Average Rating: 3.5 (1448 Ratings)

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 Type: Rx Drug

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on WELLBUTRIN XL: Reviews Summary  |  Drug Safety Information

 1  Anxiety, ADHD Insomnia, severe jaw pain, decreased appetite, dizziness I had a bad reaction immediately after taking my first dose, and have been having worsening side effects happen every day. This has honestly been some of the worst reactions I've had to a medication. F 27 5 days
150mg 2X D
 1  Depression Hair loss, leg pain, restless legs, tremors, felt like my heart was doing the jitter bug, nerve twitching in face, and lack of interest in life. I was on this drug for nearly 20 years, went off for 2 years and my return to it is a complete disaster. My doctor said some people develop symptoms and it is common. I am convinced that it isn't working for me because it is a generic drug and whatever it is cut with is the issue. Neurological problems now even after off of it. Now I am seeking advice from a Neurologist. Praying the side effects with go away. F 60 6 months
150 1X D
 5  Anxiety, depression, suicidal Hard time going to bed and staying in bed for more than 2-4 hours. M 56 5 years
 1  Adhd I am also diagnosed with anxiety & ptsd. I do not recommend this if you struggle from ptsd. I was exhausted, couldn't get off the couch. I had flashbacks & then one night I woke up thought I was dead & pretending to be alive to the point where I was yelling & grabbing my fiance asking him if he was real. I later discovered a few days later after breaking out in hives I was allergic to it. I have noticed increased anxiety since taking even after stopping the medication. F 26 6 days
150 1X D
 4  Depression and migraines Started out ok. I have started crying every day. I'm not sure if this is something that anyone else is experiencing. I do know I have to take the Wellbutrin XL brand name. Not the generic. The generic doesn't work for me. F 60 6 years
300mg 1X D
 5  Depression Lost 20lbs energy increase. Slight jitters appetite was affected otherwise this medicine works well for me Good medicine just don't let the immediate side effects spook you 39 4 months
450 mg 1X D
 1  Panic attack related to stress Confusion. Sweating. F 50 2 years
70mg 2X D
 3  Depression/low libido So far I am very fidgety and have a dry mouth. I also have a little bit of anxiety and feel pretty withdrawn on day three. Hoping the side effects calm down. I started taking Wellbutrin because I was suffering from untreated depression which I believe has killed my libido.I've only been using it three days so hard to determine a rating on it and that's why I gave it a three. Not sure if it's normal but on day three I feel withdrawn and a little more depressed than before of the medication. M 43 3 days
300mg 1X D
 3  Depression Restlessness, irritation, always have bitter thoughts or memories for closed ones, lack of emotions, lack of love feelings, increased sex desire with no love feelings , feel not to talk more, increased anxiety, brain fog, feels overexcited and due to which forget the present and what I am doing. Antidepressants alone are not the solution for depression. I take batchflower remedies along with Bupron XL. It helps me to add positive emotions. Also antidepressants removes love feeling which makes u dry of emotions and you remain with only aggression or we become robot. Try Reiki or Pranik Healing M 47 2 years
30mg 2X W
 3  Depression and anxiety Significant Hair loss (see scalp) and ringing of ears I first started on SR100 - and I had itchiness off hands and feet (rare side effect that happens to the dye). Switched to xl 150- did very well on this but started to lose effect so upped to SR200 - had severe agitation, couldn't sleep, brain zaps, heart rate through the rioof, couldn't control my anger - had to take time off work (I'm a psychologist). Was fine when I went back to xl150 - until it wasn't enough. Upped to xl300 (it's gentler than SR) and I noticed I adjuster WAY better than SR but about day 5 I noticed significant hair loss. It's an extremely rare outcome but possible. To the nurses that claim it isn't possible to have these side effects you're wrong I completely understand the pharmacodynamics and I've worked with enough patients (been in the field since I was 18) to know that it reacts differently for different people. There are enough people saying these things to see patterns emerge. When you start all you can do is hope you don't react poorly to the drugs. Some people do great, others do not. F 35 5 months
300mg 1X D
 2  Depression, GAD, possibly ADHD I am currently on the medication. Last week, my dosage was doubled and I have been experiencing tremors, muscle spasms, dry mouth, sore throat, tinnitus, body aches, swollen lymphnodes, sweating and dizziness. I am in college and still on this medication so I may be off of it soon but I'm a little worried and have been feeling sick. F 21 14 days
300mg 1X D
 4  Sick of no sex drive on Lexapro So far great appetite suppressant; have lost several pounds in short time taking it. Hard to fall asleep. I'm on the generic & have read it doesn't work as well. We will see. I know I need to give it more time. I switched to Wellbutrin XL in hopes my sex drive comes back. 2 years with numb genitals & no orgasm on Lexapro. Still waiting on that, but it's early. I drink alcohol nightly; praying I don't have a seizure. Email me if you have resolved any of the issues I listed and tell me if it worked for you & if you drink. F 53 2 weeks
150 1X D
 1  Depression, fatigue, lack of motiva My depression has worsened. Unreal panic attacks, stayed in bed, zapped energy and motivation even more. M 49 6 weeks
3oo 1X D
 4  Depression I am feeling much better. I was on Wellbutrin from 2003 to 2018. Tried to go without and fell apart so back on it. Besides not being able to sleep, my leg muscles ache and cause restless legs at night. Giving it another two weeks and if side effects don't simmer down I will have to stop. I can't take other antidepressants because they cause weight gain and other issues. I would recommend this for anyone that is suffering from depression. But take as early in the morning as you can so you can sleep. F 60 14 days
150 MG 1X D
 4  Morning So far has helped with my depression. F 45 5 days
300 1X D
 5  Depression Tried several antidepressants over the past 4 years and none of them worked for me. Doctor suggested Wellbutrin XL. Started at 150 and gradually increased to max 450mg. I felt a difference in my mood and energy right away. I’m less irritable and actually feel happy again. I’m glad I didn’t give up trying to find something that worked for me. F 39 6 months
450mg 1X D
 3  Bipolar BPD and Depression I've noticed crying spells, irritable over absolutely nothing, rage, then I'm as happy as can be right now my emotions are flying all over the place, like all my emotions in one. Some dizzy spells. Lack of appetite. F 25 13 days
150 1X D
 1  weight loss awful! rage, disorientation, profuse sweating, vertigo,vomiting F 57 10 days
150 1X D
 5  Depression I have been taking wrong i was taking 150 3 times a day 5 hrs apart.I was suppose to take 450 at one time in the morning F 59 1 years
 5  depression helped me lose weight, less of an appetite, but helped a lot with mood swings and overall I think it works very well. F 17 9 months

WELLBUTRIN XL  (BUPROPION):  This medication is used to treat depression. It may also be used to prevent seasonal affective disorder (SAD), a type of depression that occurs each year at the same time (for example, during winter). This medication can improve your mood and feelings of well-being. It may work by restoring the balance of certain natural substances (dopamine, norepinephrine) in the brain.   (Sources: U.S. Centers for Medicare Services, FDA)