METHOTREXATE SODIUM Reviews (METHOTREXATE SODIUM)

Average Rating: 3.3 (383 Ratings)

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 ANTIMETABOLITES

 Type: Rx Drug

  

METHOTREXATE SODIUM  (METHOTREXATE SODIUM):  Methotrexate is used to treat certain types of cancer or to control severe psoriasis or rheumatoid arthritis. It may also be used to control juvenile rheumatoid arthritis. Methotrexate belongs to a class of drugs known as antimetabolites. It works by slowing or stopping the growth of cancer cells and suppressing the immune system. Early treatment of rheumatoid arthritis with more aggressive therapy such as methotrexate helps to reduce further joint damage and to preserve joint function.   (Sources: U.S. Centers for Medicare Services, FDA) FDA Approval Date: 1953-01-01

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on METHOTREXATE SODIUM: Reviews Summary  |  FDA Adverse Event Summary

RATING  REASONSIDE EFFECTS FOR METHOTREXATE SOCOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 4  PA Nausea, Feeling Unwell (10mg weekly), Reduced dose to 7.5 mg weekly with 2 days instead of 5 feeling unwell. Fatigue, nausea. Also experienced a DVT last year which may or may not have been a result of the drug/health condition? Have overwhelming feeling of numbness in legs/lumbar region, walking as if on sponge cake. Cannot run or do excessive exercise as this exasperates my condition. Additional care because I am on Warfarin due to DVT. Not sure about this drug, could say that I'm concerned about the long term effect on internal organs. Had to insist on a lower dose from 10mg weekly to 7.5mg weekly due to increased nausea and generally feeling un well. Similar to having eaten something which makes you want to lie down all the time to help with the problem of fatigue and nausea. M 47 18 months
10/11/2005
 3  rheumatoid arthritis Mouth sores initially. After about 3-4 years memory loss and breathing problems started. Neurologist suspected Altzheimers?. Had to discontinue. Could go long periods with no pain killers. Seemed to stop RA progression. For last two years received Remicade infusions every two months. F 79 4 years
10/10/2005
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 2  RA Nausea, fatigue, inability to concentrate I used mtx before without side effects. Went off for personal reasons and when I re-started I experienced nausea and fatigue, which I could cope with, but the fact that I could no longer add and had difficulty paying attention (while driving!) has left me looking for a new DMARD. Otherwise, mtx helped with flares. F 39 6 months
10/3/2005
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 5  rheumatoid arthritis When taking it during the day I felt nausea but since taking it before bed, I am fine. I get mouth sores but since being prescribed folic acid, that has cut right down. I call it "magic". I have been on it for about 18 years and if I wasn't on methotrexate, I would have been in a wheel chair years ago. I am still working full time and rarely have any pain, swelling, etc. F 62 18 years
10/2/2005
 4  RA I've been taking Methotrexate (20 mg. weekly) for a year. I was in a major flare up when I started and it has helped tremendously. I do suffer from fatigue and hair loss, but if I listen to my body and rest when needed I manage to live a fairly normal life. F 53 14 days
9/6/2005
 3  Psoriatic Arthritis Severe fatigue (bedridden) the day after the dose (10-12 mg) and sometimes the day after. Mouth is sore but no visible/treatable sores, a head full of cotton, can't think straight I have a few good days between weekly doses but if I happen to catch a virus I'm in bed with that. Doc said it takes time to adjust; after four months it's starting to get better F 48 4 months
9/6/2005
 3  Lupus Headache and sore mouth I haven't been on it long so I'm checking out this site to see if the side effects are normal and worth the benifit that the drug might bring to Lupus pain. F 31 2 months
9/2/2005
 3  Rheumatoid arthritis Loss of hair! I took methotrexate for about a year, and it worked ok. It was certainly better than nothing! Then my hair started falling out by the handful! Taking Enbrel now. Much better for me. F 50 1 years
8/24/2005
 4  Lupus and RA Nausea, vomiting, hair loss, extreme fatigue, sun sensitivity I have no pain for the first time in years. I wish the side effects were less. I can't decide if I want to deal with the pain and stop methotrexate or deal with the fatigue F 44 7 weeks
8/23/2005
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 4  palindromic arthritis nausea and dizziness the first few weeks, but it went away. I take 15mg a week and when they tried to increase it the nausea and dizziness came back and didn't go away so I went back to 15. Helped with severity and length of flares. F 67 2 days
