PRILOSEC Reviews (OMEPRAZOLE)

Average Rating: 1.9 (1667 Ratings)

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 DISORDERS, ACID PEPTIC

 Type: Rx Drug

  

PRILOSEC  (OMEPRAZOLE):  Omeprazole is used to treat certain stomach and esophagus problems (such as acid reflux, ulcers). It works by decreasing the amount of acid your stomach makes. It relieves symptoms such as heartburn, difficulty swallowing, and persistent cough. This medication helps heal acid damage to the stomach and esophagus, helps prevent ulcers, and may help prevent cancer of the esophagus. Omeprazole belongs to a class of drugs known as proton pump inhibitors (PPIs).   FDA Approval Date: 1998-01-15 (Sources: U.S. Centers for Medicare Services, FDA)

  

Results are sorted by length of time drug was taken from shortest to longest duration (reviews with no time reported listed first).

Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on PRILOSEC: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR PRILOSECCOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 2  Severe, frequent heartburn I have experienced frequent, severe heartburn for several years. I have relied upon antiacids as treatment. I take no medication but am being treated for anemia, likely caused from giving blood too frequently (every 2 months for several years). My doctor prescribed a colonoscopy and endoscopy, both of which were negative. At my doctor's direction, I am taking an OTC iron pill that has corrected the anemia. Prilosec completely eliminated the heartburn but I experienced frequent bouts of fatigue, usually lasting one to four hours but on occasion longer. The periods of fatigue were usually daily experiences but there were some periods (2-3 days) that I did not experience the fatigue. I have always had tons of energy and exercise daily, walking at least 4 miles per day. The fatigue is not so severe that I am unable to exercise but the feeling is inconsistent with the quality of life I have experienced for years. I have also gained weight, about 6-8 lbs. Good medication but I do not like the side-effect. I plan to discuss with my doctor and may alter my diet and revert to the antiacids. M 68 60 days
11/13/2006
 2  ACID REFLUX diarrhea I've been told that I have acid reflux. I have seen my own throat and have seen the white sores and edges on my vocal chords that the doctor says are evidence of acid reflux. BUT, I have no pain! I have trouble swallowing, and I cough at the drop of a hat, and choke, and my singing voice is compromised...cracks easily. Prilosec was helping , I thought, but then I started having diarrhea all the time, a case that had no symptoms of sickness. However, so inconvenient! My husband has suggested that the prilosec may be causing it, so I stopped taking the medicine this morning, and no big tummy rumbles and no diarrhea! Plan to ask my doctor for a plan B. F 79 60 days
2/25/2008
 1  Recommended by Cardiologist THIRTY-TWO days of diarrhea, extreme dehydration, gas and stomach pain. I was started on P the 1st of February after a night in the cardiac unit. April 1 diarrhea started. April 10 my beta blocker was doubled by Dr. I thought this was med related, but never thought it was the P until tonight. First time in a month I didn't have D within 20 minutes of taking my meds, also the first time I skipped the prilosec. Have tried stopping all of my prescrip drugs one at a time. Upsets me Doc didn't know this side effect. Will NEVER take this again. F 50 60 days
5/3/2007
 1  Gastroesophygeal reflux disease neck stiffness and pain, severe anxiety, panic attack,armpit pain, pain in my calves, heart palpitations, increased heart rate after eating anything (106), tingling hands and feet,severe hives,high blood pressure, shortness of breath, blurry vision, freezing cold, tiredness after eating, overwhelming feeling of dreed, etc.. omg I really thought I was going crazy, have been to the ER 3 times in two weeks, afraid to eat anything. I have had cervical x-rays, MRI and was recently told by my Dr.that I would need a comprehensive phsycological evaluation, and a MRI on my brain to see if I had lesions(MS) my Dr. has perscribed Baclofen, Paxil, Klonipin, ER dr. gave me Ativan ( turned me into a zombie) So glad I am an internet searcher. My Dr. even told me to stay off the internet. I will never take Omeprazole again. F 48 60 days
40 1X day
3/25/2013
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 1  Gerd Shoulder and neck tension, fatigue, hot flashes, depression, Three months ago I was diagnosed with gerd and was given Prilosec. Ever since then which is the same time I started the medication, I have not felt good. It feels like it has been one thing after another. I have always been a very energetic person in great health, so this was of great concern to me. I went to my primary care and bloodwork and CT scan were normal. Went to a chiro for my muscle tension and got a massage weekly, it did not help. Went to GI and got endoscopy, results came back as slight esophagitis. I can't seem to figure out what is causing me to feel terrible. Prilosec did stop most of my gerd symptoms, but these new symptoms have me feeling helpless. I am not 100% sure it was the Prilosec yet, but after reading this blog I have stopped taking Prilosec and will post an update soon. F 35 60 days
40mg 1X day
