METHOTREXATE SODIUM Reviews (METHOTREXATE SODIUM)

Average Rating: 3.3 (383 Ratings)

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 ANTIMETABOLITES

 Type: Rx Drug

  

METHOTREXATE SODIUM  (METHOTREXATE SODIUM):  Methotrexate is used to treat certain types of cancer or to control severe psoriasis or rheumatoid arthritis. It may also be used to control juvenile rheumatoid arthritis. Methotrexate belongs to a class of drugs known as antimetabolites. It works by slowing or stopping the growth of cancer cells and suppressing the immune system. Early treatment of rheumatoid arthritis with more aggressive therapy such as methotrexate helps to reduce further joint damage and to preserve joint function.   (Sources: U.S. Centers for Medicare Services, FDA) FDA Approval Date: 1953-01-01

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on METHOTREXATE SODIUM: Reviews Summary  |  FDA Adverse Event Summary

RATING  REASONSIDE EFFECTS FOR METHOTREXATE SOCOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 3  Junvenille Idiopathic arthritis sore stomach, raised liver function tests F 4 14 months
3/15/2006
 3  Psoriatic Arthritis I have only noticed side effects in the higher doses (I'm at 20 mg now and noticed side effects at about 15). Now, I get some mild nausea the day after taking the pills which usualy goes away with some food like rice or cereal. Very recently I've been getting some pretty nasty diarhea about 2 days after taking it. I've only been taking MTX for 3 months, so I'm hoping these side effects will go away once my body gets used to it. When I started taking MTX, many of my joints were affected, now only my ankles, a few fingers/toes, and my wrists are affected. So I'm not giving up hope that I will continue to find relief. F 32 3 months
2/25/2006
 5  Linear morphea None. Has helped the morphea greatly. Patches are less thick and dark. F 28 3 months
2/16/2006
 4  Lupus -SLE Extreme tiredness, sickness, facial rash, mood swings I take 20mg per week, 10mg on Tuesday and 10mg on Friday. Taking the full 20mg together resulted in me feeling very sick, loss of appetite - losing approx 10kg very quickly. Generally now I dont seem to suffer from side effects but do get tired very easily and am very, very weak on my upper body. But I am now off steroids after 8 years and feel much better F 31 9 days
2/13/2006
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 5  Psoriatic Arthritis & Psoriasis 15mg Methotrexate (MTX) / week, tablet form. A few hours after taking MTX I get extremely drowsy, so now I time it just before bed with a cup of milky hot chocolate. Sometimes the following morning I wake up with a thumping head-ache, but by mid-day the head-ache is gone, I feel groggy though (bit like jet-lag). I'm used to it now, after being on it for six years. I still have to go for monthly blood tests so that my local Hospital can monitor my Liver function. My hair pre-maturely has gone grey :-( this is definitely due to MTX because my brother who is older than me still has pigment in his hair ! But I can dye it so no big deal. I feel as though I'm a little more emotional / less patient ? but that might just be old age creeping up on me. Sometimes it takes a long time for my blood to clot if I cut myself during shaving but I've got used to that now and I'm more careful. Sometimes I take the odd 5mg tablet of Folic acid but can't say that I really notice the difference. Since being Its a horrible thing to have to take and its a life sentance but if you weigh up the pros & cons my experience is that its worth taking the risk. For me, its meant having an almost normal quality of life and has made the management of the two incurable diseases bearable. Ohh and by the way, it has NOT affected my fertility at all ! M 39 7 years
2/7/2006
 5  Psoriatic Arthritis & Psoriasis 15mg Methotrexate (MTX) / week, tablet form. A few hours after taking MTX I get extremely drowsy, so now I time it just before bed with a cup of milky hot chocolate. Sometimes the following morning I wake up with a thumping head-ache, but by mid-day the head-ache is gone, I feel groggy though (bit like jet-lag). I'm used to it now, after being on it for seven years. I still have to go for monthly blood tests so that my local Hospital can monitor my Liver function. My hair pre-maturely has gone grey :-( this is definitely due to MTX because my brother who is older than me still has pigment in his hair ! But I can dye it so no big deal. I feel as though I'm a little more emotional / less patient ? but that might just be old age creeping up on me. Sometimes it takes a long time for my blood to clot if I cut myself during shaving but I've got used to that now and I'm more careful. Sometimes I take the odd 5mg tablet of Folic acid but can't say that I really notice the difference. Since being on MTX my un-stable skin psoriasis is now very well behaved and I only have a few small patches left which I treat topically with Exorex lotion (yellow, banana based coal tar). A Huge improvement and my quality of life is 10x better ! My Psoriatic Arthrtis (PA) only effects a few of my toes and I can't help feeling that going on MTX when I did stopped the PA dead in its tracks and no new joints (thank God) have been affected since I've been on MTX. So I guess you could say I'm a happy bunny. Its a horrible thing to have to take and its a life sentance but if you weigh up the pros & cons my experience is that its worth taking the risk. For me, its meant having an almost normal quality of life and has made the management of the two incurable diseases bearable. Ohh and by the way, it has NOT affected my fertility at all ! M 39 7 years
2/7/2006
