PLAQUENIL Reviews (HYDROXYCHLOROQUINE SULFATE)

Average Rating: 3.2 (667 Ratings)

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 Type: Rx Drug

  

PLAQUENIL  (HYDROXYCHLOROQUINE SULFATE):  Hydroxychloroquine is used to prevent or treat malaria infections caused by mosquito bites. It does not work against certain types of malaria (chloroquine-resistant). The United States Center for Disease Control provides updated guidelines and travel recommendations for the prevention and treatment of malaria in different parts of the world. Discuss the most recent information with your doctor before traveling to areas where malaria occurs. This medication is also used, usually with other medications, to treat certain auto-immune diseases (lupus, rheumatoid arthritis) when other medications have not worked or cannot be used. It belongs to a class of medications known as disease-modifying antirheumatic drugs (DMARDs). It can reduce skin problems in lupus and prevent swelling/pain in arthritis, though it is not known exactly how the drug works.    (Sources: U.S. Centers for Medicare Services, FDA)

  

Results are sorted by length of time drug was taken from shortest to longest duration (reviews with no time reported listed first).

Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on PLAQUENIL: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR PLAQUENILCOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 2  SLE Intense itching and rash onn back and upper chest. Chronic yeast infection. Hallucinatory nightmares. Red, rashy, and itchy palms. I was started on this drug 3 weeks ago. My SLE went undiganosed for at least 5 years. The joint pain was so intense I was practically carried into the doctor's office. I was put on 200mg of this drug, and some prednisone. The relief from joint pain was almost immediate. Two weeks into this treatment I developed a yeast infection, that usually when treated, would go away with just one treatment. I've had 3 treatments and the itching will not go away. I have been suffering from chronic itching on my upper back and chest. I have developed welts and rashes and I can't find relieve. The doctor gave me a shot of benadryl and more cortisone, but no relieve. I've used all types of creams and homeopathic itch relieve creams, but the itching would not go away. I'm strongly considering not taking this medication unless I have a flare up. My frustation level is so high, I break down and cry at least two to three times a day. F 53 3 weeks
1/27/2009
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 2  SLE First 24 hours had diarrhea then it went to rashes, swelling, joint pains, off and on one day joint pains the next day a rash.. 600 mgs a day + 10 mg Prednisone I have only been taking Plaquenil for 3 weeks and I feel I have more flare ups now than I did when I wasn't taking any medication. I was told by my doctor that it would take a month to notice a difference but I have read that it could take much longer. I'm not sure if I can hang on much longer. Some flare ups keep me from going to work & functioning properly. I guess I don't really have a choice. F 35 3 weeks
5/21/2008
Email
 2  RA type symptoms Severe depression It's possible this drug was helping me. I experienced depression that was progressively getting worse, to the point of feeling like I was crazy and out of control (in my mind anyway). I've been off of it for several weeks, however, I still feel very "off." This is the only medication I had been taking which is how I know my depression was caused by plaquenil. F 38 3 weeks
8/30/2009
Email
 2  discoid lupus woke up one morning with severe rashes on back, chest, neck area, and buttucks area, went to see my dermy, and waiting for biopsy to see if allergic to it, or flare up stopped taking it after I noticed the rash, not sure how long if I was allergic to it that the rash will go away F 50 3 weeks
200 1X day
3/9/2012
 2  ??? +ANA/possible SLE or MCTD ?? Headaches daily, fatigue, weakness, flatulence, depressed 1st week with anxiety, generally ill-feeling. F 36 3 weeks
400mg 1x/d
3/21/2012
 1  RA Plaquenil 200 mg once a day: Red, raised, rash with terrible itching appeared after 3 weeks. It covered my whole body with the exception of the palms of my hands and the bottom of my feet. Two weeks later after stopping the medication, I am still suffering from this reaction. Does anyone know how long this will last? Didn't seem to help my RA while taking it. The steroids (prednisone and methylprednisolone) for the rash helped more. Will not attempt this drug again. F 50 3 weeks
6/20/2008
