PLAQUENIL Reviews (HYDROXYCHLOROQUINE SULFATE)

Average Rating: 3.2 (667 Ratings)

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 Type: Rx Drug

  

PLAQUENIL  (HYDROXYCHLOROQUINE SULFATE):  Hydroxychloroquine is used to prevent or treat malaria infections caused by mosquito bites. It does not work against certain types of malaria (chloroquine-resistant). The United States Center for Disease Control provides updated guidelines and travel recommendations for the prevention and treatment of malaria in different parts of the world. Discuss the most recent information with your doctor before traveling to areas where malaria occurs. This medication is also used, usually with other medications, to treat certain auto-immune diseases (lupus, rheumatoid arthritis) when other medications have not worked or cannot be used. It belongs to a class of medications known as disease-modifying antirheumatic drugs (DMARDs). It can reduce skin problems in lupus and prevent swelling/pain in arthritis, though it is not known exactly how the drug works.    (Sources: U.S. Centers for Medicare Services, FDA)

  

Results are sorted by length of time drug was taken from shortest to longest duration (reviews with no time reported listed first).

Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on PLAQUENIL: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR PLAQUENILCOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 1  Sjogrens Rheumatologist prescribed Plaquenil for inflamation due to autoimmune disorder. On third day, I developed an itchy bright red rash on neck. Stopped medication and started taking Benadryl for the itch. Two days later the rash spread to my chest, stomach, and back. Went to urgent care where I was told it was most likely a reaction to the Plaquenil. Received a cortisone shot and a prescription for Prednisolone (six day pack), and an antihistamine. When I asked the urgent care doctor how long it would take to clear, he said that it was going to get worse before it got better. Well, true statement on his part! The itchy rash moved all over body except legs and feet. My face has peeled as if I was sunburned (face did not itch but was red and a bit swollen). Two weeks later, and after a follow up with an allergist and primary care physician, I am still itchy and the rash is starting to disappear. My scalp has been very itchy and flaky and lots of hair loss when I brushed after washing my hai F 63 3 days
200 mg 2X day
9/19/2016
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 1  Lupus/Auto Immune Hepatitis Extreme fatigue, itchiness,nausea, vomiting,diahrrea I dispise this drug, every since my doc put me on it Ive felt sick and tired. Ive not been able to keep any food down. F 31 3 days
3/27/2006
 1  suspected lupus ringing in the ears, visual disturbances, trouble sleeping, hair thinning. initially, the joint pains subsided, and i felt good about taking the drug. but after 2-2 1/2 months, joint pains came back, and i decided no way, not dealing with the pain and the side effects. i've started taking zyflamend (herbal type remedy. been on for almost two weeks, not alot of response yet, but am hoping.) i've been off of plaquenil for well over a month, wish someone would clue me in as to when i can expect the hair loss/thinning to subside. F 37 3 days
11/12/2004
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 4  Lupus (SLE) Only had diarhea for the first few days, it subsided and now it has been good. I think this drug is good but regular eye checkups should be done in order to catch any horrible side effects. F 29 4 days
11/13/2003
 4  RA GASSY, FOGGY MEMORY, BRUSING, NIGHTMARES. I'M A LITTLE NERVOUS ABOUT TAKING THIS DRUG. MAYBE IT SHOULD BE ALOT NERVOUS. THE MEMORY INTERFERENCE IS WHAT SCARES ME MOST. I FIND MYSELF FORGETTING HOW TO USE MY FINGERS ON MY KEYBOARD. F 54 4 days
1/27/2009
 2  Lupus/Behcets??? Shakes, sweats, fast heart rate, funny head exactly like a hypoglycaemic attack except blood sugar levels remained normal. I had to stop plaquenil because of these side effects which are not documented. A second trial after stopping the drug (with no symptoms inbetween) elicited exactly the same reaction F 40 4 days
10/27/2002
