PROVIGIL Reviews (MODAFINIL)

Average Rating: 3.6 (619 Ratings)

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 CNS, MISCELLANEOUS    DEA Schedule IV   

 Type: Rx Drug

  

PROVIGIL  (MODAFINIL):  Modafinil reduces extreme sleepiness due to narcolepsy and other sleep disorders, such as periods of stopped breathing during sleep (obstructive sleep apnea). It is also used to help you stay awake during work hours if you have a work schedule that keeps you from having a normal sleep routine (shift work sleep disorder). This medication does not cure these sleep disorders and may not get rid of all your sleepiness. Modafinil does not take the place of getting enough sleep. It should not be used to treat tiredness or hold off sleep in people who do not have a sleep disorder. It is not known how modafinil works to keep you awake. It is thought to work by affecting certain substances in the brain that control the sleep/wake cycle.   FDA Approval Date: 1998-12-24 (Sources: U.S. Centers for Medicare Services, FDA)

  

Results are sorted by length of time drug was taken from shortest to longest duration (reviews with no time reported listed first).

Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on PROVIGIL: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR PROVIGILCOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 3  Excessive Tiredness I take Provigil to stay awake, because my other 3 medications make me very tired, I sleeping a total of 12-16 hours a night, even being on this medication. I believe that this medication is immuned to me, due to the fact that this medication does nothing for me, exspecially after the first week of me taking Provigil. I also cannot tell a difference when I have missed this medication, except for the excessive amount of headaches that I receive in the duration of a day that I have missed a dose. I started on 50mg, due to not having any effect, the medication was doubled to 100mg, still no effect. F 16 2 years
10/21/2008
 3  Depression and increase focus Worst headaches I've ever had, once kept me up for over 48 hours. Tolerance developed VERY fast, and the pharmacist told me this was actually not very uncommon. Almost no appetite. Increased focus and could get tons of things done. Terrible crash though when it wore off. My psych HATES caffeine and he prescribed me this when I mentioned the first thing I do after waking was start the coffee maker. Had to get prior authorization every year bc my insurance hated this medication. The headaches became a huge problem, and once had to leave work early after snapping at fellow employees for just talking (but sounded like everything around me was amplied 100-fold). Tolerance increased VERY fast, and my doctor had to continue to increase my dose and quantity. Finally got fed up and quit this drug in Sept 2012. Plus, being a little guy anything that killed my appetite obviously bugged me. M 29 2 years
400mg 1X day
11/8/2012
 3  Extreme daytime fatigue If I take it too late in the day, it is a sleep disruptor. F 63 2 years
100mg 1X day
11/19/2010
Email
 3  Excessive Sleepiness Headache first few days, loss of appetite and weight loss, upset stomach if not taken with food, odor in urine, extreme tiredness returns around 4 p.m. Provigil works for me pretty well during the morning/early afternoon hours although I am having a problem with crashing around 3 p.m. I like Provigil especially because I do not get jittery/irritable as I have on other stimulants (e.g., adderall). I definitely am more awake on Provigil than I would be with nothing, allthough it has not completely cured me my abnormal tiredness. F 22 2 years
7/20/2007
 3  M.E. / sleeping issues / narcalepsy I have battled with M.E./ extreme fatigue for 16 years. After having a child, I needed to address and increase my wakefulness. At first I took 100mg at 8/9am, and if I needed a boost, another 100mg at 10am. This would wouldn't wake me up as expected, but rather i would force myself to get going and then it would kick in. It would send me on a cleaning frenzy and did lower ones inhibitions. I soon started to notice that i couldn't settle at night,(hence me writing this now) and would become emotionally overwhelmed and low. I dropped the dose to 100mg a day if I had work, which did help me, but it was a struggle. I soon developed horrific migraines after i lowered the frequency of taking them. (twice a week for work or if i had a 'busy' day). I found if i took 50mg every couple of days, and then 100mg on busy days, it kept the head aches/migraines at bay. However, part of my thinks this clashes with the Pill, Yasmin. Since alternating days and lowering the dosage, I don't get low moods,head aches and only mild palpitations. Though i still have trouble getting to sleep, which resets the cycle if you like, you need another pill to get up! I would advise NOT TO DRINK CAFFEINE AS WELL. This will heighten all side effects and give you the shakes and jumbled words/thinking. It is a life line to me, but the side effects are many and do suck. Though i can honestly say, i don't find it addictive. Its one to try and giggle about with a docs advice i think. F 28 2 years
