PLAQUENIL Reviews (HYDROXYCHLOROQUINE SULFATE)

Average Rating: 3.2 (667 Ratings)

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 Type: Rx Drug

  

PLAQUENIL  (HYDROXYCHLOROQUINE SULFATE):  Hydroxychloroquine is used to prevent or treat malaria infections caused by mosquito bites. It does not work against certain types of malaria (chloroquine-resistant). The United States Center for Disease Control provides updated guidelines and travel recommendations for the prevention and treatment of malaria in different parts of the world. Discuss the most recent information with your doctor before traveling to areas where malaria occurs. This medication is also used, usually with other medications, to treat certain auto-immune diseases (lupus, rheumatoid arthritis) when other medications have not worked or cannot be used. It belongs to a class of medications known as disease-modifying antirheumatic drugs (DMARDs). It can reduce skin problems in lupus and prevent swelling/pain in arthritis, though it is not known exactly how the drug works.    (Sources: U.S. Centers for Medicare Services, FDA)

  

Results are sorted by length of time drug was taken from shortest to longest duration (reviews with no time reported listed first).

Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on PLAQUENIL: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR PLAQUENILCOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 1  Sjogren's syndrome loss of appetite, depression I still get pain and fatigue while on plaquenil, some days aren't too bad but the drug is dangerous. I lost about 20 pounds since I started on it. I'm depressed, anxious and angry and wish I could just die. F 58 8 months
400mg 1X day
5/7/2011
 5  MCTD/Autoimmune Vasculitis At first, had some hair loss, but after 8 months my hair is longer than ever before... Awesome miracle drug! I really feel hopeful about my future like I never have before... I can go days without pain, and flare ups (that used to last weeks or months) now only last hours to a week. My never ending fever is gone, and I'm not bleeding out like before. F 38 9 months
2/7/2006
Email
 5  Lupus In the beginning, I did have stomach problems and also seemed to have more flare ups, however at the advise of my doctor, I stuck it out for the full 6 months trial and I'm so glad I did! I have not had any, zero,zip - symptoms of lupus at all since then... this is wonderful! I still take 2 tablets a day and for the first time since I was 17, I feel like I'm living a normal life... on occastion, depending on what I've eaten, I may still have some stomach issues but nothing worth complaining about... Plaquenil has been a miracle for me!! F 45 9 months
6/13/2008
Email
 5  Sjogrens Blurred vision first two weeks, slight itching on entire body and forgetfulness. Plaquenil has helped me with Sjogrens a tremendous amount. When I went to see the Rheumatologist and he told me I had Sjogrens, I was in denial and didn't want to take the pills. I also have Raynauds, and don't take any meds for this. I was getting worse everyday. I started with one pill in the morning and then accepted what I had and started taking the second pill. Within 3 weeks I noticed a huge difference. I couldn't even swallow my food and would wake up at night with my eyes in pain. I was having severe insomnia for about 1 year and I now sleep through the entire night. My hair looks like it did when I was 20. My skin now has oil in it. Before my hair was dry and my skin was always dry. I'm very happy with plaquenil. I've already seen the eye doctor and plan on seeing her twice a year. I still have minor problems, like my eyes hurting or dry mouth, but compared to how I felt, this is now tolerable. F 47 9 months
3/22/2009
Email
 4  SLE None Does seem to limit the flares when they come up, although the SLE has spread to brain lupus, I doubt any drug could have prevented that. M 38 9 months
4/27/2007
Email
 4  SLE Few, if any; hard to tell what is sle symptoms and what is a side effect Been on plaquenil 200mg 2x a day, and I see an opthamologist once every 6 months. I am back to working full time and can deal with things better. Gave me back part of my life. F 27 9 months
1/6/2004
 4  lupus nausea (if not taken with food) My pain and fatigue have been significantly reduced since I started on Plaquenil. F 21 9 months
200 2X day
10/30/2011
 4  Psoriatic Arthritis, Lichen Planus Nausea, Diarrhea I have always had a sensitive digestive system, but definitely worse when starting the plaquenil. The side effects after 9 months have nearly diminished now, and I have tremendous relief from the lichen planus and my psoriatic arthritis as greatly improved but far from perfect. My rheumatologist has now added methotrexate... F 38 9 months
400 mg 1X day
3/13/2011
 3  MCTD When I first started taking Plaquenil, I experienced no results. It took about 2 months to start working. I also gained increased bloating, gas, nausea, hair loss and intestinal problems. Now life is better. Life is better as far as movement. Mornings are still rough, but once I get going I have a lot of energy. As a Kindergarten Teacher I need it, but by the fourth day I'm dragging and can only go to bed when I get home. Sometimes I can't turn this energy off and find sleeping at night difficult due to restlessness and large muscle pain. I still have the intestinal problems. I am trying to work the stomach issues out with dietary changes. I have severe pain in large and small muscles during my cycle. Sometimes to the point of not being able to get out of bed. I do however have more sunny days than bad. F 40 9 months
1/19/2008
Email
 3  SLE and RA This is for the GENERIC: extreme nausea and vomitting to the point where taking Zofran to stop it did not help (and it normally ALWAYS works!). Insurance denied approval for brand name. I was able to identify 5 ingredients in the generic that is not in the name brand that could be causing the problem. Also, any cut or wound I got became difficult to heal, though rheumy said Plaq doesn't cause issues with this (my PCM disagrees). Besides the nausea/vomitting, it was helping alleviate my symptoms far more than I realized. Though I still had fatigue, it improved somewhat, the pain in my joints had decreased significantly, and I had these weird "nodules" that used to pop up under the skin of my arms and legs that disappeared. Getting eye exams every 6 months to check for Plaq toxicity...so far so good. F 42 9 months
