METHOTREXATE SODIUM Reviews (METHOTREXATE SODIUM)

Average Rating: 3.3 (383 Ratings)

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 ANTIMETABOLITES

 Type: Rx Drug

  

METHOTREXATE SODIUM  (METHOTREXATE SODIUM):  Methotrexate is used to treat certain types of cancer or to control severe psoriasis or rheumatoid arthritis. It may also be used to control juvenile rheumatoid arthritis. Methotrexate belongs to a class of drugs known as antimetabolites. It works by slowing or stopping the growth of cancer cells and suppressing the immune system. Early treatment of rheumatoid arthritis with more aggressive therapy such as methotrexate helps to reduce further joint damage and to preserve joint function.   (Sources: U.S. Centers for Medicare Services, FDA) FDA Approval Date: 1953-01-01

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on METHOTREXATE SODIUM: Reviews Summary  |  FDA Adverse Event Summary

RATING  REASONSIDE EFFECTS FOR METHOTREXATE SOCOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 4  CIDP Feel very nauseous the night I take it. Wake up feeling stunned but by the next day I'm fine. Haven't noticed any hair problems. I take 5mg twice a week. This medication has helped me a lot. The progressive numbness in my arms and legs has subsided and seems to be stabilized. M 22 5 months
11/3/2007
 5  RA Loss of sex drive, tiredness - think I can link these two to the drug Having been on 15mg for past 4 years and having almost full mobility (pain in wrists and knees from time to time) I think this drug is fantastic. I'm now into my 2nd week without it and am terrified the pain and immobility will come back. my reason for stopping the drug is that I hope to conceive next year. 31 4 years
10/29/2007
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 4  Psoriasis Arthritis Hair loss, Short term memory loss, still have flare ups, pain, no stomach pain or gastrointestional probs, no ulcers, After 3 mo I was not painwise where the docs wanted me to be, so they added Mobic to my treatment daily and its an antiflamatory/pain pill and it works ok. but nothing like a real pain pill. My knees give out while I walk sometimes and its real quick, out of nowhere. I can use my hands normally now with out pain. They look like hands again after a month. Has not done anything for the psoriasis!! I use hydrocortizone cream and that keeps the rashes under control and smells better than the tar(use daily) F 30 3 months
10/27/2007
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 2  RA chest tightness, frequent chest infections M 40 6 months
10/15/2007
 5  RA I have had no noticeable side effects from my dosage of 15 mg once weekly. It has made a significant improvement in my RA. I have not had any serious disease progression since I started taking it. I supplement the methotrexate with an anti-inflammatory as needed - usually a couple of times a week - depending on my physical activity level. M 61 3 years
10/13/2007
 3  Psoriatic Arthritis Loose bowels then constipation. Dizzyness, nausea, mouth ulcers. I first started on Sulphasalazine and had to build up to a dose but my Rheumatologist just started me on 12.5g a week with this. My joints seem a lot better though if I miss my Diclofenac I can still notice the difference. F 20 6 weeks
10/8/2007
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 3  R.A. None so far. Was diagnosed with RA 6mths ago but pain started years ago. Have strong family history but didn't think it would get me. Am a bit overwhelmed with the thought of it for life now. Still drinking but am thinking I should stop due to warnings (don't want to). Pain dropped over 2-3mths so reduced from 15mg to 10mg, man what a mistake, went back to 15mg and am still suffering 5 weeks latter. Back on prednisone but need to be careful as have osteoporosis as well. Am really struggling with coming to terms with it would love to hear from others that have been on it for decades, can I still drink, is being on metho going to eventually kill me, any other alternatives out there??? M 45 6 months
10/4/2007
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 3  Rheumatoid Arthritis extreme fatigue, nausea, mouth sores, and stomach problems. It has helped tremendously with the progression of the disease. I still have inflammation and pain on both hands after 9 months on methotrexate. I take on occasion, Naprosyn. I am afraid to take other drugs like Remicade, Enbrel, Humira. F 44 9 months
10/3/2007
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 1  RA UNCLEAR WHAT CAUSED ME TO BECOME SO VERY ILL. VILENT NAUSEA, VOMITING, ELEVATED PANCREATICE ENZYMES, BACTERIAL SINUS INFECTIONS, FUNGAL INFECTTIONS (I CAN SPELLLL, JUST SITING AT COMPUTER PAINFUL). DRS. CALL ME A DIAGNOSTIC MYSTERY, NO STMPTOMS PRIOR TO MTX, NO EFFECTVE TREATMENT BY HOSP, JUST DISCHARGED TO BE ILL. SYMPTOMS RECEDED AFTER ABOUT 6 MONTHS, BUT RECUR EVERY JULY, SO SEVERE I REQUIRE HOSPITALIZATIN. HAS ANYONE ELSE HAD THIS OR ANY PORTION OF THIS, HAPPE TO THEM? TOTALLLY INEFFECTIVE AGAINST RA. NO SIMILAR PROBLEMS WITH GOLD F 50 4 months
