MIRAPEX Reviews (PRAMIPEXOLE DIHYDROCHLORIDE)

Average Rating: 2.8 (431 Ratings)

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 EXTRAPYRAMIDAL MOVEMENT DISORDERS

 Type: Rx Drug

  

MIRAPEX  (PRAMIPEXOLE DIHYDROCHLORIDE):  Pramipexole is used alone or with other medications to treat Parkinson's disease. It can improve your ability to move and decrease shakiness (tremor), stiffness, slowed movement, and unsteadiness. It may also decrease the number of episodes of not being able to move ("on-off syndrome"). This medication is also used to treat a certain medical condition (restless legs syndrome - RLS) that causes an unusual urge to move the legs. Symptoms usually occur at night along with uncomfortable/unpleasant feelings in the legs. This medication can decrease these symptoms and thereby improve sleep. Pramipexole is a dopamine agonist that works by helping to restore the balance of a certain natural substance (dopamine) in the brain.   FDA Approval Date: 1997-07-01 (Sources: U.S. Centers for Medicare Services, FDA)

  

Results are sorted by Gender with females listed first (reviews with no gender reported listed before females).

Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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RATING  REASONSIDE EFFECTS FOR MIRAPEXCOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 2  For Secondary Progressive MS F 45
1.5mg 1X day
12/21/2010
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Patient History
 2  RLS At first, I had no side effects. Until reading this forum, I thought I was coming down with Parkinson's because I have a chronic shake! I don't drink or smoke and eat well, healthy life style. Now I shake, I have chronic headaches, very vivid and wierd dreams, disoriented, heavy night sweats and a vague feeling of being disassociated. I've gained weight and it only helps my RLS a little. I think I'll go off of it and just exercise my RLS away, gotta be better than walking around like a shakey old lady. I usually only take 1/2 of .25 mgs, still have many side effects. Tired of the shaking and headaches. F 52 6 months
.25 1X day
2/3/2010
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 2  parkinson's disease I am writing on behalf of my 49 year old mother. This drug has caused hell to everyone in our family. It got worse overtime the longer she was taking it. She gained about 40 lbs and she was hungry all the time(thats not the severe part). She was obsessed with shopping and would buy things she couldn't afford and just return them. She repeated this behavior 24/7. She would redecorate the house constantly! She started to get extremely paranoid and suspicious of EVERYONE! She trusted no one and thought everyone was out to get her! She did was abit delutional also. My dad divorced her over this was he couldn't take it anymore. Her mind was so clouded that she believed she was right and everyone else was wrong. She concentration and decision making was a total mess. It was like giving direction on common sense situations to a 13 year old. Her sex drive was out of control to the point where she wanted it so much that she even slept with my friends boyfriend( something she would If anyone feels any of this feel free to email me if you have questions. My email is [email protected] F 49 5 years
1 mg 3X day
2/26/2010
 2  Parkinson At first,no side effects.very vivid and wierd dreams, disoriented, a vague feeling of being disassociated. I've gained 42lbs . when I go off it I to am like a shakey wobbley old lady. This drug has caused hell to everyone I come in contact with. It got worse overtime the longer I take it.I am hungry all the time. obsessed with shopping and would buy things I couldn't afford. I am very suspicious of my husband, no trust in him. my mind is so clouded that I believed I am right and everyone else was wrong. My concentration and decision making is a total mess. compulsive computer use; restlessness - need to be active; tired all the time, but can't rest; all of these behaviors are totally new to me - I don't like having these feelings.compulsive gambling! started mirapex on lowest dose it worked great but had to increase to 1mg. after about a yr. Then the gambling started and became gradualy uncontrolable. I have to try to overcome this terrible compulsion, slight memory problems. But the I ditto many comments so I cut and pasted and altered them in my side effects. Will Someone - please tell me what are the alternatives!!! F 58 6 years
1.5 3X day
3/10/2010
Email
 2  rls insomnia, agitation, not able to rest, extreme emotional sensitivity, depression worked originally very well for rls, then had to take higher and higher doses...couldn't determine what was making me so agitated. awake for hours on end F 53 5 years
