PRISTIQ Reviews (DESVENLAFAXINE SUCCINATE)

Average Rating: 2.8 (628 Ratings)

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 ANTIDEPRESSANTS

 Type: Rx Drug

  

PRISTIQ  (DESVENLAFAXINE SUCCINATE):  Desvenlafaxine is used to treat depression. It may improve your mood, feelings of well-being, and energy level. Desvenlafaxine is known as a serotonin-norepinephrine reuptake inhibitor (SNRI). It works by helping to restore the balance of certain natural substances (serotonin and norepinephrine) in the brain.   FDA Approval Date: 2008-02-29 (Sources: U.S. Centers for Medicare Services, FDA)

  

Results are sorted by Satisfaction lowest to highest.

Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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RATING  REASONSIDE EFFECTS FOR PRISTIQCOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 3  GAD,OCD and Depression Dry mouth/throat, Grinding teeth, shaking, problems focusing, decreased appetite, weight loss, yawning, increased sex drive, Brain fog So far it seems to be working, slowly. I haven't taken it long enough for it to take full effect but I have noticed a few things that are better and a few things that are worse so far. My OCD seems to be getting worse however, my Anxiety and Depression are lessening. I figure that it's a good trade off-- a clean home and less depression. F 25 2 weeks
50mg 1X day
5/13/2012
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 3  depression, anxiety Pristiq seemed to really level me out when I was feeling depressed. I no longer felt suicidal on Pristiq and had no major side effects, but I was experiencing tachycardia. My cardiologist isn't sure what caused the tachycardia. They are currently doing tests and monitoring my heart. My psychiatrist and cardiologist wanted to see what affects my heart so they put me on a heart monitor for 30 days. I'm on week one and they quickly tapered me off pristiq (4 days of 50MG then none). It has been HELL. I can hardly function. These are my withdrawal symptoms: anxiety, blurred vision, concentration impairment, crying spells, dizziness, fatigue, highly emotional, irritability, lethargy, increased headaches, nausea, over-reacting to situations, repetitive thoughts or songs, stomach cramps, troubling thoughts (suicidal), vivid dreams, and worsened depression. This is only day three being off pristiq, so I have no idea how long these will last but it is terrible. My docs want me to go on pristiq during week 2 of my heart monitor and back off for weeks 3 and 4, but I am going to refuse to start it again because I know I will feel awful during weeks 3 and 4 if I go on and back off that quickly. My husband thinks I should go back on because it helped my depression, but if I ever have to go off in the future (which I don't want to be taking it forever anyway) then I am not sure if I will survive. It will probably push me to suicide. I have heard similar effects of effexor withdrawal. Now I understand why drug addicts go to rehab. I wish there was a place I could go to get help going through pristiq withdrawal. I am constantly dizzy and I can barely function. If you are thinking about taking pristiq, DON'T! Or if you are thinking about stopping, make sure you have F 24 3 months
100 MG 1X day
5/11/2012
 3  Depression So far the only side effect I have had is that I have felt a little dizzy at times and my head will really feel funny, other than that, I seem to have no other side effects. Just waiting to see if this will help me. So many others did not. I have taken over 16 others that did nothing for me or the side effects were too much that I had to get off them. F 48 7 days
50 1X day
5/8/2012
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 3  Anxiety, Mild Depression Hangover-like headache, lethargy, insomnia, lack of motivation, feelings of being outside of my body, lack of any emotion or caring about anything Okay - if you have major depression, this will work to keep you from feeling. The first day I was on it, I immediately felt a burst of energy and being happier. I was excited. All of a sudden, I became very tired. I had a hangover-like headache (which lasted 2 days). I could not sleep and slept 2 hours that day. Normally I rush around trying to get stuff done. I didn't want to do ANYTHING. I sat in bed all day and didn't care what I did, what I had to do - I didn't care about my kids, about my boyfriend, about me... I questioned why I was even alive (although I wasn't suicidal at all... just felt pointless). I pretty much had a complete lack of emotion and motivation - I felt like a complete tired zombie/robot. This scared me - I'd rather be up and down than to feel nothing. I guess if I were majorly depressed, this may be better, but not for me. I stopped immediately because I could barely make it through the day as it was. F 31 1 days
50mg 1X day
4/24/2012
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 3  PTSD The drug works great compared to other SSRI's.. Downside is clumps of hair loss at beginning of therapy that tapered off but then hair thinned out over time, now scalp showing through. F 42 1 years
50mg
4/3/2012
