Average Rating: 1.6 (104 Ratings)

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 Type: Over-the-counter Drug

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on PEPCID AC: Reviews Summary  |  Drug Safety Information

 1  Heartburn Heart racing, ringing in the ears, head ache, bad taste in mouth, dry mouth, stomach ache. F 56 2 days
40 2X D
 1  Indigestion I just started experiencing side effects,extreme dizziness, heart palpitations,brain fog,weakness in legs. Seen cardiologist, and wearing heart monitor. Read up on side effects and after reading other comments am taking myself off of this med. Surprised my doctor didn't think this might be the cause of all my problems I F 74 2 years
20mg 1X D
 1  LPR/GERD - aid weaning off PPI Severe racing and pounding heartbeat for almost 12 hours with shortness of breath. Could not sleep the entire night because of it. F 42 1 days
10mg 1X D
 1  Acid reflux voice box polyps Horrible heart palpitations heart rate up to 210. This went on for 5 hours. Went to md now they recommended I see a cardiologist. I will follow up with a cardiologist but the Pepcid went right in the trash! F 50 75 days
40 1X D
 1  Heart burn, sharp back pain I have been taking prescription famotidine with no issue until My insurance wouldn't allow me to refill the script unless it's mail order (apparently some change In policy) so the pharmacy recommended taking Pepcid ac 2x a day in the interim while my medication comes in. Randomly, 12 hours after I took it I will get weird heart palpitations that would just not go away! Followed by some crazy anxiety out of nowhere. It really freaked me out. I really thought I was losing my mind. I told my husband there's got to be a correlation with this new medication. Then I stumbled upon this blog and thank God I did! Stopping usage immediately F 37 2 days
2 2X D
 1  Atrophic gastritis flare My first few days I felt fine but by day five it all went down hill. My heart started pounding, my heart rate increased, started having terrible leg pains, pains near my kidneys, fatigue, chest pain, anxiety and dizziness. I knew it was this because I don't take anything other than this. I went to the doctor told me everything was fine but had me fitted for a heart monitor just in case. I've have these terrible reactions to ppis also but they were never as bad as this. Pepcid AC takes the cake on all of them, I can't believe how bad the side effects can get. I went from working out and weight training six days a week to maybe two because of how scary my heart issues are. I'm praying the side effects subside. F 31 7 days
40mg 2X D
 3  LPR Love and hate relationship for pepcid. Its super duper helpful if you have LPR symptoms. Had to take it a few days ago and I knew I would get mad side effects from it (due to past experiences) but I had no choice since my reflux prevented me from having any sleep. I get internal tremors and anxiety as my side effects every time I take it which isn't a great combo! I took it for 2 days and surprisingly no side effects on those 2 days i took it, but 2 days later I got the side effects (starting from yesterday). Man if only this didn't have side effects for me it wouldve been perfect Take it when you really need it because it truly helps, but beware the side effects isn't going to be a great ride! 17 2 days
20 MG 1X D
 1  Heartburn/GERD I was just diagnosed with PVCs & V Tach... came to look up Pepcid and so glad I did! Like others, I went to Pepcid after Zantac was recalled. I am stopping Pepcid ASAP and they are doing another holter monitor, very interested to see if there's change (it is a 30 day monitor). F 42 4 months
20mg 1X D
 1  Gerd Works good for my Gerd symptoms but since taking it I have trouble falling asleep and when I do fall asleep I have horrible vivid dreams that wake me up all night. I never had this problem when I took Zantac. F 50 1 months
20 mg 1X D
 1  Gerd Symptoms Severe Heart Palpitations/PVCs, Extreme anxiety, tingling in fingers and legs, tunnel vision on waking, muscle spasms, ringing in ears, vision abnormalities, TMJ, dizziness/vertigo symptoms, breathing difficulty I thought I was losing my mind. It took over a year for me to find Pepcid may have been the cause. I'm so sick with anxiety due to all of these strange symptoms. I've spent thousands of dollars for tests that always come back normal. I stopped taking it yesterday, hoping these side effects pass. F 38 1 years
20mg 2X D
