MIRAPEX Reviews (PRAMIPEXOLE DIHYDROCHLORIDE)

Average Rating: 2.8 (431 Ratings)

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 EXTRAPYRAMIDAL MOVEMENT DISORDERS

 Type: Rx Drug

  

MIRAPEX  (PRAMIPEXOLE DIHYDROCHLORIDE):  Pramipexole is used alone or with other medications to treat Parkinson's disease. It can improve your ability to move and decrease shakiness (tremor), stiffness, slowed movement, and unsteadiness. It may also decrease the number of episodes of not being able to move ("on-off syndrome"). This medication is also used to treat a certain medical condition (restless legs syndrome - RLS) that causes an unusual urge to move the legs. Symptoms usually occur at night along with uncomfortable/unpleasant feelings in the legs. This medication can decrease these symptoms and thereby improve sleep. Pramipexole is a dopamine agonist that works by helping to restore the balance of a certain natural substance (dopamine) in the brain.   FDA Approval Date: 1997-07-01 (Sources: U.S. Centers for Medicare Services, FDA)

  

Results are sorted by Gender with females listed first (reviews with no gender reported listed before females).

Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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RATING  REASONSIDE EFFECTS FOR MIRAPEXCOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 1  Rls I took the pill few hours before bed time. I immediately started vomiting it continued all night until eleven the next morning. I had terrible headache for two days felt extremely weak still had nausea after two days. I also had flu like symptoms and felt drugged. I don't know if the dose was to strong but I will be looking for something else. Would not recommend the drug.. F 66 1 days
1
8/13/2015
 1  restless leg Lost money, jobs,divorce, alcohol abuse,and spending sprees F 45 7 years
25
3/25/2015
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 1  Restless Legs compulsive gambling, feel asleep while driving, helped with RLS but ruined my life! Mirapex caused me to become a compulsive gambler. It has put such a financial strain on my family. I also have become very depressed because of the person it turned me into. I've had a hard time forgiving myself for the things I have done and the pain I have caused my family. I had no idea Mirapex was the reason I had become this way. STAY AWAY!! F 39 1.5 years
1 1X day
5/21/2015
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 1  Fibromyalgia Immediate massive headache, muscle twitches, inability to sleep, and didn't feel like myself. I knew immediately that this drug was messing with my head and would do the same damage to my life that Ambien did. Not worth the side effects at all. F 46 1 days
.5mg
6/2/2015
 1  Restless leg syndrome Severe gambling addiction and shopping addiction I would not recommend this drug to anyone. It has ruined my life. I have lost everyone close to me. Since discontinuing this medication, I am no longer addicted to gambling I have suffered severely from taking this drug. Any comments from anybody else who also affected with an addiction from taking this drug or Its generic, Pramipexole, please don't hesitate to contact me. F 65 10 years
3 MG
1/4/2015
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 1  rls after 1 month started getting rls10x worse..during the day...in other parts of my body...twitching in the face, legs all over horrible...tried to taper off and had terrible withdrawal spent all night pacing for 3 days before giving up.. F 60 4 months
.125
7/24/2014
 1  RLS Woke up groggy with the worst sinus congestion I have ever experienced; horrible headache and neckache; weakness in limbs; nausea. This scared the heck out of me - I only took a very small doseage because I am so tired of RLS symptoms. I did feel, for the first time in years, my body totally relax and the RLS vanished - NOT WORTH IT! When I woke up, the side effects started. Thank God I found this website - I'm just now coming out of it - the half life time is about 12 hours for someone my age. I'm on my way to the health food store to see if there are any natural ways to help control RLS. F 64 1 days
12/28/2009
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 1  Brief User--Beware Mirapex is a dopamine agonist. Dopamine is the neurochemical in your brain that , when hyperaroused, can cause OCD in people, exacerbate OCD in others (like myself), and cause rapid mood swings due to its short half-life. Dopamine is not a chemical of pleasure per se. It is actually a chemical in our brains that is used to reinforce positive experiences by hitting a high (as during orgasm) and then dropping to a low (after sex). By the up and down sudden rise and fall in dopamine, a person becomes "addicted" to the experience. That is why an orgasm is so addictive. Same with cigarettes and caffeine. I was fortunate in that Zoloft was making me dull after two years on it for depression. I took Requip in tiny amounts and it got me hooked on a new hobby (dopamine rise and fall)--World War II. I took Seroquel at night, which dampens dopamine a bit, and thus was able to adjust dose to finally allow my hobby to become part of my life without triggering OCD. Higher amounts of Requip brought back OCD--which comes from too much active dopamine. So, dopamine "rise and falls" are how we get hooked on things. F 45 1 days
11/11/2009
 1  RLS Severe weight gain 50+ excessive sleepiness during day, incontinence Worked for the RLS but didn't figure out the problems I experienced were from the medication until I did research on the Web. I would never take this again. F 53 1.5 years
11/12/2009
 1  RLS compulsive gambling! started mirapex on lowest dose it worked great but had to increase to 1mg. after about a yr. Then the gambling started and became gradualy uncontrolable. I have to try to overcome this terrible compulsion, I have a drs. appt. but not for another 2 weeks, I pray he can give me something else to relive the rls as it is the most miserable pain I'v ever experienced. I also have dizzeness, nausa, slight memory problems. But the gambling is running my life. Ican't deal with the self louthing as well as the finacial devistation after a binge (for lacke of a better word) I saw the warning this med causes but thought gambling,thats crazy. Take the warnings serious. DO NOT START THIS DRUG!!!!!!! F 57 2 days
11/18/2009
 1  RLS paranioa.confusion,mental changes,sucidal thoughts,halluciations i only took mirapex for five months and i had these symptoms and i almost killed myself because of the hallucanations and i cut my left wrist.luckly i did not die so if there is anyone with a story like mine please email me F 33 5 months