 3  Depression / Anxiety Weight loss - vivid dreams Unlike many comments here, I have lost weight - 5 kg in my 2 weeks on Pristiq. I started at 130kg, so it's not hugely significant. My main thing is the dreams. I have never (or maybe 3 times in my life) remembered my dreams. After a week on Pristiq, I had a vivid dream. I remembered so many details. I was on a high for 2 days just thinking about the possibilities if this was going to happen again. I loved that dream ( I was backstage at a concert with so many interesting people ). I didn't remember a dream for a few more days - then I had my first ever nightmare. I am 40 years old and this was a major shock. I am still wound up about it. I have read about others having violent dreams as a side effect of Pristiq. If the nightmares come back, I may reconsider this drug. Aparrently my temprament has improved, but I have not felt much change. M 40 15 days
50mg 1X day
3/12/2012
 3  Mild Depression Experienced -Increased appetite and awful nausea if I did not eat after taking my dose -Subsequent weight gain from increased appetitie due to having to eat so as not to feel nauseous (gained a total of 8kg) from 60kg to 68kg (all this whilst doing personal training 4 times a week and not taking ANY other medication except the pill which i have been on for 7 years) - mood changes were significant - " brain fog " feeling lifted, able to concentrate and focus more and able to deal with reasons for depression and thus work through the causes of it - increased water retention - insomnia - Severe discontinuation/withdrawal symptoms including a week of the following after which I was off the medication and had no more side effects or withdrawal symptoms - Headaches (minor but don't respond to parecetamol or ibuprofen) - Severe pins and needles and numbness in face, hands and feet - loss of feeling in hands - unable to hold items for long or feel light touches - Diziness All in all this medication helped me through my brief period of depression but in the future i will seek a more natural way of dealing with my depression as it was what I consider mild, and in hind sight not in need of medication. The added effects of weight gain and AWFUL discontinuation symptoms add to my opinion that this is not the best option for people looking to go on a SRI/anti-depressant but then it is different between people. As a final note I have quickly lost all weight gained due to my appetite been back to normal and my exercise acitivty still been moderate-strenuous 4 times a week. F 24 6 months
50MG 1X day
2/29/2012
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 3  Major Depression Major Weight gain, Dilated pupils, Dry mouth, Lethargy, Withdrawal symptoms ( brain zaps). Because of the weight gain (30 lbs) on this med, my Dr prescribed me Wellbutrin. Other than that, this med has given me more motivation and has helped with my shyness. F 32 10 months
100 mg 1X day
12/30/2011
 3  Fibromyalgia, CFS feeling jittery in the beginning, slight stomach upset/ all disappeared after a couple of weeks, restless legs got worse I started taking Pristiq after weaning off Prozac, which had made me tired and emotionally flatlining. 3 years ago I started taking Cymbalta after being diagnosed with Fibromyalgia, and it helped a great deal. I really loved it. Then the poop-out came... :( I started taking Pristiq with my hopes being high. I don't really have any significant side effects, except maybe my restless legs worsening. I probably would have dealt with that side effect, but the problem is that Pristiq might be working well for depression and anxiety but it doesn't do ANYTHING for Fibromyalgia related pain. The pain came back with a vengeance after being off Cymbalta. I have just started weaning off Pristiq and giving Cymbalta another shot. If that doesn't work out then I will ask my doctor for Savella. F 42 4 months
50 2X day
12/6/2011
 3  anxiety/depression I have gain an excessive amount of weight. I am not as depressed as I was before taking pristiq, but now I am starting to get depressed about the weight gain, because I cannot fit any of my clothes. I used to weigh 135 lbs, now I weigh 185 lbs. F 41 12 months
1X day
11/14/2011
 3  Depression & anxiety panic, low self thoughts, just getting through day, questioning if I really want to be around, general feeling depressed and quick tempered and argumentive towards anyone in my path, withdrawn from family members Pristiq is better than effexor xr 250mg at first but I've slipped into just cannot be bothered anymore when I should be happy and positive. I've lost my constant planned thoughts of how to commit suicide like on effexor but now it is replaced recently over last two months that I do not see myself alive forward to today. I dont care if I live or die anymore M 49 7 months
100mg 1X day
8/12/2011
 3  Depression By the fourth day, I experienced profuse sweating and periods of extreme anxiety that would last for 4-6 hours per day. I never suffered from anxiety or panic attacks prior to taking this med. I gave up after ten days when I got tired of not being able to get anything done at work due to the irrational anxiety. This drug worked great for depression if it wasn't for the prolonged anxiety. I felt great, had tons of energy, and it did not make me drowsy or yawn. Maybe if I had been able to stand taking it long enough the anxiety would have passed, but the duration of the anxiety made it too difficult to continue to take the medicine. F 34 10 days
50 mg 1X day
8/1/2011