200 MG 2X day
4/13/2016
Email
 1  Autoimmune disease After taking Plaquenil (hydroxychloroquine) for several months I noticed I was in a severe depression. I suffer from depression off and on but had never felt this bad. I read that depression/mood changes is a possible side effect so I went off the plaquenil to see how I'd feel. Within about a week I was already noticing a difference. Now it's been a month since I went off and I feel a thousand times better. That drug is bad news. Don't take it if you don't need to. F 36 9 months
2X day
7/17/2010
Email
 5  Arthralgia I just recently started feeling depressed and angry.. But then again it just could be because my husband is being an inconsiderate drunk... It's greatly eased my pain and swelling and my energy level went up to 90%.. it's a miracle drug !.!.! Thank you ;) F 33 10 months
100 2X day
6/27/2011
Email
 5  Lupus I have experienced basically no side effects from it. Though, I have noticed that I have more gas. I didn't think to equate this to Plaquenil, but after reading some posts, maybe it's the reason. I was diagnosed with Lupus, and my main symptom was a low platelet count, and that has started to rise. As far as I can tell, it works great! F 25 10 months
200 2X day
10/7/2011
 5  SLE Nausea during first week or so. Nothing since. I feel thaat it has been extremely helpful. Not as tired, joints rarely swell, aches have dramatically reduced, flare ups are rarer, etc. Also tolerate stress related situations better without the usual full blown flare up resulting. F 37 10 months
2/1/2003
 4  Sjogren's Syndrome/Fibromyalgia Quite a bit of nausea & diarrhea for first 2 months which went away. Also, hair lightening/gray hair not accepting color, yellow spots on lower cheeks. Laser therapy erased them. It has reduced some of joint pain, peripheral neuropathy pain, and extreme fatigue. Have opthalmology exam later this month, do not have any eye problems (other than SJS dryness)that I know of. F 55 10 months
6/5/2009
 4  UCTD It took about 3 months before I saw real improvement but unless I am having a "flare" I feel great most of the time. The first thing I noticed was that I was less stiff in the morning. Then I gradually saw improvement in my energy levels and my all around well-being. I do see an optometrist every 6 months to check for vision changes. So far all is well. I am grateful that the drug is extremely affordable and I have not had any real side effects. My rheumatologist explained that this is something I will have to take for the rest of my life. I also take Levothyroxin for my Hashimoto's Thyroiditis and completed a round of prescription Viyamin D after initial diagnosis. This is my second flare in 2 months. My doctor prescribes a two week dose of Prednisone and that seems to help. Since I am newly diagnosed I appreciate everyone's comments and suggestions. It is very frustrating when others just don't/can't understand how horrible you can feel. F 47 10 months
200 MG 2X day
3/24/2011
Email
 4  Lupus and sjogren's Itching in hands and feet when first started taking it, hair loss after about 3 months of taking it, headaches when I forget to take it I take the generic brand and it has really helped me with all my symptoms of lupus and sjogren's!! In the beginning my hands and feet itches to the point where I would start crying and couldn't sleep but that went away after the first couple of weeks and inhale never had that problem again. My hair was thinning for a couple of months but has now stopped but my hair is a lot thinner :( and when I forget to take it I can tell because I will start to not feel good! Overall this drug saved my life and gives me to do whatever I want with all my symptoms of my diseases under control !! I would recommend it, thank you plaquenil for letting me be just another teenager like all my friends!! F 17 10 months
300 mg 1X day
1/20/2011
 2  Lupus At first it helped with my pain,but that didnt last long maby 3 months at the most.And now for the past 10 months every time i take it the inside of my ears get very hot and itchy, and i itch all over so i dont get much sleep,plus my pain is worse then ever,my whole body get numb and tingle like every thing is going to sleep even my face and my head hurts, and feeling sick to my stomach. I spend most of the time in my bed exhausted or sick,in 10 months my cushion between my joints in my knees and my neck have worn to the bone. I thought its supose to protect my bones and organs,and i also have cronic stage 2 kidney disease. How so fast Its just not working for me F 50 10 months
400mg
3/19/2016
Email
 5  RA and Sjogrens low white blood cell count I absolutely loved Plaquenil. I had saliva and the swelling in my joints was gone. I started to exercise again. I had no other side effects except it caused by WBC count to plummet and my rheumy had to give up on it. Now its onto MTX and I resent it. I wish I could stay on the Plaquenil. F 43 11 months
200mg 1X day
8/17/2010
 4  UCTD (lupus-like), Fibro Have been taking for almost 1 year. The drug was nothing short of a Godsend and I experienced more relief from inflammation and pain than in years, even though there was a mild adjustment period of a few weeks with dizziness and some nausea. Now, am experiencing moderate hair loss and inability to grow my hair beyond a certain length, experiencing odd reactions to the way my hair responds to hair color when I color my hair, and now an overall body rash, which I would currently consider mild. The other thing that I notice is that for the first time in my life, I am depressed much of the time, which interferes tremendously with my daily routine, motivation, and general outlook on life. While I appreciate that this medication offers fewer long term issues and side effects than most drugs used for this type of autoimmune disease, am still quite concerned about these side effects that are now presenting themselves! F 59 11 months
1/27/2010

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