PROVIGIL Reviews (MODAFINIL)

Average Rating: 3.6 (619 Ratings)

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 CNS, MISCELLANEOUS    DEA Schedule IV   

 Type: Rx Drug

  

PROVIGIL  (MODAFINIL):  Modafinil reduces extreme sleepiness due to narcolepsy and other sleep disorders, such as periods of stopped breathing during sleep (obstructive sleep apnea). It is also used to help you stay awake during work hours if you have a work schedule that keeps you from having a normal sleep routine (shift work sleep disorder). This medication does not cure these sleep disorders and may not get rid of all your sleepiness. Modafinil does not take the place of getting enough sleep. It should not be used to treat tiredness or hold off sleep in people who do not have a sleep disorder. It is not known how modafinil works to keep you awake. It is thought to work by affecting certain substances in the brain that control the sleep/wake cycle.   FDA Approval Date: 1998-12-24 (Sources: U.S. Centers for Medicare Services, FDA)

  

Results are sorted by length of time drug was taken from shortest to longest duration (reviews with no time reported listed first).

Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on PROVIGIL: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR PROVIGILCOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 2  EDS related to sleep apnea Funny taste, blurred vision, headache, sloooow brain at times. Initial dosage no longer worked. Worked great the first week, then my vision became funny when looking at green colors. Kept me awake at first, then I would get drowsy like before. Tried Ritalin SR and that has been working fine. M 41 3 weeks
9/8/2006
 1  hypersomnolence I took provigil daily as soon as I woke up. 1st week: ½ 200mg tablet – I don’t feel much of any effect at all. 2nd week: 1 200mg tablet – Still don’t feel much of an effect. If anything, I’m more drowsy. 3rd week: 1½ 200mg tablet – At the beginning of the week, I felt more drowsy than ever and could hardly concentrate on anything. My short-term memory feels much worse. Towards the end of the week, I still feel drowsy and out-of-touch and still can’t concentrate... but now I’m wired and edgy, too, with an increased heart rate. That was the last straw. Time to start the decrease. Based upon scanning this forum, I would not recommend this drug for hypersomnolence or daytime sleepiness. I did try to do some homework before taking it, but I guess I should've read more. M 26 3 weeks
11/9/2007
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 5  major depression, ADD None I feel like this is a wonder drug. I have depression which seems to require I take SSRI's, but they cause chronic fatigue. Not only does the Provigil take care of that, it seems to have mood-lifting properties. ADD is practically just a memory--the Provigil does a great job of controlling confusion, brain fog and forgetfulness. No jittery side effects which is great F 24 4 weeks
6/24/2007
 5  Extreme fatigue-only up 6 hrs daily @200mg to start stomach pain & nausea too much,but was super woman with speedy speech. Had to cut dose to 100mg & can tolerate. A little nap or rest around dinner,but this medicine has given me my life back. My stomach has been gurgling,but no pain. It causes me to smoke more due to being up & a little more hyper,but I will get a handle on,because I was in the process of quitting. My speech sometimes gets faster,but I think is leveling out some. Overall,this medicine has given me my life back. Hope a tolerance doesn't develop May try to increase back to 200 later only if my stomach will tolerate it,so that I won't poop out in the late afternoon. We'll see after another couple of weeks Hope this review helps you F 60 4 weeks
100 mg
1/22/2016
 4  sleep apnea, chronic fatigue headache, itching, anxiety, jaw clenching, smelly and dark urine, palpatations It really helped me stay awake and alert, it helped with mood and depression, I could stay awake all day without having to take a nap. It helped me to think clearly. F 29 4 weeks
8/7/2008
 5  ms none Almost immediately, I had energy. I was able to play with my kids all day. My patience and mood are much improved. Yet I can easily take a nap if I need to ( after a long day at the beach in the waves). I feel like myself again! I am so grateful! F 45 5 weeks
200 mg 1X day
9/18/2011
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 2  Chronic Low Grade Depression Headache for the first week. Loss of appetite. Soft bowels. Faster heart beat/chest fluttering at time and some loss of breath. Initially this drug seemed to work wonders for me. I started at 100mg a day and increased after a week to 200mg a day. I felt energized and my depression completely dissapeared. I was very motivated in a way I haven't been in a long time. However by the 4th week I began to crash in the afternoon. (I was taking the provigil in the AM) I would become overwhelmingly exhausted around 2-4pm regardless of how much sleep I had the night before. The fatigue was accompanied by a strong depression, much stronger then before I started taking the Provigil. I have had chronic low grade depression for years but it got much worse after 3 weeks of Provigil. I began to taper off about a week ago. I don't know what doctors are thinking when they say there are no withdrawl symptoms. I have been clumsy, forgetful, highly anxious (nervous tics) and very depressed since stopping the drug. I never have problems with clumsiness and forgetfulness so I know this is a result of withdrawl. But the thing that wo F 38 5 weeks
