PRISTIQ Reviews (DESVENLAFAXINE SUCCINATE)

Average Rating: 2.8 (628 Ratings)

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 ANTIDEPRESSANTS

 Type: Rx Drug

  

PRISTIQ  (DESVENLAFAXINE SUCCINATE):  Desvenlafaxine is used to treat depression. It may improve your mood, feelings of well-being, and energy level. Desvenlafaxine is known as a serotonin-norepinephrine reuptake inhibitor (SNRI). It works by helping to restore the balance of certain natural substances (serotonin and norepinephrine) in the brain.   FDA Approval Date: 2008-02-29 (Sources: U.S. Centers for Medicare Services, FDA)

  

Results are sorted by length of time drug was taken from shortest to longest duration (reviews with no time reported listed first).

Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32


RATING  REASONSIDE EFFECTS FOR PRISTIQCOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 3  Mild depression and edginess hot flashes, some difficulty sleeping,increase in appetitite after first two weeks I had taken Lexapro and celexa for a few months many years ago and experienced a weight gain so I stopped all medication. I started taking 50 mg of Pristiq and it seemed to take effect within a few days. It really took the edge off and put me on a more even keel. But that only lasted a few weeks I suppose I got used to the dose and the positive effects just dissipated and I started to gain weight -even though I work out 6 days a week. I really don't understand why these medications make you gain weight. At the end of the day the weight gain really adds to my low self esteem F 51 2 months
4/21/2009
 3  Anxiety depression Brain fog at higher dose. Lower libido Better for anxiety than depression M 40 2 months
75 mg
12/9/2019
 2  panic attacks, major depressive d/o urinary incontinence, feeling of deja vu @ times, memory & word retrieval problems, night sweats, racing thoughts, depression worse, bizarre dreams. Weaning off this drug! After all comments I am dreading w/d symptoms but I must get off this drug!!! Am going to get genetically tested to see ssri or snri that may work or maybe atypical med. I'm taking 350mg Bupropion already. F 68 2 months
150mg 1X day
10/17/2019
 2  Depression, PTSD Dizzy, Stomachache [like food poisoning], Trouble Breating, Generally feeling unwell. This drug did not help me at all. It was constant painful side effects even weeks after starting & stopping the meds. If I went a few hours late taking the pill, I would be so dizzy I could hardly walk. And didn't help. Pointless pain. F 18 2 months
50mg 1X day
9/15/2010
 2  depression major weight gain, nightmares, headaches, menstral spotting several times during a month I took this drug in the morning on the first day. It made me very sleepy so I learned quick to take it later in the day. As time went on, I noticed I started getting headaches. After that I started having nightmares and really weird dreams. The worst problem of all is that I gained a lot of weight and I craved sweets ALL of the time. My doctor has switched me to something else now. Hopefully it will work better than pristiq. F 43 2 months
30 1X day
10/27/2010
 2  Anxiety/Depression Overeating / Weight Gain Pristiq helped with my worrying and some of my obsessive thoughts, but made my eating out of control. I had zero sensation of feeling full and have been gaining weight in my mid section, which has never happened to me before. I'm discontinuing Pristiq. I had high hopes for this medication, but it's just not working out for me. If you're considering this drug, please give it a try. It does have the least amount of side effects compared to other meds I've taken (Prozac, Effexor, Zoloft). F 31 2 months
50 MG 1X day
4/10/2011
 2  mild depression headaches, nauseau, feel lousy...i felt great for the first three weeks...then the side effects started every day...going to go off...i'd rather feel a little blue than feel like crap every day! M 58 2 months
50 mg. 1X day
3/3/2011
 2  Depression; General Anxiety first 3-4 weeks I felt wounderful. After a full month and a half or so I started to feel worse than before. * Worsening depression * Irritability * Pounding rapid heart rate (even while resting/sleeping) * Horrible sweating * Teribble mood swings * Shaking in hands * Terrible nightmares/dreams * Difficulty waking up * Don't sleep as well as I used to * Constipation * Fatigue After finally deciding to discontinue this med I experienced... * Brief but very very frequent pulsations/"Zapping" feelings in my head * Still sweating alot * Still having strange and very scary dreams * Still hard to wake up after experiencing strange dreams ( which terrifies me even more) I've only been off of this med for 3 days now. Hopefully these terrible side effects will go away soon. I certainly would NOT reccomend this med to any one specifically within my age group. I'd much rather depend on the Lord to help me overcome my battles than to deal with these side effects. I've never felt this bad. F 22 2 months
1/27/2010
 1  Depression agoraphobia, right arm numbness, brain zaps, suicidal thoughts,insomnia, no sex drive,increased appetite, craving sweets, weight gain, blurred vision, foggy head, intense dreams, lower back pain, racing thoughts The first two weeks of taking this drug, I felt like it was really helping. After that, it has gotten progressively worse. I feel like I'm losing it and I'm getting off this stuff as soon as possible. I am convinced that none of us truly know how much harm these prescriptions are doing to us long term. I feel like this has really screwed up my brain and my body. This stuff is poison, I would strongly recommend that no one take this and try to find a holistic approach to treatment. F 33 2 months
50 mg 1X day
3/21/2011
 1  Depression Eye pressure seen ophthalmologist severe muscle tetany had to quit drug will never try new one again F 56 2 months
50mg
4/17/2013
 1  Depression & Anxiety Was on Effexor before hand (6 months), never worked & I only felt strange. Switched to Pristiq per doc to wean off. 9 days off & I am dizzzy, have been from day 1, exhausted, muscle aches, racing thoughts, hair loss. I wouldn't put my enemy on this poison. Tried calling Pfizer, on hold forever 3x gave up. Filed complaint with FDA. Do your homework before starting this med. People complain the withdrawals can last months. Most docs don't even know this. F 22 2 months
50
11/8/2016
Email
