METHOTREXATE SODIUM Reviews (METHOTREXATE SODIUM)

Average Rating: 3.3 (383 Ratings)

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 ANTIMETABOLITES

 Type: Rx Drug

  

METHOTREXATE SODIUM  (METHOTREXATE SODIUM):  Methotrexate is used to treat certain types of cancer or to control severe psoriasis or rheumatoid arthritis. It may also be used to control juvenile rheumatoid arthritis. Methotrexate belongs to a class of drugs known as antimetabolites. It works by slowing or stopping the growth of cancer cells and suppressing the immune system. Early treatment of rheumatoid arthritis with more aggressive therapy such as methotrexate helps to reduce further joint damage and to preserve joint function.   (Sources: U.S. Centers for Medicare Services, FDA) FDA Approval Date: 1953-01-01

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on METHOTREXATE SODIUM: Reviews Summary  |  FDA Adverse Event Summary

RATING  REASONSIDE EFFECTS FOR METHOTREXATE SOCOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 3  extrme excema really bad diarrhea ,bloated and disorintated at times but skin is good M 30 3 weeks
10 mg 4X W
3/25/2014
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 1  Rheumatoid Auto Immune Disease Aspergilloma lumps in both lungs half of left lung cut off. On Metho. tablets or injections. After 6 years of use. Went off it till 2012 when they insisted I try again Within 5 months Rheumatoid nodules large formed on my elbows and arm. I ended up with a 10cm x 4 cm nodule on my coccyx (because am in a wheelchair and it gets pressure there like on arms/elbows.) This stuff is totally sick for me. Off it since end January 14 and had 40 ml cortisone injection into coccyx nodule and now half it's size the large arm/elbow nodules nearly gone. Am getting real good results with alternative SAMe methionine CRP 14 + ESR 30 lowest ever since diagnosis 30 yrs. ago. Better than at any time on Methotrexate. Odly ? my Rh.Factor gone down a bit first time ever. F 64
17.5 week 1X W
3/19/2014
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 2  RA nausea, vomiting, headache, peeling flaking skin on face around eyes, greatly increase eye irritation, eye infection, constipation, dizziness and vertigo, fatigue The headaches and GI distress were so great that I had to stop taking one of my other meds. The combination caused too much nausea, stomach pain, and vomiting. I also sometimes have to stop my NSAID because the MTX along with it is more than my stomach can bare. So far it had not touched the pain. The doctor put me back on prednisone which helps but they don't recommend you take that all the time. I had to miss work last Fri because of vomiting and feeling really bad. Didn't want to move all weekend and then had vertigo on Mon so I miss work again. Now I have to take medicine to help the vertigo too. Today is Thursday and I still have some vertigo but it is mild now. I plan to ask the doctor to start Enbrel next trip F 50 2 months
17.5 1X W
11/14/2013
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 3  Sjögren's Syndrome Nausea, vomiting, hair loss, easy bruising and worsened fatigue. I switched to injections and the side effects got much better. F 25 5 months
15 mg
7/4/2013
 2  psoriatic arthritis I feel sick all the time ,constant sore throat,memory loss and confusion I feel tired bad tempered ,I feel chesty and weezey in the morning my period is all over the place and a small amount of weight loss and to top it I keep getting Candida F 41 2 months
17.5mg
5/12/2013
 2  RA/UVEITIS IRRITABLE, TIRED, FOGGY, HEADACHES (MOST DAYS) I WAS DX WITH RA WHEN I WAS 17 YRS OLD BUT HAVE MANAGEABLE JOINT SYMPTOMS. I TAKE MDX FOR UVEITIS (RA IN YOUR EYE) AND HAVE NOT SEEN IMPROVEMENT WITH MDX USE, EVEN WITH A STEADY INCREASE IN DOSAGE. EVEN WITH 20MG I HAVE RECENTLY HAD THE WORSE FLARE UP IN YEARS. I AM CURRENTLY LOOKING FOR ALTERNATIVE NATURAL REMEDIES THAT DON'T HURT ME TO HEAL ME F 27 18 months
20 1X W
8/25/2012
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 5  Crohn's Disease No side effects besides some upper back pain. I felt a huge improvement in my health after just 2 weeks and all of my symptoms have disappeared. I was very anemic and couldn't put on any weight, had bloody diarrhea and rectal pain, night sweats, skin problems, arthritis, eye inflammation, and absolutely no energy. The folic acid that I take keeps away the mouths sores. F 25 3 months
25 mg
6/10/2012
 5  Rheumatoid Arthritis Terrible, terrible nausea for 2 days after dose, diarrhoea, tiredness BUT cures my arthritis and allows me to live an active life free from pain. Side effects mean I struggle to keep taking MTX consistently, when I do my arthritis is cured. F 23 11 years
20mg 1X W
6/8/2012
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 5  RA very slight nausea the first few doses, but none after that. I think MTX gets a bad rap. Never had a problem with this drug; been taking it since 2007. Along with Enbrel injections and folic acid to reduce (in my case, eliminate) any side effects, my RA is effectively controlled. F 49
1X W
3/18/2012
