M 35 6 months
20 MG 1X day
8/9/2010
Email
 2  acid reflux I started taking Prpilosec OTC about 6 months ago to control occasional acid reflux because I noticed there seemed to be a relationship between acid reflux and my atrial fibrillation episodes. It controlled the acid relux very well so I continued to take it. Recently I noticed some swelling in my ankles, then started experiencing some joint pain. Last week I started having some severe stomach pain, headaches, and extreme fatigue which would start in the morning and last until evening when it would finally abate but would recur again the next morning. It suddenly occurred to me that there might be a relationship between taking Prilosec (which I always took in the morning upon rising) and the fatigue I was experiencing. I stopped the Prilosec and immediately the fatigue was gone and soon I didn't have the joint pain either. However, the stomach pain was worse than I have ever experienced in the past. I am hoping this rebound effect will not last long but from the sounds of it I may be in for a real battle. F 72 6 months
20.6 mg 1X day
5/31/2010
Email
 2  Heartburn, acid reflux Toward the end of my 6 months taking Prilosec I began having soreness in my neck and occaisional pain in the back lower area of my head. I kept feeling like I had to stretch my neck from side to side and if I may say so I had the unsubstantiated perception that blood flow in the vessels of my neck was decreasing. It was just a feeling. I went to the doctor who did a physical exam and listened for telltale blockage and he said he found none. I stopped taking Prilosec and the feeling went away though my strong acid production returned. I have decided to be more conscientious about when, what, and how much I eat and have started taking some papaya enzyme tablets to aid digestion. Prilosec worked well at profoundly reducing my acid production but in doing so I would have to say that I stopped paying attention to the quality of my diet and other factors that contribute to acid reflux. I am glad to be off it and transitioning to a better diet. The two things I feel are most important to combat acid reflux are eating a probiotic diet with kefir/yogurt regularly and walking. Walking promotes regularity and I perceive that my acid reflux was always worse during sedentary periods. Think of it in pure plumbing terms. You must keep things flowing to prevent backups. M 40 6 months
1X day
11/10/2010
 2  GERD and sinus infections anxiety, panic attacks, depression, affected my other medications I had acid reflux for years, did over the counter meds when necessary. A few years ago I started getting frequent sinus infections. An ENT saw me in January and said nothing was wrong, but prescribed 20 MG omeprazole daily just to shut me up. There is a link between sinus infections and GERD, and at first, omeprazole was great. Slowly I started having side effects, like my BP and glucose being higher, plus panic attacks. The PCOS which causes my high blood sugars was in full force. Panic attacks felt like I was going to completely lose it, where objects near me actually looked like they were slowly moving away and out of my sight, ears ringing, feeling like I would faint, cold sweats. Neither the ENT or GP told me that omeprazole could cause this, but two weeks ago I just happened to stumble across someone at work (I work in a medical clinic) who said omeprazole made her nervous. I looked it up online, found medications and minerals may not absorb properly because of omeprazole (see the NY Times article about it for more info) AND it can also cause anxiety. I stopped omeprazole -- now my anxiety is gone, and my BP and PCOS meds seem to be working again. But of course after only 10 days off, the sinus irritation is already coming back. I've taken other acid reducers (NOT preventers like omeprazole) but they're not quite enough. I have no idea where to go from here, but I don't think I can take omeprazole again. F 39 6 months
20MG 1X day
8/15/2012
 2  GERD On Zegerid the past 6 mo---did wonders for my night time reflux---but after 5 months of treatment began having intermittant paresthesias (hands, feet, scalp)---labs showed Vit D and Fe deficiency. Now have to take prescription Vit D to combat the Side effect of zegerid. Had been on Protonix prior with no side effects, but less night time acid control and that's why I switched to zegerid. The tingling is worrisome. F 53 6 months
7/25/2007
 2  Gas pain, unable to belch air up. It made me belch alot and helped to relive some pain. I get better results eating manna bread and drinking kombucha tea. It has titanium dioxide in it. M 6 months
1/29/2008
 2  Acid reflux Headaches / possible migraine trigger Minimal improvement in symptoms. M 45 6 months
2/1/2008
 1  acid reflux very bad bloating,dry mouth,cough,neck pain,dizzyness,out fo focuse,abdomine pain like stabbing,head aches,anxiety,depression,lack of energy,tired feeling all day,tingle in hands,back pain,itchyness,eye twitch I was never aware of the side effects before taking this medicine.It was recomended by my doctor to take this for acid reflux,i could not figure out what was wrong with me there was days i couldnt hardly function.DO NOT TAKE THIS PRODUCT IT IS THE WORSE THING I EVER DID!I'm just worried to see how long these horrible side effects last this is day one of me not taking this horrible product.I can't beleive they don't give more warning,im shocked and discusted.All side effects seem to hit slow snd then all at once.ONCE AGAIN STAY AWAY!!!!!!! M 29 6 months
4/24/2008
 1  reflux dizziness, shortness of breath, depression, anxiety, chest pains, bloat, nausea. ect. i have posted about five months ago descirbing some of my experiences with this drug or other ppi's.. they are all junk, i had all the sides that everyone has listed here.. life does get better. when experiencing all the sides i had all the precautionary stuff to make sure it was not cardiac related. ekgs, labs, er visit, stress tests, and not to mention numerous dr. visits. after a total of seven or so odd months of being off of ppi's, lot's of diet modifications, and i added some probiotics with a digestive enzyme i have found relief. i still experience some of the sides on an occasional basis, but a lot better.. there is hope. M 27 6 months