 1  Gerd, Heartburn Severe heart palpitations, increased blood pressure, back pain, joint pain, swollen hands & feet, numbness in extremities, headache, constant tinnitus, dizziness, extreme fatigue at this point I have been in the heart hospital twice for overnight observation, after visits to the ER! My labs come back perfect. The doctors give me anxiety meds & BP meds that "don't work the way they're supposed to", so we try different meds. On and on this goes, for years... Until I found this page!! After multiple Dr visits in which I list Pepcid as a daily medication, you'd think someone in the medical community would know about these side effects and say something! Why is this crap still available OTC?! F 39 0 years
10-20mg 2X D
 1  GERD Palpitations each time I have taken it F 28 3 days
20 mg 1X D
 1  Supposedly Gerd? Severe heart palpitations and back pains in kidney area. Unable to sleep at night. I would not recommend this medication to anyone as it does have long term affects. I was in good shape until I took this now I can hardly exercise. F 63 2 weeks
40mg 1X D
 1  Supposedly Gerd? Severe heart palpitations and back pains in kidney area I would not recommend this medication to anyone as it does have long term affects. I was in good shape until I took this now I can hardly exercise. F 63 0 weeks
40mg 1X D
 1  acid reflux palpitations started 10 days after taking. The palpitations are so bad that I called my cardiologist and he ordered an event monitor for me. I stopped taking the drug 4 days ago and already see an improvement, but still not back to normal. If anyone else had severe (very scary) palpitations, can you tell me how long they lasted after stopping pepcid. F 57 3 weeks
10mg 1X D
 1  GERD I can't believe these comments I'm reading. It's so reassuring that women my same are age feeling EXACTLY what I'm feeling. Over the last five months I've had increasing anxiety to the point that it's constant. Waking with heart palpitations. I have GAD and take the lowest dose of Effexor. Was thinking I need to up my meds. Meeting with cardiologist and I am taking these reviews. Stopping Famotidine immediately! I'd rather deal with the acid reflux. Do not take!!! F 41 5 months
1X D
 3  Stomach Acid Works well for stomach acid BUT experienced some pretty strong heart palpitations over the last hour. Like drive me to the ER level. To the degree that I came online to see if others had this experience as well. Subsiding now. I have extremely bad stomach acid, but will probably avoid using this, OTC or not. Palpitations are scary. Back to the TUMS looks like. Arghhh! Good luck Everyone. F 51 2 months
10 MG 2X D
 1  Heartburn Palpitations and anxiety I had been taking this intermittently over the past few months. Symptoms just as other's have described. Very scary to have palpitations and anxiety for hours after this med. It took me awhile to figure out the connection. F 42 90 days
10 1X D
 1  Acid reflux Blood pressure extremely low. Heart palpitations. Shortness of breath. F 71 4 weeks
10 mg 2X D
 1  Gastritis, ulcer Heart racing/ pounding, anxiety, PVCs , increased pulse, fatigue, weird dreams. Took Pepcid for about 3 months for gastritis and an ulcer. Side effects happened pretty much right away, I thought they would go away with time. They did not. They got so bad I went to the ER with heart palpitations. All tests came back normal but was showing some PVCs on monitor. EKG was normal, all blood work and cardiac enzymes normal, CXR normal. I stopped taking Pepcid that day. It's been 10 days and I'm slowly starting to feel better. Still having PVCs with exertion. I hope this goes away soon. F 44 3 months
20 mg 2X D

PEPCID AC  (FAMOTIDINE):  Famotidine is used to treat ulcers of the stomach and intestines and to prevent intestinal ulcers from coming back after they have healed. This medication is also used to treat certain stomach and throat (esophagus) problems (such as erosive esophagitis, gastroesophageal reflux disease-GERD, Zollinger-Ellison syndrome). It works by decreasing the amount of acid your stomach makes. It relieves symptoms such as cough that doesn't go away, stomach pain, heartburn, and difficulty swallowing. Famotidine belongs to a class of drugs known as H2 blockers. This medication is also available without a prescription. It is used to prevent and treat heartburn and other symptoms caused by too much acid in the stomach (acid indigestion). If you are taking this medication for self-treatment, it is important to read the manufacturer's package instructions carefully so you know when to consult your doctor or pharmacist.   (Sources: U.S. Centers for Medicare Services, FDA)