IMIPRAMINE HYDROCHLORIDE Reviews (IMIPRAMINE HYDROCHLORIDE)

Average Rating: 3.5 (106 Ratings)

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 ANTIDEPRESSANTS

 Type: Rx Drug

  

IMIPRAMINE HCL  (IMIPRAMINE HYDROCHLORIDE):  This medication is used to treat depression. It is also used with other therapies for the treatment of nighttime bed-wetting (enuresis) in children. Using this medication to treat depression may improve your mood, sleep, appetite, and energy level and may help restore your interest in daily living. Imipramine can help your child control nighttime bed-wetting. Imipramine belongs to a class of medications called tricyclic antidepressants. It works by restoring the balance of certain natural substances (neurotransmitters such as norepinephrine) in the brain. For bed-wetting, this medication may work by blocking the effect of a certain natural substance (acetylcholine) on the bladder.   FDA Approval Date: 1990-06-05 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on IMIPRAMINE HYDROCHLORIDE: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR IMIPRAMINE HYDRCOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 1  Post Prostactomy incontinence Headaches, stomach cramps, constipation, muscle cramps, insomnia and indigestion. 50mg dose reduced to 25mg some improvement but for what little improvrmrnt in incontinence there was the side effects proved to be more detrimental than its benefits. I've flushed the remainder of my 90 day supply. M 63 6 days
6/18/2006
 5  anxiety & high blood pressure none... It really helps!...sometimes I try to do without after every 2 years...I want to be a puritan...but I truly feel normal and best...I sleep well with no panic attacks! Old med...with no side affects with me! F 42 5 years
4/27/2006
 4  Major depression Dry mouth, urinary retention, blurred vision, "foggy" mental state, reduced libido, hunger at the end of the day that requires lots of exercise to counter. I've tried about 15 other antidepressants to avoid the side effects, but (a) they're all less effective, and (b) their side effects are generally worse. Every doctor should be required to take a drug for 6 months before being licensed to prescribe it. M 51 20 years
1/21/2006
 1  misdiagnosed bipolarism crying, violent behavior It caused me to suffer incomprehensible bouts of depression. I usually wound up crying for hours in a dark corner. After punching a friend in the face I finally realized the drug was at fault and stopped taking it. The symptoms went away at once. This happened when I was in my teens. M 31 4 weeks
11/22/2005
 5  depression, unable to fall asleep involuntary noticeable muscle twitching, difficulty urinating,hot flashes, dry mouth, inability to speak occsionally (feels like my tongue quits working) Has helped my depression a great deal. I also take Welbutrin daily F 45 3 weeks
9/30/2005
 5  depression, unable to fall asleep involuntary noticeable muscle twitching, difficulty urinating,hot flashes, dry mouth, inability to speak occsionally (feels like my tongue quits working), exteme craving for sweets, 10 lb weight gain Has helped my depression a great deal. I also take Welbutrin daily F 45 3 weeks
9/30/2005
 5  anxiety M 56
7/6/2005
 2  Anxiety, mild depression At an initial dose of 50mg/day (in the evening), I've had horrible dry mouth (to the point that I nearly choked on a muffin the first week). I've also had an odd sexual side effect whereby when I ejaculate I feel a strange pressure/dull ache in my groin area. It's not enough to stop me doing it, but it's odd and it's somewhat disconcerting. Contrary to most things I've read, I've actually had *more* trouble sleeping since I started taking it. Overall I can't really say that after a month at 50mg/day I can see any effect on anxiety at all, and absolutely none on depression. I responded very well at first to Prozac, but the side effects made me stop it. I did okay on Effexor until I tried to get off it (evil stuff, don't use it!), and I did very well for depression on Remeron. None of those did anything noticeable for my anxiety and nail biting long term however. M 42 1 months
3/27/2005
 2  Depression, Bladder problem dry mouth, NO libido, bladder problems I've been struggling with the fact that I take anti-depressents for a long time. I didn't really feel that it was doing anything for my depression, although it did help me sleep and it decreased the pain associated with my bladder problem. My medical history is so fuzzy, though, that I can't remember if my bladder problem developed after I started taking Imipramine for depression and then it simply helped to regulate the pain once it was in full swing. I decided two months ago to stop taking my medication (I was at 125 mg a night and now I'm down to 75 mg - I'm taking it slowly!) and I feel so much better. I was really concerned that I wouldn't be able to sleep once I stopped taking it, but my sleep has gotten better (it's less difficult for me to fall asleep) and so has my bladder problem. I feel best about the fact that I no longer feel like an 8 year old girl and that I'm starting to discover my sexuality. Oh yes, the dry mouth. When I am nervous my mouth dries up so much that my lips stick to my gums and there's nothing I can do to unstick them - highly embarrassing and unpleasant! F 19 2 years
12/13/2004