 4  Palmoplantar Pustulosis As yet, I have not suffered any side effects whatsoever. My Dermotologist did precribe me 5mg of Folic Acid TO BE TAKEN AT THE SAME TIME to help with any side effects. I know this goes against the thought of not taking it at the same time but I beleive that, although it may diminish the effectiveness of the MTX to a certain extent, the fact that I have not had side effects means that I can carryon taking it. However,early days! Since taking the tabs (7) days the itching has stopped and my hands and feet have dried up considerably. F 48 7 days
10mg 1X W
3/11/2012
 3  Finger joint stiffness. two finger None so far. I also have mild psoriasis and starting to see minor improvement. Less plaque formation. M 63 3 weeks
15mg 1X W
3/2/2012
 3  RA I take my 4 pills (10 mg in total) on Monday. For the next 48 hours after, I feel exhausted, head feels heavy and I feel really bloated. I have been having trouble sleeping and been very moody also. The symptoms for my RA have drastically improved but I just feel crappy for 3 days out of 7. Now I have to increase to 15 mg. starting my next dose. I hope it doesn't worsen the side effects. F 40 30 days
10 1X M
2/29/2012
 2  PA INCREASED MIGRAINES ANS AFTER 4TH DOSAGE, NAUSEA THAT KEPT INSTANTLY COMING BACK. I THINK IT RUINED MY LIVER AND DOESN'T SEEM TO HELP MUCH, I HAD TO TAKE PREDNISONE HERE AND THERE TO KEEP UP WITH JOINT PAIN. (AS FOR PSORIASIS IT DIDN'T HELP A TINY BIT). F 27 4 weeks
2.5 MG 1X W
2/26/2012
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 4  JRA Tiredness, mood changes, foggy state of mind F 16 3 months
25
1/23/2012
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 5  Seronegetive RA loose stools at times For about 1 month my ankles and joints hurt so bad I couldn't wear heels and it hurt to walk. I went to the rheumatologist and he started me on methotrexate 10mg/week and prednisone 10mg/day. I ended up getting off the prednisone after a year and instantly after I started the meds my joints felt great and I was able to be active again. Last year I was in numerous races, bike rides & ski events all because of the methotrexate. I'm very thankful for the increased knowledge the medical world has about RA. Hope someday they will find the true reason behind this disease. F 23 1.5 years
10mg 1X W
1/18/2012
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 5  Rheumatoid within 24 hours horrible migraine, tired, can't remember things, can't form the words I need to say, hot flashes, weight loss (good thing for me) the benefits far outweigh the side effects I experience. the folic acid appears to be helping with the side effects but still have to take pain pills for the migraine for about 2 days. F 46 60 days
15 mg 1X W
12/27/2011
 2  RA Hair loss, Fatigue, Nausea, and diarrhea. I did the the injection once a week. And my doctor told me the side effects but at the time I was willing to try anything. My hair was falling out so bad that I had to wear hats all the time, and I am not a hat wearer. I also was in the "Meth Fog" that is when you are so tired that you sleep your whole weekend away and had no idea. My doc recommend that I take more folic acid to help. That did not help I stayed on it and tried for 6 months and did not feel any better joint wise. I know that everyone is different but explore your options. I now take 2 tablespoons of Apple cider vinegar with 1 tablespoon of Honey with 8 oz of water 2 times a day and for the joints works way better and not the extreme side effects. And best of all I still have my hair!! and I am not sleeping my life away! F 29 6 months
0.6 ml 1X W
11/1/2011
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 3  Behcets For the first 5 or 6 months ON METHOTREXATE- nothing. In the past 7-8 months I have found my memory has become very poor, my brain seems to be foggy, a loss of sharpness, very tired all the time, irritability, stomach problems come and go, weight gain- nothing seems to show correlation between this drug and weight gain, but it's the only negative change in my intake - diet and excercise are better now then 2 years ago, yet I have increased in weight since. Methotrexate does the job in suppressing my behcets problems. But has a few side effects that are causing different probelms. M 30 16 months
15 1X M
10/26/2011
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 4  psoriatic arthritis Hair loss, fatigue, low immunity against colds,sore throats etc, weight loss, nausea. I can walk now without too much pain. i was pretty much housebound before i started this treatment. apart from catching colds and sore throats the side effects so far haven't been too bad. I have lost a stone in 6 weeks. F 37 6 weeks
20mg 1X W
10/8/2011
 4  RA Nausea, diarrhea, headaches, just general feeling of malaise. Diagnosed 4 months ago, take once a week feel horrible for about 2 days and then I slowly start to come out of it just in time to start all over again. Admittedly has been working for me. Still hurt and am stiff all over in morning but at least am walking without dragging one leg now. Cant take anything else because of other stomach problems. Next increase will go to injections. I take folic acid doesnt help really. Take vicoden and cymbalta for pain. F 42 4 days
15 mg 1X W
9/10/2011
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