PRILOSEC Reviews (OMEPRAZOLE)

Average Rating: 1.9 (1667 Ratings)

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 DISORDERS, ACID PEPTIC

 Type: Rx Drug

  

PRILOSEC  (OMEPRAZOLE):  Omeprazole is used to treat certain stomach and esophagus problems (such as acid reflux, ulcers). It works by decreasing the amount of acid your stomach makes. It relieves symptoms such as heartburn, difficulty swallowing, and persistent cough. This medication helps heal acid damage to the stomach and esophagus, helps prevent ulcers, and may help prevent cancer of the esophagus. Omeprazole belongs to a class of drugs known as proton pump inhibitors (PPIs).   FDA Approval Date: 1998-01-15 (Sources: U.S. Centers for Medicare Services, FDA)

  

Results are sorted by length of time drug was taken from shortest to longest duration (reviews with no time reported listed first).

Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on PRILOSEC: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR PRILOSECCOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 2  Acid Reflux Headaches, abdominal pain that comes and goes, dry itchy skin, fatigue, gas, bloated, belching, tingling in arms, muscle cramping, panic attacks (never experienced anything like this before). After reading this message board about Prilosec, I intend to stop taking this medicine tomorrow because it has been making me feel worse the past two weeks. I can't live like this, so I'm hoping that the symptoms are relieved by stopping this medication. F 32 2 months
5/25/2007
 2  LPRD 15 lb weight gain in first 4 weeks and rising another 2 lbs per week. Severe headaches. Hyper-sensitivity to light. Insomnia. Very happy there are other prescription options available. Even combined with a strict diet change, the Prilosec didn't alleviate the reflux. I would not be so ignorant as to tell someone to not take the drug; we all have different body chemical makeups and what works for some may not work for others. Prilosec doesn't work for me but I personally know others who have been very happy with this medication. Weight gain is disconcerting considering I am very active and follow a strict low-fat low-calorie diet. F 35 2 months
8/10/2006
 2  heartburn/reflux ANXIETY! Depression. Chest pain. Dizziness. Panic Attacks. Fatigue. I have taken Prilosec off and on for several years. I was under a lot of stress which was causing heartburn and gastric issues and began taking it daily. Shortly after, I began having these symptoms. I went to the the walk-in clinic feeling like I had a sinus infection. A round of antibiotics later, I was no better. During the visit my BP was up a bit and a couple days later I began having panic attacks. I only have major med. insurance, so I was putting off going to the DR or ER. I have lowered my BP with diet and lifestyle changes, but the other systems are persisting. This has been quite debilitating: mood swings, irritability, always feeling unsure of my self. My wife found this site today and I was completely blown away by how many others suffer the same symptoms. Prilosec is the only medication I take, so I am stopping immediately. I will keep you posted on what happens over the next few days. M 42 2 months
20 MG 1X day
6/16/2010
Email
 2  GERD Dry mouth, bad taste in mouth, diarrhea, lump in throat. My initial visit to the doctor was for a lump feeling in my throat. I have been taking prilosec for two months, the lump is still there, plus its worse than ever. I now can feel the liquid coming up my esophagus into my throat, and now I have a terrible taste in my mouth every day and am worried that my tastebuds are ruined. I feel so confused, like I have to think about everything I put in my mouth, which isn't much lately, and wake up worrying every day if I will feel terrible again. I am trying something called orange peel extract you get at the health food store, and also reading up on changing diet and meditation, since stress has a terrible effect on digestion. Oh, and also I have read that probiotics(like yogurt) and a digestive enzyme supplement are very helpful. I'm going to the natural food store today to ask some questions. You think you are helping yourself when you listen to doctors orders, but what they give you might just be exacerbating your condition. If you even have a condition! How can I be so much worse than when I initially went to the doc?? Oh, and also, I HAVE noticed lots of knee pain, but thought it was just over-exercising. I have felt like I have no energy, go to the gym and just feel exhausted. I'm going off of prilosec today and I'll report back and let you know how things are going. I know how desperate you all feel. F 47 2 months
20 mg 2X day
11/23/2010
 2  Stomach and throat ulcers, gerd Unable to focus, slow memory recall, depression, feeling low, hopeless crying, anxiety, panic attacks, bad circulation in arms, tiredness, insomnia. Feeling of doom. Gas. After about 2 months. And upper endoscopy it had almost completely healed my ulcers. Thats nice but have been off a few days and dont feel better yet. Im kinda scared i wont get back to normal. F 36 2 months
40-80 mg 2X day
10/25/2020
Email
 1  Possible stomach ulcer As time went on I experienced excess gas and stomach rumbling. It also didn't seem to help with pain. I stopped taking it and have experienced anxiety, inability to sleep well, general unwell feeling. Had heartburn for the first time ever, and the first day horrible stomach pain. Switched to Pepcid. Wish in had read through these comments before I started taking the drug. I would have avoided it. F 62 2 months
20 MG 1X day
5/31/2021
 1  Possible ulcer Started having a lot of intestinal rumbling and gas. Please don't take this drug! I'm so sorry I did! Withdrawal is horrible! So many issues that I Never had before I took it! Didn't realize the need to taper off this drug. Withdrawal has been horrendous. At varying times: heartburn, nausea, diarrhea, gas, intestinal rumbling, inability to sleep, jittery, hopelessness, headache, and The Worst, no appetite! Used to love chocolate! Lost weight to a scary point. Before this drug, all I had was occasional ulcer pain. 6 weeks off, things have gradually improved, but still struggling to gain weight and have an appetite, and feel normal again. F 62 2 months
20 MG 1X day
7/7/2021
Email
