ACCUTANE Reviews (ISOTRETINOIN)

Average Rating: 3.3 (746 Ratings)

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 DERMATOLOGICS

 Type: Brand name discontinued; available as generic

  

ACCUTANE  (ISOTRETINOIN):  This medication is used to treat severe cystic acne (also known as nodular acne) that has not responded to other treatment (e.g., benzoyl peroxide or clindamycin applied to the skin or tetracycline or minocycline taken by mouth). It belongs to a class of drugs known as retinoids. It works by decreasing facial oil (sebum) production. High amounts of sebum can lead to severe acne. If left untreated, severe acne may cause permanent scarring.   FDA Approval Date: 1982-05-07 (Sources: U.S. Centers for Medicare Services, FDA)

  

Results are sorted by Gender males first.

Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on ACCUTANE: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR ACCUTANECOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 4  Severe Acne Dry chapped lips, dry skin in shoulders, groin area, buttocks area....led to peeling simliar to a sun burn. Nosebleeds a several times a week. I've been on accuatane for 3 months now and I'm hoping to finish all 5 months with success. I wish I had taken it sooner. It is a very effective drug and I recommend it to everyone who is dealing with embarrassing acne! M 20 5 months
40mg 1XD 2X day
10/19/2010
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 4  mild Acne and very oily skin Dry lips, dry skin, manageable joint pains. I have been taking a low dose because thats all that is really needed. Anyone on a higher 60 or 80 mg dose needs to speak to their doctor about lowering it to 20 or 40. The dose does not determine your results, the length of time you are on it does. A lower dose over a longer time would eliminate 90% of the griping and complaining on here. Yeah I do get sore joints and occasionally a sore back. I take fish oil and vitamin D and that helps a ton. Fish oil 2X daily, no joint pain. Taking fish oil is a small price to pay for the amazing skin I have. 20 years of fighting acne is over and I have my life back. M 35 4 months
20 1X day
6/14/2010
 4  I have little girl skin (sensitive May cause lips to be dry, strange sleep pattern, very exhausted for no reason, lack of concentration, varying in mood, lack of motivation. I find all external things very manageable by doing the following. Although lips can very quickly become dry. I use “Blistex Complete Moisture” and have no issues. I apply like 10 plus times a day, but as a result I have perfect lips with no issues and don’t go anywhere without it. Skin becomes dry easily, so I use “Aveeno Moisturizing Lotion” after the shower. The doc told me the 3min role. Meaning put all lotions, lip chap, etc on your body within 3mins of washing that area to prevent dry skin and it works for me. I find the mental thing a whole different game that requires constant attention that is difficult to give. I am an average kind of guy, get good marks. But it all changed with the drug. Dropped my Avg. 10% due to a few things. Lack of concentration would be the main thing and I am exhausted very quickly, rendering me almost useless to concentrate for long periods of time, even if I am interested. As a result I have went from an avg. 5-7 hours sleep a night to a minimum of 8-9 hours. If I get less than 8 hours, I am junk. Can’t do much, days are hard, very low motivation, question my existence, oddly emotional?. Basically makes me think I am going crazy. There were some warning signs of this prior when I was only on 20mg, but now at 60mg it is full out. So if I were to suggest anything it would be. 1. Don’t do things that are important to you in life when you take this drug i.e. College, making first M 28 5 months
1/26/2010
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 3   Chapped lips, dry nose, ridiculous muscle pain I've gone through a pattern of side effects....first it was dry lips, than random nose bleeds, back to dry lips now its dry skin (face), little red bumbs on the back of my hands, really uncomfortable muscle pains in both my thighs and I still have dry lips. I'm really hoping this is all worth it!!!!!!! M 25 1 months
80MG 2X day
2/12/2010
 3  severe acne mood swings while taking and depression has lasted 6 months after. Acne is 70% better but not as good as we expected. not worth the depression and anxiety. This drug is more dangerous then they tell you. Marijuana seems to increase depression and suicidal tendencies. M 16 4 months
30 mg 1X day
4/21/2010
 3  Bad Acne Nose bleeds, dried skin, sunburn very easily, slight depression, etc... I started when i was 20 years old and stopped about a year and a half later. Acutane helped all of my acne, but the after effects are horrible. Im convinced it caused my extreme heartburn, hair thinning, low energy levels, digestive problems, trouble concentrating, anxiety, and several other problems. If i could go back,would i take it agian? its hard to say if my acne going away was really worth all these problems. I just hate that there is nothing i can do about it now... M 28 1.5 years
2X day
4/21/2010
