PRISTIQ Reviews (DESVENLAFAXINE SUCCINATE)

Average Rating: 2.8 (628 Ratings)

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 ANTIDEPRESSANTS

 Type: Rx Drug

  

PRISTIQ  (DESVENLAFAXINE SUCCINATE):  Desvenlafaxine is used to treat depression. It may improve your mood, feelings of well-being, and energy level. Desvenlafaxine is known as a serotonin-norepinephrine reuptake inhibitor (SNRI). It works by helping to restore the balance of certain natural substances (serotonin and norepinephrine) in the brain.   FDA Approval Date: 2008-02-29 (Sources: U.S. Centers for Medicare Services, FDA)

  

Results are sorted by length of time drug was taken from shortest to longest duration (reviews with no time reported listed first).

Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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RATING  REASONSIDE EFFECTS FOR PRISTIQCOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 1  Major Depression Weight gain, sleepy all the time, yawning... I would go to sleep at 10:00 PM and it was impossible to drag myself out of bed until 9:00 AM. At 2:00 PM, I'd take a nap until 5:30 PM What good is an anti-depressant if you sleep all night and most of the day? M 54 5 weeks
50mg 1X day
5/31/2010
 1  Depression Good for my depression but side effects were bad. I started having severe leg cramps, heart pounding and heart rate jumping up to 120 from 70 beats several times a day, hand and facial swelling and dry cough. Fatigue. Up to bathroom 6-7 times a night (usually up 1-2 times a night). I quit taking this med after 5 weeks before I had a heart attack! F 49 5 weeks
11/1/2009
 1  Panic Disorder **Do not take this for panic disorder! It was like adding fuel to panic attacks. Felt like i was on speed. Excess energy, pseudo happy too energetic but with tired weak feeling legs. Restless legs at night, waking up with tensing jaw scared shitless. Nightmares. Excessive crazy sweating. Major heart palpitation episode at night where i called an ambulance. Not good for panic attacks at all. Was hell. And more hell coming off it. Severe panic attacks worse than before i went on it. F 38 5 weeks
50mg
4/20/2014
 1  Depression Major side effect was my severe mood changes. Found myself getting angry for no real reason. Screaming at my children scared them and myself. I am talking about total rage. Have taken myself off Pristiq and returned to Effexor. Had no problems with that. My children might learn to trust me again. F 43 5 weeks
11/12/2009
 5  severe bipolar disorder with ADD !st through 4th week, weaned off of Paxil and worked up to Pristiq 100mg. (25% change each week for both meds) 5th week (pristiq 100mg), had a headache and became quite manic, but stuck with it and now in the 6th week, I FEEL GREAT. Best side effect - hugely increased libido! I developed a very serious depression during/following menopausal hormonal changes which basically paralyzed me and left me bedridden. I have been on Paxil (60mg), Welbutrin (300-450mg) and Buspirone (60mg) for the past 10 years adding Adderall (40mg) for the last 3 years, and I have been fighting a depressed fog for the better part of that time. After a shift from Brand to generic earlier this year, I had a serious dive into the dark side, then got back on brands hoping to fix it. I stayed in the dark trying my best to make it work, but after finally realizing I couldn't get out of bed, my Doctor switched me to Pristiq, while leaving me on the Welbutrin, Buspar and Adderall. I feel better then I ever have in my entire life. It is an absolute miracle. I have lowered my Adderall dosage to 20 mg. When I am driving and doing normal activities, I feel sharper and more alert then I have for at least 10 years. AND, I don't feel like all activity is worthless anymore! ALSO, I have had difficulty achieving orgasm ALL of my life. It was like running the marathon. This week, tried and achieved orgasm within seconds. And I thought Pristiq was great before I even discovered that aspect. I wake up wanting to do things, and ABLE to do them, whereas in the past 20+ years it was a monumental struggle to do anything. I am hoping against hope this med does not stop working. It is a MIRACLE for me. F 58 6 weeks
100 mg 1X day
12/9/2010