2/9/2006
 2  Restless Legs Everything was great on Mirapex until I started having weird buzzing feeling in heart and heart rate sent me to the ER. Twitching now is far worse than before I was taking Mirapex. I tried to wean myself off of it and the RLS was so bad.. it felt like I was having epileptic seizures in my lower calves. I have had to see a Cardiologist and they did CT of heart, EKG, Stress Test, Holter Monitor and now wish to perform a cardiac catheterization because they cannot figure out what causes my heart rate to go from 88 to 133... Last night.. I purposely did not take Mirpex and then the twitching got so bad that I had to find it... and take it..(I split the pill in half) and BAMB!!! I could feel my heart pounding and the weird buzzing sensation in my chest. I am going to pay dearly tonight.. going cold turkey.. but I do NOT take any other pills or prescriptions. Mirapex... I think it caused some heart problems for me. F 43 8 months
10/14/2007
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 2  fibromyalgia Started off on very low dosage. When I got to 50mg, experienced increasingly frequent palpitations. Withdrawal made them worse for a few days along with very vivid dreams. Seemed to help the fibromyalgia but not worth the side effects. F 60 2 months
7/8/2006
 2  RLS I've taken mirapex for about 4 weeks - I've had very memorable or emotion-laden dreams, my left leg and foot have had muscle spasms/cramps; I've been unable to get to sleep, I've felt increasingly anxious and depressed since I'm already taking other meds for depression, I can't sort out what is mirapex vs. non-mirapex; I don't know how bad the RLS is/was, but (IMHO) I feel worse than 'before' F 55 4 weeks
4/16/2005
 2  Fibromyalgia neurological twitching I made 2 attempts to try Mirapex. Both were terminated within 48 hours due to severe side effects. During the early hours of the 2nd attempt, hives, itching and rash resulted in my needing to immediately discontinue using this medication. Mirapex did seem to lessen the constant twitching. Unfortunately, the side effects made it intorerable to continue taking this medication. F 53
2/8/2005
 2  Parkinson's Disease occasional sleepiness; leg cramps I've been taking Mirapex for 9 months and have not noticed any improvement with my tremors or rigidity. My dosage was increased to 1mg after 3 months. I'm still shaking like a leaf. F 37 9 months
6/18/2004
 2  fibromyalgia Nausea and loss of appetite. Taking it with food seems to help the nausea, but not the appetite problem. Talk about a vicious cycle! Don't see much, if any, improvement with this med. I still hurt as much as ever and still have non-restorative sleep (and horrible fatigue). I am no longer sleeping all day and I'm sure it's the mirapex, but now I'm awake and in pain instead of being able to go sleep through it. I'll give it until the refills are gone and then go on to see what the next experiment will be. F 39 1 months
12/8/2004
 2  RLS A little nausea I didn't have bad side effects, but it didn't help the RLS one tiny little bit. F 26 2 weeks
7/10/2007
 2  RLS For the first couple of weeks, I felt fine. My RLS had died down a bit, and I was beginning to sleep better at night. However, in the couple of weeks, I have began to experience intensely weird dreams, lack of energy, paranoia, depression, fatigue, and a return of my RLS, although not as bad as before. My stress level feels like it's risen about a thousand times for absolutly NO reason what so ever, and nausea has also become a problem, mostly in the mornings. Upon waking, I feel rather hung over which makes it extremely hard to start the day. Hunger/cravings are limited until about three hours before I go to bed, at which point I feel like I've been starving all day, even though I haven't felt hungry at all before then. RLS is still HIGHLY prominent during the day. F 17 4 weeks
5/21/2007
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 2  restless leg syndrome & plmd Headached, fatigue, woozy the next morning, very fuzy headed in the morning. clumsy. Fuziness stayed with me through the day. Was prescribed for periodic limb movement disorder and restless leg syndrome. It DID help the restless leg disorder but I don't care for the side effects F 51 1 weeks
7/15/2007
