IMIPRAMINE HYDROCHLORIDE Reviews (IMIPRAMINE HYDROCHLORIDE)

Average Rating: 3.5 (106 Ratings)

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 ANTIDEPRESSANTS

 Type: Rx Drug

  

IMIPRAMINE HCL  (IMIPRAMINE HYDROCHLORIDE):  This medication is used to treat depression. It is also used with other therapies for the treatment of nighttime bed-wetting (enuresis) in children. Using this medication to treat depression may improve your mood, sleep, appetite, and energy level and may help restore your interest in daily living. Imipramine can help your child control nighttime bed-wetting. Imipramine belongs to a class of medications called tricyclic antidepressants. It works by restoring the balance of certain natural substances (neurotransmitters such as norepinephrine) in the brain. For bed-wetting, this medication may work by blocking the effect of a certain natural substance (acetylcholine) on the bladder.   FDA Approval Date: 1990-06-05 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on IMIPRAMINE HYDROCHLORIDE: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR IMIPRAMINE HYDRCOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 4  Insomnia Hair loss but I had some before I started these meds and 1 week of worse depression but I held on knowing it would get better. I take 100 trazodone, 50 mg Imipramine, .50 xanax and 8 mg Rozerem every night. I wake up usually 2 to 3 times a night but usually get 5 hours straight sleep. Also I read in my oxygen magazine 1000 mg of calcium and 500 of magnesium would help too. It does seem to help. F 37 2 years
50 mg 1X day
7/5/2010
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 1  i had the jitters real bad dry mouth,slow pee, when i had sex and climaxed man did it hurt in a weird place under my testis . Gave me the jitters and bad bad anxiety. imipramine did not work for me ..Good luck M 35 2 months
150mg 1X day
4/20/2010
 5  Migraines None Helps control vascular headaches. Reduced occurrences of headaches from one per week to less than three per year. I periodically try to reduce dosage to 50 mg per day, but eventually the headaches begin to return. 75 mg per day dosage controls the headaches without additional medication. M 66 24 years
25 mg 3X day
4/13/2010
 1  depression, urinary frequency Seemed to make me jittery, which is odd for an antidepresant People react differently to all ADs. My doc hoped this would help me sleep, relieve depression and anxiety, lessen my trips to the bathroom, but "None of the above." I gather it does work for many people. If you want a TCA (tricyclic anti-depressant) be aware that Wal-Mart, Target, etc have several for $4 per month, while imipramine costs a lot more. M 52 1 months
20mg 1X day
3/3/2010
 5  Major Depression/Anxiety Dry Mouth, Weight gain, Head rush when standing up quickly, Constipation. This drug has helped me to have quality of life. I first took it when I was 23 for Major depression and Anxiety. The weight gain and Dry mouth are the worst side effects, however I tried taking Zoloft and Prozac. Zoloft helped but not like this drug, and while taking Zoloft I experienced sexual dysfunction. Prozac gave me the worst headaches. I was able to be drug free for about six years and then had a relapse, so I started taking it again. Hope this helps someone who's looking for some direction. God Bless M 49 22 years
12/26/2009
 1  mild depression and restless leg s dry mouth, dizzyness, can hardly urinate, bad taste in mouth, destroys sex life, severe loss of memory lasting about 2 hours resulting in trip to emergency room W/EKG, BRAIN SCAN, BLOOD WORK< all checked out normal.ER Doctor said this is a dangerous drug. Constipation. I also had bad head shocks a couple times a week, usually in the evening. I stoped this medication after taking it for about three months at 50 mg each night. I tappered off by dropping to 25mg for about a week and then to 12mg for a coupled af days stopping about a week ago. I feel much better. Some side effects are still with me but think in a week or so they should be gone. On the plus side it cured, while taking it, my restless leg syndrome and dryed up a post nasel drip that i've had for a long time and all signs of my mild depression. But the side effects we're not worth it. IF nessessery I'll try something else. M 73 90 days
7/11/2009
 2  Anxiety/OCD/Depression Dry mouth, insomnia, forgetfullness, frustration, anxiety, and constipation Worked OK on a low dose (25mg) initialy for sleeping and depression. But anxiety was always present and as my dosage increased to 100mg so did the other side effects until taking the drug became unbearable. I amost "lost my mind" and forgot how to speak my language and associate with others. M 36 4 months
6/7/2009
 5  eurinesis initially; mood disorder dry mouth My son has been taking this for 9 years since age 7. Initially he took it for bed-wetting but when I tried to wean him off, his previous "melt-downs" returned. I had thought this was a stage he was outgrowing. He had intensive implosive melt-downs prior to going on this drug. I realized that it was the same drug that cured my father from debilitating long-term depression and put two and two together. At age 11, my son stopped taking it cold-turkey without my knowledge. He suffered two days of nighttime hallucinations--very scary stuff. After that, he toyed with going off it again in middle school but decided that the anxiety he felt without it was worse than taking the drug. He only has dry mouth as a side effect. He has a really high iq and tests in the 99th percentile so I guess it didn't hurt his brain development. He does have a small stature and is skinny. I don't know if the medicine stunted his growth in any way. I would be interested in any comments from other long-term youth users of this drug to see if they had normal growth. He is 5 ft 8 inches which is a lot smaller than my husband and my brothers. M 16 9 years
5/31/2009
 3  incontinance Constipation Some times get a little dizzy. M 76 30 days
5/27/2009
 4  Depression and bladder problems Dry mouth , constipation , sweet-tooth , dizzyness , blurry vision. I wish I never had to depend on pills to funtion in life in general. I started out taking about 50mgs of imipramine and now i'm taking 150mgs of it a day. I also take Seroquel and i'm now taking 450mgs of that a fay. ( that was something i failed to mention in my Seroquel rating ) Anyway , the main reson the psychiatrist put me on imipramine because i was experiencing urinary incontinence when i was asleep. My bladder is much better now and i only wet the bed when i'm constipated. I don't feel as depressed as i used to feel and i can't recall when i started taking imipramine. M 34