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 5  depression I have depression, induced by an unpleasant divorce and have been taking Pristiq (50mg) for 6 weeks. First 3-4 days made me feel drowsy, but no other side effects. Positive effects were noticed after about 4 weeks, particularly in work which had become a big problem. Lethargy, lack of interest and concentration have all improved a lot. Outside of work, appetite has improved and sleep patterns are starting to improve M 51 6 weeks
50mg 1X day
1/19/2012
 4  anxiety and depression While starting Pristiq I had some head aches, low sex drive,and some body/muscle twitching when relaxed and trying to fall asleep. All of those side effects have since disappeared and I am so glad now that I hung in their and stayed the course. I feel like myself again and seems to be better than being on Paxil for 15 years. M 47 6 weeks
100 MG 1X day
1/25/2013
 3  GAD, PTSD First few days couldn't function, like the drugs withdrawl symptoms, without the brain zaps. Nausea, dizziness, confusion, dream like state that I'm still in. A lot of jaw clenching and tension, mood swings and some rage. Suicidal ideation, and other ideation at various moments. Overall i have experienced a 75% improvement in general, the remaining is a bit intense, not gonna lie. Its about coping and controlling your mind, and side effects with the positive aspects outweighing the latter. Exercise extreme caution when deciding to take this drug. Spousal or family support, care, and supervision are important. F 28 6 weeks
50mg daily
1/8/2015
 3  Depression I did not have any side effects the first couple of weeks, but as time goes by I am now experiencing terrible constipation along with extreme dry mouth. I tried to wait it out hoping the side effects might diminish once the drug has taken full effect, but they have not gotten any better, and I am afraid this is a deal breaker for me. I am thinking at this point, I will need to try another medication, which is a shame because they worked well for the depression but the side effects are just too much. F 51 6 weeks
50MG 1X day
2/18/2014
 3  Bipolar 2 Nausea, lack of concentration, reduced appetite (7kg weight loss first 4 weeks), mild night sweats, anxiety and mood change I’m in the 6-8 week efficacy period. If my headspace and motivation don’t change for the good will most likely wean off. Always difficult to deal with side-effects with the stresses of teaching. M 53 6 weeks
100mg
12/11/2020
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 2  Depression No real side effects that I could pinpoint. No improvement after 6 weeks. I switched from Lexapro to see if there would be less side effects. There were less side effects but I was sliding back into depression again. I had to add 10mg of Lexapro to start feeling better again. So I have stopped taking Pristiq several days ago and back to 15mg of Lexapro which does have side effects. But still better that feeling down. M 57 6 weeks
5/30/2009
 2  Clinical Depression with anxiety Increased appetite with record WEIGHT GAIN-so much that my clinician called other staff into the exam room to LOOK at me (look at the FAT lady),I'd been underweight before.Also I am becoming increasingly withdrawn & reluctant to even step outside of my home or to answer the phone & be social.My bills sit unopened while I avoid reality eating & in a stupor watching TV.My eyeballs feel bulging & I am in a HAZE mentally,not really so depressed, BUT not FEELING (anything). NUMB. I want to give this some more time, but my world is spiraling downward....... I've been reading comments with so much honesty & emotion,it's quite frightening.If you want your experiences to be counted & documented,this is a great avenue to help others, but remember to contact the FDA to report ADVERSE SIDE EFFECTS!!! Otherwise, all of our wisdom & consequent suffering in way too many instances, won't be heard & the drug companies continue to profit by other's suffering! It's a toll free number, or contact FDA.gov & click on medication side effects. F 50 6 weeks
50mg 1X day
1/14/2013
Email
 1  moderate depression Insomnia, loss of labido, nightmares,mood swings, headaches,feelings of insanity. Hated this drug. Early on I felt wide awake to the point where it felt like my eyes could not open any wider if I tried, and only couple hrs sleep. Horrible vivid nightmares that I would think about most of the following day. Totally negative impact on my mild depression.i advise to avoid!!! M 42 6 weeks
50mg
4/3/2015
