PLAQUENIL Reviews (HYDROXYCHLOROQUINE SULFATE)

Average Rating: 3.2 (667 Ratings)

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 Type: Rx Drug

  

PLAQUENIL  (HYDROXYCHLOROQUINE SULFATE):  Hydroxychloroquine is used to prevent or treat malaria infections caused by mosquito bites. It does not work against certain types of malaria (chloroquine-resistant). The United States Center for Disease Control provides updated guidelines and travel recommendations for the prevention and treatment of malaria in different parts of the world. Discuss the most recent information with your doctor before traveling to areas where malaria occurs. This medication is also used, usually with other medications, to treat certain auto-immune diseases (lupus, rheumatoid arthritis) when other medications have not worked or cannot be used. It belongs to a class of medications known as disease-modifying antirheumatic drugs (DMARDs). It can reduce skin problems in lupus and prevent swelling/pain in arthritis, though it is not known exactly how the drug works.    (Sources: U.S. Centers for Medicare Services, FDA)

  

Results are sorted by length of time drug was taken from shortest to longest duration (reviews with no time reported listed first).

Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on PLAQUENIL: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR PLAQUENILCOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 5  mixed connective tissue disease After a little over a month of taking 200mg of plaquenil daily, I experienced headaches, dizziness and blurred vision. I read on a lupus web-site that if this happens, to stop taking the drug immediately so I called my Rheumi and she confirmed. prior to taking plaquenil, I could barely get out of bed in the morning and my knees would give out on me at least once per week. the medicine was really starting to make me feel better rather quickly even though it can sometimes take up to 6 months to work. Since i stopped taking plaquenil a little over a week ago, my morning aches have returned and the flare ups are every other day. I have an appointment with the Rheumi next week and hope I can continue taking plaquenil...perhaps in smaller doses. F 36 45 days
10/30/2003
 4  RA/possible lupus Migraine, vivid frightening dreams, panic attacks, diarrhea, ringing in right ear, weight loss I have been on for about a month and a half, just recently I started to get migraines followed by panic attacks(haven't had in over 3 years). I'm hoping they go away! This drug has worked miracles for me, I'm holding out the panic attacks dissipate and I can continue or I may have to stop taking plaquenil F 31 45 days
3/18/2009
 3  UCTD Diarrhea,gas,nausea and bloating. Big mistake...Got off Plaquenil and have been experiencing horrible symptoms of fatigue and pain. Unable to work for the past few month.Got back on it about six weeks ago and still waiting for it to kick in. Won't go off it again if it starts working like it did before! F 54 45 days
400 1X day
10/5/2011
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 4  osteo arthritus/fybromyalgia excessive wind,severe depression been taking this for aprox 2 months with no severe side effects ,until i had a period of severe depression which i could not shake off.it wasnt until reading this site that i thought it could be this drug.almost to the point of wanting to killl myself i stopped taking this 3 days ago and am a changed person ,what a sda shame as it made such a fantastic difference to my life joint wise,70% better most days nearly back to being 21 again ! but alas i coulnt risk being so depressed again , F 47 60 days
11/11/2008
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 3  Discoid lupus I've been on this med for two months. Started at 400 mg per day. First few days felt terrific. Now developed itchy upper arms. Really can't tell what's the drug is doing. I'm still getting lesions on my forearms and I still bruise easily. Hair appears to be growing back. I am much more wide awake on the drug and sleeping is difficult even though the dreams are very interesting. I have discoid on my arms and sometimes legs but arms are the worst. Hope this drug stops any further development of the disease. I used to get stiff knees from walking but not so much now. Have a lot of nasal congestion but can't tell if it's related to the drug. M 57 60 days
200 mg 2X day
12/7/2010
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 3  MCTD After about a month, excitation. So I stopped it completely for about a montth, then started taking it again, this time 200mg a day and have started feeling depressed. Mood changes are the only side effects I have experienced so far. F 49 60 days
12/11/2009
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 2  Sjogren's Syndrome Stomach cramps, some diarrhea, nausea Thought I had CFS for 15 years. Specialist has now diagnosed SS. have been in relapse and off work: fatigue, excess muscle/joint/ligament pain especially in legs and ankles, feet. Have not felt any relief of symptoms of SS, since beginning plaquenil 9 weeks ago. Recent side effects seemed to be elevated following use of pilocarpine [salagen] M 53 60 days
10/24/2003
 1  tias horrible pain all over to include feet,hands,feet,temples,chest,knees,bottom of feet. I thought I was dieing,sleeplessness and very sore eyes. F 50 60 days
10/31/2002
 5  Lupus and Sjogrens I've really not had any side-effect except maybe less appetite the first week, and maybe a little depression for a day or two. But nothing big. I think it's a miracle drug and I feel 20 years younger. I love Plaquenil. It started to go to work at about 2 weeks, and one by one my joints stopped hurting. My legs stopped hurting; my eyes cleared up from Sjorgren's. Now I have more energy and I feel more "normal" than I have for 20 years. Plaquenil is a MiracleDrug as far as I'm concerned. The first couple days I had little appetite, and was a tad depressed for 2 days but that passed quickly. No bad reactions and I feel better now than I have in years. F 65 90 days
200mg BID 2X day
7/11/2011