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 3  Acne I started the accutane course when i was 17 1/2 due to my very bad skin that posed a scarring threat on my cheeks. Even after the first week I had tremendous results- inflammation decreased and white/blackheads disappeared. As my treatment went on, the side effects became apparent. Suicidal thoughts, severe depression, moodiness, dry everything, etc. My skin cleared up even more as my dosage was doubled to 80mg. The second checkup brought alarming results- my creatine production in my kidneys was dangerously high. I was referred to a nephrologist only to discover that both my kidneys were working at 70% normal function. I was very frustrated but nonetheless I stopped the treatment. This was when things got worse. Two weeks after I stopped taking accutane, I became severely depressed and angry. I made my girlfriend cry almost every day and we were on thin ice. But the thing that troubled me most was my sex drive. Before my accutane treatment everything was fine, my girlfriend and I woul I have been off accutane for almost two months now and I am still experiencing problems. It seems as if every other week i'm horny, and others I am not at all. I feel very awkward, as I am young and i'm used to feeling horny all the time, and getting up never used to be an issue before I started treatment. I've decided that I need to see a doctor about this issue to receive any type of treatment or advice on how I can get back on track. I really want to return to my normal state as sex is very important to me. Please email me if you have any questions or advice on this matter. From my experience using this drug, I would not recommend it as the after-effects outweigh the benefits of clear skin. My sex life is much more important than my skin and I know there are other routes you can take other than accutane (Retin-A). M 17 2 months
up to 80mg 1X day
5/7/2010
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 3  Severe nodular acne Chapped Lips, Dry/itchy scalp. I've been taking Accutane for almost 2 weeks now and I haven't seen any actual results yet. My lips became chapped around the fourth and fifth day of taking it and my scalp has been really dry and itchy lately. I was in desperate need of something to help my poor face! I've had acne on and off since I was 16 but for some reason my acne has been really bad the last 6 months. I hope this medication works. I'll update yall in a month and let you know where I stand in my treatment. M 21 10 days
40 mg 1X day
11/6/2010
 3  Persistant Acne Chapped lips, feeling dehydrated, just overall dry Here is the thing. If you have tried everything else for acne and nothing works then I would consider using it. Just know that everyone will react differently. About a year after i stopped treatment i began having panic attacks. I still have panic/anxiety disorder. I cannot say that the panic was induced by the meds but if i had to bet what caused it i would say accutane. Use as your own risk but you will have a significant reduction in acne. M 30 5 days
40 2X day
11/14/2011
 3  To clear mild, but persistent acne Dry, disgusting skin, mood swings, bloody nose, mild hair loss and psoriasis. Not worth the side effects unless acne is severe M 17 4 months
2xD
11/29/2012
 3  acne on face and chest dry nose, eyes, lips, hands, ears, mouth, and more.. kidney infection, loss of appetite, always tired, horrible joint pains, loss of weight, redness in skin, acne got worse for first 3 months, easily cut skin, ...pretty much everything if this doesn't work I will be furious M 17 4 months
12/4/2005
 3  moderate acne dry lips, dry nostrils, dry skin, dry eyes, joint & muscle pains and headaches towards the last month and up until now (3 weeks after stopping accutane), slight anxiety attacks and dizziness I took this drug for 4 months as perscriibed by my dermatologist. In my 3rd month I started having aches (muscle, joint and head). I have stopped taking this drug for 3 weeks now and still feel all of the symptoms. Although my skin is now clear, I wonder what price it will have on my body. I take an Advil or Tylenol a couple of times daily just to deal with these aches and pains. Overall, Im thinking that this drug is not worth taking. I would never take it again or recommend it to people unless they are fully aware of other peoples experience with the drug. M 26 4 months
1/31/2006
 3  foliculitus Very dry Lips, dry skin, sleep disruption, mild depression, tiredness. stomach acid,pain after gym workouts, vomiting, weird night vision and A COMPLETE LOSS of ALL Sexual LIbido will never take this drug again..the lips and backpain were not too bad but the depression was quiet horrible and my sex drive and ability to have sex disappeard overnight.... M 37 8 weeks
3/12/2006
 3  Severe Scaring Acne Chest/Back/Face I took this back in my late Teen years. I am 33 now. Around age 31 I began experiencing palpitations of heart. I am a marathon runner, no palpitation history in my family, so kinda a weird deal that I get it late in life.. It may have been the accutane, especially because I see other folks are reporting that. Other minor long term: I experience extremely dry skin during winter months. I must shower with a special soap or I have painful dryness. Accurate did clear my acne.. and I did have it bad. People talk about the emotional and depression part of Accutane.. I did not experience anything related to that. The huge open acne wounds were a pretty depressing thing, so it doesn't surprise me that folks who take it show a higher rate of depression over normal folks, they're depressed from their acne, not the drug. If I die from a heart attack or condition associated with the palpitations.. then obviously, accutane wasn't worth it.. its a pretty scary thing to live with heart palpitations, you slowly get used to them, but you never know when it might need a jumpstart.. M 33 1 years
