PRISTIQ Reviews (DESVENLAFAXINE SUCCINATE)

Average Rating: 2.8 (628 Ratings)

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 ANTIDEPRESSANTS

 Type: Rx Drug

  

PRISTIQ  (DESVENLAFAXINE SUCCINATE):  Desvenlafaxine is used to treat depression. It may improve your mood, feelings of well-being, and energy level. Desvenlafaxine is known as a serotonin-norepinephrine reuptake inhibitor (SNRI). It works by helping to restore the balance of certain natural substances (serotonin and norepinephrine) in the brain.   FDA Approval Date: 2008-02-29 (Sources: U.S. Centers for Medicare Services, FDA)

  

Results are sorted by Satisfaction lowest to highest.

Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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RATING  REASONSIDE EFFECTS FOR PRISTIQCOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 4  depression, anxiety Nausea during the first week or so. Restless legs, vivid dreams, decreased libido, delayed orgasm. If I miss even one dose, I feel it right away. My head feels strange, like it's swirling and I feel sort of nauseous. I also have nightmares if I miss a dose. This is the first antidepressant I've taken and it seems to be helping. I am more outgoing now and more sure of myself. I have more motivation to do things. However, I do still have suicidal thoughts and sometimes severe anxiety. Despite that, Pristiq does seem to have positive effects. F 18 5 months
6/24/2009
 4  depression The first day i experienced nausea and heartburn but that disappeard when I took it with a full meal. I have been on it for 6 weeks now and hands down it is the best experience I have had with anti-depressants.Naturally, I still have many other issues but I am not lying in bed crying and can now enjoy life.I have always had very bad sleeping issues and it hasnt done much to correct that. There are no side effects that interfere with daily functioing and I am very appreciative that my doctor gave me this. Originally he wanted to try me on cymbalta but felt it was over my head financally. F 47 7 weeks
6/21/2009
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 4  anxiety nausea in the beginning, now only side effect is sweating ALOT when i sleep i've been on almost every antidepressant out there and so far this one has worked the best for me. other than the terrible sweating at night there aren't any side effects for me. i am able to enjoy myself without constant fear of....well everything. the only problem is when i forget to take a pill i'm in BAD shape! withdraw happens the day of your first missed dose so i make sure to keep them with me all the time. F 25 1 years
6/11/2009
 4  
6/6/2009
 4  Bipolar, Anxiety Jittery, Headaches, Constipation then diarrhea, Mood swings,Delayed Ejaculation When I started taking this I had been unmediated bi choice for 9 years, I was at a breaking point where reality had to trump my pride. I went into it with apprehension to begin with. For the first couple of weeks I was miserable, but I was miserable anyway. Stick with this, Medications have changed since the last time I was on them. It does work, and the side effects do get better. It will make sleeping a little more difficult. I still take ambien to sleep, however I had sleeping problems before the meds. 50mg was a rolercoaster ride daily, so I switched to 100mg, For the most part the switch from 50mg to 100mg was mild. All in all, a rough ride at first, but worth the wait when it started working for me. I am now looking back over the last 9 years and wishing it had been there. M 34 2 months
5/17/2009
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 4  Postpardum Depression Tense jaw clenching and grinding teeth, extreme sleepiness and fatigue, loss of appetite and slight pressure headaches. I have some uncomfortable side effects (the jaw clenching is the worst!) but, I feel a lot better on this. I was suprised I felt a difference in my mood right away. F 25 4 days
4/30/2009
 4  Major depressive disorder None on 50mg, sleepiness on 100mg I have tried everything and nothing works. I am in Australia and my psychiatrist referred me to the Black Dog Institute in Sydney (on Medicare and fabulous if you are Australian) - they recommended Pristiq because I was having problems metabolising other meds and this is through the kidneys not liver. Plan says to augment with Welbutrin which is only available cheaply here for smokers(!) if I need "more grunt". Sor far - felt like taking aspirin on 50mg so went up to 100mg and feel ok but sleep a lot. Not working at the moment so that is ok. Appetite decreased - thank goodness. Also on Lamictal. Parnate was my best ever but made me insane with no sleep. F 52 4 weeks