 5  Anxiety, ADHD Paraesthesia, insomnia (take it at night, my advice), dulling of the senses, lowered appetite [which i like], inability to recall words, increased tremor as elicited by anxiety, onset of panic attacks quelled by alprazolam. Extreme difficulty in concentration and by third week, a VERY strong feeling of dysphoria and lack of motivation, none of which i EVER had before in my life. Very original. An antidepressant that made me depressed when formerly I had never been depressed. A supposedly effective cure for ADHD according to my doctor who should really retire by now because he's starting to forget his name...which made me have ADHD times 10. And anxiety increased with time and dose, and best of all, a nice healthy tremor to top it off. M 25 7 weeks
4/15/2009
 4  depression The first day i experienced nausea and heartburn but that disappeard when I took it with a full meal. I have been on it for 6 weeks now and hands down it is the best experience I have had with anti-depressants.Naturally, I still have many other issues but I am not lying in bed crying and can now enjoy life.I have always had very bad sleeping issues and it hasnt done much to correct that. There are no side effects that interfere with daily functioing and I am very appreciative that my doctor gave me this. Originally he wanted to try me on cymbalta but felt it was over my head financally. F 47 7 weeks
6/21/2009
Email
 2   I suffer from ocd, depression and anxiety. This medication worked quite quickly but was worse for my anxiety! Increased my heart rate 24 hrs a day! Had a major panic attack week 4 into taking it! Felt wired and tense! Had to come off it as It wasn't helping. It did help decrease my worrying thoughts but side effects were toatally not worth it! Prestiq was the 2nd drug i have tried. Citalopram was the first and worked sooo much better so I am now back on that and am much calmer and relaxed about life :) Dissapointed as i was told that it would work better for my anxiety than citalopram but it was way worse! I felt really anxious even after 6 weeks on 50mgs tried going up to 100mg and neally took myself to the emergency department! It increased my blood pressure daily and increased anxiety! I back on citalopram and am feeling much more relaxed and happy! citalopram kicks pretiqs butt for anxiety!!!!!!!!!!!!!!! very dissapointed! F 31 7 weeks
50mg 1X day
4/4/2012
 1  Depression At first, depression worsened, feelings of sadness, crying, moodiness, agitation. Those symptoms eased, except for sadness and crying, but then my ears started ringing (typically toward evening and night) - sounds like constant chirping or a faucet running at a low flow. Just awful. Have been on Zoloft (Sertraline for approximately 13 years). Doctor recommended going off Zoloft because of ED issues, and prescribed Pristiq. M 54 7 weeks
50MG 1X day
12/18/2010
Email
 1  anxiety I switched from Effexor to Pristiq because the phy doc thought it is stronger. Probably is because it made my anxiety and agitation much worse to the point that i could not lie still in my bed. Switched back to Effexor XR and symptoms dissapeared. If you don't feel better or even worse don't take it, try something else i had a bad experience with it. M 36 7 weeks
50mg 1X day
5/19/2014
Email
 5  depression, anxiety First two weeks-yawning,sleepiness, slight spaced out feeling,insommnia. All side effects disappeared after two weeks. Absolutely NO sexual side effects or increased appetite! Great med. Very mild side effects. It seemed to go in and out of effectiveness for the first month, but once it kicked in- awesome. Not sedating at all, maybe even a little activating without being jittery. Don't get discouraged in the first 6-8 weeks if you feel it's not working, this med definilty needs time to kick in and stabilize. Highly recommend! F 34 8 weeks
11/10/2008
 2  Major depressive disorder loss of appetite for the first few days I've been on 50 mg for almost 8 weeks now and I'm sad to say I have yet to see any results. For the first few weeks, I stopped my daily ritual of sobbing multiple times a day for no apparent reason. The tears have returned. I still suffer from fatigue, even after supplementing my AD with a prescription-only derivative of folic acid (which is said to boost neurotransmitter levels). I am suicidal, but I attribute that to my hopelessness and not the AD. I am now bumping up to 100 mg daily. I am just praying that I don't experience any side effects... I can't wait much longer. F 22 8 weeks
3/23/2009

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