 3  Depression, chronic fatigue jittery, slight nausea, mild anxiety This is my 3rd day on Pristiq and I am still taking 25mg (breaking the 50mg in half). I am tapering off Prozac which has eased my depression but still left me fatigued all the time and with zero libido. I take Pristiq in the AM and I can feel a slight burst of energy already. Despite the mixed reviews I have high hopes for this med as I used to take Cymbalta which was amazing for 2 years...then the inevitable "poop-out" came. Withdrawal was god-awful but I'd rather LIVE my life in 2 year increments instead of just dragging through it. Will keep you posted on how the next days are going as I go up to 50mg tomorrow. Wish me luck... F 41 3 days
25 1X day
7/29/2011
 3  Depression Pristiq worked well for me for 6 months on the 50 mgs than it stopped working switched to the 100mg and know its working again. Works really well for depression and anxiety makes you feel really confident, talkative, makes it impossible to orgasm and it does keep you up at night.Hopefully it won't poop out on me. WHen switching doses you have to give it at least 3 weeks to feel the effecs. Initial side-effects do subside M 20 7 months
100mg 1X day
7/5/2011
 3  Depression originally - weight gain .. when i tried to come off med .. Horrible headaches during sexual climax. Got a pinched nerve. Couldnt focus / vision issues. Total medical cost trying to come off the meds was easily a thousand dollars out of pocket.. just crazy Was on celexa - first few weeks pristiq was great. As time goes on it seems like the drug is not working. I did try to come off of this med with HORRIBLE SIDE EFFECTS. Ultimately stayed on med - very concerned at what this drug has done to my brain. I think we will try to come off of it again in short future. M 50 9 months
1X day
4/1/2011
 3  Major Depression Headaches, Nausea, Dry Mouth, Tingling (Only Dry Mouth was persistent 24x7) Pristiq was the first anti-depressant I ever took in my life after falling into a deep depression in Fall 2010. It took 34 days to work well enough to cure my depression and take an edge off my anxiety. However, I had to add Buspar to truly feel better (I strongly believe my depression was caused by my intense anxiety). Eventually, the doctor switched me to Paxil (an SSRI, Pristiq is an SNRI) since it also works to help alleviate anxiety and panic attacks related to social situations such as public speaking. It took approximately 8 days to withdraw from Pristiq... I suffered from severe brain shock sensations whenever I moved my head and at random, and I was extremely irritable. I strongly recommend you ween yourself slowly off of Pristiq as I could not imagine doing it 100% cold turkey. Though I stopped 'cold turkey,' Paxil still works on some similar Serotonin receptors in the brain, so it was not as bad of a withdrawal as it could have been. I strongly recommend that you give this medicine time to work, as it took over a month for it to start making me feel 'happy' to be alive once more... M 21 4 months
50mg 1X day
3/16/2011
 3  Seasonal Affective Disorder After 1 month I had gained 10 pounds - have gained a total of 20 pounds. I went through surgically induced menopause 10 years ago and had not had a hot flash since then. Since being on Pristiq, I have severe hot flashes, night sweats, headaches, and insomnia. I tried going every other day, which helped a tiny bit. Since it is getting closer to spring, I have weaned myself off of pristiq and have not had a hot flash in almost 2 weeks. I am having an extremely difficult time getting the weight off. I do food journals and exercise journals logging usualy around 6 plus hours of cardio per week and don't go over 1500 calories. I haven't lost any weight..... Hopefully my metabolism will come back. It did help with my SAD - which was crying for no reason, but the side effects, to me, were so not worth it! F 51 4 months
50 1X day
2/21/2011
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 3  Anxiety, depression Hot flashes, slightly drowsy, trouble falling asleep I feel great for once. I haven't had any anxiety attacks, or thoughts of suicide. I finally feel normal. F 20 4 days
50 MG 1X day
1/20/2011
 3  Depression anxiety and chronic pain My doctor convinced me to try anti-depressants again because I have lost another job due to chronic pain and depression. I started feeling results right away. Good and bad. I have been feeling a surge of motivation which is helping against the dissabling feelings of depression. I have never been so productive! However, since day one of taking Prestiq, I have been experiencing persisting heartburn, insomnia, inability to climax (loss of sex drive which was NEVER a problem before)and a slight increase in anxiety. (nothing like the anxiety I felt with Cymbalta-difficulty breathing)I have been taking the med in the morning. Maybe I will try to take it at bedtime. The motivation has been great but I have been experiencing severe heartburn all day long since day 1. Also, I wake up at 3AM-4AM every night since taking Prestiq! This is odd for me because I usually sleeped like a log. It's 4:30AM as I am writing this!!! Waking up with an increased heart rate. The bouts of productivity have been I would like to be able to continue this drug without the side effects because I have been laughing more, feeling more excited about life and more productive than ever! It's a toss up!!!!!! F 30 20 days
50mg 1X day
11/17/2010
 3  Depression/Anxiety Weight gain 45lbs, tired, go to gym 4 days a week No sex drive at all, If I miss a dose, I will not go out of my house, feel like a crazy person. Break out in sweats!!! My doc says we will try something else, feel like a science project!!!!! F 47 2 days
100mg 1X day
11/9/2010

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