FEMARA Reviews (LETROZOLE)

Average Rating: 2.5 (1087 Ratings)

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 HORMONAL BIOLOGICAL RESPONSE MODIFIERS AROMATASE INHIBITORS

 Type: Rx Drug

  

FEMARA  (LETROZOLE):  This medication is used to treat certain types of breast cancer (such as hormone-receptor-positive breast cancer) in women after menopause. Letrozole is also used to help prevent the cancer from returning. Some breast cancers are made to grow faster by a natural hormone called estrogen. Letrozole decreases the amount of estrogen the body makes and helps to slow or reverse the growth of these breast cancers.   FDA Approval Date: 1997-07-25 (Sources: U.S. Centers for Medicare Services, FDA)

  

Results are sorted by Age from youngest to oldest (reviews with no age reported listed first).

Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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RATING  REASONSIDE EFFECTS FOR FEMARACOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 2  Multifocal DCIS & LCIS Was on Tamoxifen for 2 years with no side effects. Started taking Femara 6 months ago. Now have severe foot pain and an MRI of my foot showed a torn ligament and numbness of my right hand with an MRI showing cervical radiculopathy. I may need both neck and foot surgery. My oncologist felt the side effects were unrelated but is having me go back on Tamoxifen instead. Like others, feel like I have aged 10 years in 6 months. Have difficulty walking because of foot pain and doing weights because of arm numbness. Hard to exercise when everything hurts! F 50 6 months
7/28/2007
Email
 2  post tamoxifen 5 years Extreme fatigue, acute muscle and joint pain-painful swollen right knee, now bilateral trigger thumbs.Breathlessness with minimal exertion,insomnia,detrussor muscle instability,vaginitis and generally feeling extremely old and stiff.Frightened to continue taking this drug frightened not to take it.Also low white cell count following breast cancer treatment even lower now!Also raised cholesterol. F 50 9 months
5/8/2007
 2  estro+/progest+, HER2-, Breast CA Just about all of those commonly described here, unfortunately. My particular interest, without reading every post, is in those experiencing KNEE CARTILAGE DAMAGE or, as yet undiagnosed, severe knee pain, limitation of movement and range of motion etc... ... AND which is being, or may be, "attributed to OA (OSTEOARTHRITIS)". Also,in anyone who has suddenly developed BAKER"S CYSTS with knee joint effusion (swelling) after taking aromatase inhibitors, including, but not limited to Femara -such as ARIMIDEX etc. Patsy ------- P.S. I can only assume 'it' is doing what it's supposed to, as I am almost two years out - S/P lumpectomy, AC (also), and radiation. So far so "good"! F 50 4 months
4/18/2007
 2  breast cancer severe joint pain, depression, hot flashes. loss of energy, whole body aching I have been on letrozole for 1 year and it is horrible. I can hardly get out of a chair, walk, sleep, (thank god for ambien and oxy), can't bend my hands hardly walk. no energy to do anything with friends and I usually cancel. the only thing that has helped me is seeing a pain management doctor who has helped me lessen the pain so that I can atleast party live my life. Also, water aerobics is the only thing that I can do and forget about my pain for an hour. TRY IT, IT really works. I am afraid to go off for I never had chemo and stats were based on talking the Femara. My life is a mess. I thought that once you go off the side affects go away and now I am a afraid that is thisl is going to be my life. A cannot work for I cant sit, walk for long times or do anything for more than an hour...I am afraid of eventually will be living on the street. F 50 352 days
1X day
4/30/2013
Email
 2  to prevent return of breast cancer WEIGHT GAIN, joint pain, depression, massive sweating once off femara, I dieted off the weight but it seems to creep up more easily now, within a few weeks of stopping the drug my mood returned to happy, sweating subsided and aches and pains went away. 50 3 days
1/20/2006
Email
 1  breast cancer joint pain and hair loss F 50 6 months
12/30/2006
 1  stage 1 breast cancer headache, joint pain(severe leg pain) tiredness. F 50 4 months
2.5 1X day
5/26/2010
Email