10/13/2011
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 1  acid reflux palpitations, muscle spasms, tremors, abdominal pain, anxiety, generally not feeling well. F 47 60 days
40 mg 1X day
11/23/2011
Email
 1  GERD Major depression and insomnia that went away within a day or two of stopping the med. I'm not the depressed type, but this drug made me really bummed. I've tried other PPI's with the same result. Every doc I've talked to about this has said they've never heard of the side effect. After reviewing the ratings on this site, I somehow doubt that it's all that rare. Someone is withholding reaction information from the appropriate entities about this class of drug. They're either discounting it as some sort of emotional problem or they just don't care or haven't made the connection. I don't even have a guess as to why it would make some people depressed, but I strongly believe it happens. M 27 60 days
20mg 1X day
10/30/2010
 1  Heartburn Gerd Blurry Vision, Dry Eyes, Dullness, Urinary Problems, LUMP LEFT SIDE of throat. After reading about others with same symptoms, I AM STOPPING RIGHT NOW!! Why did my doctor not tell me of side effects? This is poison. I will use tums instead.I hope symptoms go away after I stop.Did anyone have symptoms reverse after stopping prilosec? I am afraid I have ruined my health. M 56 60 days
20mg 1X day
9/2/2010
 1  LPR/GERD SEVERE ANXIETY. Insomnia. Depression. Headaches. Constantly feeling dehydrated. When I was first prescribed this I felt like it was a miracle drug. It made the constant lump in my throat (caused by LPR/GERD) disappear, which helped lower my anxiety levels (I already had pre-existing generalized anxiety disorder). Looking back, I'm not entirely sure when the anxiety started to get worse - but I know that after being on the medication for 1 month (Fourth of July weekend) I was already feeling incredibly anxious. It got to the point where I was unable to go to work because I was having near constant panic attacks and I missed nearly a full week of work, not to mention taking a lot of 1/2 days. I made an "emergency" appointment at my regular doctor, who did a full battery of blood work (all fine) and - on top of prescribing me stronger anti-anxiety medications and recommending a therapist - advised I stopped taking the Prilosec because "I probably didn't need it". After 1 week of not being on it I noticed a drastic difference in my anxiety level. I had gone from literally thinking I was dying and almost hoping my parents would have me committed, to feeling normal. It's been about 3 weeks since I've been off the drug and although my LPR/GERD is back in action, my anxiety level is next to nothing and I'm able to sleep and eat without feeling like the world is ending. It DOES work to eliminate acid, but I'd rather deal with the acid reflux than constant anxiety. F 23 60 days
20mg 1X day
8/13/2010
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 1  Acid Reflux I had extreme hypertension 165/115, which is not characteristic of my unusual readings after stopping Omaprazole. I will continue monitoring my BP, but it's the only thing that was different, it's very scary and I wouldn't recommend taking this drug. M 63 60 days
40MG 1X day
3/13/2010
 1  AFTER GALL BLADDER REMOVAL None for the first month or so. Then I started experiencing horrible leg and foot cramps at night. They would occur every night and wake me up in horrible pain. Had to stand up and walk around for a while to make them go away. They were ruing my sleep. Plus, my mouth felt dry as the dessert all day and night. Was drinking tons of water and even carried a bottle when I went shopping. My wife, who had been put on this drug didn't experience leg cramps but suffered from the dry mouth. She was only taking 1 prescription tablet, whereas, I was taking two per day. I decided to check the internet about this drug and found that the prescription dose does warn you about this effect but the OTC version does not. I didn't read the instructions while taking the prescription version. Apparently, these symtoms occur only after prolonged use (8 weeks or more). I stopped taking the drug a few days ago and the cramps and Charlie Horses went away!!. So, use it with caution and not for very long time. M 67 60 days
11/24/2009
 1  barrets esophagus lost hearing right, came back and now have constant ringing 2 friends experienced some hearing loss after a couple months after starting prilosec they had thought hearing loss was due to hitting 60s M 62 60 days
30 2X day
12/11/2013
 1  Voice breaking & Throat aching I had no symptoms of acid reflux only Voice breaking and throat aching after being rear ended in an accident. He thought I MIGHT have reflux and wanted to try Prilosec. He put me on Prilosec 40 mg twice a day (with no symptoms). Very soon after beginning I started having severe depression, extreme fatigue, severe headaches, heart racing, and then started having numbness in my right leg approximately 3 weeks after starting Prilosec. Two and 1/2 months after beginning I called my doctor and told him the Prilosec had not helped the problem, he wanted me to take it 6 more months (I stopped it that day). The day after stopping Prilosec I had full right sided numbness (thought I was having a stroke). Went to my doctor who sent me to ER for CAT SCAN (Negative). Sent to Neurologist (who I told I thought my symptoms were from the Prilosec), he disagreed saying he thought I had Multiple Sclerosis and ordered MRI's which were negative. I was sent for Cardiac workup, to an endocrinologist, Anyone taking any H Proton Pump Inhibitor (Acid Reducer) should have their B-12 checked. All of the literature I have researched said when a physician prescribes them they should order vitamin B supplementation with it. F 51 69 days
