PRISTIQ Reviews (DESVENLAFAXINE SUCCINATE)

Average Rating: 2.8 (628 Ratings)

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 ANTIDEPRESSANTS

 Type: Rx Drug

  

PRISTIQ  (DESVENLAFAXINE SUCCINATE):  Desvenlafaxine is used to treat depression. It may improve your mood, feelings of well-being, and energy level. Desvenlafaxine is known as a serotonin-norepinephrine reuptake inhibitor (SNRI). It works by helping to restore the balance of certain natural substances (serotonin and norepinephrine) in the brain.   FDA Approval Date: 2008-02-29 (Sources: U.S. Centers for Medicare Services, FDA)

  

Results are sorted by length of time drug was taken from shortest to longest duration (reviews with no time reported listed first).

Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32


RATING  REASONSIDE EFFECTS FOR PRISTIQCOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 4  Anxiety Brain fog every day about noon, lasts for 1-2 hours. Forgetfullness. Was having major anxiety including panic attacks. The pristiq worker wonders for the anxiety. Side effects are a concern but controlling my anxiety is more important. Plan on staying on the drug for 4-6 months than weaning off. M 51 30 days
50 mg 1X day
1/30/2014
 4  PMDD Reduced sexual desire, yawning, tiredness. Pristiq has helped lift my chronic depression before and during menstruation. It has improved my relationship and I have not had suicidal thoughts since taking it. I don't experience overwhelming sadness and hopelessness anymore. I don't feel emotionally numb however, I think since the cloud has been lifted I am feeling love towards my family more. I have lost 4kgs as I am not binge eating also. F 28 30 days
50 MG
6/20/2020
 2  anxiety/depression For the first two weeks felt horrible. Insomnia, shaky hands, Diahrrea, anxiety attacks, loss of appetite, Almost impossible to orgasm and a strange sort of tingling/burning sensation in my forearms and hands. Most of which subsided by week three but still have insomnia. Mood sort of improved but still feeling very anxiouse with alot of negative thoughts. Seems to work better when used with alot of cardiovascular exercise. Was on remeron before this which was awesome and worked soooo well for me but stoped working after about three years. Compared to remeron I think pristiq is crap. This medication is a seriouse case of "the cure is worse than the disease" M 29 30 days
50mg 1X day
10/7/2010
 1  depression **THIS DRUG IS DANGEROUS!!** I have been taking SSRI meds for 16 years, and after 'plateau' is reached, I switch...Prozac, Paxil, Zoloft, then Lexapro. No problems, other than weight gain (50lbs!). I took Pristiq for exactly 30 days. On the 3oth day I had a meltdown at work: hallucinations, panic attack, uncontrollable crying, suicidal thoughts, soaring blood pressure...I could go on. Suffice it to say I ended up in the ER for 30 hours while I stabalized. My kidneys shut down, I was extremely consitpated, and by blood pressure got up to 204/110. I had 2 IVs, Xanex, and water. It took a week for me to feel 'normal' again (today). I'm back on Lexapro and am on a mission to let everyone know how very dangerous this drug is. Some people, of course, have no problems, and I'll admit, the first two weeks I felt euphoric. But when the crap hit the fan, it hit hard! Be careful. Read every post you can before you take this. And beware the withdrawal symptoms! Horrible drug. F 61 30 days
50mg 1X day
11/1/2010
 1  Depression Headaches,Sleepyness,Blured Vision,Huge Pupils,Aches in my legs,weight loss due to not being hungry,loss of breath and yawning,feeling drugged,lack of concentration,loss of sexual pleasure,lack of co-ordination,dizzy spells,extreme jaw clentching. The first few days of taking this med felt like I was takin E, or other drug.It made me need to grind my teeth and chew all day.Huge pupils and surge of energy.The after few hrs got very tired.No desire to eat for about a week.Painful headaches.It also dehydrated me.After first week, the "high"was gone, other side effects still there and I feel drugged.Like my brain is foggy.I hate it, want to get off this Med. F 22 30 days
50MG 1X day
5/8/2010
 1  Depression, Bipolar 1, GAD/Panic D short-term MEMORY LAPSES/gaps/blanks (SEVERE!!) which aggravates anxiety/depression/panic attacks++. Night sweats!, reduced libido(++), intention tremor (e.g.. difficulty writing addresses on letters), depression =only mildly improved; anorexia++, florid dreams/nightmares++, early morning awakening, slight weight-gain despite anorexia. Anorexia: severe! Anergia: severe. Mood *snaps*/fluctuations: rapid cycling and mixed states. On averages, and based on my own experience, i do not recommend Pristiq for people with Bipolar 1 (depressive phase). I'm planning to taper off (am on only 50 mg every 2nd day)..It may work for some but, so far, not for me. Did not really have a noticeable pos effect on anxiety. Depression has been marginally improved.But would/will it last? I doubt it M 54 30 days