 1  Possible ulcer Started having gas issues, and lack of appetite. Not sure what else as I look back, but withdrawal was hell for 2 1/2 months. I want to give hope to those of you who think you'll never feel good again, going through withdrawal. At different times I experienced heartburn, over fullness to where I couldn't eat much, severe anxiety for about a week, heart palpitations, high BP, headaches, diarrhea, absolutely no appetite, nausea, lower intestinal rumbling, gas, and couldn't sleep past 3:00 a.m. and lost 8lbs. Things got somewhat better, then 2 steps back. Finally at almost 3 months I've been able to eat(still don't like my usual foods quite yet) and sleeping is better. Still tired and trying to gain back my weight. Evil poison pill!!! I thought I was dying! F 62 2 months
20 MG 1X day
8/19/2021
Email
 1  GERD/Hiatal Hernia Severe Anxiety/depression, panic attacks, shortness of breath, loss of appetite, stomach pain, muscle fatigue, nausea, chills, sweating, clammy hands/feet, bad taste in mouth I have been healthy and happy my whole life. I was diagnosed with GERD and a Hiatal Hernia (runs in my family). I was prescribed 40mg of omeprazole a day for life. I took it for 2 months and everything was great, my symptoms were gone and I had no side effects. I was off of it for a few days without withdrawal symptoms because I went on vacation and forgot my meds. I came back and started taking it again. 2 days into taking them I was just standing around and I had a horrific panic attack out of nowhere. I almost passed out about 5 times in the span of an hour, I had chills, I was shaking, I could barely breathe, my heart was racing. So naturally I went to the ER. All of my tests came back perfect. I then talked to my uncle (who is a doctor) and he told me it's just anxiety, and that I must be stressed about something in my life. The only thing is that I'm happier than I've ever been at this stage in my life, and ive never even had anxiety or depression. Theres no way that 2 days into taking the meds again, I feel these side effects without them being correlated. Every doctor ive spoken to has said that omeprazole doesnt cause side effects. This pisses me off because I know my body better than anybody else, a PhD doesnt make you god. I stopped taking the meds a few days ago and have started taking B12, magnesium and 5htp supplements to combat the sever anxiety that I'm feeling constantly. I've also decided to abandon prescriptions for my GERD and am trying to change my diet. M 25 2 months
40mg 1X day
1/8/2023
Email
 1  Gerd, gastritis i started taking 60mg after having a bad bout of gastritis. It worked for two weeks and after two weeks, i started experiencing grawling in my stomach, constancy chest burn, stomach burn, back burn, leg burn, vagina burn, throat burn. I was BURNING all over. The doctor felt it was best to up my dose to 80mg. That helped for one week and back to the same ole BURN. After reading these reviews..i am going to stop taking this med and see what happens. Will update later F 32 2 months
80mg
5/31/2020
 1  Acid reflux Bad anxiety, chills M 43 2 months
80mg
8/24/2016
Email
 1  acid reflux Palpitations, burning, sensation on my throat. Terrible acid rebound when I stop this poison. Omeprazole gave me all the symtomps it was suposse to treat. Dr gave me omeprazole for 2 months. After 5 days I fell something weird on my throat. Then dr told to take claritin. Palpitation were terrible, difficulty swallowing, burning 24/7. When I stop first 5 days were ok then the nightmare started. Its been more than one month and Im still feeling bad. I have a lot of irritation on my throat that I didnt have before my only symptom was nauseas. Im praying the inflamation goes away. I feel terrible acid rebound. I thought I was dying!!! Im still suffering due to this poison. Dont take!!!! Now Im using natural medicine. F 42 2 months
20mg daily
12/21/2015
Email
 1  Acid Reflux Fatigue, muscle cramps, rash over 70% of my body, chills, frequent urge to urinate, dry mouth, dehydration. My doctor said it was OK to extend the dosage but I only took it for 2 months. I noticed fatigue when doing simple things like walking to my car or climbing stairs, then I got severe muscle cramps, particularly at night. This drug depletes magnesium which, I assume, caused the cramping. The piece de resistance was the rash. It began in my genitals and quickly spread to over 60% of my body which felt like it was on fire. The itching was similar to that of poison oak. After three conversations with advice nurses who just didn't get it and who prescribed ineffective meds I finally was seen by a doc. Now I'm on a steroid and other stuff and it's finally calming down. But I can't wear clothing without discomfort which is a bit of a problem. I have been off Prilosec for a about a week and feel so much better, even though the reflux has returned. I'll find another way to deal with it. Never again will I take PPI. F 67 2 months
30 mg 1X day
5/2/2015
 1  GERD AND H-PYLORI if u can especially magnesium and vitamin d i have had lots of test done and they all was normal but vitamin d which is in level the d pill helped with my symptoms but comes back when i stop my levels are at 70 so what i think is d helps with depression and maybe it helps with anxiety too maybe why the pill helped so maybe the doc was right it in my head so my next step is to see the crazy doc yeah that's right never thought i say or do it but i'm desperate i have lost both grandparents and my father of cancer my father died about a year and half ago and cpl months after i found out about my cancer always have been a tough fellow and pick myself up but i believe these med no i know this med caused all this maybe the other added too it i am broke from these doctors back and forth so please don't do it to yourself o prayed cancer would take me as i insure u this is way worst its torture and it last for ever i hope some anxiety meds and the crazy doc can set me straight i surrender i need help!! i cant take or live like this anymore been living with burning eyes and mouth and joints and confusion for 24/7 for over a year now o cant think or function at all pray for me as i will u and if doc or fda read this shame on you to let this go on and yet walmart has em soon as u walk in i spent my birthday my christmas my holidays suffering crazy doc here i come 2 days away i cancelled the 1st but i'm coming this time hope u can put me back together again M 35 2 months
20MG 2X day
6/30/2015
Email

