METHOTREXATE SODIUM Reviews (METHOTREXATE SODIUM)

Average Rating: 3.3 (383 Ratings)

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 ANTIMETABOLITES

 Type: Rx Drug

  

METHOTREXATE SODIUM  (METHOTREXATE SODIUM):  Methotrexate is used to treat certain types of cancer or to control severe psoriasis or rheumatoid arthritis. It may also be used to control juvenile rheumatoid arthritis. Methotrexate belongs to a class of drugs known as antimetabolites. It works by slowing or stopping the growth of cancer cells and suppressing the immune system. Early treatment of rheumatoid arthritis with more aggressive therapy such as methotrexate helps to reduce further joint damage and to preserve joint function.   (Sources: U.S. Centers for Medicare Services, FDA) FDA Approval Date: 1953-01-01

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
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More on METHOTREXATE SODIUM: Reviews Summary  |  FDA Adverse Event Summary

RATING  REASONSIDE EFFECTS FOR METHOTREXATE SOCOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 3  psoriasis/psoriatic arthiritis originally on 15mg once a week for 3 months. No improvement in skin, completely stopped painkillers for joint pain. Upped dosage to 20mg once a week. Bleeding gums, really sore, loose teeth!feeling completely washed out, more joint pain,bad headaches almost constantly, bad flu like symptoms(maybe flu). Doc organised blood tests, no results yet. Dosent help being diabetic!!! M 46 5 months
4/28/2005
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 4  psoriatic arthritis Initially, extreme fatigue, some hair thinning, mouth sores, some bowel disturbance. Began at 7.5 mg weekly. Now at 17.5 mg weekly. My Dr. increased folic acid dosage and that has helped with fatigue and mouth sores. Drink lots of water when taking this drug! Has almost cleared psoriasis. Has decreased arthritis flares but still lots of joint tenderness and aching. F 50 9 months
4/12/2005
 3  Inflammatory arthritis Fatigue/apathy, fuzzy memory, some hair loss, really feel the cold, and every few months I get a really bad headache together with sickness which puts me out of action for a day, with a few days to get my appetite back and get fully back to normal. Specialist denies any of it being tablet related so there’s been no investigation or confirmation of whether it definitely is the methotrexate or not... I’m really not comfortable being on methotrexate but it does seem to be working and I have less joint pain…its just a shame I’m too knackered to enjoy it! F 30 2 years
4/11/2005
 2  Morphea Nausea, chronic fatigue causing lack of interest in most things, headaches, loss of short term memory, mouth ulcers, emotional, dry mouth and throat F 32 6 weeks
4/2/2005
 3  Severe RA and Psoriasis Sore gums, weakness and fatigue for a couple of days after dosage, minor scalp tenderness, hairloss I take 15 MG per week. There has been some improvement in the intensity of pain related to the RA- from severe to moderate on most days now. Psoriasis has improved more than RA. F 44 7 weeks
3/23/2005
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 1  RA Ill feeling the next day after taking, nausea, Low blood count dizzy. I am writing to warn the elderly of this medicine. My father just past away last week from Methotrexate. All doctors stated that it was the Methotrexate that shut down his Kidneys, and main organs, So if you are an older adult. BEWARE. This was fast, my Dad was working just 7 weeks ago, and now he's gone. M 72 10 years
3/23/2005
 3  RA Hair thinning F 46 4 months
3/9/2005
 3  RA hair loss, light sensitivity (vision), dizziness, mouth ulcers, periodic stomach cramps was taking orally for 2 years, recently switched to injections...that is when I noticed the hair loss....I'm going to be more on top of taking my folic acid F 31 2 years
2/22/2005
 4  uveitis/SLE Nausea and general achy, fluish feeling for up to 48 hours after 1 mg injection. Extensive fatigue. Thirst! Extreme sensitivity to sunlight -- must use lots of sunscreen. For one or two days I feel awful. For the rest of the week I feel better than I would on steroids. By the way, taking methotrexate allows me to be mostly steroid free. 44 34 months
2/16/2005
 1  chron's dizzy, really really dizzy F 17 6 months
1/29/2005
 5  RA Not very many, mainly stomach F 46
1/27/2005
 4  RA dry throat, slight cough, and my memory seems to be slower (might just be age). also i get an ear infection that keeps coming back. nothing too serious. i take 15mg a week with 5mg folic acid one day before and one day after took a few months to work but reduced my symtoms from being nearly crippled to some stiffness in the morning and the occasional twinge. i hope it doesn't fuck my liver and i can stay on it for years. M 59 18 months
1/14/2005
 4  Rheumatoid Arthritis Major hair loss, nausea, headaches F 28 1 years
1/11/2005
 1  Rheumatoid Arthritis Extreme back pain, prostatitis, general weakness, and it did relieve the RA Symptoms, but incapacitated me in the process. My reaction was probably idiopathic...it may work well for some people, but there needs to be some genetic testing or other predictor of how the side effects will develop in individuals. M 74 1 weeks
1/11/2005
 3  psoriatic arthritis For the first five months, actually, I didn't notice much of anything, but now that my rheumatologist increased my dosage, I'm starting to feel the shortness of breath and dizziness that every side-effect page has since warned me about. Since the dizziness came with a sore back, a sore throat, a fever, and a cough, I assumed it was the flu or something similar. Methotrexate for me has worked really well for the first few weeks after I started it, and the first few weeks after my doctor increased the dose. But afterwards, I have had pain every morning and some days when it is almost unbearable, although for the most part after noon, the pain is controlled, while the swelling remains constant. F 17 7 months
1/10/2005
 1  ra hairloss not effective in my case. Even taking 8 mg of prednisone a day, I still have disabling swelling and pain. F 36 9 days
12/8/2004
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 3  RA some naseau and intestinal complaints for many years but increased infections including pnemonia. Had to stop taking for 2 months recently due to pnemonia. After restarting the side effects are far worse including naseau/vomitting (couldn't keep anything down for 3 days). Severe headache that kept me pretty much bedridden and also diarhea. It is very effective. During the two months that I wasn't taking it, I became painfully aware of what it was doing for me and couldn't wait to begin taking it again. Not sure that was so smart at this time though due to the new side effects F 47 7 years
12/7/2004
 3  Athritis Fatigue, sickness (mainly for the first 2 days after taking it) feeling DEPRESSED for the whole week, wanting to die. Why me? At this age? Hasn't really made much different to the painkillers and anti-inflamatorys I was already on! M 18 2 months
11/26/2004
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 5  Rheumatoid Arthritis Vomiting, Nausea, Anorexia Ive lost about 10 Kilos taking this stuff. Makes me feel sick and has killed my appetite but it works really well plus it kicks in fast (about 3 weeks). I can put up with the side effect because it works so well. M 48 16 months
11/23/2004
 3  sarcoidosis stage IV and asthma stomach problems with the initial weekly dosage. Thursty, easily agitated and tired. I have been on high doses of prednisolone 100mg daily for 5 years. My sarcoidosis is in the fibrosis stage and the methotrexate is helping me lower my dosage of prednisolone. With my white blood count high my doctors are trying to lower the prednisolone to 10 mg a week and switch to remicade with the methotrexate. I have been researching the side effects of methotrexate and remicade. I have monthy blood tests now and so far so good. If anyone else has sarcoidosis and is on methotrexate and remicade I would appreiate your comments. F 51 6 months
9/20/2004

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