5/7/2007
 1  unexplained sleepiness Near-death. I have already commented about how this drug nearly killed me. I have studied it more since. If you are like I was, when you read that a drug has killed or badly injured someone, you will say, "Well, for every drug there are a few people who cannot tolerate it. That's life." But Provigil is not one of THOSE drugs. Consider this: In its own testing, Cephalon, the company which makes Provigil, found that 2%, 1 out of every 50 people people who took Provigil developed low blood pressure, also called hypotension. Then look through this list of over 300 people. Count how many of these 350+ people reporting here say they developed hypotension after starting on Provigil. I count exactly one person. Yet if Cephalon's own statistics are true, then there should be closer to 7 people (1 out of 50) reporting low blood pressure. So why aren't there another 5 or 6 people on this list reporting low blood pressure? Well, the one person who DID report hypotension was me. And it was hypotensio M 5 weeks
7/28/2008
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 5  Sjogren's syndrome related Fatigue Smelly Urine (but when does urine smell wonderful anyway?), Weight loss (needed) due to having the energy to be active again...also the lethargy I had before caused me to instinctively want to eat for energy, and that is gone. Lost 10 lbs in the first 6 weeks (had gained 30 due to inactivity and lethargy). Didn't give me a caffeine-like high (thankfully). I feel *normal* for the first time in ages. I can do housework and carry on with a normal day like before I had Sjogren's. Occasional days, the fatigue is too much for provigil, but rarely. It's been a miracle for me. F 30 6 weeks
5/23/2007
 5  MS/depression-related sleepiness I've only been diagnosed in the last six months with MS, but I had been overcome with overwhelming exhaustion. After about two to three weeks taking Provigil, I started to finally feel like I had energy to do normal, every-day things. I haven't noticed any unpleasant side effects, except the strong urine odor, but I can deal with that. However, the best "side effect--if you can call it that--is that this has increased my libido unbelievably. I haven't felt like this since I was in my twenties. My husband wants me to thank my doctor for him for prescribing this medicine to me. However, he now thinks he'll have to get some Viagra from his doctor to keep up! lol I'm just worried that this "side effect" will wear off soon. F 45 6 weeks
1/13/2006
 3  narcolepsy Itchy rash on arms and legs I had taken Provigil several years ago for a span of about 3 months. Although it was a great alternative for my narcolepsy, it was not generic and quite expensive.I opted for Concerta instead. Now that Provigil is generic (Modafinil), I began taking it again over a month ago. Not a single side effect at first and I as very alert with a natural feeling of wakefulness. Last week I developed a symmetrical rash on my forearms. The next day it had spread slightly and I applied hydrocortisone cream which helped a little. With each passing day, the rash continued to spread and increased in intensity ( a maddening itch). Currently, it is on my arms from the elbows to my wrists and on my legs from the knees to ankles. Oddly enough it feels as though I'm itching from the inside out! I stopped taking the med after 5 days of having the rash. I will be going back to Concerta. Nuvigil did not work for me (stomach discomfort), but it has helped my 16 year old daughter. F 37 6 weeks
200mg 2X day
1/4/2013
 3  Fatigue/Lethargy Headaches, Dizziness...eventually subsided though. Depressive thoughts. Decreased libido. Decreased appetitie. Not jittery, but a "rush" feeling. If I'm involved in a task, I can focuse really well, but if I'm not doing anything that is focused, I tend to "spin my wheels" at nothing, if that makes sense. My inner dialogue seems more critical (negative). Flushed face, dehydrated. I'm satisfied with the alertness. I'm concerned about long term effects. Some days I still feel lethargic, but then can't nap because I'm too "wired" on it. F 39 6 weeks
11/1/2007
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 2  PBC, Fatigue, Fibro After almost 10 weeks, I seemed to have developed a tolerance to this medication. I can't tell a difference now whether I take it or not. I am wondering if this med is causing depression to worsen, or if I am depressed because it no longer seems to be helping me. I am disappointed as I felt so good for the first 5-6 weeks! I never had any of the negative side-effects others have experienced. It was truly a miracle drug while it lasted. I posted about 6 weeks ago - now I have been on this medication about 10 weeks. It seems to have lost all the positive energy effects I had the first month or so. I don't know if I am fatigued and depressed because of this med, or because my body seems to have developed a tolerance to it? I take 200 mg every am. I see my prescribing physician (Rhuemy) next week so will see what he thinks. I am bummed as it totally changed my life while it lasted! F 52 10 weeks