100-150mg
3/27/2014
Email
 3  MS,FATIGUE HALLUCINATIONS, DREAMS BECAME EXTREMELY VIVID, APPETITE LOSS. UNEVEN SLEEPING PATTERNS, SOME DAYS I STAY AWAKE FOR 48 HOURS AROUND THE CLOCK. WHEN I FIRST STARTED THE MEDICATION, I LOVED IT. I WAS MUCH MORE AWAKE, ALERT. PROVIGIL WOKE MY BODY UP, LIKE IT WAS BEFORE THE MS AND THE COMPLICATIONS THAT CAME ALONG WITH IT. I DID HALLUCINATE ALOT, STILL DO. HOWEVER, THEY ARE NOT AS STRONG AS IT WAS WHEN I STARTED. NOW I AM GETTING TIRED AFTER I TAKE 50MG IN A.M. WHEN I STILL AM TO TIRED TO FOCUS, I WILL TAKE THE OTHER 50MG . I STARTED OUT WITH 200MG A DAY. I WAS TO WIRED, HYPER. SLEEPING BECAME MORE DIFFICULT. THEN I ASKED MY DOCTOR TO WEAKEN THE DOSE. I THEN STARTED TAKING 100MG DAILY. 50MG IN A.M. ANOTHER 50MG IN EARLY AFTERNOON. I MELLOWED DOWN A LOT. I LIKED THAT BETTER, MELLOWED AND ABLE TO STILL STAY AWAKE. SOON BECAME SO TIRED AGAIN, DIFFICULT TO STAY AWAKE. MANY TIMES I GET VERY TIRED AFTER TAKING THIS MEDICATION. SOME DAYS I ADD ANOTHER 50MG UP TO 100MG, TOTALING 200MG A DAY. IT HAS BEEN AN UP AND DOWN EXPERIENCE ALL AROUND, I HAVE BEEN ON THE PROVIGIL ROLLER COASTER APPROX. 2 YEARS NOW. WHEN I TAKE 0MG ON A GIVEN DAY, I WILL SLEEP ALL DAY INTO THE NEXT DAY. I STOPPED DRIVING, FOR THE SAFETY OF OTHER DRIVERS AS WELL MYSELF. I HAVE HEAVY MOMENTS OF VERTIGO, LOTS OF DIZZINESS, BLURRED VISION, DOUBLE VISION, NO VISION. HEAD FEELS LIKE UP IN THE CLOUDS, SOME OF THESE SYMPTOMS MAY BE MS RELATED. ANYMORE I AM NOT SURE. THIS MEDICATION HAS MANY EFFECTS UPON WHOM IS TAKING IT, I WILL NOT RECOMMEND PROVIGIL, NOR WILL I RECOMMEND UPON IT. EVRY BODY HAS DIFFERENT EXPERIENCES. THESE WERE SOME OF MINE.... F 38 2 years
1/9/2010
Email
 2  narcolepsy/excessive daytime sleepy dry eyes, dry mouth, blurred vision in mornings, eye inflammation (IOI) when I tried to increase the dosage from 200mg to 400mg for less than two weeks. back to 200mg for 2 months, just tried to increase dosage to 400mg again for less than a week, I start to feel pain behind the eyes. Hands/fingers weakness and stiffness seems increased. My energy level is lower than when I was on Cylert (took it for more than 20 years.) Most of the time I just want to sit or lie down and do nothing because I feel weak. On 200mg, I will need to go to bed before 8pm, many days I found myself in bed at 6pm. Although my eye doctors said the IOI I had have nothing to do with Provigil, but I don't believe it, especially reading many comments from people who have taken Provigil. F 46 2 years
5/14/2006
 2  ADD Very dizzy, cannot feel the difference of taking it and not. Does not "wake me up" as most say. F 22 2 years
7/27/2002
 1  wakefullness effect dopaminergic ( plearure ) from day one. Tolerance and need to increare dosage. Addictlon. M 46 2 years
2200 mg
1/7/2013
Email
 1  trying to feel better.( dopamine) addictive very strong neuropathic pains depression Major withdramal recomended by Doctor= Mission Impossble. M 47 2 years
2,500 mgs
10/24/2013
 1  sleepiness/weight gain from Seroque Panic attacks, blurred vision, RASH, RASH, RASH!!!! I had taken Provigil about 1.5 years ago, and it was wonderful! No problems whatsoever. I had discontinued it because the blurred vision was getting a little intolerable, though. I started again about six months ago, got this nasty rash all over, including my face! I didn't link it to the Provigil until I googled it and read the FDA black box warning about the possibility of Stevens-Johnson syndrome and other possible fatal rashes. My last dose was a couple of days ago. I still have an intolerable rash and I can't wait for it to go away - if it does. F 45 2 years
3/6/2009
 5  Post Lyme disease EDS & yawning Took 1st dose at MD's office, noon after 42 ounces diet coke. Twitched-paced like a meth addict-laughed maniacally...slept sometime the next day. Had to learn how to balance caffeine and prvgl. sometimes clench teeth, not much. CAN PROVIGIL PRECIPITATE A MANIC EPISODE IN BIPOLAR DISORDER? I THINK YES! (and I love it sometimes)I think yes...The main adverse reaction comes monthly when I have to pay $215 for the pills..........better provigil than ephedra or meth! Battled lyme disease for 7 years. It is kind of like having MS, but with massive prolonged antibiotics lyme goes away and I got better. I was left with a brain that doesn't wake up fully some days and seems to shut down in the afternoon. I was only able to return to work 2-3 partial days a week, going home early to sleep or actually having a cot in my office and napping behind my desk. I have a problem with yawning...like episodes of yawning where it looks like (red, watery eyes)I haven't slept for weeks in spite of having 12 hours sleep and a nap. As an addiction counselor, it is not ok to yawn through my clients entire session(and look like I am coming down from meth). I spent my life waiting to sleep. I craved sleep and never was satiated. Sleep study went ok. I started on 100-200 mg daily, depending on how I felt. Now I am up to 200-400mg daily, averaging out at 300mg. I try to skip doses whenever I can in an effort to slow building tolerance.I hate being dependent, not addic F 45 2.5 years