12/15/2006
 3  off/on acne, even cystic; 20 yrs only on 2nd month but on the 1st month: dry skin, major chapped lips, slight nose bleeds, moodiness (more than normal), minor back aches and acne flare ups. now on 2nd month and no more nose bleeds, minor chapped lips (seems to be lessening), moderate/acute back/neck pains (difficulties getting in/out of bed), minor joint aches, moods seem normal, still some acne flare ups. almost midway with 2nd batch of meds but hoping the back pains go away...and eventually the flare ups. hopefully only 1 or 2 more batches/months on accutane..... M 36 1 months
11/6/2006
 3  mild acne that caused scaring Dry lips, dry skin, joint pain at first went away eventully, bad break outs at first that caused bad scaring since skin's ability to heal is impared, red face, flushing, and hair loss!! The dry skin, lips is easy to deal with. The hardest parts have been the red face with flushing and the hair loss. I have now been off the drug for about a month and the facial redness has subsideed somewhat however blochy patches of red remain espically around my eyes and upper nose. The hair loss has by far been the worse! It started allmost immeditaly once I started the medication and never went away. I stuck it out and was told the hairloss would stop once I stoped the medication. So far that has not been the case just as much hair falling out as when I was on the medication. With all this in mind I have not had the smallest zit in over 4 months. I cleared my skin up and I know I wont ever have to worry about acne ever again, however I feel I might have traded in my acne for a permentaly red face and a thiner haired head. Time will tell if these side effects eventually go away. If they do then the drug is worth it, if they dont it might have been a mistake for me to go on M 21 4.5 months
3/4/2007
 3  Cystic Acne resistant to other tm I have taken accutane in 1999 and 2001 for about 6months each. During the 99 episode, I experienced severe hair loss, severe depression, and all the ordinary "dry" side effects. I became so depressed that I had to stop school, but I had beautiful skin. I also had really high triglyceride levels. The 2001 episode was similar but with less depression because I was prepared and took the drug for less time. This drug affects all parts of your body in addition to your skin. Perhaps the gi system, joints, brain. We are the experiment...isnt that comforting. DO NOT TAKE THIS DRUG UNLESS U HAVE ACNE THAT IS SO BAD, UNLESS YOU ARE WILLING TO ACCEPT POSSIBLE PERMANENT SIDE EFFECTS, (possible with clear skin). This drug is not a joke. This is from someone educated in the medical field and has suffered from acne for a long time and tried other methods. It has helped my acne, but I would have taken it for less time. If I had to do it again, I would, but I would stop when I had some relief with accutane and could take topical medicines that would take care of the rest of the acne. M 30 6 months
5/1/2007
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 3  severe acne severely chapped lips and dry skin, bloody nose, muscle soreness, joint and lower back pain, dry eyes, sunburn easily, high cholesterol good results on face, but not on my back, but the side effects are horrible, higher than usual doses M 16 7 days
4/7/2005
 3  Mild but persistant acne Bloody nose, dry lips, flaky skin, lower back pain (not sure if from accutane), occasional testicular pain/weird urination/mucous in urine, slight loss of sex drive, pus in eyes. It got rid of my blackheads and I never felt depressed, which is good. However, I'm paranoid now that something may become wrong with me in the future and I have these strange urinary symptoms (though doc said not to worry)! M 17 5 months
10/14/2007
 3  bad, ugly acne Lips were pretty damn dry. always carry chapstick. my lips are out of shape towards the corners of my mouth, real screwed up, I dont know why. other than that, nothin serious. maybe tiredeness, but hey-Im a teenager. no noticibale mood changes or depression thats different from the norm, but like I said, Im a teen. occasional brief minor rash, a little sore back, but thats all for me. It was slightly helpful to me, and for that, it was worth it. I have one month yet to go. when I started, face was real bad. plain ugly. its definitely gotten better, but there are alot of small but noticable darkspots that just dont seem to fade,Im hoping they will yet; Ive heard many people see major improvement after they stop the drug. I hope thats me. Its helped me emotionally, because everyday I wake up and think 'I gotta take my accutane!' thinking it will help. and it has, even if its not completely gone. One thing I reccomend is swimming while on the drug. the combination of accutane and chlorine on your face will dry it out significantly and promote new skin growth. Its helped me alot; I try and swim almost every day! M 18 5.5 months
6/23/2007
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