10/3/2007
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 3  Psoriasis and Psoriatic Arthritis 7.5mg/week - Just tired but at 15mg/week Tired with slight Nausea, dry eyes. Very Little improvement at 7.5mg...Just started 15mg can't say its helping enough vs. side effects M 40 30 days
10/1/2007
 2  RA Day after (evening dose of 15mg) muzzy head, slow thinking, flu like fatigue, nausea, headache, hot flushes. Longterm - general malaise, feeling like I've been poisoned, insominia, itchy scalp and sores, mouth sores, thinning skin (rolls off like a peel after sunburn- leaving sores) changes in moles (dry, rough, raised) brittle hair, itchy dry eyes and throat, burning lungs. No relief from pain even in combination with Meloxicam (anti-inflammtory). Blood work shows inflmmation still very high. No analgesic that I can take safely (allergic to aspirin and ibuprofen) works. Only relief from pain is after intramuscular corticosteroid injections which only lasts a few weeks. F 49 14 months
8/29/2007
 4  psoriatic arthritis loose bowels, gastro stomach problems, hair loss and rash sometimes feel winded, exhausted, and sort of " out of focus" F 42 2 years
8/16/2007
 2  autoimmune uveitis - pars planitis nausea and fatigue, infections i took it for almost 3 years. it did very little to stop my bouts of inflammation. took it once a week and felt ill for a day afterwards. also developed a bronchial cough that has persisted for years and i am very prone to infections (mostly mouth and nail bed). F 32 900 days
8/15/2007
 4  R A (HLAB27 Positive) I am only on a low dose (7.5mg per week)but still developed breathing problems after 3 weeks on MTX. The medication was discontinued for 6 weeks and the respiratory problem cleared up. I've now been on MTX again for 30 weeks and the main side effects are extreme tiredness, scalp soreness and a slight cough. The dose is due to be increased to 10mg / week next month. I have had 2 flare ups of RA whilst on MTX, but no problems with Scleritis which was a serious problem before starting the medication. I feel uneasy about taking MTX because I am aware of the possible side effects. I work in the NHS in the UK so (fortunately) can contact a Rheumatology nurse relatively quickly if problems with the medication seem to be setting in. M 62 9 months
8/7/2007
 4  RA Nausea & fatigue & days where i feel "blah" (ie no desire to do anything). I had to divide up my dosage on two separate days to curb the nausea. Had alot of mouth sores, but now i take folic acid along with it and dont get as much. It really helps with the arthritis, i used to also take enbrel, but has recently (in the past couple of years) switched to remicade. F 24 11 years
7/31/2007
 1  Psoriatic Arthritis Headaches, extreme fatigue, hair loss, caught every bug that came near, bad depression (don't take this if you already low or depressed). Regular diarrhoea. It wasn't until I stopped this drug (against rheumatologists advice) that I realised how badly it had affected me. My quality of life is so much better without it. The nasty side effects far outweighed the small improvement to my arthritis pain & swelling. It just wasn't worth it. M 49 5 months
7/30/2007
 4  RA Fatique, and experience loose bowels on a daily bases Symptoms of RA have improved with no major flare-ups. Would like to get control of this bowel problem...any comments F 63 6 weeks
7/17/2007
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 4  Rheumatoid arthritis nausea/bloating/unsettled gut/diarrhoea for a day or two after taking. Also mouth sensitivity/ulcers, feeling low and often very tired (this could be the RA),dizzyness. MTX has brought about a big reduction in joint inflammation although the stiffness and discomfort remain to some extent (I also take tramadol and diclofenac) M 57 9 months
7/16/2007
 3  S L E Hair Thinning, Slight Light headedness, Pleurisy. Experiencing some kidney pain ?related? Its worrying to read some of the reviews! Ive been on it for about 24 weeks and am now on a regular 25mg weekly dose. I had to build it up from 7.5mg gradually and havent touched a drop of alcohol since i started. F 22 24 weeks
7/13/2007
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 3  RA Incredible nausea, especially on oral dose, 4-5 days and I take it every 7. Have been on it for 10 years (4 years orally, 6 years by injection). Hair deterioration (very marked) and loss. Weight gain (although that could be the cyclosporin I also take?) which is the hardest to deal with. Hasn't really helped my disease but has slowed down the progression. Its a good drug for a wide range of uses, but the nausea is incredibly hard to deal with over as long a period as I've been on the midication F 35 10 years
7/11/2007

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