 1  Rheumatoid Arthritis The first day I took it, I just didn't feel right. I had abdominal cramps and nausea. On the 4th day, I had had a severe headache for 3 days. That evening, I started wheezing, couldn't catch my breath, felt like a weight on my chest, rash on neck and face. I started taking benadryl and albuteral puffer because I couldn't breathe. I felt like I had a focal seizure. I finally got myself under control late that night. I didn't take it the next day, but I felt like I had the flu. I couldn't get out of bed. My eyes would barely open and felt like they were raw. I'm on my 4th day off of it and I'm just now feeling a little better. Still no energy and I'm having muscle shakes. I'm still having wheezing and hard time breathing. Also, on the few days I was on it, my BP and hear rate were high. I could hear my heart beat loud in my ears. Anyone else experience this? I have tried to get in touch with my Rheumatologist with no luck. I'm scared to try to take it anymore. F 47 4 days
400 mg a d
6/3/2020
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 1  Lupus Broke out in a horrible rash, from scalp to soles. Rash is still not responding to high doses of steroids nor high antihistamines. F 24 4 days
200mg
8/9/2015
 5  SLE Stomach cramps, diarrhea, and gas, all lasting only about 1 week Started with a blood clot in left leg in Feb 08. Was diagnosed with Lupus Anticoagulation and was put on Coumadin for the rest of my life. Other symptoms began appearing shortly after the clot (TMJ, rashes on arms, joint/muscle pain, hand swelling, fatigue). Was finally diagnosed with SLE in July 08 but it was 5 months of pure hell not knowing what was wrong with me, one symptom after another popping up with no relief in sight. Started Plaquenil last week. Was told it would take about 4 months before seeing any results. However, after less than a week, have already noticed a good amount of decrease in muscle/joint pain and increase in energy level. Like many others on this site, I feel like I've gotten my life back and now have a renewed hope for my future and living with this disease. F 44 5 days
8/20/2008
 3  erosive inflam osteo both hands possible photosensitivity, feeling a little wired, no GI Hard to sort it all out in light of simutaneous taper of darvocet(bad drug for chronic pain)and use of NSAID only prn now. I also have found intjection into joints under fluor as outpt procedure very helpful to function-I have need to hand right for my profession and I've accepted a new project F 67 5 days
4/18/2009
 3  Severe Chronic Urticaria Diarrhea, loss of appetite, fatigue Today is the 5th day taking Plaquenil 100mg daily. It is also the first day ive had pain free! Although very tired, no pain is definitely worth it! It has also been 5 days since i have had a flare up of other symptoms. Next week i start on 200mg a day. I almost cannot wait. I am hoping this also means i can slowly decrease the amt of steroids i am taking! My fingers are all crossed!! F 30 5 days
4/24/2005
 3  Severe Chronic Urticaria Diarrhea, loss of appetite, fatigue Today is the 5th day taking Plaquenil 100mg daily. It is also the first day ive had pain free! Although very tired, no pain is definitely worth it! It has also been 5 days since i have had a flare up of other symptoms. Next week i start on 200mg a day. I almost cannot wait. I am hoping this also means i can slowly decrease the amt of steroids i am taking! My fingers are all crossed!! F 30 5 days
4/24/2005
 3  Lupus like symptoms in hands., The medication helped my Raynauds symptoms and reduced the redness and swelling in my hands. I was taking it with an anti-inflammatory, Sulinac and 5 mg of Prednisone every 2 days for 5 weeks and broke out in a rash all over my body. They upped my prednisone to 30 mg and after 5 days I am still waiting for my rash to disappear. The medication seemed to help and my doctor wants to put me back on it after the rash disappears. M 49 5 days
6/29/2005
 2  Skin conditions related to lupus I was prescribed it as I am diagnosed with auto-immune disease. I have skin conditions stemming from it since childhood. My mom took my off Plaquenil as a kid for a reason, but now I'm older, I decided to restart the course and this is my 5th day and the irony is that I am experiencing small blisters on my palms and sole, and a patch of rash on my back and arms. I don't know if I should continue. I would appreciate any sort of advises. F 21 5 days
200 1X day
4/13/2010