 4  anxiety+depression weight gain, cravings for sweets, irratibilty. Good drug for me. I have tried the whole array od SSRI's and nothing compares to tofranil. M 40 15 years
11/25/2004
 4  Depression I have gained weight, approx 10kgs, have trouble peeing and crave sweets, particularly at night. I have a constantly dry mouth and often bad breath as a result. I have tried many times to wean myself off Imipramine but always feel worse so can't be bothered in the long run. Life's too short to feel like crap all of the time! F 43 3 years
11/1/2004
 4  PTSD/Anxiety After trying all the SSRI's and multiple reuptake inhitbors I requested Tofranil PM specifically. I read on this site that others had good luck with this medicine. Unfortunatly I went to my GP instead of my pdoc to get it because I could not get in soon enough with my pdoc. My GP started me out at a dose that was much to high (100mg per night). It wacked my brain so hard that my memory quit working, I got lost in the middle of sentences when attempting a short interchange, I lost words that were normally a part of my vocablulary, I was like...Duh! After one week at 100mg I was able to see my pdoc who reduced my dose to 50mg per night. After one week my mind has cleared, but now I am easily agitated and fly off the handle at the most minor irritations. I spoke with my pdoc today and he wants me to up my dose to 50mg in the morning and at night for a total dose of 100mg per day. I dont want to mess with taking pills all the time so I am going to try to get a script for 75mg of Tofranil PM and work back up to 100mg. I am having some negative sexual side effects and I cant drink beer anymore, too bad. (I like German Wheat Beer...Its gooooood!) No sex and No beer is a very good reason to be depressed and anxious. After I was able to think again the Tofranil/imipramine works well for depression and helps me sleep better. I am still not on the final adjusted dose, at this point it helps a little with anxiety but not enough. I think it will work well once I am on the correct dose. Starting dose for outpatients should be no more than 50mg per day increasing the dose by 25mg every seven to ten days until reaching the level that is correct for the patient. Even though my pdoc wants me to up my dose by 50mg all at once I dont intend to do that, not after my first experience. I cant afford to be stupid. M 50 3 weeks
10/20/2004
 3  depression My mouth is a little dry. Sweating is profuse and absurd. I take a non strenuous walk and sweat is running down my face and soaking my shirt. It's so bad that if I play a 10 minute game of ping pong I have to change all of my clothing. I like my moods. I am always a little anxious now, but I am happy enough to have fun around people. Before I took this drug, even if I knew I should be enjoying things, all I felt was a big hole where emotion should be. M 19 17 days
9/10/2004
 5  anxiety or panic blurred vision; dry mouth only at first; possible weight gain of 25 lbs. I only take 10mg at bedtime but if I miss 2 doses I have a major panic attack. Hate being on a drug. Stops all panic/anxiety when I take it. F 60 2 years
6/26/2004
 4  clinical depression Dry mouth, weight gain of 50 pounds, STRONG cravings for sweets. I have been taking imipramine for 16 years as it seemed to be the only antidepressant that worked for me. I have tried going off it many times (because of the weight gain) and have found the symptoms of depression returned within a week (or are they withdrawal symptoms?). I would appreciate any info or tips others may have in how to successfully get off of the medication. I do not want to keep gaining weight.(I was thin all of my life until I started taking it). Thanks. F 49 16 years
6/9/2004
 5  depression, anxiety, ADD drowseness this medication is wonderful M 13 9 days
4/16/2004
 5  Depression I've experienced urinary hesitancy, and a minor decrease in libido. This is a great drug. I was worried, at first, that it would decrease my range of emotions this was not the case. I can still feel sad I just don't feel sad all the time and without reason. Side effects have been very minimal although I was glad to read that a few other people have had some urinary hesitancy, and that my problem is in fact caused by the imipramine. As for the libido decrease it hasn't been a real problem at all and is just something I noticed, and not necessarily something I'm complaining about. This is such a great drug with a lot fewer side effects than SSRI's and it works really well. M 20 6 years
3/31/2004
 3  depression, ADHD, anxiety drowsyness ok for depression accompanied with nothing else...but it does not help attention/focus nor anxiety M 27 6 months
12/6/2003
 5  Depression with Insomnia I didn't notice side effects. I took the one capsule every night before bed, and it helps me sleep too. I guess the dry mouth occurs when I am sleeping. Anyway this is a great drug. I tried SSRI's and new generation SSRI's but they caused a lot of weight gain, sexual problems, etc. Tofranil-PM is great. I learned about it on this message board. I am glad I read this board, and asked for Tofranil-PM versus regular Tofranil. The once a day dosing is much more convenient. Thanks everyone! M 33 6 months
3/18/2003
 5  Major Depression Dry mouth, constipation, urinary hesitancy F 48 5 years
2/28/2003

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