PRISTIQ Reviews (DESVENLAFAXINE SUCCINATE)

Average Rating: 2.8 (628 Ratings)

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 ANTIDEPRESSANTS

 Type: Rx Drug

  

PRISTIQ  (DESVENLAFAXINE SUCCINATE):  Desvenlafaxine is used to treat depression. It may improve your mood, feelings of well-being, and energy level. Desvenlafaxine is known as a serotonin-norepinephrine reuptake inhibitor (SNRI). It works by helping to restore the balance of certain natural substances (serotonin and norepinephrine) in the brain.   FDA Approval Date: 2008-02-29 (Sources: U.S. Centers for Medicare Services, FDA)

  

Results are sorted by length of time drug was taken from shortest to longest duration (reviews with no time reported listed first).

Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32


RATING  REASONSIDE EFFECTS FOR PRISTIQCOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 5  depression pretty severe nausea the first week or so. Hurray!!! FINALLY after about 20 years of depression, therapy & various drugs, PRISTIQ has come to my rescue. I never thought it would happen. I don't think about suicide anymore. I am not negative about everything anymore. I don't pull the car over to cry, I don't cry at work-- geez, I don't cry at all! Thank you, Pristiq! F 40 5 months
11/16/2008
 5  Anxious None that I have notice, but I have much more energy. I feel good. F 63 5 months
50mg 1X day
1/29/2011
 4  situational depression First week, light headed then surpassed. Strange dreams. Mood more positive,feel great. No loss of appetite but no weight gain. Some moments of hot flashes. Increase of sexual appetite, intense orgasms, high volume of ejaculate. M 40 5 months
100 mg 1X day
3/12/2012
 4  Anxiety, Depression The first 2 weeks were hell. I threw up the first 2 nights and was having alot of trouble sleeping. My mind was racing, i was nauseous and unable to concentrate. I had the jitters and was very shaky all the time. I would sweat so badly at night my pillow was soaked and i had to get a towel. I began locking my jaw while i slept which caused migraines and alot of pain. My sex drive does not exist any more. Most of these symptoms went away accept the locked jaw lasted a few months, i still sweat at night but not as bad, and my sex drive is still dead. My new side effect is exhaustion. The last few months i have only ever wanted to sleep. Despite all the bad side effects, which mostly went away, this drug has been a life saver. After about a month of taking it i remember walking my dog on a sunny morning and actually feeling happy again. It was amazing. It took another month or 2 for the depression to finally lift. I still have a ways to go and the recent exhaustion is hard on me, but it lifted the depression enough for me to be able to get back to my life and make changes to help myself. F 27 5 months
50 MG 1X day
3/27/2013
Email
 4  Hotflashes Constipation, no libido I was on Effexor and was hungry all the time. Also kind of irritated. I tried Pristiq and had a hard time to move to it and returned to Effexor. Then, I understood I should return to Pristiq and I am on it now for 5 months and doing great. I did have to increase the dosage to 100mg. I'm strugling tho with very strong constipation problems. Besides the hotflashes I had several pain symptons. Neck, shoulders, low back, waist, ankles... Pristiq put them away as well. I had no depression or anxiety and I keep not having. Although my hotflashes make me miserable (Pristiq did reduce them to 3 to 4 a day and turn them very mild), I am not sure if I can keep on this drug. I have no insurance and to get a 3 month dose costs me $350. This is a new drug and there is no generic for it. I heard that Maca (a supplement)helps with hotflashes besides being an aphrodisiac, or at least an energiser. I can't find tho where to go to check for interactions as Pristiq is not mentioned on the sites I went F 50 5 months
1/27/2009
Email
 4  depression, anxiety Nausea during the first week or so. Restless legs, vivid dreams, decreased libido, delayed orgasm. If I miss even one dose, I feel it right away. My head feels strange, like it's swirling and I feel sort of nauseous. I also have nightmares if I miss a dose. This is the first antidepressant I've taken and it seems to be helping. I am more outgoing now and more sure of myself. I have more motivation to do things. However, I do still have suicidal thoughts and sometimes severe anxiety. Despite that, Pristiq does seem to have positive effects. F 18 5 months
6/24/2009
 3  menopause and anxiety mild side effects to start with like headaches, dizziness, no weight gain Being on pristiq 50 mg for 5 months now. At after a couple weeks on the tablets and things settled down i was amazed how good I felt back to my old self but as time has gone on I have notice if I miss a tablet I end up with vetigo and nasea and has been expericeing really bad dreams and feel like I have no soul as I have always been a caring person I do not like the person I have become, the memory loss has been unreal and feel like you are going crazy. I have decided to start taking myself of pristiq slowly. All I can say is it is a shame that pristiq did not work for long and I will not be recommending them to anyone.... F 51 5 months
50 mg 1X day
11/27/2012
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 3  anxiety/depression the usual trembling of the hands-otherwise none- but see below switched from Prozac- better feeling affect- tears-laughing etc. took in am-it did seem to fade later in the day. However, both times i missed a dose-had frightening/disturbing nightmares- seriously considering going off. M 68 5 months
50 1X day
10/18/2010