4/13/2009
Email
 1  gastric reflux nausea, headache, fatique, muscle cramps, constant soreness, general malaise, belching taking zeolife (mineral) thru nutrimetics thru friend now, didn't realize how great it is and will help you get it too. safe, nontoxic, no chemicals, capsule that attracts to free radicals, toxins that cause disease and illness = dramatic change and difference and no more drugs. her email below for info M 53 6 months
6/8/2009
Email
 1  Acid reflux Increasingly severe joint aches sometimes causing me to wake up at night--hip, neck, fingers (sharp and intense attacks of pain that felt like pin pricks), shoulders and lower back pain; dry mouth at night; chest tightness; irregular heartbeats; unusual fatigue At first I attributed the symptoms to age since they came on gradually, but finally I was feeling almost crippled with neck, hip, and back pain. I have been an active person--tennis, rowing, skiing etc, and I was having trouble just walking. I visited my doctor several times with each of these complaints. He said heart irregularity was not serious enough to worry about and told me to cut down on drinks with caffeine. Joint aches were explained away as arthritis. I just had a chest xray at my request because of aches and tightness in my chest--negative results; Dr. told me to increase Prilosec--I was taking OTC 20 mil 1 tablet a day--to 2 tablets. By coincidence I had just read the recent NY Times article on dangers of some acid-reflux drugs including Prilosec and decided to stop taking it without consulting Dr. Today 3 days after I have stopped taking Prilosec I realize that I am free of joint aches and feel like the person I was before all of the symptoms started piling up on me. I knew something was wrong and that something had to be done, but it never occurred to me that Prilosec might be the cause. Out of curiosity I went online to check side effects, and I was stunned when I read this report. I am really distressed that my doctor never questioned Prilosec as a possible cause and instead advised me to increase the dosage. As many have already commented, I will find my own way to deal with acid reflux but I will definitely stop taking this drug. M 71 6 months
5/29/2009
 1  upset stomach high blood pressure and back pain I stopped taking yesterday but over the last month my blood pressure & heart rate has climbed from 123/74/53 to 169/97-80 fairly steadily. When can I expect to see a reduction? Please help me with any infromation. M 65 6 months
3/11/2009
Email
 1  Crohn's disease diarrhea, nausea, heart palpitations. someone else said she couldn't concentrate while taking it and she was depressed. the same thing happened with me, but i was on a lot of other drugs that are known to do that, too, so i'm not sure if it was prilosec or not. maybe it made it worse. Not sure why I was prescribed this for CD, so maybe it's not fair to give it a 1, but certainly it is stupid to prescribe this for CD. M 6 months
6/6/2008
 1  GERD/Acid Reflux Six months of: Fluid in left Ear, Headaches, Dizziness, Panic Attacks, Depression, Agoraphobia, Severe Abdominal Pain with Terrible Diarrhea cycling ever two to three days and lasting for a 24 hour period each time. Passed blood in stool and was dehydrated and had to go to emergency room. Had not been out of house alone in over 5 months due to the severe panic and anxiety. Acid Reflux can be altered by MUCH SAFER MEANS which does not take your life away from you. Thank God I finally figured out that the cause of my life altering conditions for the past 6 months were due to this stupid over the counter medication. I will NEVER AGAIN intentionally cause such horrors in my life. I am so very thankful to have my life back. After trashing Prilosec I now have: No anxiety or panic- I'm going out shopping and to lunch with friends- No more headaches AND NO MORE 24 hour AWFUL bathroom issues!!! Eating Live Culture Yoplait Yogurt and keeping Mylanta handy now for acid reflux/GERD is a much better alternative! Life is Good Again! Thank You Lord for returning my common sense to me and guiding me to trash the Prilosec OTC!!!!!!!!!! F 51 6 months
11/15/2008
 1  acid reflux from hiatal hernia headaches, back pain, sore ankles, hives on feet, depression, heart palpitations, high blood pressure, chest pain, tingling in left arm I had no problems with Nexium when I took it. But I ran out and I tried to control my disease with diet, but it was not working. Rather than go back to the doctor, which was like pulling teeth to get Nexium, I started on Prilosec OTC, taking it sporadically. I went to the doctor because I was having some strange symptoms and got the full workup and found nothing to do with my heart. Then he suggested I increase my dosage of prilosec to 20 mg 2x a day and things got exponentially worse. Debilitating side effects, including severe depression. Seems to have subsided with stopping the medication, but I will have to keep an eye on my BP to be sure it goes back to normal. F 32 6 months
11/1/2004
 1  extreme anxiety Horrible runs of extreme anxiety, a feeling like there is a ton of adrenalin pumping through my body. Anxiety went away after stopping prilosec. Took awhile to figure out that it was the drug and not me. Didn't cause anxiety until I'd been taking it for more than 6 months. Coincidentally, the side effect of anxiety started a few weeks after the relief of gerd no longer occurred. Do whatever you have to do to get rid of gerd:lose weight, don't wear tight clothes. Just DON'T take prilosec F 44 6 months
3/20/2006

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