50 MG 1X day
11/6/2012
 1  Anxiety/panic attacks Inreased heart rate, constant anxiety, increased panic attacks I HATE this med (I mean POISON!!). I have only been on it for 30 days and I feel like I am going crazy!! My anxiety and fear are worse than they have EVER been. I used to only need to take a small dose of Xanax 0.25mg). as needed, but since starting on Pristiq, I am taking a total of 1.0 mg or more a day, just to deal with this increase in panic and anxiety! I have weird, vivid dreams and wake up several times during the night with a racing heart which then of course spirals into a panic attack!! I am weaning myself off this crap starting today! STAY AWAY FROM THIS MED!!!!!!!!! F 40 30 days
50 mg 1X day
10/17/2011
Email
 1  Depression, insomnia High blood pressure, palpitation, ringing in my ears (tinnitus), dizzines, extreme pain in my joints, dry mouth, apathy, hot flushes I took Pristiq for a week in conjunction with Cymbalta to wean myself off Cymbalta. At the time I thought it was working great, because I could finally fall asleep and stay asleep all night. So, I told the Dr. that this might finally work!! Boy was I wrong!! After discontinuing Cymbalta my problems began. See the Side Effects I had. I have been off for a week and my ears are still ringing so BAD I just hate it!! Still have somewhat high blood pressure (never had problems with my blood pressure before). I hope these symptoms will go away. And now unfortunately my insomnia is back. I think they ought to outlaw this medication. F 62 30 days
11/25/2009
 1  Depression severe headaches After 30 days on Prostiq, I had to quit taking it due to severe headaches. Everyday on it I had some sort of a headache. The real problem was getting off. It was horrible. Days of severe nausea, ringing in the ears, mental unbalance, brain zaps, vertigo, etc. Several times it was bad enough to feel like I should go to the emergency room. F 44 30 days
4/19/2009
 1  MDD, HAD, PTSD It was causing headaches, sexual dysfunction, zer9 appetite, increased heart rate, dry mouth, increased anxiety, irritability. It did help the depression slightly, but brought along a host of other issues I can't live with. F 47 30 days
25
12/29/2019
 2  Depression and anxiety Extreme nausea to the point where it hurt to move or do anything other than lay in bed, constipation, loss of appetite While this medicine did improve my mood, the physical side effects are unbearable. What good is feeling great mentally if I'm physically too sick to get out of bed? F 24 33 days
50 MG 1X day
4/30/2021
Email
 4  Depression I had almost every side effect for the first week. After 35 days, the one remaining side effect is blurred vision. It is quite alarming and I am debating whether I should stop the drug. I have had almost every other SSRI, and this one is by far the most effective. And, other SSRI's had side effects that forced me to stop. None however caused blurred vision. I am hoping that this condition improves because I do not have any other options in the drug world. F 56 35 days
12/18/2009
 4  Menopausal depression A little jittery at first and my ears felt stuffy like I had a cold. I have tried quite a few antidepressants and these side effects are pretty mild. I was feeling low and having symptoms like PMS every day. Taking estrogen has not helped , I think because it's such a low dose . Pristiq is a good medication for depression that makes you feel slow, heavy and tired . It hasn't made me anxious. I have read some comments about withdrawals coming off this and other antidepressants. Your doctor can prescribe some medication to take for a short period of time to help with those symptoms. It really helped me getting off some migraine medication which had terrible withdrawals. One is Clonidine and the other is Hydroxyzine. I'm sure there are others , too. F 57 45 days
50 mg 1X day
3/13/2021
 2  Major Depression Horrible mood swings, anger, hostility, sadness, crying for no reason, headaches. This medicine turned me into a crazy person! It was like having the worst PMS x 10. My moods changed on a daily basis. I began having anger outbursts out of the blue, throwing things, slamming doors and yelling at anyone who got in my way. I cried hysterically for no reason. I began to hate the job I actually normally love. Everything irritated me. I have now stopped taking the drug and went back on Celexa. I am really hoping I get better because this is no way to live. F 34 45 days
50 1X day
8/2/2011
Email
