PLAQUENIL Reviews (HYDROXYCHLOROQUINE SULFATE)

Average Rating: 3.2 (667 Ratings)

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 Type: Rx Drug

  

PLAQUENIL  (HYDROXYCHLOROQUINE SULFATE):  Hydroxychloroquine is used to prevent or treat malaria infections caused by mosquito bites. It does not work against certain types of malaria (chloroquine-resistant). The United States Center for Disease Control provides updated guidelines and travel recommendations for the prevention and treatment of malaria in different parts of the world. Discuss the most recent information with your doctor before traveling to areas where malaria occurs. This medication is also used, usually with other medications, to treat certain auto-immune diseases (lupus, rheumatoid arthritis) when other medications have not worked or cannot be used. It belongs to a class of medications known as disease-modifying antirheumatic drugs (DMARDs). It can reduce skin problems in lupus and prevent swelling/pain in arthritis, though it is not known exactly how the drug works.    (Sources: U.S. Centers for Medicare Services, FDA)

  

Results are sorted by length of time drug was taken from shortest to longest duration (reviews with no time reported listed first).

Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on PLAQUENIL: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR PLAQUENILCOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 1  Linear Scleroderma Horrible rash covering face and body that does not respond to Prednisone or antihistamines as well as bloating and pain in ribs. This drug is like poison. I was at the doctor, ER and dermatologist and the rash is getting worse. I can't go out in public. I've been off Plaquenil for 6 days and the rash is getting worse. I was told by the ER that the half life of the drug is 50 days, which means it takes 50 days for 1/2 of the drug to leave your system. Please do your research on this drug before taking it and make sure the benefits are worth the risks. F 51 20 days
300 MG 1X day
4/12/2016
 4  RA small amount of nausea; some diarrhea; curbed appetite; gassy & gurgly GI (almost like Winnie the Pooh--a rumbly in my tumbly)sorry, the only way I could describe it I do feel better, but the last couple of nights have been sleepless (can't get to sleep, even with Ambien CR until very late)I was originally diagnosed with Fibromyalgia and now a confirmed diagnosis of RA. I am hoping I can go off some, or most, of the the other 11 meds I take at bedtime. I am a pharmacist and need to be able to stand all day and not take meds that make me foggy. I haven't been on very long but have noticed some improvement. I am still a good barometer as to when the weather will change,(achy, exhausted, depressed) hopefully after some time on the Plaquenil that will change. My rheumatologist seems to think I will respond well. I want my life back!!!! I have 2 small children and a husband who want me back!!!! F 43 21 days
3/26/2008
 3  ra Increase or return of depression/anxiety that has been under control with Prozac until now. Feeling of 'coming out of my skin" - xanax no help. Unfortunately, alcohol does. Can't keep doing this. Will try to d/c med to see if I cheer up and cut down my beer (4-5/day) wondering if anyone else had this happen. Some increase in acne and only mild GI symptoms. Great dreams!!!! I was getting by fine on 5mg prednisone/day with Vicodan 10mg 4x daily for aches and fatigue (hydrocodone gives me energy), but my doc wants me to try this. My symptoms are very mild and felt my original treatment was fine. The depression/anxiety is really starting to suck. Don't need to drink and take MORE vicodan (I know - liver interaction - take milk thistle to help combat this) to be on plaquenil. Any feedback will be appreciated. I wake up ok, but after my meds I'm having a light beer by 11am - NOT GOOD!!! but it gets rid of the anxiety. F 47 21 days
5/15/2006
Email
 3  RA & Sjogrens stomach cramping, gas & gas pains, headahes, increased depression & irritability (not sure if this is due to not feeling good or directly from the drug) Not far into treatment yet, but feeling somewhat less achy. However, headaches stomach cramps and mental state are not good. Feel like crying all the time & have no motivation. I used to be a regular runner & self-motivated self-employed person. Just want to feel like 'myself' again...hoping the Plaquenil helps me return to 'normal' after a few more weeks of treatment. Doc said 6-8 wks for results to show. F 38 21 days
200 MG 2X day
1/29/2012
 2  dermatomyasitis after 3 days rash on whole body and itchy,radiating burning heat , redness intensified. went off after 21 days, my GP said it was allergic reaction, took atarx for last 12 days it's helping alot. Rheum said not likely a drug reaction that I should stay on it. I may try it again after a few more weeks . F 56 21 days
200 1X day
5/29/2011
 1  MCTD Symptoms started with a sore throat and general overall flu-like symptoms and then a horribly itchy red rash all over my torso, back, arms, thighs, and butt. Never felt well while taking them - acutally worse than my regular disease symptoms. The steriods prescribed to clear up the rash made me feel GREAT - the best I'd felt in years. F 39 21 days
200 2X day
11/3/2011
Email
 1  arthritis After 14 days-sore throat,headaches, diahorrea,rash on torso,arms & thighs;muscle twiching at night; relieved arthritis pain but side effects too unpleasant F 53 21 days
200 1X day
10/31/2011
 1  Lupus Awful drug, started 3 weeks ago, since then I have constant diahrea, headaches are worse, little red dots on my face, and woke up yesterday to a dark circle under my eye, and lost 4 pounds. Called DR. said there was no way it could be related to Plaquenil since I had been on it for 3 weeks and to continue. Ughhh at a loss never had these symptoms before. Has anyone had similar expierence? F 45 21 days
200mg 2X day
6/22/2013
Email
 1  rheumatoid arthritis steven-johnson syndrome will never take it again, it is dangerous F 49 21 days
4/7/2008
Email
 1  Lupus On 200 mg 2x per day - severe muscle pain/weakness & joint aches. After lowering to 1 tab per day - within 1 week, severe reaction - large itchy purple patches. Started with itchy scalp & burning indegestion feeling, trouble swallowing. Turned within a few days into large purple hot itchy welts head to toe - hospitalization was necessary. Admitted from ER spent 5 days in hospital on heavy doses of steroids, antibiotics & atarax (benedryl didn't cut it) after a week, I'm home - rash more like prickly heat now - hands and feet (top and bottom) incredibly itchy feel very run down. I guess it works for some people, not me - if you have ANY reactions that are abnormal - talk with your doctor IMMEDIATELY I don't wish this on anyone F 44 21 days
5/23/2009
 1  Sjogren's I am writing this for my 17 year old son who took Plaquenil for Sjogren's. He experienced severe depression, anger, anxiety while on this medication. No longer will be taking Plaquenil. M 17 21 days
12/26/2009
 1  Seronegative arthritis Extreme anxiety, felt like I was going crazy, depression, low blood sugar, weight loss, panic attack with palpitations, extreme fatigue. Felt absolutely awful. And now I have to wait for it to get out of my system with a ridiculous 1/2 life of 50 days!! F 43 21 days
400m daily
7/27/2017
 4  RA Mostly good except I had a funny turn today while driving. My vision kind of went all wobbly - like I was on a boat in rough weather?? It lasted about 10 mins and afterwards I felt really tired/and scared!! Please email if you have experienced anything like this. I have only been on it for 21 days at 400mg per day I'm not sure if this is a side effect or not. I feel great in every other way. The plaquenil has helped with joint pain so much and I haven't had any probs like other people. My doctors are no help and are only interested in prescribing loads of medication - some of which I am not taking eg: prednisolone. F 38 22 days
7/4/2007
Email
 1  tendinite polimialgia diverticol vista appannata , sonnolenza , 2 incidenti auto ho avuto 2 incidenti auto e problemi agli occhi . sparito pene , problemi vita sessuale a zero per il pene sparito . il beneficio mi sentivo bene calmo e guidavo auto da cinque a venti kilometri ora per paura e tutti dietro a suonare clacson . vorrei smettere prendere plaquenil M 62 22 days
20 2X day
7/6/2012
 4  possible ra none, a little gas the first few days still have lots of stiffness in my hand and middle finger, but I am not so tired and dragged out any more, sleep a little better at night. But I am still a little apprehensive if there will be side effect the longer I am on this. F 55 24 days
6/7/2005
Email
 2  utcd F 53 25 days
200 mg 1X day
10/8/2011
Email