 1  Mixed connective tissue disease After 2 1/2 weeks on Plaquenil I developed flu-like symptoms, fever, could'nt get out of bed for days and a rash over my entire body. Doctor confirmed an allergy to Plaquenil and put me on a two week course of prednisone. I am so itchy I'm ready to jump out my skin. They said the rash will go away in two weeks. Don't know what I'm going to do next medication wise. 3 weeks
1/26/2009
 1  RA 3 1/2 weeks after being on medication. Severe rash over body except for palm of hands, bottom of feet and face. Rash became welts, welts formed into one big blotch with dark center, skin started peeling like a sun burn. Hospitalized for 6 days. Severe itching...... I will never have it in my house! Concerned about future health problems caused by this medication F 52 3 weeks
5/29/2008
Email
 1  primary sjogren's most horrible medicine,from a happy mom I turned into a monster mom,couldn't sleep,the brain was awake all the time,agitated,furious,angry at the smallest thing,went totally crazy,pain in right ear,heavy headedness,weird scary dreams..NEVER listen to your doctor,my rhumotologist said it was harmless.......*%&$#@ still recovering! I thought I would try this but am sorry I even started it,I trusted my doctor and took it but regret to this day.She should have honestly told me that it could have other side effects ,all I was told was maybe stomach upset/rash etc. I honestly was close to having a nervous breakdown.....I thought I had gone crazy!My kids/husband was so scared!I was ANGRY!AGITATED! F 46 3 weeks
3/23/2009
 1  LUPUS After 3 weeks on medication I began with intense itching at night (no hives or visible marks) on scalp, face, neck, upper arms, chest and back. Hair bleaching and falling out as much, if not more, than before the med. Intense gas and bloating (very noticeable). Immediately discontinued the medication (3 days ago). Still having intense itching at night and hoping that it goes away soon! I will not go back on this medication. F 32 3 weeks
12/29/2009
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 1  Sjogrens Diarrhea, blinding headaches, eye pain and dimmed vision, insomia,itching everywhere, ears ringing, emotional, muscle weakness, dizziness Yes it helped within a week of taking it for joint pain but the side effects were overwhelming F 40 3 weeks
400mg
6/15/2016
 4  Undifferentiated Auto-immune Dis. I, as many others, experienced some nausea in the beginning, and for the first 2 1/2 weeks thought my symptoms may be worsening instead of getting better. After about 2.5 weeks, I woke up one morning, and noticed feeling better. Less achy, more energy, etc. After a year of being unable to breathe, all of a sudden I could actually breathe again, and I didn't feel nearly each day like I'd been in a car accident (w/ the overall joint aches). I've now been on this medication for about 4 weeks now, and have already lost 5 lbs without trying. I am LOVING this medication! I feel 10 years younger and can now do a better job of chasing my 2 small ones around! I still feel some achiness and it is still tight and hurts in my lungs a little, but it's hard to describe how this medication has already changed my life in just 4 weeks time. Thank you to the Rheumatologist that finally stopped saying "Fibromyalgia" and found the right dx and medication to treat my problems! No side effects other than good ones. Slight nausea is very bearable. Good weight loss/appetite management and boost of energy to boot. F 32 4 weeks
1/16/2010
Email
 4  SLE and CIDP Loss of appetite completly, and my stomach hurst when I do eat. Weirdly enough I have been uncontrollably happy since I started taking it. Oh and my boyfriend has to force me to eat. It really does help with the tendom and joint pain. If it will help control the SLE then I will suffer the side effects. I would recommend it to anyone who wants some relief in pain and is will to exchange on bad thing for another. F 20 4 weeks
5/30/2009
 3  SLE Itching like crazy on extremities, embarassing gas. I don't have the nausea that others have described and so far my hair is staying in, but I have only been on this for a month or so. My main complaint with the SLE is severe and constant migraines (cerebritis) and I have had no real relief there, but the Plaquenil has helped a lot with the extreme fatigue. I definitely feel more peppy. My aches and pains come and go as opposed to being continual. I will discontinue this med if my sight is effected. I started on Methotrexate for my SLE and was on my way to pneumonia after only three weeks. That was TERRIBLE and hope no one else has to go through that if they don't have cancer. F 59 4 weeks
4/21/2006
Email
 3  RA Headaches and eye pain It seemed to help with the Arthritis, but the side effects (headaches) out-weighed the benefits, so I have temporarily been taken off it. I will try it again in a couple of weeks (at a lower dose). I was taking 200mg in the morning, and 200mg at night. F 40 4 weeks