 2  Major depressive disorder dry mouth, insomnia, sweating, weight gain, decreased libido, irritability, itchy skin, tiredness, some anxiety Also take 450 mg Wellbutrin, but that stopped working as an antidepressant so only taking it to "charge" system. Changed to Pristiq after Cymbalta worsened my depression. Very little change in depression on Pristiq, periods of weepiness, vivid dreams and insomnia are driving me insane. Not sure what to do at this point, but I have taken almost every antidepressant and out of options. M 40 5 months
50 mg 1X day
7/29/2012
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 2  Major Depression, Anxiety, OCD In the beginning I had urinary discomfort and severe constipation. Then it threw me into an aggressive mania like a demon possessed me or something. This mania made me very angry and impulsive which is the complete opposite of my true nature. Sadly enough, I even became physically aggressive to my husband (he is a true trooper!). Once that subsided, I was just left feeling anxious and on the edge with a positive side of increased assertiveness (something I've been working on for years). I guess the good part is that I'm more empowered to stick up for myself and the depression isn't as severe. I also have bizarre dreams and wake up feeling totally exhausted. My libido has almost been lost completely with difficulty reaching orgasm. One last thing, if I forget to take the Pristiq, I go into a crazy mood swing. Now that I've written that all out I'm left wondering why I'm still on this pill? Don't know if this is the right medication but too scared to try yet another!! Been on at least 7 psych meds so far. Getting kinda discouraged....sorry if I'm passing it on.... F 24 5 months
9/21/2009
 2  depression and anxiety. Felt great very quickly. I thought is was a miracle. I noticed my heart rate was up but I liked having an uncluttered brain. The feeling didn't last long. Within a month I was back where I started. Dr upped the dosage from 50 to 100. My blood pressure and heart rate went crazy high. Dr then put me on 50 one day and 100 the next. It was still too much and wasn't doing anything for my original symptoms. I was finally down 50 every other day. After about a month of that I quit. My gp said it was bad for my heart. The first 30 days after I quit were really wonderful. I don't remember ever feeling that happy. Then I basically crashed. I feel worse now than before I started. I was wondering if anyone has had those kinds of euphoric feelings after quitting. F 61 5 months
50-100mg
6/5/2014
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 1  Depression Severe headaches, severe muscle pain, weight gain, blurred vision, itchy skin, increased lack of focus (since I already had a problem with that) and I became extremely moody The 1st week I was on this I started getting the chills really bad all day long. Then when I would try to go to sleep I would sweat horribly all night long and have intense stomach pain so bad I wanted to vomit. Also my nose clogged up and got little sores in the openings of my nostrils on both sides. The 2nd week my muscles started to get really really sore to the point walking across the room was exhausting and made my heart pound and then I would be in utter agony because every muscle in my body ached so badly. A couple weeks after that my jaw started locking up and I started getting very intense headaches that no amount of pain killer could help. But I'd started 2 other meds so I had no idea this was the one causing it. So my doctor finally just took me off this one. She tried to wean me off of it by putting me on a low dose of effexor for a week but this withdrawal is no picnic. Dizziness, brain zaps, irrational anger and can't sleep. But my head aches are far less painful and my muscles are getting a little better hope the other problems start to clear up. This definitely needs to come off the market! This has killed my health and my doc said it was brand new when she prescribed it. F 25 5 months
50 mg 1X day
5/10/2012
Email
 1  anxiety extreme fatigue, dizziness,yawning, lethargy, unmotivated If I knew what I would be going through, or how I would be feeling I would find ANOTHER SOLUTION AND NOT PUT THIS POISON IN MY BODY! I'm mad at my doctor (although she put me on this med to help)for suggesting this med, after I told her I didn't want to go on ad's. I tried to stop on my own and ended up with bad anxiety attacks. F 44 5 months
50mg 1X day
8/22/2010
Email
 1  Clinical Depression, anxiety diarrhea, increased anxiety, still depressed, but not suicidal, I also tend to be more impatient with outbursts here and there (which isn't normal for me) My doc told me that this medicine wont be more effective in the higher dose of 100 mg (and he chuckled to himself as he said this) it will only increase the side effects... This is one of the worst meds I have been on since taking paxil for 6 years of my life. The withdrawls from this medication is horrible and unbearable...I intend on getting off this med to something more effective at my next doctor's appoitment. I would suggest to anyone given this med or any medication, do your own research on the medication both postive and negative before you decide to let it mess with your brain. My doc is an idiot and also told me that all antidepressants were the same. I can't see how any medication having such severe withdrawl symptoms (discontinuation symptoms) can be good for someone's body or state of mind. I have 3 little children who are all under the age of 6 years old who are dependant on me there mother to be coherent, and capable of being mentally and emotionally there...and with this drug since I have taken it...I can now see how it has messed up my life, taken me away from things I love, and enjoy. I seriously regret this medication...look into withdrawl symptoms before you decide to start taking a medication such as this. So that you are aware of what could happen if this medication doesn't help you and you need to get off. Furthermore, regular MD doctors who haven't specialized in these types of medicines should never be allowed to prescribe them...it should be left to a phychiatrist or a type of psychologist who is able to prescribe medication. Not all antideppresants will effect you the same...my doctors are morons!!! F 29 5 months