Patient History
 1  Stage 1 breast cancer I had bone pain/joint stiffness which was almost disabling, hot flashes, hair loss, depresssion, fatigue, loss of appetite, insomnia, mental confusion, & loss of strength in my entire body, and constipation. I stopped taking the medication 4 wks ago and am very slowly seeing the side effects improve. My doctor tells me it takes 8 wks for Femara to get out of your system entirely. I felt very guilty and scared stopping the medication, but I had no quality of life. I will never take this medication again. F 50 3 months
1X day
7/14/2010
Email
 1  Stage 1 breast cander I'm just curious if anyone taking Femara has had frozen shoulder (adhesive capsulitis). I took Femara 3 mos. but was unable to continue because I could not tolerate the side effects. I had ALL known side effects to the medication. About two months into it, I developed frozen shoulder, which is the most painful thing I've endured since my diagnosis. And I have severe loss of range of motion of my shoulder/arm. Anyone one else develop that? My radiation oncologist thought it was triggered by Femara. I've now had frozen shoulder for 4 mos. M 50 3 months
1X day
9/22/2010
 1  breast Cancer All the normal ones- headache- joint pain- depression, weight gain- 18 pounds! I also have just developed eye problems- am curious if any one else has this.. dryness-----hot flashes Has any one a suggestion for the weight gain- it seems to be just in the stomach area---I run 3 miles at least 3-5 times a tweek and lift weights etc.. I can't loseit! Also, anyone else experiencing eye problems???? F 50
3/9/2009
Email
 1  stage 2 w/no node involvement I have had to give up Jazzercise (one of the only things that kept me sane during chemo and radiation) due to joint pain. Weight gain of 15 pounds in 3 months, no libido, anxiety attacks, can't sleep, and memory - what? The side effects are more debilitating that chemo!! Dr. is looking for alternative. And I thought the taxoxafin was bad. F 50 4 months
7/26/2009
 1  stage 1 breast cancer Nuclear hot flashes, and crippling polyarthralgia. All of my joints are painful. I have taken Femara since July '08. My joint pain has increased since initiation of the drug. I am a physical therapist, so it really interfers with my job.I am getting used to the hot flashes,Effexor is helping, but my heart rate is ~ 130bpm. I took a 2 week vacation from Femara and my pain level decreased substantially.I would rather have total mastectomies than take the Femara if it meant I didn't have to take Femara.(I had a lumpectomy). I am back on Femara (until I see my oncologist again. Oh yea the pain is back. F 50 8 months
4/9/2009
 1  Breast Cancer Weight gain, headaches, joint and muscle pain. I have been going crazy trying to determine why I am in such pain. I keep attributing all this pain to my age, even though at this age I shouldn't feel like this. I get concerned when I know I have to walk long distances, I can't take my shirt off over my head because I can't raise my arm, my ankles, elbows, ribs are in constant pain. I have gone to my doctor and they attribute it to my weight gain (30lbs over weight) and 'in my head'. I also began to think it was me......FINALLY I realized that the only change in my life for 2 years has been the Femara. Am stopping taking it TODAY. Wished I had read the comments here a year ago. I can only pray and hope that all this is reversible as I cannot imagine living the rest of my life with such pain and discomfort. F 50 2 days
1/6/2008
Email
 1  Breast cancer I have been taking Femara for 10 months, my hip and back is causing me so much pain. It felt like someone kicked my in my hipWhen I woke up. It was devastating, my bones were so tight, I could not move my fingers, wrists, my knees were aching terribly. I woke up in the middle of the night it felt like everyone of my toes was broken. I started missing appointments. I don't remember what word is next in a sentence. I stopped taking it 2 weeks ago, I am still in terrible pain, all of my joints hurt, and my memory is awful. F 50 10 months
2.5 MG
2/17/2016
Email
 1  breast cancer Extreme knee pain, tired all the time, cough, shirtness of breath, trouble sleeping, weight gain that you cant loose I used to be a very active and high energy person, until I started taking Anastrazole. The arthritis like pain in my knees became unbearable so my doc switched me to Letrozole/Femara, pain in knees continues and I feel like I have been hit by a truck on most days. Even after getting 8 hrs sleep I wake up feeling tired! I have not even been onthis drug a year yet and dont know how I can live like this for 4 more YEARS! THIS REALLY SUCKS THE LIFE OUT OF YOU. I am working full time and its a chore just to keep plugging along through the pain of just tryinf to walk! F 50 9 months
1
7/27/2015
 1  breast cancer Extreme knee pain, tired all the time, cough, shirtness of breath, trouble sleeping, weight gain that you cant loose I used to be a very actuve and high energy person, until I started taking Anastrazole. The arthritis like pain in my knees became unbearable so my doc switched me to Letrozole/Femara, pain in knees continues and I feel like I have been hit by a truck on most days. Even after getting 8 hrs sleep I wake up feeling tired! I have not even been onthis drug a year yet and dont know how I can live like this for 4 more YEARS! THIS REALLY SUCKS THE LIFE OUT OF YOU. I am working full time and its a chore just to keep plugging along through the pain of just tryinf to walk! F 50 9 months
1
7/27/2015
 5  recurrent BC w/mets in lungs loss of weight, extreme muscular and skeletal pain especially in neck, right arm, wrist and right leg also pain in both my feet. Sometimes I feel like I have the flu. Great for keeping my TM down - my CEA range from 2.4 to 2.7 and the CA27.29 ranges from 44 to 48, tumor not growing. Femara definitely is managing my progression and I am happy with the results. F 51 8 days
8/17/2006
Email
 5  Following 5 years of Tamoxifen I have noticed thinning of hair and a slight elevation of my ALP in my blood tests. I feel GREAT...no joint or bone pain, no weight gain, have tons of energy. I exercise for a minimum of 60 minutes every day and have lost 26 lbs in the past year from weight watchers and exercise. I do a weight bearing exercise class 3x a week. Appears it is working. I was Stage IIA Breast Cancer with 2/12 lymph nodes involved. Diagnosed in 2000. F 51 1.5 days
12/20/2006
 4  Metastatic Inflammatory Breast Ca Severe bone, joint and muscle pain.Lower back, hands and feet are the worst. Even more severe when I'm still for 15 minutes and then try to move. Hot flashes and sweating at the slightest exertion. Some hair loss. Was on Tamoxifen for a year after IBC diagnosis & treatment(chemo, mastectomy and Rads) and then was Dx with brain mets. After brain OP and radio surgery, and another chemo for the brain mets, I started with Femara and Herceptin. Still taking both but am cancer free right now. I'll put up with the pain if this keeps me from having a recurrence. F 51 11 days
9/20/2006
 4  Stage II Breast Cancer Hot flashes, muscle cramps I was on Tamoxifen for a yr which caused joint stiffness and pain, muscle aches, hot flashes, thinning hair, trigger fingers, carpal tunnel syndrome, fatigue and wt gain. Then I wasd switched to Arimidex for a year had same symptoms with constant intolerable foot pain. I was switched to Femara as suggested by my GYN doc and the symptoms are definately better so far at least. F 51 45 days
30 mg 1X day
10/23/2010

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