4/22/2009
 4  anxiety, depresson when I miss a dose...bad dreams, unmotivated, dilated pupils in the beginning, hard to describe...kind of like you want to clench your jaw, but don't. would like to know why. beleive it or not after reading my list of side effects, this antidepressant works best for me so far. I have taken many antidepressants. I have a lot of anxiety and this helps my anxiety as well as depression. Just would like to have something that would help me be more motivated. I am less motivated. I just want to take a nap sometime, instead of get up and do what i need to do. F 44 7 months
4/12/2009
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 4  Depression, with anxious symptoms Nausea, Dizziness, excessive sweating at night, dry mouth, some sore joints, tight facial muscles, sore teeth. I am still waiting for it to start to work at 10 days, and many of the side effects are the physical symptoms of the depression I was feeling before the treatment. I had bloating, cramping guts, achey bones, foggy brain, dizziness, burning sensation on tongue and hands, breathlessness and fast heartbeat in bed at night, and a red face at bedtime, even though I had not been out in the sun. I am not sure if the side effects are remnants of the initial depression or part of the Pristiq effect. My gastroenterologist is also looking into an underlying gut problem and suspects malabsorbtion, which may have started the depression. I really hope 50mg works for me. I just had a spasm of sleepiness just then !! Thanks for all the comments, it helps to see others on the same path further ahead, who can warn of signs along the way. M 47 10 days
4/3/2009
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 4  Hotflashes Constipation, no libido I was on Effexor and was hungry all the time. Also kind of irritated. I tried Pristiq and had a hard time to move to it and returned to Effexor. Then, I understood I should return to Pristiq and I am on it now for 5 months and doing great. I did have to increase the dosage to 100mg. I'm strugling tho with very strong constipation problems. Besides the hotflashes I had several pain symptons. Neck, shoulders, low back, waist, ankles... Pristiq put them away as well. I had no depression or anxiety and I keep not having. Although my hotflashes make me miserable (Pristiq did reduce them to 3 to 4 a day and turn them very mild), I am not sure if I can keep on this drug. I have no insurance and to get a 3 month dose costs me $350. This is a new drug and there is no generic for it. I heard that Maca (a supplement)helps with hotflashes besides being an aphrodisiac, or at least an energiser. I can't find tho where to go to check for interactions as Pristiq is not mentioned on the sites I went F 50 5 months
1/27/2009
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 4  Dysthymia Wellbutrin XL stopped working for me after 6 years. Pristiq was the third med my doc had me try, after Celexa and Cymbalta failed me. I took 50 mg Pristiq first thing in the morning. I really needed it to wake up and was pretty groggy until it kicked in about 30 minutes after taking it. I had some nausea for the first few days. I also had mouth dryness, but not as severe as on Cymbalta. My doc warned me Pristiq could make my blood pressure go up. I had my blood pressure checked at my GI docs office after a week on Pristiq, and it was my normal 120s over 70s. A week later (2 weeks on Pristiq), I had my BP checked again and it was mid-140s over mid 90ssignificantly higher than normal. About a week later (3 weeks on Pristiq), my BP at my gyns office was 130s over mid-80s. Since my dysthymia wasnt fully controlled on 50 mg daily, my psychiatrist would have raised my dose to 100 mg dailybut she was concerned about the in My dysthymia manifests as apathy, cynicism, lack of motivation, head-to-toe body, joint and muscle aches, dyspepsia/IBS, overeating, physical and mental fatigue, word retrieval difficulty, 'brain fog', insomnia, and a generally unsociable, 'bah humbug/grumpy old hag' attitude. 50 mg Pristiq did nothing for my aches and pains, but it really helped my mood, energy level, motivation and attitude. I was much more sociable, outgoing and willing to converse on Pristiq. I took more pride in my appearance; I even went shopping for clothes and experimented with different hairstyles and makeup techniques. I was more productive at work and didnt suffer from my usual midday or mid-evening slumps. I felt happy and optimistic. I noticed no sexual side effects and no significant interaction with alcohol. At the end of the day, I felt genuinely tired and ready for bed. I slept better on Pristiq with fewer awakenings. My IBS and urinary frequency problems were greatly improved. If not F 46 4 weeks