7/31/2007
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 1  ADHD perminent decreased ability for word recognition. Permiment loss of certain short term memory abilities. After only 2.5 months on this drug my word recognition and memory was partially destroyed. Over 6 years later it has not gotten any better, I still lose my train of though quite often and have much worse word recognition than before. M 27 10 weeks
6/20/2006
 3  Excessive sleepiness At first, none. The meds helped to to be alert and make it through the afternoon without a nap. Though somedays now, I sleep real hard in the afternoon.After 3 months, severe headaches that cannot be resolved with pain relievers (I have had a splitting migraine for one month, throat/esophogas restriction and dryness/tightness in the bronachial area. I am stopping these meds today. To add ALL the info about me: I am on Effexor XR for imbalance for 1 year. I have been examined by family doctor, dentist, Oral and Maxillofacial doctor and Endodontist to rule out sinus infections and migranes,respitory and dental problems. This is a good drug if you are able to take this. F 45 12 weeks
12/29/2004
 5  Severe Sleep Deprivation/Apnea decreased appetite (good side effect for me) My wife calls this my happy pill, I take 200 mg at 6 am and 200 more at around 1 pm. It is wonderful! Has changed my life, I used to come home from work and just go to sleep in the chair, was constantly tired and no motivatin at all. Been on it a month and not one single nap since day 1. My wife calls me everyday at lunch to be sure I take my second dose, we actually talk again instead of her having to watch me sleep and nap in the chair. I actually look for things to do again. WONDERFUL!!! M 43 1 months
3/30/2007
 5  narcolepsy, diagnosed by a mslt break-through bleeding even though i was taking birth control pills, i discontinued the birth control pills since provigil lowers their effectiveness and i had break-through bleeding; on days when i have taken 400mg i had massive headaches, but i haven't had any headaches at 200mg (the dose we determined i need) the first day i took provigil i felt 'awake' and 'energized' for the first time in over ten years...it gave me more energy than i was used to, which was a 'normal' level - not hyper...i still have trouble waking up in the morning because i feel so absolutely horrible when i wake that i want to die (this pre-dates provigil, but provigil has not improved this except for the first week on it)...i sometimes snooze my alarm for an hour or more before waking up without realizing that im doing it half the time...but once i get up and take provigil, i gradually awaken to my normal self again within an hour...also, i havent had any sleep attacks during the day at work or had to take a nap at lunch in my car since i started the medication...and i can concentrate again, which is great! im still late for work frequently as i find it near impossible to wake up in the morning, but im lucky to have an understanding boss! F 28 1 months
9/24/2008
 5  sjogrens, sleep apnea strong urine, morning rush, hyper with too much coffee, must take sleeping aide. The first two week "rush" does become regular life. I love it. I feel like my life would not be worth living without it. I feel 20 years younger. My depression lifted. My weariness lifted. My joint and muscle pain stopped and my energy went from 0 to 100. My body is working on keeping up. F 41 1 months
11/13/2005
 5  Major Depression Early a little increases anxiety but not overwhelming. I have tried 4 antidepressants Lexapro,Remeron,Wellbutrin and I am currently on Zoloft and Lamictal which keep me slightly above the bottom. My days are usually full of heavy depression related tiredness. The Dr prescribed me Dextroamphetamine 10mgs to take on the bad days. This gave me immediate results knocking out the depression the day I take it and the positive effects lasted up to 2 days after taking it. He said I could just stay on it but since it is addictive perhaps Provigil would work as well on a daily basis. I started the first 2 days on 50mgs and it worked beautifully keeping me alert and depression free. On the 3rd day it did not feel as effectve so I upped it to 100Mgs first thing in the morning at 6AM on an empty stomach and within 1 hour I am alert and feeling great. This is an expensive drug with no US generic. My insurance will not cover it. I buy the generic overseas "Modinifil" for a fraction of what the brand name sells for here. It worked the same as the Provigil samples I got from the DR. THis is not an approved med for depression which is a shame. As long as it works I will never stop it. M 57 1 months
100 MG 1X day
7/8/2012
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 5  MS Tinnitus and jitters. I've been taking Provigil for 2 years. It's helped me a lot. I also take Baclofen for tremor but the side-effects add to my MS Fatigue and I have trouble doing anything. I recently upped my dosage from 200 MG to 400 MG per day and I've noticed tinnitus (noticed! It's hard not to notice - but it's worth it.) M 46 1 months
100 MG 4X day
9/25/2010
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