10/24/2004
Email
 2  unpleasant side effects Experienced all side effects mentioned by others, which made it almost impossible to continue. I also have fear of this med.; after all, it is suppressing the immune system! Have any of you tried the Antibiotic treatment for all rh. diseases? Although few doctors use it, and med. schools don't really teach it, research has revealed that these diseases aren't "immune systems gone haywire," but they are the result of tiny Micro. bacteria which hide deep within cells. Even tho they can't always be seen on slides, when treated with PARTICULAR low-dose antibiotics, the diseases respond greatly; most go into remission, and some patients declare themselves cured. (Doctors don't, however, because of the ability of the bacteria to hang on.) Long-term treatment with THE antibiotic has not proven harmful, when the patient is properly observed. And, the doctor doesn't even have to be an RH one; any who will agree to use this protocal is fine. (Dermatologists already use this antibiotic in treating skin diseases.).....Go to link, "The Road Back," for more info. With all the harmful drugs you are or will be on, it makes no sense not to give this a try. (This research was conducted primarily in the 80's & 90's, but was successfully used by the doctor who 'discovered' it as long ago as 1948! F 40 4 weeks
1/30/2010
 2  Rheumatoid Arthritis First week experienced diarrhea, cramping, bloating, and gas. Nightmares started right away as well. Around the third week, muscle weakness in legs and hair loss. Now after 4 1/2 weeks I have anxiety and severe chest pain. I also have a strange inner shaking. I take 100 mg a day at my rhem's suggestion. I have many drug allergies, but felt I had no recourse. My RA was getting so unmanageable. I have been avoiding this drug for years. I also have fatigue that is worse than it is with the RA. I already had acid reflux, but since I have been on Plaquenil, it is off the charts painful. I am going to decrease to 50 mg a day and hope these side effects go away. If not I may have to discontinue med. F 54 4 weeks
200 mg 1X day
2/10/2010
Email
 2  Polyarthritis Eyes a little dimmer when reading - I have spoken to at least 3 Dr/ Specialists and have had Ross River fever some 20years ago - I took about 18 months to recover from ROss River fever ( which according to the world "you never ever really recover" as it is an immune response problem and I was treated with Feldene etc over 2-3 years - the Drs told me that I would have recurring "bouts of hectic pain" in the future accompanied by Malarial type reaction about twice a year - tiredness , exhaustion, and stiffness followed but I rowed my machine daily , ate good healthy food , few red wines and became pretty fit & well again / My previously damaged joints like toes ( football) and hands -fingers / wrists ( boxing etc ) have now erupted into a very painful state whicb varies in intensity day to day .... The Gurus label it - Polyarthritis - and its just 'wear & tear' and have suggested Methotrexate as a final solution but introduced me to every other pain relief like Diclofenac - Ibuprofen - Celloxocib - Paracetamol - and all of these in various generic presentations ? I sleep at night after Panadol x 2 but usually wake twice or so on the night with soreness and by 6am I am feeling exhausted - I am a reasonably robust person , I walk & swim comfortably but I am generally declining in my self - The pain ha at times in my wrists agonizing and I really don't know how to control or maintain at 76 4 weeks
20mg 2X day
9/27/2020
Email
 1  Undiff. connective tissue disease Nueropathy, anxiety and depression, insomnia. Gas and abdominal pain. Diarrhea. Mild itching. Could not continue beyond four weeks. Overrated drug with underreported side effects, especially when it comes to neuropsychiatric manifestations. M 39 4 weeks
1/23/2010
 1  RA Severe abdominal pain, bloating, constipation. Increased leg spasms @ night. Hair loss, accelerated depression. At the 4th week, itchy, red dots appear along with scalp itching. I have been off plaquenil 3 weeks. Red rash is worse now. Itching driving me crazy! Was hospitalized for admonimal pain @ cost of 20 k all from this drug! This is insane! Have been given 3 rx for RA, after plaquenil....maybe the disease is better to consume me than killing myself with man made POISONING! Now I'm scared. Oh yea, I clearly told Rheumy I am allergic to sulfa and was told the kind and amount in plaquenil would not hurt me.. Patient BE AWARE! F 48 4 weeks
100 2X day
4/1/2013

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