 2  Primary RLS Have been on Mirapex for 5 weeks, having stopped Gabapentin to try the Mirapex. At first, it worked well - even better than the Gabapentin - no breakthrough symptoms. Sleep disturbances did not improve, however - have great difficulty falling and staying asleep in spite of either medication... even though my legs are more relaxed. Recently, symptoms much worse! Terrible muscle cramps and spasms, nausea, pounding heart, headaches, tiredness and fatigue, and in the last two weeks, I have developed extreme stiffness in all my joints and muscles. I don't seem to be able to "walk it off", either. I have also been having a lot of mid-back pain which has been increasing over the past three weeks. My side effects are now bad enough that I must consider stopping the medication. What started out as a "miracle" is now a "nightmare". So far, I have tried three different meds for my RLS, and the net negative impact was the "least" with gabapentin - even though I did not experience complete relief. I have severe to moderate primary RLS which I have had since I was too young to even remember. It started out as only an feeling of "ants and crawliness in the legs".. now I get throbbing pain as well as extreme jitteriness/ ants in the legs. Worse... it is no longer confined to my legs, or even my arms and legs. The worse experience I have is when it actually affects my entire body - perhaps the progressive nature of the disorder. I am glad that there are finally treatments and a name for this disorder... for years, doctors and friends thought I was "really weird"! I just hope they come up with things that really work,and that my insurance will cover (Requip is not covered, so I haven't been able to try that one yet.) F 51 5 weeks
11/1/2007
 2  for nerve endings instantly bloated, constipated, can't sleep, if i take more than 1 pill I become hot, dizzy, nauseous. Can't keep my eyes open during the day (even tried taking it early in the day thinking by bedtime i could sleep, didn't work) I took this for a few days felt horrid (nauseous, hot and dizzy) and stopped. Told my Dr. I would try again and now I can't sleep for more than an hour at a time at night, I immediately felt bloated and swollen (clothes are tighter) and have an increase in appetite, and constipation. I think I will stop after reading everyone's similar problems. F 28 3 days
1/24/2008
 2   Severe weight gain, compulsive eating, twitching, fragmented sleep, waking up after several hours of sleep, nearly impossible to drive during the day works ok for the restless leg, but I am now pushing 300 pounds, and can't seem to stop eating. F 34 2 years
11/24/2008
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 2  PLMD clinically documented constipation, severe unrelenting temper tantrums, OCD type behavior, sensory issues, difficult to wake up in morning, possible visual hallucinations It was definitely causing terrible tantrums over trivial things, i.e. her pants didn't fit right or we were out of peanut butter. She had a terrifying hallucination this morning even though she has been off of it for a week. I could not take this drug myself, but have no memory of the time in which I took it. I definitely do not recommend this drug for people with mood disorders, either potential or diagnosed. F 7 21 days
12/7/2008
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 1  RLS Constipation, bloatedness, nausea throughout the day, overwhelming sadness, binge eating, weight gain, hives on arms, itching, chest pains, hot flashes, headache, agitation, teeth clenching, joint pain, after 4 hour sleep, I'm wide awake, almost ran a red light while driving All this after only 5 days! This is a dangerous drug. I would not recommend taking this medication to anyone. I stopped taking it and am starting to feel like my old self again. I'd rather deal with the tingling in my legs then those side effects any day. I think this drug should be recalled. F 51 5 days
4/23/2008
 1  RLS I am writing on the behalf of my mother whom has nearly lost her mind because of this drug.It is very dangerous! Unaware of what she was doing my mother became an Obsessive Compulsive Gambler.She has lost over $500,000 in the last year.It wasn't until the money was gone and she was off her medication did she relize what she had done.By then it was too late.Now my mother owes the IRS a lot of money and they don't want to here about what Myrapex did or did not do.She has lost her home and probably most of her children.What make this even harder is that my dad died for the money that she gambled away. I have not heard of this medicine causing this side effect until my mothers Rhumetologist told her what it was doing to her. He noticed the changes in her from the moment she started taking it and he discontinued the medicine.The OCD brought on by this drug does not appear to effect people with Parkinsons Disease as it does those whom take it for RLS. I wish everyone the best and I hope your story does not end like ours.May God be with you. F 39 1 days
4/29/2008

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