 1  Depression/Mild Anxiety first couple of weeks seemed ok, experienced some memory loss but attributed that to the Valium I had started at the same time. Now the Valium is a thing of the past, and so is my memory. I cannot remember anything! literally impossible to book an appointment and show up on time, my keys are lost, my wallet is regularly lost, remote always lost, 3 pairs of sunglasses and 3 hats lost. Some of these items show up for a day or two, then are lost again. My sex drive is zero, I have had strange episodes which have been quite hallucinatory, my vision is often shaky and now I have started getting 'zaps' also. I'm confused and feeble minded, from a normally high functioning person. I have had strange violent thoughts when waking, that I quickly forget, that make me wonder what's going on in my head while I'm sleeping. My doctor never warned me about the dependence issues associated with this drug and I'm not happy. I'm scared to come off it and not sure about how to do it. I keep booking appointments at the doctor, but missing them because my memory is so screwed. I can't cook food for my family properly any longer as I cannot properly multi-task. I even forget to pick up the kids from school! I don't know what to do with myself unless I drink strong coffee or something, anything to pull me out of this haze. This is a very dangerous substance, and I would advise extreme caution for any new users. AVOID!!! M 34 45 days
50mg 1X day
9/6/2012
Email
 1  major depression night sweats, extream dry mouth, still depressed, loss of appatite dont start this drug M 40 45 days
50 mg 1X day
11/18/2010
 1  Anxiety Tremor, heart palpitations, increased anxiety, extreme emotional lability, restless energy, anger. After stopping the medication: numbness in random extremities, electric shock sensations, nausea, sharp tension headaches Made me hypomanic, was sent to the hospital, still feeling withdrawl symptoms a week later. Caused me to lose my entire personality and my livelihood for weeks F 19 45 days
50 1X day
11/8/2022
Email
 5  Depression I started at 25mg and saw improvement so stepped up to 50mg. I was jittery for about a week and a half after stepping up to 50mg, and got a little sleepy after taking it. Also had dryness in the back of my mouth, but that's gone away as well. The only other negative side effect is difficulty reaching orgasm, in fact it's nearly impossible; so still trying to figure out what to do about that. I read "alternative sex practices" may be a solution on a couple different websites, whatever that means. I honestly have to say this drug saved my life. I fought depression for years and started trying medications three years ago, they either did nothing or made everything worse. After my brother took his own life last year, I was at the end of the rope. I tried a couple more medications with no success and then I started the lower dose of pristiq about eight months after his suicide and noticed I felt better. After going up to 50mg, in a week the endless loop of negative thoughts vanished. My wife said to me, β€œIt's good to finally have you back, I was starting to think you may be lost forever if something didn't change.” I really had no idea how deeply I had fallen until the fog lifted and I could look back at the hole I'd been in for years. The last side effect I listed is disappointing, but worth it considering I'd had pretty much zero interest in sex (or anything else for that matter) for over a year. It's all about finding a medication that is a good match for you; I didn't realize how much depression is an illness, not just an attitude or personality issue until I was finally out from under it. M 51 60 days
50 1X day
2/21/2022
Email
 5  Anxiety/Mild Depression I've had a very interesting and unexpected side effect from taking Pristiq. Having taken Pristiq last year for several months and then going off due to co pay costs being so high at the time, I switched to Effexor (wasn't as helpful as Pristiq was for me) so recently, the cost of Prestiq went way down and I knew I wanted to switch back to it - I was positive if this was a side effect of Pristiq last year when I took the medication, but I feel very confidant saying I believe it was because when I stopped taking it I noticed it stopped, but when I started taking Prestiq again it came back ... I don't quite understand how or why, but I believe that not only does it help me, doesn't make me gain weight and has minimal to no negative side effects, the most interesting things I observed while taking Pristiq is that I have much longer and more intense oragasms with my husband. I feel funny sharing this, but it's 100% true! I've always had a good and healthy sex life with my husband, except I have taken medications in the past that I thought slowed my libido down a little so I stopped them - but not only does Prestiq not interfere with my sex drive, I really believe for some reason, some way, some how it absolutely has improved sexual satisfication and oragams. I truly wonder if this has effected of women in a similar way, because of so this could be the start to like a mild version of Viagra, but for women! How amazing would that be for all the women our there who feel they're sex d Love!!! Truly helpful! F 32 60 days
50
4/29/2018
Email
 3  depression reved up F 44 60 days
10/5/2008

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