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 2  Lyme Disease Headache (all the time!), nausea/anorexia, general stomach ickiness, dizziness. (Note: I started plaquenil simultaneously with zithromax; it may be that some side effects resulted from the latter. I think it's mostly the plaquenil.) Side effects began soon (within 24 hours) after I started taking it. I stopped taking it over a week ago, but the side effects still have not subsided. Due to stomach problems, I have to FORCE myself to eat, I can only choke down a bit of fruit anytime before 4 or 5 pm, when hunger simply wins out over stomach upset. Meanwhile, I have had a nonstop headache; it waxes and wanes, but sometimes is almost migrane-like in severity. I have continued working but not with my usual efficiency. IMPORTANT QUESTION: How long did it take side effects to end? I was surprised to find that this drug can take 1-2 months to be completely eliminated from the system -- does this mean that I could have side effects for that long? :-( I have stopped taking the zithromax, in case side effects are related to that drug; the zithromax takes a week to clear, so if I still have these problems in a week, it's caused by the plaquenil. I will update then. I am reluctant to rate this medicine because I did not take it for long enough to see if it would have helped (and lyme disease isn't one to respond immediately to antimicrobials, anyway). I'm giving it a 2 for side effects. Had I known more about the side effects, I still would have tried it anyway, because many people are able to take it without problems. F 36 5 days
200 2X day
6/12/2010
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 1  Dermatomyositis I left the review below, this is a follow up on my condition: I withdrew myself from plaquenil n rushed to my derm who immediately put me in hospital for observation. By then I'm running a high fever, rash, swellings oh lips tongue and lymphnodes. My face is also pustulating. While the doctors were checking me, I heard them using the word "DRESS syndrome" a couple of time and I went to google it to find out that it is a severe reactions to drugs with High mortality rate of 10% with a high possibility of damaged organs e.g. Liver, kidney, lungs n hepatitis of 50%. I was give prednisone n the fever came down and I'm crossing my fingers n hoping to turn out well. I hope anyone who's considering plaquenil PLS research thoroughly and not end up like me...ask questions n make sure you're not allergic to sulphate or has history of dermatitis conditions, which will retrigger and bring out the worst. F 21 5 days
200 1X day
4/16/2010
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 5  SLE Didn't have any at all.Have been on it for 6 years. It has helped me tremendously,especially in the area of joint pains. F 67 6 days
10/27/2005
 5  autoimmune (SS or Lupus?) I have been on the drug for about 6 months. My skin seems to itch a little more but that could also be the thyroid condition. To me, it is a miracle drug. Before Plaquenil, it was a feat to just make it out of the bed. My doc had tried flexiril which helped my restless legs and I could actually stay asleep for most of the night. She added cellebrex which was also a big help. It took a little over 3 months for the plaquenil to really kick in. And once it did, I was able to begin living a pretty regular life again. Before taking this drug I was missing at least a day of work every week - 2 weeks. And on the days that I managed to get out of bed, it took all I had to make it through the day whether working or not. The fatique has been the worst part of my illness. I am now reducing the amount of flexiril and cellebrex that I take. I can now work 10-11 hours a day but I keep a pretty rigid bedtime. I told my doc that I don't really care what name my illness ends up having - I just am so grateful for this drug and all it's benefits. I still have flareups when I spend most of my weekend resting whereas before I spent most of my life resting. It really is a wonder drug! F 51 6 days
8/29/2003
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 5  Eosinophilic fasciitis little gas and feeling tired a bit (body feeling heavy!) only just started not done a week yet but swelling has gone done so much have more flexibility in ankles joints (where problems are)its amazing - so pleased so far after being on steriods for over 10 yrs (still are due to reduce if this drug works! i do hope so!) F 35 6 days
6/10/2009
 1  ra sle severe nausea hair loss ring in ears and hearing loss no sleep for 36 hours so much nausea i could not even get a sip of water down. falling hair was everywhere-bed,clothes, all over bathroom floor. the ear ringing was so loud could not concentrate on anything as well as significant loss in one ear. the day this all started (only day 6)! i went 36 hours with no sleep. this drug is poison. i will take my pain and manage it any day before doing this again. F 65 6 days
11/20/2008

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