METHOTREXATE SODIUM Reviews (METHOTREXATE SODIUM)

Average Rating: 3.3 (383 Ratings)

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 ANTIMETABOLITES

 Type: Rx Drug

  

METHOTREXATE SODIUM  (METHOTREXATE SODIUM):  Methotrexate is used to treat certain types of cancer or to control severe psoriasis or rheumatoid arthritis. It may also be used to control juvenile rheumatoid arthritis. Methotrexate belongs to a class of drugs known as antimetabolites. It works by slowing or stopping the growth of cancer cells and suppressing the immune system. Early treatment of rheumatoid arthritis with more aggressive therapy such as methotrexate helps to reduce further joint damage and to preserve joint function.   (Sources: U.S. Centers for Medicare Services, FDA) FDA Approval Date: 1953-01-01

  

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More on METHOTREXATE SODIUM: Reviews Summary  |  FDA Adverse Event Summary

RATING  REASONSIDE EFFECTS FOR METHOTREXATE SOCOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 2  Crohns/RA constant vomiting,constant nausea,all symptoms were worse and it just made life miserable. Noticeable improvement in quality of life and symptoms after this medication was stopped. F 36 3 months
12/1/2003
 4  Rheumatoid arthritis Fatigue for 2-3 days following injection. Mild hair loss. Occasional mouth ulcers. It helped me immensely with minimal side effects. I recommend the injections as opposed to oral tablets, as I have heard the nausea is much greater when it is taken orally. F 31 8 years
11/27/2003
 1  RA severe fungal infections in places I had no idea I had places!!! Helped my RA, but side effects were awful!! Wont do that again F 58 6 weeks
11/3/2003
 5  myasthenia gravis nausea- first few weeks of treatment, diarreha- worse first 2 days after weekly dose. Extreme fatigue 1-3 days after dose- worst on the 1st day. A tendancy to cry my way thru the first day after dose. More pain related to dental work than before I started taking it. I started taking this after a 5 day span in hospital just before Christmas. Myasthenia causes severe muscle weakness, and I was having breahing problems- it had been getting worse for some time. This is like a miracle drug!!!! I have much better strength, and much fewer crisises. Blood counts for liver were hinky for 2 months, but fine now. I take 15mg every monday night. Taking it at night with a light snack helps the nausea. Make sure you are taking extra folic acid with this!! It helps! F 35 10 months
10/28/2003
 4  R.A. Extreme fatigue the day I take my 15 mg. weekly dose. Dr. told me to take it three times in one day, two pills each. This made me very nauseated. I do fine if I take all six pills at once on Friday night. Saturday I am very tired, but function OK. F 42 5 months
10/17/2003
 4  RA I had been taking 15mg orally once a week for about three months and all I have noticed is the occasional stomach upset. I also take a Folic Acid supplement which alleviates any side effects. Am now on 20mg per week which I inject and have noticed occasional dizziness and am lethargic about 5 hours after injection. Increase in doseage has helped with my RA. M 50 4 months
10/17/2003
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 2  rheumatoid arthritis fatigue, nausea, bowel disturbance,sore throat,weight loss,sensation of pressure to back of my head lasting 2-3 days after meds. although I have been somewhat disappointed with the results, on the 2 occasions when I stopped medication I was very quickly reminded of just exactly what they were keeping at bay! F 43 3 years
7/28/2003
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 4  Rheumatoid Arthritis Extreme fatigue and general weakness for 2-3 days after weekly dosage. Nauseous too. The first 2 months I was only taking 10 mg and had NO side effects. The last two weeks the dose was upped to 15 mg taken on Mondays. The next two days are the worst for the fatigue resulting in missing work. Thursday the energy is back to almost normal. F 34 2.5 months
7/25/2003
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 3  R. A.(Adult Onset Still's Diasease) i think this drug gives me nausea and is making me lose my hair and also decreasing my immune system. but i can be sure because i also have taken high doses of cortisone that may have the same efects. i went on methoaxate to faclalitae getting off high doses of cortisone(80mg) it seemed to have helped at some point but now i think the side effect are worse. but i can be sure my side efects can not be attributed to my daily cortisone because i alredy have those (cushing? syndrome> round face, hump, incresed body hair and loss of hair. i take 22.5 mg of methotrexate and 5mg of cortisone now and want to get off both but i am still in pain and afraid of getting a flare up of my disease wich is rae and very severe. F 20 6 months
7/24/2003
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 2  Psoriatic Arthritis Fatigue, lack of energy to do anything, shortness of breath, dry cough worse at night, feeling sick usually for 2 to 3 days after. On 15g once a week. Does not seemed to have worked at all but Doc says to stay on it (even though I have asked to come off it)! Have recently had cortisone injections into both sides of collar bone and knee, this has not worked either, perhaps I'm just difficult! F 25 7 months
7/23/2003
 2  ankylosing spondylitis ulcers in mouth; headaches; sore eyes; tired; weakness M 55 6 weeks
6/25/2003
 4  P A / Gittate Psoriasis nausea first 24 hrs after dose , mouth sores third week then went away, short term memory loss , moodiness first 24hrs after dose,dull ache in right side of ribs mostly at night. my hands and feet feel some what better started to experience an increase in pain recently after having some short term relief, my skin is almost 100% clear amazing considering I was 95% covered with Guttate Psoriasis. F 37 6 weeks
6/17/2003
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 5  rheumatoid arthritis Nausea. Generally subsides a couple of days after the injection. Dizziness that just comes and goes. Unlike what others have said, I have not experienced weight loss as a result of the methotrexate. In fact, for about 2-3 days after the injection I get very bloated and weigh about 2 pounds more. This comes off usually by the 3rd day. Methotrexate has helped me quite a bit. I still have to take pain medicines, however. Unfortunately, the positive effects are beginning to be less pronounced, and my condition seems to be worsening--just not as fast as it was prior to the use of this drug. F 51 10 months
6/11/2003
 5  Rheumatoid Arthritis Do not experience any noticeable side effects. I take 15 mg. in a single dose once a week on Monday mornings before breakfast. I used to take meds with food but this made me slightly nauseous. This medication allowed me to go from being bed-ridden to being able to fully function and work fulltime. So far, I've stayed healthy, even after 15 years of taking this drug. F 49 15 years
6/10/2003
 5  Rheumatoid Arthritis EXTREME tiredness, almost complete loss of energy. Sore gums periodically (every few weeks). Involuntary twitching of arms and legs at night. Recently extreme depression (may not be related). This has completely subdued my RA, although I still need painkillers due to damaged wrist joints. I can't get any doctors to acknowledge that this drug causes tiredness - yet look at other's comments! M 54 4 years
5/29/2003
 5  rhuematoid arthritis bowel disturbance M 33 4 months
5/11/2003
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 5  rhuematoid arthritis Some bowel disturbance...some hair loss...that's all,, till now. at first 15 mg now i am on 7.5 mg..i become nearly a normal person,,,it is great till now...i take antioxidants,folic acid,and multivitamins,drink more than 3 litters of water per day..may be i can avoid any side effects in the future. M 33 4 months
5/11/2003
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 2  RA Intermittent nausea, mouth sores, some hair loss, extreme fatigue the day after Have not had any noticeable improvement in RA since taking this drug F 38 5 months
4/28/2003
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 5  rheumatoid arthritis extreme tiredness, nausea, headache, loss of energy This drug had been a miracle for the treatment of my RA. I am able to function daily with a minimum amount of pain. F 46 15 years
4/11/2003
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 4  Rheumatoid arthritis Nausea, especially the day after I've taken it. More effective than any of the other medications I've tried. F 30 1 years
4/9/2003

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