DIFFERIN Reviews (ADAPALENE)

Average Rating: 3.0 (197 Ratings)

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 DERMATOLOGICS

 Type: Rx Drug

  

DIFFERIN  (ADAPALENE):  This medication is used to treat acne. It may decrease the number and severity of acne pimples and promote quick healing of pimples that do develop. Adapalene belongs to a class of medications called retinoids. It works by affecting the growth of cells and decreasing swelling and inflammation.   FDA Approval Date: 1996-05-31 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on DIFFERIN: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR DIFFERINCOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 1  mild to moderate acne dryness, burning, tingling, tightness, wrinkles, peeling After the fourteenth day or so of taking this medication I started to experience a burning sensation where the application was applied (cheeks and chin). Also, my whole face started to peel a lot and my face felt very tight and dry. The most alarming side effect of this medication is the wrinkles it produced. I got new fine lines under my eyes and near my mouth and nose. It seems like the places near where I placed the cream wrinkled. Before I started using any vitamin A products I had no wrinkles. I used Retina-A two years ago for a few days. After I used this product I saw a fine line under my left eye. But I thought maybe I never noticed it before because I wasn't paying close attention to my face. After the first wrinkle, I've been paying very close attention. I now have fine wrinkles under both eyes and near my mouth and nose. These wrinkles were not here before I started using differin. To me it isn't worth wrinkles to have very clear skin. If wrinkles bother you, do F 26 14 days
4/30/2008
 5  acne Initially, had to start with every third night and work up to every night due to burning. Also had a mild increase in acne, small bumps all over, for a few weeks. And some initial peeling. Was annoying but I could live with it. After that, I still get some dryness/peeling every once and a while but nothing else. I love Differin. It has helped both my acne and my acne scars. It also has greatly improved my overall skin texture! I saw some change at 3 months, but real change came around 6-8 months. So do be patient and keep using it! Far too many people quit before the medication has a chance to work. F 27 9 months
4/9/2008
 4  adult acne I didn't have any major side effects, but it seemed like my skin became much oilier for a few weeks (and it is back to normal oiliness now). My skin didn't turn red, dry or flaky ever, nor did i have any irritation. I had acne in late high school and early college. I started on ortho-tri cyclen and had terrific results for about 8 years. My skin was as close to flawless as I could have hoped. For a couple of reasons, I had to get off the pill 2 years ago and within about 3 months, my face started to break out again. I thought I could handle it but in the past 6 months it's really gotten worse and I felt pretty self-conscious about it. As an alternative to the pill which I know will clear me up, I started Differin 1% at night and Clindamycin lotion in the morning. Like many, my face got worse. It was bad and pretty horrifying as I was just starting to date someone. But after about 7 weeks, my face started to clear up. I'm on week 8 and my face is pretty smooth. I still have the marks from zits past, but i'm hoping they will fade in time and the medicine keeps new ones in check. So, to add more testimony to the others', this might work for you if you are willing to stay on it for several w F 31 8 weeks
3/17/2008
 5   very little drying Those of you who reported an increase in acne when starting… don’t stop! This is what the drug is supposed to do! It’s bringing out pimples deep in your skin. After 6 months this stopped. Then, my acne disappeared for good. Let it work. The pay-off after a few months is well worth it. A little acne now, then gone for good. I’ve been almost acne free for 3 years. Be patient, and let it work. I think it’s a miracle drug. M 39 3 years
1/20/2008
 5  severe acne, in combo w/other drugs Initially, burning and peeling. Had to work up to every night. Started with every 3rd night, then every other night, then every night due to burning. Peeling was more of a nuisance and subsided in a couple of weeks. Did notice an increase in acne during the first month or so, lots of very small pimples in places I usually didn't get them. It was frustrating but bearable. It eventually subsided and now it's smooth. I still experience occasional burning and peeling but overall no more side effects. I really like it. It's helped my acne and my skin tone is really good. Fine lines are gone, skin tone is more even and brighter overall. It also seems to have helped some of my pitted scarring. I noticed some improvement in the scarring around 3-4 months, but not much. I'm at the 6 month mark now and I am really seeing some good results - both with scars and with overall skin tone. My skin looks really good overall. Very happy with Differin. You really do need to give the drug time to work though, many months. F 27 6 months
1/2/2008
 5  Acne problems. My face was dry for the first two weeks. I used a prescribed facial lotion on my face morning and night along with only using differin every other night for the first two weeks. My skin is still dry if i forget to apply the lotion, but its not as bad as those beginning days. It really works! It's not a cure-all though. Nothing is. You just have to be patient and endure the annoyance of applying it on your face EVERY night for 12 weeks to get the full results. But its totally worth it! It doesn't get rid of acne scars majorly, but does help them fade. F 15 14 weeks
12/3/2007
 4  Adult acne Dryness, tightness, redness, mild discomfort, peeling, irritation, sensitivity and headaches. I have had mild but chronic acne since puberty and hoped once I hit adulthood it would go away. Instead in my mid to late thirties it got a little worse. It got even worse when I went through seven months of army training (eating only army food and daily physical training which raises testosterone level). I decided to get something for it so my skin would be halfway decent when my husband returned from his third deployment in Iraq. There was some initial discomfort and it is absolutely neccesary to use strong sun protection and moisturizer. I have been using the product for about four months. Overall I am very pleased. However it is extremely drying and I have experienced headaches which I believe are associated with dehydration. I think has something to do with my age. I'm all dried up anyway. Ha ha. I have found that it really helps to drink a ton of water which is also good for the skin. F 43 4 months