10/15/2009
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 1  severe rls tics in eyelid lasting about 3 weeks. Ongoing tearfulness and unexpected crying at work. spending spree can not emphasis the problems this side effect has on daily living. Eating benge cant figure out why I am eating and have wieght gain and water retention. Hypersexuality (controlled but exessive for this patient and unwanted due to unmarried status) too much flirting.No gambling but other problems are similar to gambling and risk taking. Calming effect translated into lack of concern for daily routines such as bill paying and work requirements. I sleep much better. I quit some of my activities(reduce stress) and will discontinue its use immediately. F 46 4 months
5/24/2008
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 1  RLS OCD type behaviors, selfishness,Money mangement and overall personal worth diminished,Approx 40 lbs weoight gain in 4 mos,Massive appetite for sugar products,over all personality change, suicidal at times, depression, anxiety and loss of energy Since on the drug wife has become very self absorbed and irrational,started compulsive shopping for items of no use,Began online chatting with strangers,Drove our company into bankrupcy,suicidal at times,very bizarre behavior which is unlike her since taking mirapex,Doesnt seem to have priorities in line like childrens welfare, house cleaning etc.Sometimes goes 2 days without showering,She also takes MS contin (morphine) for back pain in conjunction with this drug, F 36 4 months
1/29/2009
 1  Restless Legs Sydrome I started taking this drug in August 2004 weighing 140 lbs (5'8"). It worked miracles for my RLS symptoms. I experienced some augmentation, but was willing to live with it. By April 2004 I weighed 148 lbs, but didn't think to attribute the gain to Mirapex. By January 2006 I weiged 160 and in January 2007 173 lbs. That's a 33 lb gain in 2 1/2 years. I work out a lot and watch my weight, but still it's extremely hard to lose the weight. I have also had weird "spells" that neurologists think are partial seizures, but I think these are not seizures but altered consciousness from Mirapex. I also have developed a terrible short-term memory. I have a Ph.D. in philosophy. I've written three books and I'm very accomplished, so I couldn't understand how all this is happening to me. Now I think it's the Mirapex. The only other drug I take is synthroid, but only for the past few months. I'd like to find some good alternatives to deal with the symptoms of RLS. Next I'll explore acupuncture. F 48 4.5 years
1/5/2009
 1  RLS Nausea, diarrhea, lightheadness/fainting spells, headache, sweat and chills. I've suffered from RLS for about 10 years. My doctor gave me a prescription of Vicodin to take--1 or 1/2 tablet before sleep to help with the symptoms--and a prescription of Mirapex. The vicodin has been working for, but I'm not too thrilled about taking codeine every night. So I tried Mirapex one time and believe me, I will never take it again. I felt as if I had been poisoned, and had all the symptoms of poisoning. I had alternate sweating and chills, diarrhea. I fainted twice when I got up to use the bathroom, and I threw up continuously for about 10 hours. Aside from the physical, I was very agitated and nervous. I did not have food poisoning because nothing I ate was different from what my family ate. I have never been so sick in my entire life. It was a horrible, horrible experience. If you have had side effects like mine, you are not alone. F 29 1 days
1/18/2009
 1  RLS 3 lbs/month weight gain, shifted but not relieved pain in my legs, very vivid dreams. The .25 mg dosage is no longer effective. But I'm 9 lbs heavier and feel deceived by the doctor at the sleep clinic who should have clearly explained this common side effect. I am so angry with Dr. Wright at the Minnesota Sleep Clinic who didn't warn me of the weight gain side effect. My RLS symptoms were so mild. Now I have to deal with this massive weight gain and the self esteem problems that go with it. F 47 4 months
3/23/2009
 1  parkinsons At first, it worked well, I could sign my name again and the tremors stopped. However, I had nausea, vomiting and fatigue, which I hoped would clear up in time. Instead, these symptoms intensified over the next 5 months. I was also experiencing increase depression and anxiety. I was napping 3 times a day and still sleeping all night. The first day I went off, I had amazing energy, no upset stomach and could eat chocolate again. The second day off, I did have some withdraw symptoms, like muscles aches and fatigue. These past. For me Miraplex goes on my list of evil drugs, along with Effextor. For weeks my husband told me the problems were due to the Miraplex. I couldn't believe him. I think the drug clouded my thinking ability. F 49 6 months
9/29/2008
 1  Severe RLS Chronic headache, diarrhoea, nausea and unable to get out of bed for over a week until I stopped the tablet Within two days of taking the smallest dose of Mirapexin, I was confined to bed feeling more ill than ever in my life. I thought my head was going to burst, one sip of water gave me chronic diarrhoea and the nausea was unbearable. Never again. F 56 10 days
4/13/2009
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 1  Restless legs Hives, itching, poor sleep, but the worst thing was the deep depression with paralyzing sadness and a feeling that my heart was breaking. I am so glad I figured out that it was the Mirapex causing my depression. I was almost ready to go back on Effexor when I decided to just stop the Mirapex instead. I felt better in one day and, after two day off of it, I feel fantastic. I still have the RLS, although it has gotten better as I get my ferritin level up. In the case of Mirapex for RLS, the medicine is worse than the disease. At least with RLS, once I get to sleep, I sleep well. With Mirapex, you wake feeling like you haven't really slept, which might be what causes the depression. Lack of sleep shrinks the amygdala, the part of the brain that processes emotion, and small amygdalas are linked with depression. F 51 5 weeks
8/9/2008
 1  restless leg syndrome I vomited after about two hours and the medicine did absolutely nothing for my restless legs. I have severe RLS. It occurs every time I lie down. Klonopin has not worked and the only meds that have worked are Hydrocodone. I'm about to try Requip. F 51 1 days
9/18/2008
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