 4  Psoriatic Arthritis & Psoriasis 15mg Methotrexate (MTX) / week, tablet form. A few hours after taking MTX I get extremely drowsy, so now I time it just before bed with a cup of milky hot chocolate. Sometimes the following morning I wake up with a thumping head-ache, but by mid-day the head-ache is gone, I feel groggy though (bit like jet-lag). I'm used to it now, after being on it for six years. I still have to go for monthly blood tests so that my local Hospital can monitor my Liver function. My hair pre-maturely has gone grey :-( this is definitely due to MTX because my brother who is older than me still has pigment in his hair ! But I can dye it so no big deal. I feel as though I'm a little more emotional / less patient ? but that might just be old age creeping up on me. Sometimes it takes a long time for my blood to clot if I cut myself during shaving but I've got used to that now and I'm more careful. Sometimes I take the odd 5mg tablet of Folic acid but can't say that I really notice the difference. Since being Its a horrible thing to have to take and its a life sentance but if you weigh up the pros & cons my experience is that its worth taking the risk. For me, its meant having an almost normal quality of life and has made the management of the two incurable diseases bearable. M 39 7 years
2/7/2006
 5  Psoriatic Arthritus At first slight loss of hair and total loss of eyelashes (on one eye - very attractive!)stomach cramps occassionally but now take it at night which helps. Loss of sex drive and seem to be more forgetful. Feet and hands have improved drastically since taking it. Was worried about taking it at first and it took about 6 months to see real improvement but its worth the side effects it just to be able to dance again. F 49 3 years
1/19/2006
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 4  Sero-negative arthritis Nausea on the day of taking it, and sometimes the day after. can be pretty bad but not unbearable. Extreme problems with concentration, lethargy and fatigue - could quite happily spend the whole day in bed! I take 25mg per week and it definitely helps my arthritis. I tried coming off a couple of years ago and instantly had a bad flare up so for now I'm happy putting up with the side effects! I've noticed some people on this site are saying they've had no benefit but have only been on for a few weeks/months - it took 6 months to really kick in for me so give it time... plus the side effects get less as your body builds up tolerance F 27 4 years
1/11/2006
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 4  Ankylosing spondilitis Oral - Nausea and vomiting, bleeding ulcers, mouth sores if not taken with folic acid suppliments, occasional leg and arm ulcers, tooth deterioration. With the injectable I don't get the vomiting or stomach ulcers but I still get nausea for the first day or so after the shot and the other side effects apply to the injectable as well. Also unable to take any NSAIDS or COX-2 inhibitors without raising my liver enzymes and upping my blood pressure so I am limited to small doses of Tylenol and opiates to control my pain. This rating applies for me only when used with a TNF blocker/remover such as Enbrel, Remicade, or Humira. By itself it doesn't work nearly as well and would rate a 2. M 38 12 years
1/10/2006
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 5  psoriatic arthritis Head-ache the day after taking my weekly 15mg dose. Fatigue, but that could be due to recent weight gain from prednisone. I am off the prednisone now...yeah! Has worked wonderfully for me. My psoriasis is totally clear for the first time in 7 years. My arthritis is doing well...didn't know how much discomfort and stiffness I had until I had been on MTX for awhile. 1/9/06 F 50 4 months
1/9/2006
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 3  rheumatoid arthritis neausea, extreme fatigue, headache it helped a good deal for 9-12 months. Then it did not seem to be effective and the dr continually raised my dose until it got to the dosage that I could not handle. I went off it for several months when I started Remicade. Now I take 5 mg per week to work with the Remicade. The side effects are not as made at this dosage. F 34 19 months
1/5/2006
 4  Rheumatoid Arthritis Dizziness, Mood swings Other than the side effects this has worked extremely well for my RA. I take 25 MG on Fridays M 18 2 years
12/10/2005
 3  R A SLIGHT DIZZINESS AT THE START O.K NOW. Feel nervous taking methotrexate,a pharmacist told me to try and get my doctor to prescribe something a lot safer.I dont . honestly know if its working that well for me as noticed 3 weeks ago a deformity at the side of my right foot, it looks actually like another little toe what is for sure working is (arthotec 75) its for pain and inflamation its brilliant....... F 42 4 days
12/6/2005
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 3  
12/6/2005
 3   F 42 4 months
12/6/2005
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 4  Psoriatic Arthiritis Fatique, Memory loss, lack of concentration, and headaches. It's like I have a fog over my brain sometimes... the type you encounter with lack of sleep. It's hard to wrap my brain around thoughts and projects, like I did before I started taking it... by the way this is the first time i have seen this website. My doctor keeps telling me that memory loss isn't one of the symptoms. But these symptoms are undeniable!!! M 31 1 years
11/15/2005
 2  RA Headache, hair loss, intestinal problems, dizzy, but most of all that bothered me is the cough and shortness of breath. Weight gain as well. I have tried this medication, this will be my third time and each time, I have a cough, and tightness in my chest which makes me feel as if I can't breath. F 58 5 weeks
11/14/2005
 5  RA extreme fatigue on day of dose; slight nausea for 1-2 days after dose I've only just started it and already my RA is MUCH better. I can lift my kids again, have more energy during the work week, and my pain is dramatically improved. I was able to stop taking prednisone this week because I feel so much better. F 29 3 weeks
10/22/2005
 3  RA The only thing I have noticed is that I have had trouble staying asleep, It feels that every time I start to go to a deep sleep I wake up.. I am quite tired and do have a busy life so I don't know how much of it is the drug. Thats about it though.. hopefully that will be all.=) I am on 5mg every Friday evening and after 2 weeks will be switching to 7.5mg every Friday evening. F 25 1 weeks
10/17/2005

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