3/28/2009
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 2  Depression Severe constipation, Increased heartrate, sleepiness, weight gain, dry mouth, "foggy" head. I began taking 25mg a night for depression and within a couple weeks increased the dosage to 75mg. It put me right to sleep each evening, but I felt tired and foggy headed all day the following day. My resting heart rate increased to 100bpm for the first month and has almost gone back to normal after a couple months of being on Imipramine. It has been effective in treating the depression, however the side effects are too terrible to remain on the drug. The most severe side effect I've experienced is constipation. I have not been able to go to the bathroom for over two weeks, even with the use of laxatives, enimas, and stool softeners. I have begun to wean off this medication and hope the problem is resolved shortly. I will be going back on Paxil which has been most effective in treating my anxiety and depression. F 27 3 months
2/12/2009
 5  Panic Attacks/Agoraphobia Dry Mouth, Constipation, hand tremors, weight gain, sleepiness, irregular heartbeat. Side effects stayed with me the entire time I was on drug. After suffering with totally dibilitating and constant panic attacks and agoraphobia for several years, imipramine incredibly helped to a point I could get out of the house and work again. But, after 5 years I had a life threatening cardiac reaction and was immediately taken off of it, leaving me totally dibilitated again. Nothing since has helped like this drug did. Too bad it had the side effects it had. F 32 5 years
1/28/2009
 2  Relieve pain of nerve damage Insomnia, severe headache, abdominal pain, dry mouth. Commenced Imipramine 10mg for relief of pain for nerve damage caused by a parasite in the abdominal area. Tried it for two nights and had although I felt drowsy I just could not get to sleep. Had a severe headache and stomach pain, dry mouth with strong metallic taste. After speaking with the Doctor he suggested lowering the dose to 5mg. I know I do not have a great tolerance for some medications so I think it is just a totally individual thing with your reaction to medications. F 38 2 days
12/11/2008
 5  Panic Disorder Dry mouth I was having severe panic attacks and this medication saved my life. It worked very well for me. I took it for about 3 years after my divorce. Since then I only need it when in a very stressful situation. F 61 25 years
12/9/2008
 2  Depression and anxiety dry mouth, minor pain during urination or ejaculation, constipation My doctor has me on a nightly dose of 25mg of Imipramine to treat me for mild depression and anxiety. Does this amount seem too low? It's been 2 weeks now, so maybe it's too early to determine any real mood improvement other than a few side effects. Also, he put me on 4mg of Pherphenazine, 5 mg of Diazapam, and 10 mg of Proponolol. Should I wait longer before asking for a higher dosage or does it take more time for Imipramine to 'kick in'? M 35 2 weeks
12/7/2008
 5  depression and anxiety dry mouth, slow urination in the morning Nine years ago I was prescribed zoloft first then celexa. Both had side effects that I couldn't tolerate. A friend told me about Tofranil and that it helped her more than anything. I asked my doctor and he told me it is one of the older tricylic meds but was usually effective. I took 50 mgs. of imipramine hcl (generic Tofranil) daily for about 8 years and tried to go off. After a couple of months, I began to have extreme anxiety. I'm back on imipramine 75 mgs a day and plan to continue as long as necessary-maybe for life. Dry mouth is a small price to pay for feeling normal. I believe doctors try the more expensive meds first because imipramine hcl is very inexpensive. F 54 9 years
12/5/2008
 5  Depression Dry mouth, hesitancy with urination, some constipation, decreased memory, often searching for the name or word I want, very new, STRONG craving for sweets (never cared for sweets prior to this) with 10 lb weight gain and increased difficulty achieving orgasm. With all those side effects you'd think I would have stopped the drug by now, but this medicine saved my life. Been on/off various medications since age 16 yo. Been on SSRIs, Effexor, Wellbutrin, then 5 years ago finally tried on Imipramine and it is like a miracle. No longer depressed. Now able to have normal highs and lows like everybody else. No relapse yet. Would be very nervous trying to lower dose or doing a trial off the med. M 34 5 years
11/7/2008
 4  Overactive bladder Dry mouth, insomnia. I took 10mg at bedtime for about 2 weeks I think...However, it did not make me drowsy, but it seemed to keep me awake. The frequent bathroom trips at night did decrease though. F 46 2 weeks
6/5/2008
 5  Migraines dry mouth, funny taste in my mouth I have been taking this medication every day for 18 years. I was experiencing extreme visual problems such as temporary blindness, double vision, etc... and had been through tons of doctors, procedures, tests... Tofranil was prescribed to me for what they suspected was migraines in the occipital lobe of my brain, although I never experienced headaches. I got better immediately and have been maintained on 75mg a day since. I was young, in graduate school and thought I was loosing my mind. This medicine saved my life. One strange thing I noticed right away. I get a very funny taste in my mouth if I am late taking a dose or miss a dose. Now I take the PM brand so it does not happen near as much. F 43 18 years
3/19/2008
 5  Depression, anxiety, eating disorde dry mouth, constipation, fast heart beat, developed some speech problems which got better when lowered dosage to 125mg, no sex drive, I found imipramine to be one of the many tried anti-depressants that worked. I was once on 300mg a day through some bad times but have been on 150mg since 2003 and now for the last month am on 125mg. Found i developed speech problems and would say the wrong words and clutter my speech. This has improved now i am on 125mg. Having headaches tho and some down moments but determined to not increase dose again. Trying to get past the withdrawral symptons. F 28 6 days
2/19/2008

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