10/21/2005
 4  MS Fatique I have been taking this drug for over 3years, It does help with fatique-some days thou-it has no effect at all. One thing, I have noticed lately I am really on edge. I am going to cut back and stop the drug for awhile to see if the edgyness goes away. Also, the drug does tend to go in bursts of energy sometimes. I take 200 mg. daily. I wish I could find some research on the drug-seems that no one knows how it works. Like what are the longterm effects??? F 51 2.5 years
10/30/2004
 4  Fatigue/daytime sleepiness When I first started taking it my skin felt like it was vibrating. An odd feeling, but not painful. It went away after a month or two. Provigil has been life changing for me. I take 200 mg everyday and if I didn't I would be unable to function. F 30 2.5 years
2/8/2008
 5  CFS A bit of euphoria! This has been a wonderful med. Of the many I take I applaud this one for it's effectiveness and lack of side effects. I have taken as little as 50mg a day up to 100mg in two parts. I feel well rested and not artificially alert. F 51 3 years
3/8/2008
 5  MS Weird "euphoria" feeling shortly after taking med, upset stomach (occasionally). This is a lifesaver for lots of MS'ers out there. F 35 3 years
6/29/2007
 5  Narcolepsy The only negative side effect I’ve had with Provigil are very mild, occasional headaches, but they are easily taken care of with some Tylenol. The positive side effects though are amazing! I was diagnosed with narcolepsy in my early 20’s…I had always felt like I was more tired than other people but I realized there was something really wrong when (even though I was sleeping 9-10 hours a night) I feel asleep in the middle of an air shift at a local radio station that I was working at! But since starting the drug about 3 years ago I can only think of once or twice where I have fallen asleep inappropriately...miles better than the every few hours I was falling asleep before! Something else I’ve found interesting is that the longer I have taken it, coupled with trying to stay on a pretty consistent sleep schedule, my sleep quality seems like it has gotten better. I used to have a lot of very vivid dreams and hypnotic hallucinations but they seem to happen much less One thing I’ve noticed (and I think I remember reading this in an article somewhere) is that Ibuprofen seems to interact with Provigil. For me it seems like it might speed up the metabolism of it…I’m not sure, but I know that if I take an Ibuprofen just a few hours after taking a dose of Provigil I feel like I’ve taken too much Provigil…I get that kinda weird, kind of hyper/nervous feeling, and then I’ll ‘crash’ a few hours later and be very tired. But I’ve used this to my advantage too a few times…if I start getting tired in the late afternoon (I just take 200mg in the AM) if I take an Ibuprofen it’s almost like I’ve taken another dose of Provigil but it wears off in plenty of time for me to go to bed. This has not happened when I’ve taken Tylenol. F 25 3 years
1/18/2009
 5  Nightmares Speedy heart rate, headaches, irritability, increase in OCD symptoms, panic attacks, delusions, shortness of breath. Severe long and short term memory loss. My doc prescribed Provigil to me when I stayed at a sleep clinic for a few days to determine the cause of night terrors. I hate pills and rarely took the sleep aids I was prescribed to I tried it out. It is supposed to "keep me up all day so that at night I crash and have deep sleep to prevent night terrors." Horrible headache at first and I was totally "speeding". My OCD symptoms came back...disappointing. Now I have panic attacks and an underlying feeling of dread. I still take it, otherwise I would be asleep at my desk every day. I do feel it is a greatly beneficial drug but you def must determine if the side effects are worth it. F 30 3 years
8/27/2008
Email
 5  Narcolepsy None! Was diagnosed with narcolepsy and this was the first and only medication I've taken so far. I was first on 200mg in the morning but had to quickly add a second dose in the middle of the day. It has given me my life back!! Of course I'm still somewhat tired throughout the day (the meds help, not cure) but I can actually be awake and do things like normal. Very happy with this medication F 22 3 years
200mg 2X day
5/21/2014
 5  Narcolepsy Decreased effectiveness if taken consistently. Occasional headaches. Panic attacks if I mix high doses with other stimulants. Insomnia if taken after noon. Anxiety with dose of 200mg or more. This medicine is a life-saver for me. Taking it keeps me from falling asleep in classes, airports, at work, or while eating, but 100 mg doesn't disrupt my sleep cycle at all. It helps me concentrate and keeps my thoughts from wandering off as often, too. Taking it has made me a much better student without negative psychological effects. F 19 3 years
5/1/2009

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