1/17/2009
 4  anxiety, deppression and ocd Chronic tiredness, dizziness, increased anxiety and depression, suicidal thoughts and a feeling of 'out of body'. first weeks i was on pristiq was terrible, but the side effects, no matter how bad, do go away. YOU MUST STAY ON THIS DUG FOR AT LEAST 4 TO 6 WEEKS TO SEE THE BENEFITS. Unfortunately i started to plateau around the 7 week mark on 50mg, so upped it to 100mg. First week was great, best i've felt since needing the medication. Unfortunately i got some worse side effects after around 6 days. But now it seems that they're going away. M 18 10 weeks
1/11/2009
 4  Depression, Cyclothymia Headache, "edgy feeling", numbness I have tried them all, except Lithium. I have seen a dramatic difference in ME. I felt better after 2 days! Still have headache, no nausea, do have a decreased appetite. I am happier, calmer, sleep better, (though I still us Ambien every night). My husband has noticed a dramatic difference in my mood and disposition. So far so good. I am hopeful, but like everyone I hate taking any drugs to function, again I must remember the Brain is an organ just like the kidney, pancreas, etc. and sometimes it too is diseased. So there are those of us who need medication for our brains....for life. I also take 2 mg. Xanax, 200 mg. Tramadol and 10 mg. Ambien nightly. I think it is always helpful to include all meds taken on these boards. Remember we only have this moment. Just be. F 54 2 weeks
11/18/2008
 4  Depression None. I had severe sexual side effects with Effexor (loss of libido, genital anesthesia) and no problems with Pristiq. Pristiq had similar effects to Effexor for me. Effexor had a little more of a feel-good quality, Pristiq is a little more activating. I couldn't put up with the sexual side effects of Effexor, though, which are gone with Pristiq. M 51 3 weeks
10/30/2008
 4  anxiety excessive sweating and some brain flashes both have faded away and rarely resurface M 46 2 months
10/25/2008
 4  depression sexal disfuntion,constipation. has worked well F 41 2 months
10/21/2008
 4  DEPRESSION I have been on Many anti-depressants, so far this one is a "happy pill" for me, I just hope it remains this way!! F 35 2 weeks
9/29/2008
 4  OCD None The medicine has been very well tolerated and worked for me very quickly. I also don't have the sexual side effects that have plagued me with the SSRI's over the years. M 45 1 weeks
8/24/2008
 4  anxiety/depression nausia the first day, the next day was pretty hyper. yawning constantly since then Only two weeks on it so far so can't say much. The side effects are not bad and actually paxil was ALOT worse side effects for me. So far I've seen a small improvement compared to paxil once again where I took for 8 month with no improvement whatsoever. I feel less overwhelmed all the time and less fears about something bad going to happen. So far so good, we will see. F 24 2 weeks
8/23/2008
 5  Depression I started at 25mg and saw improvement so stepped up to 50mg. I was jittery for about a week and a half after stepping up to 50mg, and got a little sleepy after taking it. Also had dryness in the back of my mouth, but that's gone away as well. The only other negative side effect is difficulty reaching orgasm, in fact it's nearly impossible; so still trying to figure out what to do about that. I read "alternative sex practices" may be a solution on a couple different websites, whatever that means. I honestly have to say this drug saved my life. I fought depression for years and started trying medications three years ago, they either did nothing or made everything worse. After my brother took his own life last year, I was at the end of the rope. I tried a couple more medications with no success and then I started the lower dose of pristiq about eight months after his suicide and noticed I felt better. After going up to 50mg, in a week the endless loop of negative thoughts vanished. My wife said to me, “It's good to finally have you back, I was starting to think you may be lost forever if something didn't change.” I really had no idea how deeply I had fallen until the fog lifted and I could look back at the hole I'd been in for years. The last side effect I listed is disappointing, but worth it considering I'd had pretty much zero interest in sex (or anything else for that matter) for over a year. It's all about finding a medication that is a good match for you; I didn't realize how much depression is an illness, not just an attitude or personality issue until I was finally out from under it. M 51 60 days
50 1X day
2/21/2022
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