50mg 1X day
8/2/2010
Email
 5  Depression, Anxiety, Severe Fatigue Pristiq is great but I have had side effects. The first week or two of taking pristiq were a bit difficult, nausea, dizziness, tired, runs, blurry vision (but keep in mind I was swapping anti-depressents therefore some of this would have been withdrawals as well). After 6 moths the side affects have come and gone and also changed. First few months was lack of appetite , then heaps of energy which later levelled out but I do find it hard to sleep at night. mild increased appetite, hair loss, decreased sexual drive, mild overheating, mild headaches and mild ringing in the airs. My bowels also don't move as often. Good side affect is that it has cleared up my acne which seem to be a result of stress and hormones or hormones causing stress that caused acne.... So in other words I believe the Pristiq has levelled out my hormones. I was taking luvox for a number of years and swapped to Pristiq. I wish I had done that sooner... I obviously have a fair few side affects but the side effects I have listed are fairly mild. For instance yes I find it hard to sleep of a night but I feel fine in the morning so its ok... Yes I get headaches but nothing a nurofen won't fix. I was very interested to read about the hair loss and ringing in the airs as this has just started for me even though i have been taking the drug for 6 months now.... I find that the side affects come and go such as the headaches and appetite changes. In saying all I recommend Pristiq. Pristiq has done what I need it to do and that is, feel normal again. I don't have the major symptoms, that I had as a result of depression. I don't have severe fatigue anymore, I don't have severe nausea and throwing up. I don't dwell as much, don't cry and actually enjoy life and don't have to force myself to do things. My anxiety is much better and moods are much better as well as my overall confidence in myself to cope. I was very hesitate to change from Luvox to Pristiq but I am so glad I did as Luvox was just ok where as Pristiq has really made a huge improvement to my life. I will see the doctor about my hair loss and ringing in the ears even though the ringing is mild. I also want to mention that it has cleared up my acne so much that I barely have any at all. Thats a bonus side affect for me! Pristiq is worth a try. F 30 6 months
100 1X day
2/24/2010
 5  depression None Pristiq has helped my depression alot. I was on Prozac for years and then was switched to Wellbutron. I started having uncontollable crying spells where I would cry for hours/days. I had memory loss and times when my mind would just go blank. Pristiq made me feel more normal than I have for years. Unfortunately I lost my job and my insurance. I get the Pristiq when I can, which isnt very often as the price is so high. When I dont have it I'm back to the crying, staying in my bedroom and having suicidle thoughts. I had some Wellbutron left and I take that when I dont have the Pristiq. It doesnt work nearly as well, but at this point its better than nothing. F 54 6 months
50
6/9/2015
 5  Bipolar Spacey head spins if a dose is missed. I found this to be extremely effective with the depressive side of bipolar and when used in conjunction with Epilim it appears to be keeping me quite stable. F 44 6 months
25
3/1/2015
Email
 5  Depression and anxiety First couple wks was forgetful and was hard to come up with words I wanted to say I was on Paxil for about three years then tried Effexor and now Pristiq! Pristiq has helped me be so much more confident, where I can actually speak in front of a group of people. Everyone reacts differently to medication. I hope this helps:) F 26 6 months
100 mg
11/5/2016
 5  Depression/Nerve pain/Mood Lability None I have taken almost every antidepressant over the last twenty five years as I suffer from reaccurring bouts of moderate to severe depression. This drug has given me the fewest side effects. I am surprised by the lack of sexual side effects that seem to be the norm for these drugs and am very pleased about that! I did notice quite a big "bump" into a much more happy upswing!! If you are bipolar and not on a mood stabilizer, be careful, as always, if taking an antidepressant,you do not get manic when taking this. I think it is an awesome medication for me. As the summer turns to fall it is a trigger for me to have a downswing, so I am really hoping the Pristiq can help me hang on to the non depressed months I have so enjoyed and keep them going :). Remember you can't tell whether a drug works in a day or two-sometimes when I read these reviews I wonder what is up w/ that? Thanks so much to everyone who shares their thoughts to help others. F 45 6 months
9/17/2009
 5  Depression occasionally irritable. I was very skeptical about trying PRISTIQ because of all the negative comments about it being an "effexor retread". My experience has been that PRISTIQ is superior to effexor, in terms of side effects, and antidepressant effects. Specifically sexual side effects are minimal, and weight gain has been no issue. M 58 6 months
7/17/2009

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