11/28/2007
 4  Moderate adult acne Redness, some peeling I have been struggling with this so long, espceially been breaking out terribly in the last yr. Now, after some of the intial pimples and peeling, the whiteheads have all but disappeared and my skin is finally becoming smooth! Now, some red marks from previous zits are still there but they will fade in time....it looks worse at first but after 3 weeks I am seeing improvement, and the scars are red marks, not indents, I think they will fade in time. Keep using it...the redness and peeling isn't so bad after a couple weeks. Use a good matte mosturier under makeup if you have oily skin (I recommend tea tree oil products) and a heavier moisturizer at night on top of the differin to keep skin hydrated) F 28 3 weeks
10/27/2007
 4  teen almost terrible acne None It's worked great for me! My skin's almost clear & i've only used it for a week F 15 7 days
9/5/2007
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 4  acne Dryness, but not terrible. Just a minor break-out at the beginning. But with most of the stronger acne meds. this is not unusual. Ive been on Accutane 3 times, so im used to the majority of the symtoms. Im taking Differin in the morning, and a high lvl benzoil at night. 19
8/10/2007
 3  teenager with mild acne redness,dryness and my pimples started coming out even worse then before after the first week i could see a change, my face went even redder and drier then before and i was ashamed to go outside, since i had to stop using foundation i was embarrassed to see friends and even to see my cousins! now after two weeks the dryness is still there but the redness is starting to clear and settle down, i would recommend this product to all people who are willing to go through the redness and dryness to achieve their goal of clearer, healthier skin IT WILL BE WORTH IT =] F 13 2 weeks
8/9/2007
 3  acne red marks well, i started treatment in may 07 and didn't seem to be getting many results until about mid-april. my acne in the area was cleared up by mid-june but i now have some red marks that still havent gone away. they seem to be fading with tanning in the sun and drinking lots of water. once you keep using it your skin grows prone to it and you start seeing results much quicker M 15 3 months
8/1/2007
 5  Acne Vulgaris (Mild to Moderate) None I have a lot of patience with retinoids because I used Retin-A for more than 10 years beginning with my late adolescence. As I've gotten older, Differin has been a miracle because my skin just can't handle the harshness of Retin-A anymore. Here's the thing. Not every retinoid is right for everyone, but if you're using these products, you have to use them exactly as directed, be consistent and patient. I would NOT recommend starting retinoids within a few weeks or months of a major life event (i.e. wedding), because your acne will get worse before it gets better. I noticed an overall improvement in my skin in 2-3 days, with a major improvement after using Differin for 6 months. Judging by my prior experience with these drugs, it takes app. 1 year to really get the full effect of the retinoid. Again, there are different retinoids for different people. I have very sensitive skin, but break out monthly from hormonal changes with horrible cysts, and also get deep blackheads and whit F 39 8 months
7/25/2007
 4  mild acne from Birth Control first 2 months acne got severly worse. After the first week I could see white bumps under my skin where I was about to break out I was prescribed diffrin because or hormone irregularity after being on Seasonale Birth Control. I previously didnt have acne but then I got it. This product seems like h*ll at first, making you breakout everywhere, even if you never really did there before, BUT STICK WITH IT. I'm on week 9 and my skin is significantly clearer (A few scars but they will fade with time). i know the pimples are painful but they will go away. dont quit early! F 21 9 weeks
7/9/2007
 5  Mild Adult acne on face,pms brkout No side effects except for making skin even more sensitive. Took only days to see skin improve. I use at night. Saw improvement almost immediately. I love this product. Also makes skin look brighter and refreshed. Note: do not have any part of your face waxed when using this product. It will cause burns. F 30 1.5 years
6/22/2007
 4  acne Red VERY dry skin, tender around eyes, broke out worse for first 2 weeks I went on ti because I am getting married May/08 and wanted picture perfect skin. Starting to notice improvement. Skins still a little red on my chin and getting small red pimples but nothing like before I started. Maybe doesn't work for everyone but try to be patient if it doesn't work right away and keep mosturizing. My doc said 2 to 6 weeks to really notice chance. F 29 23 days
6/18/2007
 1  very mild acne dry skin, burning sensation, rash and more spots than ever appeared within two applications. seriously do not use F 24 3 days
6/5/2007
 3  acne - face, back None. I am taking this together with tetracycline. I am using differin at night and Lachydrine (or generic AmLactin) during the day as moisturizer. Using DOVE as a soap. I am always careful to have my skin hydrated since dehydration worsens acne (some of the red color is due to that). I am using this a little on my face (since I don't have a bad condition there) but mostly on my back. There is a slight improvement on my back but not yet significant. However, I have been using the product only for a month now. Doctors told me that my back condition is a combination of acne and KP. KP is not an easy thing to treat. M 27 1 months
5/28/2007
 1  very mild acne caused by Eumovate Reddness, Papules became bigger, itchiness and dry skin. Lots more blackheads and whites by using this product Everybody says that Acne will get worse before it gets better well with Differin it certainly does. I am 32 and for the first time in my life I got acne as a reaction to a steroid cream and by using Differin I am in a much worse position than I was. Be very careful and use only on one spot to begin with I am now on Duac - see what that does ! F 32 5 weeks
5/21/2007
 1  i was taking deriva-c gel my face has become extremely oily, red, starting getting a lot of acne i never used to get so many at a time even my skin started to peel this is the worst expierence of my life i just used for 4 nights continously acctually deriva-c gel is a combination of duac and differin on top of this my derm prescribed me salicylic acid face wash which is not supposed to be used while on treatment i feel like killing my derm M 20 4 days
5/9/2007
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