 4  SLE / SCLE Gas indigestion, memory loss-short term, mood swings, Some hair loss. Sometimes I get this feeling that something is caught in my throat but it was in the 1st 4 weeks and has become less frequent I have been taking Plaquenil 200 mg a day for 3 months.Diagnosed March 06. Did not want to take this med. Told my Rheumotolgist no for months. Prior to taking this med I suffered from fevers, extreme fatigue, rashes, headaches ,and body aches and stiffness almost everyday. There has been a big improvement . I still have some bad days but they are becoming far and few between. Hope my eyes hold out. I do not want to go back to feeling the way I felt 4 months ago.I was barely able to get out of bed. I would recommend to at least give it a try it may work for you. F 49 90 days
1/4/2007
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 3  Sjogrens Horrible diarrhoea, nausea and dizziness with migraines. I also had chronic stomach pain that woke me in the night. Continued because Dr said these side effects were usual with this drug. Thought I would faint upon standing. Tried to push through because it helped with my joint pain and muscle fatigue/pain, however, on the last day of treatment, I woke feeling hungover. (I do not drink) I felt so unwell, I didn't know how I was going to get out of bed. Stopped the drug after finding it affected my liver. This was due to me having no gallbladder and advanced disease. I'm now taking the drug once a week, under sufferance. Still having side effects and since cutting the dose back, my pain is back with a vengeance. F 43 90 days
150 1X day
3/24/2022
 2  Autoimmune disorder I would be walking normally, then I would just fall forward. I went through many tests including a spinal tap. It is a very rare side effect of Plaquenil I was told. Since stopping it I have not fallen. F 53 90 days
1X day
1/1/2013
 2  MCTD/Lupus Rash on my sides and back that I could not tolerate - extremely itchy. The doctors thought maybe I was allergic to Plaquenil. I stopped this medication and was started on Imuran. The rash or itch did not leave for quite a while after I stopped the taking Plaquenil. I then learned that medications to control Malaria (Plaquenil)can sometimes cause the development of Large Plaque Parapsoriasis. It took weeks for the rash and itch to go away. The Large Plaque Parapsoriasis has not come back. F 66 90 days
8/2/2008
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 3  Osteoarthritis This drug *did* help with my joint pain, diagnosed with severe osteoarthritis as result of Ehler Danlos. Rheum suspects additional autoimmune disease, but tested neg for Lupus. Initial gastrointestinal issues, vomiting, nausea. Like morning sickness all the time. Was on 400mg day at that point. VIVID, epic length dreams. Exacerbation of OCD that was previously under control. Dosage stepped down to 200mg and moved from PM to AM to counteract dreams and OCD flares at night preventing sleep. AM dosage caused massive brain fog. As mother and full time psychology student this prevented me from performing to standard both academically and as a human. Last four weeks have been dealing with constant, overwhelming anxiety, huge upswing in OCD symptoms, and worsening depression with suicidal ideation, lack of focus and ability to stay on task. Having gone off the drug for only two days, I can report that I slept for a full five hours last night (miraculous!), my OCD symptoms have stepped back down, and I'm looking at my behavior of only last week in disbelief. I'm not ruling this drug out yet, but may need to combine it with an SSRI and strict monitoring. Would STRONGLY recommend that patients with anxiety disorders do not take this drug without discussion with a Psychiatrist first. Am much more cheerful today, despite the fact that I'm in a lot of pain. (Psychosomatic? Seems unlikely the drug has cleared enough yet to cause remission of psychiatric symptoms and reoccurrance of physical. But I'll take it - it's like the sun came out!) F 40 120 days
200mg 1X day
3/1/2011
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 3  Antiphospholipid syndrome, SLE early side effects - nausea, gas mid- liver problems late - hairloss It did help my joint pain, but it is not worth the side effects. F 39 300 days
11/9/2006
 1   have lupus I am worse than when I started takink plaquenil why is it being sold to help persons with lupus when it is not helping? F 60 360 days
200 mg 2X day
10/29/2011
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 5  suspected lupus due to celiac disea no side effects/and many celiac lupus symptoms such as hair loss, ringing in ears, facial pain and rash, digestive issues and fatigue and severe pain are so much better after 1 week. I had lost 30 lbs in 3 weeks and am starting to put weight back on. Also awake almost too much in comparison. Am told results can take awhile, if I continue to feel better am thinking I may someday feel like normal again. Still have very dry eyes, mouth and skin-but had that before rx. I have been off work for 2 months and was fearing there was no solution. Everyone reading this research celiac-it is usually the original root for all of these diseases and so many more. Left untreated ie: not changing diet-most often leads to CANCERS. No one tells you this...insist to get tested for celiac! F 49 1 weeks
200 mg 2X day
8/31/2011
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 5  APS and Fibromyalgia Nausea, diarrhea, stomached cramps, gas I am working my way around the side effects because I have not felt this good in five years. I hope it lowers my blood clotting proteins so I can lower my Coumadin or get off of it all together. I feel almost like a normal mom of the best 7 year old girl in the world. F 42 1 weeks
200 2X day
9/8/2013
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 5  RA / Sjogrens Nausea, gas and bloating...but it completely went away when I stopped taking vitamins and minerals at the same time. I now take vitamins with lunch instead of breakfast. I have been off and on Plaquenil for 15 years. I am back on it after a 2 yr break, but just discoverd now the vitamin/plaquenil link to nausea. It has always helped with the "flares" and I am already near pain free with reduced swelling. I feel it is the one drug that will keep me off anything more potent for a long time. I hope the vitamin/mineral discovery will help other people who may have a nausea problem. F 57 1 weeks
8/7/2009
 3  Sjorgren's Syndrome Having issues with swallowing and feeling like food is stuck at the back of my throat? Has anyone else had this issue? F 44 1 weeks
200 mg
12/20/2012
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