 1  depression pristiq gave me weight gain and headaches. I was on wellbutrin but it lost its help for me was great but was on it for 6 years. and pristiq is not generic. going back to psyc doc and get something else. pristiq is not generic. in between my insulin and other meds the higher price isnt worth it. F 47 2 months
50 mg
5/8/2015
Email
 1  Depression and anxiety Anxiety symptoms worsened and became unbearable... I was paralyzed with anxiety while taking this med. My depression worsened and I became suicidal, had to be hospitalized. Anorgasmia and loss of libido was troublesome as well. I was taken off Pristiq gradually and began Luvox about a week and a half ago... doing VERY well now with the Luvox, not much anxiety at all anymore and my libido is back/no more anorgasmia, feeling hopeful and getting back into life now. M 37 2 months
12/21/2009
 1  Depression severe At first I began to feel better, then after about 15-20 days I became glittery. I would experience loud noises going off in my head, then a jerking sensation would occurred if I got upset. About a month into the drug I began to have seizures which is a side effect, my doctor waited another three weeks to take me off pristiq, and try something else. I have been off the drug for two years and am still suffering from seizures. F 29 2 months
75 mg
3/15/2014
Email
 1  Anxiety Started pristiq at 50 mg on 11/13/20 . First 4 weeks very noticeable difference in anxiety (health) for the good. It worked, finally I feel normal I thought to myself. Well it was short lived, I noticed in the beginning I was tired, but that's to be expected on meds. Been on Zoloft it pooped out, lexapro od on 20 mg . But only med I'm on is prestiq . Lately past couple weeks it's all went downhill. I am so jittery , exhausted, my stomach and intestines hurt at times. shoulders, overall achy, it's almost a chore working all day. I get home and I'm so tired but can't sleep, have 2 kids and a wife that I don't even want to talk to or be around. And I love them so much, I'm emotional, rage for no reason. Jittery, and can't seem to sit still , just scroll through channels on the tv for hours . I do clean my house all the time, not sure if that is a bad thing but comes in part with not being able to sit still . Can't focus on anything, don't care attitude. It's a terrible drug. My body twitches for no reason, scared to drive and don't want to leave the house . Almost scared to. So dizzy , feels like there's a wall in front of my brain, blurry vision and chest tightness. Check my pulse ox and blood pressure 10 times a day Oh and the chills, can't seem to get warm. Some sweating episodes but mostly cold to the bone. Just a feel of dread , don't recommend. Please feel free to email me M 42 2 months
50 1X day
1/11/2021
Email
 5  Depression/Anxiety Increased sweating, weight loss I live in Quebec Canada. The Covid-19 measures, confinement, curfew at 8 pm, stores and gyms closed made my life a living hell and I tried to kill myself twice. I lost 5 of my friends because they killed themselve because of that pandemic crisis. So I went into a deep depression but Pristiq saved my life. I am able to go back to work and live my life. The gym reopened so it helps. But I have to loose the 60 pounds I took since the pandemic started. I lost 20 lbs but still have to loose. My energy is back. M 41 3 months
100 mg 1X day
4/5/2021
 5  Panic disorder Slight weight gain but i have never felt better. Pristiq definitely working for me. F 48 3 months
100mg
7/20/2013
 5  DEPRESSION, ANXIETY The first 2 weeks I noticed sexual side effects, but only a few hours after I took it. Less hungry, more thirsty. Nausea was a problem for about 2 weeks, gone now. The best thing about this medication is that all the side effects have either disappeared or leveled off for me. My anxiety is greatly curbed and depression is much less severe too. I'm able to concentrate on things better and I have more energy. My family has noticed that my temper rarely flares like it used to. Overall the results are great. F 47 3 months
11/23/2009
 5  Severe depression & anxiety During first few weeks, and with insufficient dosage (50 mg), same odd flashes as on Effexor XR when dose is overdue. After that, very few effects attributable to the med. With sufficient dosage (100 mg) and sufficient time to acclimate, Pristiq is as good as Effexor XR ever was, but has very little in the way of tangible side effects. I am very even-tempered, but do not feel numbed-out emotionally or physically. Energy level is pretty good, mind reasonably clear for a guy entering early geezerhood. I was on the minimum dose for Effexor XR, so my Dr. initially put me on 50 mg Pristiq. This did not work. Upon reporting this to her, she put me on 100 mg Pristiq. First 10 days were NOT a lot of fun, then everything smoothed out. A word regarding soem of the previous responses here: You cannot judge ANYTHING about an SSRI or SNRI in a few days. Unless your are experiencing extreme anguish that is different from how you previously felt, or you have some kind of new life-threatening physical symptoms, give the drug a chance! It really does take quite a few weeks before your brain chemistry settles into a new stable pattern. I know very well that patience in the face of severe depression is very difficult, but please try to muster it up, and give timely and accurate feedback to your doctor. M 66 3 months
3/25/2009
 5  severe depression loss of libido I have been taking this medicine for 3 months. I have been doing very well on it. I take 50 mg on the onset of my menstruation and then take 100 mg after I ovulate (2 weeks 50mg, 2 weeks 100mg). I was taking Effexor XR for 5 years. I started with 37.5mg and eventually ended up at 300mg. I was having a lot of problems taking such a high dose (memory loss, loss of libido, skin lesions, weight gain). I was on Effexor for such a long period of time because I was a bit out of it and didn't realize that my health problems were due to such a high dose. I went off Effexor (process of about 6 months) and was clean from the drug for 2 months. I realized my depression problem was the result of the onset of the second part of my cycle (after ovulation). Pristiq works for me without all the bad side effects of Effexor (no memory problems - I test myself with crossword puzzles, no skin problems). F 40 3 months
1/4/2009

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