7/4/2007
 1  Silent reflux Terrible anxiety Afib depression chest pain stomach pain arm pain neck and head pain sinusitis,nervousness extreme lump in throat. Hard to swallow. Eyes hurt, trouble focusing,memory lapses. Feeling scared not knowing why trouble sleeping foot pain. This is a terrible terrible drug. Go the natural route and find a good natural Dr. Change your diet use Apple cider vinegar and good probiotic and cleanse your body of this poison and never use it ever ever again. F 61 70 days
30 mg 1X day
2/12/2015
 1  dysphagia(difficulty swallowing multiple neurological symptons, heart palpitations, Two months ago I was started on 20 mg of prilosec twice daily for one month, then decreased to daily for difficulty swallowing, that my MD insisted was gerd. shortley after I began having ringing in my ears, headaches numbness and tingling and weakness in my legs and palpitaions I have been to ER multiple times ,everything normal, my Md said I am having anxiety attacks. Last week I noticed a sudden increase in the weakness in my legs then I woke up in the middle of the night with severe dizziness, profuse sweating, body tingling all over and palpitations, I thought I was having a stroke, when I got out of bed, my arms ,legs and body were jerking uncontrolaby, I managed to drive myself to the ER, the Md was extremely concerned, they did a head CT which was normal, again all the tests were normal, they referred me to a neurologist, that was two days ago and now my muscles are so tense, I feel like I am coming out of my skin!!, I feel like I am going crazy, these symptons are not in my mind I have been on the internetf or the past two days trying to figure out what it might be, then this morning something made me look up prilosec side effects, I am in total shock after reading all the postings, I am going to stop the prilosec immediately and am hoping that the symptons will go away, also my MD never told me to limit the time taking prilosec in fact she recently told me to increase to two times a day as it has not helped my swallowing. F 52 75 days
1/18/2010
Email
 1  Heartburn This is a frightening drug! Twice in the last couple months I've had exactly five days of the most severe stomach cramps I've ever had in my life. The first day started out with vomiting along with the cramps and continued until I had nothing left to vomit up other than sips of water I'd managed to get down. These cramps were so severe I lost a couple nights sleep- the only relief I had was sitting in the whirlpool, which I did most of the day and night. I just put two and two together. The only thing that was the same with these instances was that I forgot to take my Prilosec! It’s the closest thing to food poisoning you can imagine! I will take my chances with the heartburn- NO MORE PRILOSEC FOR ME!!! F 59 90 days
20 MG 1X day
7/6/2017
Email
 1  Acid Reflux I gained 4 pounds in the first month while taking Prilosec each day. My doctor said weight gain was not a side effect, so I went on a very strict diet, and couldn't lose any of the weight I'd put on. It's a good thing I went on the diet, tho. It appears as tho weight gain on Prilosec is common. I've been on Prilosec for 3 months now. If I hadn't gone on the diet, who knows how much I would have gained by now! This is unacceptable. Headache and constipation F 55 90 days
7/22/2006
 1  severe heartburn all over joint pain, stiff neck, bloating, flu symptoms, terrible ankle pain I started taking 3 months ago. Although it stopped the severe heartburn I developed side effects that I didn't realize until recently. I felt fine 3 months ago except for the heartburn. About a month ago I developed severe joint pain. I felt as if I had the flu and it was in my joints. I developed a severe ankle pain in my right ankle that prevented me from walking at times. I started having hot flashes which I haven't had in years. I started thinking about why I felt this way and what had changed. I realized that the problems all started when I started taking Prilosec. I went off of it two days ago and I am starting to feel like myself again. I had no idea that this over the counter drug could cause such bad side effects. I will deal with my heartburn with Pepcid from now on. I will never take Prilosec again. F 58 90 days
20 mg 1X day
3/30/2010
Email
 1  Acid reflex Pain in jaw,irregular heart beat, tired, gas, dry cough. Scary experience. No prior heart problems. Back to Tums! Feel warning should state the irregular heart beat effect. F 80 90 days
30 mg 1X day
9/20/2010
Email
 1  GERD. Bloating, irritable bowel, weight gain, same abd pain I started with. I was completely controlled on Nexium, but my prescription drug company NGS took Nexium off of the formulary and substituted with Prilosec. I am going to stop taking this today. F 59 90 days
40 1X day
5/22/2011

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