Patient History
 1  H Pylori Where do I start: pain all over body, particularly joint pain, depressing thoughts, mild headaches, extreme fatigue, dizziness that would last pretty much the whole day. This drug has been hell on wheels for me. It had me believing that something serious was going wrong with me. I have been off it for about 3 weeks now & I feel so much better. I am back to my normal self again but the acid reflux is back, going to change my diet to see if that helps. I welcome any suggestions on controlling the acid. Best wishes to everyone suffering from this horrible drug. F 33 2 months
20 Mg
5/17/2015
Email
 1  GERD swollen tongue. Lump in throat. Depression. Sinus problems. Muscle twitches. Burning mouth and ulcers. Vitamin B deficiency Was too scared to eat or drink because of the pain in my mouth & throat. New ulcers were appearing every day and whole mouth was on fire. Vit B deficiency showed up on blood test two weeks after starting Omeprazole even though was tested for same thing a month earlier & all was fine then. The depression was awful & can honestly say I would have been happy to die there and then! Uncontrollable crying & desperation. Avoid this med at all costs! F 54 2 months
20mg x2
11/10/2014
 1  heart burn @ pain stomack Right hip extreme pain unable to left leg, severe radiating pain from spine with pins needles over entire body. if bending down was severe. I have Celiac Sprue and Osteoporosis which the doctor knew. I have stopped taking the medicine but still having side effects but not as severe. i would advise a person who has Osteoporosis and Celiac to find another solution for Gerd/ M 74 2 months
20 MG 1X day
3/2/2014
Email
 1  Gerd Not beneficial at all! Achy joints, anxiety, worsened stomach issues, AND hair loss!!! I've always had thick hair and could not figure out why my hair thinned dramatically. Was getting tests for thyroid issues and never thought to contribute it to Prilosec. Stopped Prilosec months ago and my hair is filling in again! My friend is the one that pointed it out because it hapoened to her as well. This crap only causes more issues-does NOT solve them. Take at your own risk! So sick of doctors giving us crap that makes us worse so that we need more meds. F 30 2 months
?
11/5/2013
 1  gastritis Im in England. Im taking omeprazole. Terrible side effects. Nausea. Unbelievable gas. The worst side effect for me are the muscle pains. I can hardly move my arms. Both knees are sore. I will never take this poison again. Took my last one yesterday and Im still in agony. My doctor has some questions to answer about this awful stuff. F 55 2 months
40
12/21/2013
 1  Gerd Depression, fatigue, very achy hands, wrists and knees. This drug is awful. My info package used the words "if any mood changes" contact Dr. This was on the last page barried at the bottom. It should say in big bold letters "Depression". I've never been depressed in my life. I was so depressed while taking this drug that I didn't want to live anymore. I didn't realize it was this drug until it stopped working and I was put on Protonix. What a difference I noticed in just one day off this drug. This drug should have stern warnings about depression! If it weren't for my 2 little girls I may have ended it all. Also had severe joint pain. I have mild carpal tunnel but it never felt as bad as it did on this drug. F 45 2 months
8/21/2009

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