Patient History
 4  MCTD I haven't had any side effects so far. I don't know if it's making my hair thinner since my hair was already thin from thyroid disease. I haven't been on it long enough to know if it's helping me or not. I'm really concerned about the side effects I might have from taking this medication. F 47 26 days
10/30/2006
 3  RA, Sjogren's vomiting, diarrhea,rash that itches, sun sensitive, return of menstrual cycle after 5 yrs. After this short amt of time I have less pain. My fatigue hasn't gotten better yet. My dr says it may take up to 3 months before it helps all my symptoms. F 48 26 days
200 2X day
9/2/2012
Email
 3  SLE On the original dosage I was suffering from chronic diarrhea and hair loss within two weeks. Second time around (with 200 mg taken at morning and night 4 days a week) these have taken longer to kick in. Have started to experience a lack of motivation and feel like I am not quite connected to the world. I am also quite anxious for large parts of the day and having never been a big sleeper I am sleeping even less which isn't helping me cope with anything else Am relieved that I am not going mad with respect to the anxiety and the insomnia, but I agree that the benefits even after such a short space in time have been worth it already. F 46 28 days
200-400mg 1X day
3/17/2012
 2  UCTD noticed more headaches, but not too bothersome. had a huge allergic reaction on day 27 and by day 28 i went to urgent care at the advice of my rheum. to get steroid shot and a dose pack. now 24 hours later, i still have a nasty looking rash covering my lower arms and hands. i think this med has a lot of potential, but i wish i had been aware that it isn't all that unusual for an allergic reaction to happen after any length of time. i hadn't been on it long enough to notice a difference, but i had great hope that it would help. it is an older, much cheaper medication that has been proven to work well with these diseases. this isn't my first reaction to medication, but most definitely the worst. it just didn't work for me. back to square one! F 40 28 days
200 mg 2X day
4/21/2010

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