8/14/2005
 5  Psoriatic Arthiritis None apart from raise liver thingys. I take Meth and Enbrel and it is a miracle combinaiton. My Psoriatic patches dissapear back into the woodwork, and the pain is gone like a wild goose in winter! M 70 2 years
7/25/2005
 1  RA Substantial amount of hair loss even after only one dose. Blood in my urine. I can't say for sure if methotrexate was the cause of blood in my urine because I only took it the first week, but it occured only once and it was right after i took the methotrexate. F 23 1 weeks
7/19/2005
 3  Rheumatoid Arthritis Hives on my scalp and in my ears. Initially, sores on my tongue and in my throat, but they went away. Swollen abdomen. Feelings of inability to cope and hot flashes, so it messes with my hormones and an otherwise good mood. Helps in a positive way with the stiffness so that I can move, totally does wonders for my blood pressure, and helps with some of the pain. Was on Plaquenil for 2 years until it messed with my color vision. For now, it is better than nothing (I think) and cortisone is not an option. I have to totally fail all of the cheapest and oldest drugs before I can try any of the newer ones and then I'm sure even with insurance, it will be cost prohibitive so I still won't get enough relief. I work and like my job, so I'm not ready to pack it in. If you have a doctor that tells you that your side effects are not from methotrexate, find a new doctor who wants to be a doctor instead of someone just after your money. The side effects are nasty, but having a doctor blow you off is worse. F 58 7 months
6/23/2005
 5  Rheumatoid Arthritis Dizziness, mouth sores, gums sensitivity, severe itching, skin rashes, severe fatigue day after dose The side effects are nothing compared to the pain I suffered before taking the medicine. F 41 3 years
6/20/2005
 2  AIED Dry cough, tight chest and sore throat F 40 8 weeks
6/16/2005
 4  RA Highly emotional, Dry eyes and queazy stomach the morning I take it, fatigue quickly and am ready for bed *way* earlier than normal. I've been taking it 3 weeks now and have started seeing some great improvements. My left knee's been swollen for 3 months now. I can finally see my kneecap (started 2 days ago) and today I can walk for a long time and even stand on my left leg for a time! I can't wait to go to PT tomorrow and try it out :) F 36 3 weeks
6/14/2005
 3  psoriatic arthritis I started out on 7.5 mg a week for 2 months which did nothing for me and I still had to take 2400 mg of Advil and Tylenol with codeine. Recently the dosage was upped to 15 mg a week. Right after the first 15 mg dose I developed hoarseness followed by a sinus infection and a persistant slight sore throat. I didn't take the next 15 mg dose until felt better. I now think I am turning a corner as don't need Tylenol with codeine and am tapering off of the Advil. Seem to feel better in the mornings now. F 49 3 months
6/7/2005
 4  connective tissue disorder nausea initially, but take antiemetic prior to dose which works. flu like for several days after, extreme fatigue, dry eyes, mouth/gums sore nearly all the time, irritability - just don't feel like myself. After about 6 weeks, I did notice an improvement in the joint pain. The joints on my hands in particular appear less swollen and I only require pain medicine rarely. I am concerned about the trade off or am I worse off taking the methotrexate. I don't like feeling like this and sometimes think the pain medicine was the lesser of the 2 evils. F 54 3 days
5/29/2005
 5  psoriatic arthritis Take 15mg on Saturday mornings with food and coffee. Take folic acid every day along with hydrocodone and other stuff. Sometimes, Saturdays can be a little seasicky, but nothing to worry about. If you are just starting on this drug, hang in there. I was hurt pretty badly with psoriais and p.a. About two months after I started taking Methotrexate, the psoriasis started to retreat. Pain is still there from PA in great quantity, but after first seven years of taking Methotrexate, I am virtually free of skin psoriasis and I had it all just about everywhere. Great stuff! Hang in there. M 66 12 years
5/4/2005
 5  RA Fatique quite heavy later in the day. Feel about 85% better then I did with initial flare, and after the cortisone shots for 2 months wore off, this had kicked in, and feel quite good, recently added 200 mg plaquenil. So far blood test okay. Switched to injections because of nausea, stomach upset, this has been really good, less side effects, really only fatique now! F 37 7 months
5/1/2005
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